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| 1 | Use of probiotics for prevention of radiation-induced diarrhea显示文摘AIM: To investigate the efficacy of a high-potency probiotic preparation on prevention of radiation-induced diarrhea in cancer patients. METHODS: This was a double-blind, placebo-controlled trial. Four hundred and ninety patients who underwent adjuvant postoperative radiation therapy after surgery for sigmoid, rectal, or cervical cancer were assigned to either the high-potency probiotic preparation VSL#3 (one sachet t.i.d.,) or placebo starting from the first day of radiation therapy. Efficacy endpoints were incidence and severity of radiation-induced diarrhea, daily number of bowel movements, and the time from the start of the study to the use of loperamide as rescue medication. RESULTS: More placebo patients had radiation-induced diarrhea than VSL#3 patients (124 of 239 patients, 51.8%, and 77 of 243 patients, 31.6%; P < 0.001) and more patients given placebo suffered grade 3 or 4 diarrhea compared with VSL#3 recipients (55.4% and 1.4%, P < 0.001). Daily bowel movements were 14.7 ± 6 and 5.1 ± 3 among placebo and VSL#3 recipients (P < 0.05), and the mean time to the use of loperamide was 86 ± 6 h for placebo patients and 122 ± 8 h for VSL#3 patients (P < 0.001). CONCLUSION: Probiotic lactic acid-producing bacteria are an easy, safe, and feasible approach to protect cancer patients against the risk of radiation-induced diarrhea. | P Delia G Sansotta V Donato P Frosina G Messina C De Renzis G Famularo | 2007 | World Journal of Gastroenterology2007，13，6： | 29 |
| 2 | CHK2 kinase in the DNA damage response and beyond显示文摘serine/threonine kinase CHK2 是 DNA 损坏反应的一个关键部件。在人的房间,跟随 genotoxic 应力, CHK2 被激活并且 phosphorylates >导致适当细胞的反应的 20 蛋白质,它,取决于损坏,房间类型,和另外的因素的程度,能是房间周期检查点激活, apoptosis 或老朽感应, DNA 修理,或损坏的忍耐。最近, CHK2 也被发现了有独立于原子 DNA 损害的存在的细胞的功能。特别地, CHK2 参予涉及 DNA 结构修正和房间周期前进的几个分子的过程。在这评论,我们在不着重的房间响应 DNA 损坏并且在生物功能的维护讨论 CHK2 的活动。这些活动也在 tumorigenesis 在与 CHK2 的一个可能的角色的关系被考虑并且作为后果,作为癌症的一个目标治疗。 | Laura Zannini Domenico Delia Giacomo Buscemi | 2014 | Journal of Molecular Cell Biology2014，8，6： | 12 |
| 3 | Role of osteoprotegerin/receptor activator of nuclear factor kappa B/receptor activator of nuclear factor kappa B ligand axis in nonalcoholic fatty liver disease显示文摘Concomitantly with the increase in the prevalences of overweight/obesity, nonalcoholic fatty liver disease(NAFLD) has worldwide become the main cause of chronic liver disease in both adults and children. Patients with fatty liver display features of metabolic syndrome(Met S), like insulin resistance(IR), glucose intolerance, hypertension and dyslipidemia. Recently, epidemiological studies have linked obesity, Met S, and NAFLD to decreased bone mineral density and osteoporosis, highlighting an intricate interplay among bone, adipose tissue, and liver. Osteoprotegerin(OPG), an important symbol of the receptor activator of nuclear factor-B ligand/receptor activator of nuclear factor kappa B/OPG system activation, typically considered for its role in bone metabolism, may also play critical roles in the initiation and perpetuation of obesityrelated comorbidities. Clinical data have indicated that OPG concentrations are associated with hypertension, left ventricular hypertrophy, vascular calcification, endothelial dysfunction, and severity of liver damage in chronic hepatitis C. Nonetheless, the relationship between circulating OPG and IR as a key feature of Met S as well as between OPG and NAFLD remains uncertain. Thus, the aims of the present review are to provide the existent knowledge on these associations and to discuss briefly the underlying mechanisms linking OPG and NAFLD. | Lucia Pacifico Gian Marco Andreoli Miriam D'Avanzo Delia De Mitri Pasquale Pierimarchi | 2018 | World Journal of Gastroenterology2018，24，19： | 11 |
| 4 | Key nodes of a micro RNA network associated with the integrated mesenchymal subtype of high-grade serous ovarian cancer显示文摘Metastasis is the main cause of cancer mortality. One of the initiating events of cancer metastasis of epithelial tumors is epithelial-to-mesenchymal transition(EMT), during which cells dedifferentiate from a relatively rigid cell structure/morphology to a flexible and changeable structure/morphology often associated with mesenchymal cells. The presence of EMT in human epithelial tumors is reflected by the increased expression of genes and levels of proteins that are preferentially present in mesenchymal cells. The combined presence of these genes forms the basis of mesenchymal gene signatures, which are the foundation for classifying a mesenchymal subtype of tumors. Indeed, tumor classification schemes that use clustering analysis of large genomic characterizations, like The Cancer Genome Atlas(TCGA), have defined mesenchymal subtype in a number of cancer types, such as high-grade serous ovarian cancer and glioblastoma. However, recent analyses have shown that gene expression-based classifications of mesenchymal subtypes often do not associate with poor survival. This 'paradox' can be ameliorated using integrated analysis that combines multiple data types. We recently found that integrating m RNA and micro RNA(mi RNA) data revealed an integrated mesenchymal subtype that is consistently associated with poor survival in multiple cohorts of patients with serous ovarian cancer. This network consists of 8 major mi RNAs and 214 m RNAs. Among the 8 mi RNAs, 4 are known to be regulators of EMT. This review provides a summary of these 8 mi RNAs, which were associated with the integrated mesenchymal subtype of serous ovarian cancer. | Yan Sun Fei Guo Marina Bagnoli Feng-Xia Xue Bao-Cun Sun Ilya Shmulevich Delia Mezzanzanica Ke-Xin Chen Anil K. Sood Da Yang Wei Zhang | 2015 | Chinese Journal of Cancer2015，34，1： | 10 |
| 5 | Ovarian cancer:a molecularly insidious disease显示文摘In this issue of the Chinese Journal of Cancer,European,American,and Chinese experts review the current management and future perspectives of epithelial ovarian cancer(EOC),the leading cause of gynecological cancer deaths.Although major advances have been made in understanding the cellular and molecular biology of this highly heterogeneous malignancy,the survival rate of women with EOC has changed little since the introduction of platinum-based treatment as a front-line therapy.The papers describe the progress in deciphering the molecular complexity of this disease and the newly available molecular-driven therapies,which have been applied by shifting trial designs toward restricting eligibility to specific subgroups of patients rather than testing agents in unselected populations.These new trial designs provide potential opportunities for improved efficacy in targeted populations.Given the molecular complexity of this disease,patient survival may be increased by searching for new molecular prognostic/predictive signatures as well as by translating the recent insight of microRNA involvement in EOC progression into new,targeted therapies.Particular attention has been given to the issue of fertility sparing for women affected by curable diseases. | Delia Mezzanzanica | 2015 | Chinese Journal of Cancer2015，34，1： | 7 |
| 6 | Seasonal and geographical distribution of bacillary dysentery(shigellosis)and associated climate risk factors in Kon Tum Province in Vietnam from 1999 to 2013显示文摘Background:Bacillary dysentery(BD)is an acute bacterial infection of the intestine caused by Shigella spp.,with clinical symptoms ranging from fever to bloody diarrhoea to abdominal cramps to tenesmus.In Vietnam,enteric bacterial pathogens are an important cause of diarrhoea and most cases in children under 5 years of age are due to Shigella strains.The serogroups S.flexneri and S.sonnei are considered to be the most common.The main objective of this study was to,for the first time,assess the seasonal patterns and geographic distribution of BD in Vietnam,and to determine the climate risk factors associated with the incidence of BD in Kon Tum Province,where the highest rate of bacillary dysentery was observed from 1999 to 2013.Methods:The seasonal patterns and geographic distribution of BD was assessed in Vietnam using a seasonaltrend decomposition procedure based on loess.In addition,negative binomial regression models were used to determine the climate risk factors associated with the incidence of BD in Kon Tum Province,from 1999 to 2013.Results:Overall,incidence rates of BD have slightly decreased over time(except for an extremely high incidence in 2012 in the north of Vietnam).The central regions(north/south central coast and central highlands)had relatively high incidence rates,whereas the northwest/east and Red River Delta regions had low incidence rates.Overall,seasonal plots showed a high peak in the mid-rainy reason and a second smaller peak in the early or late rainy season.The incidence rates significantly increased between May and October(“wet season”)across the country.In Kon Tum Province,temperature,humidity,and precipitation were found to be positively associated with the incidence of BD.Conclusions:Our findings provide insights into the seasonal patterns and geographic distribution of BD in Vietnam and its associated climate risk factors in Kon Tum Province.This study may help clinicians and the general public to better understand the timings of outbreaks and therefore equip them with the knowledge to plan better interventions(such as improving water,sanitation,and hygiene conditions)during peak seasons.This can,in turn,prevent or reduce outbreaks and onwards transmission during an outbreak. | Hu Suk Lee TTHa Hoang Phuc Pham-Duc Mihye Lee Delia Grace Dac Cam Phung Vu Minh Thuc Hung Nguyen-Viet | 2017 | Infectious Diseases of Poverty2017，6，1： | 5 |
| 7 | Malfunction of outer retinal barrier and choroid in the occurrence and progression of diabetic macular edema显示文摘Diabetic macular edema(DME) is the most common cause of vision loss in diabetic retinopathy,affecting 1 in 15 patients with diabetes mellitus(DM).The disruption of the inner blood-retina barrier(BRB) has been largely investigated and attributed the primary role in the pathogenesis and progression in DME, but there is increasing evidence regarding the role of outer BRB, separating the RPE from the underlying choriocapillaris,in the occurrence and evolution of DME.The development of novel imaging technologies has led to major improvement in the field of in vivo structural analysis of the macula allowing us to delve deeper into the pathogenesis of DME and expanding our vision regarding this condition.In this review we gathered the results of studies that investigated specific outer BRB optical coherence tomography parameters in patients with DM with the aim to outline the current status of its role in the pathogenesis and progression of DME and identify new research pathways contributing to the advancement of knowledge in the understanding of this condition. | ŞtefanŢălu Simona Delia Nicoara | 2021 | World Journal of Diabetes2021，12，4： | 5 |
| 8 | 重庆地区TORCH感染的血清学调查显示文摘本研究对重庆地区正常人群的TORCH感染进行了血清学调查。共收集160份成人血清,多数为育龄期妇女者,以及100份脐带血清。对上述标本以IFA法检测了弓形体抗体(IgS和IgM),以ELISA法检测巨细胞病毒(CMV)抗体(CMV-IgG和CMV-IgM),以乳胶凝集法检测风疹抗体,以及以补体结合试验(CF)检测单纯疱疹抗体。成人的弓形体、CMV、风疹、单纯疱疹感染率各为32.6%、72.0%、89.4%和79.4%;脐带血清的阳性率则各为21.4%、79.3%、78.9%和90.7%。 | 王其南 曹珍修 郑兴平 Donald Armstrong Pamela Berge Delia Budzko | 1989 | 重庆医科大学学报1989，14，3： | 4 |
| 9 | Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?显示文摘The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer. | Delia Cortes-Guiral Dominique Elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael Guijo Castellano Ana Isabel León Carbonero JoséIgnacio Martín Valadés Jesus Garcia-Foncillas Damian Garcia-Olmo | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 10 | Extrahepatic cholangiocarcinoma:Current status of endoscopic approach and additional therapies显示文摘The prognosis of patients with advanced or unresectable extrahepatic cholangiocarcinoma is poor.More than 50%of patients with jaundice are inoperable at the time of first diagnosis.Endoscopic treatment in patients with obstructive jaundice ensures bile duct drainage in preoperative or palliative settings.Relief of symptoms(pain,pruritus,jaundice)and improvement in quality of life are the aims of palliative therapy.Stent implantation by endoscopic retrograde cholangiopancreatography is generally preferred for long-term palliation.There is a vast variety of plastic and metal stents,covered or uncovered.The stent choice depends on the expected length of survival,quality of life,costs and physician expertise.This review will provide the framework for the endoscopic minimally invasive therapy in extrahepatic cholangiocarcinoma.Moreover,additional therapies,such as brachytherapy,photodynamic therapy,radiofrequency ablation,chemotherapy,molecular-targeted therapy and/or immunotherapy by the endoscopic approach,are the nonsurgical methods associated with survival improvement rate and/or local symptom palliation. | Alina Ioana Tantau Alina Mandrutiu Anamaria Pop Roxana Delia Zaharie Dana Crisan Carmen Monica Preda Marcel Tantau Voicu Mercea | 2021 | World Journal of Hepatology2021，13，2： | 3 |
| 11 | Moro orange juice prevents fatty liver in mice显示文摘AIM:To establish if the juice of Moro,an anthocyaninrich orange,may improve liver damage in mice with diet-induced obesity.METHODS:Eight-week-old mice were fed a high-fat diet(HFD) and were administrated water or Moro juice for 12 wk.Liver morphology,gene expression of lipid transcription factors,and metabolic enzymes were assessed.RESULTS:Mice fed HFD displayed increased body weight,insulin resistance and dyslipidemia.Moro juice administration limited body weight gain,enhanced insulin sensitivity,and decreased serum triglycerides and total cholesterol.Mice fed HFD showed liver steatosis associated with ballooning.Dietary Moro juice markedly improved liver steatosis by inducing the expression of peroxisome proliferator-activated receptor-α and its target gene acylCoA-oxidase,a key enzyme of lipid oxidation.Consistently,Moro juice consumption suppressed the expression of liver X receptor-α and its target gene fatty acid synthase,and restored liver glycerol-3-phosphate acyltransferase 1 activity.CONCLUSION:Moro juice counteracts liver steatogenesis in mice with diet-induced obesity and thus may represent a promising dietary option for the prevention of fatty liver. | Federico Salamone Giovanni Li Volti Lucilla Titta Lidia Puzzo Ignazio Barbagallo Francesco La Delia Shira Zelber-Sagi Michele Malaguarnera Pier Giuseppe Pelicci Marco Giorgio Fabio Galvano | 2012 | World Journal of Gastroenterology2012，18，29： | 2 |
| 12 | Iron Activation of Natural Aluminosilicates to Remove Arsenic from Groundwater显示文摘 | Irma Lia Botto Maria Jose Gonzalez Delia Gazzolli Edgardo Luis Soto | 2013 | Journal of Environmental Science and Engineering(A)2013，2，12： | 2 |
| 13 | Aluminum site structure in serum transferrin and lactoferrin revealed by synchrotron radiation X-ray spectroscopy显示文摘 | Congiu-Castellano A Boffi F Delia L S | 1997 | Bio Metals1997，10，： | 1 |
| 14 | Genetic diversity evaluation of a loquat ( Eriobotrya japonica ( Thunb ) Lindl) gerrnplasm collection by SSRs and S-allele fragments显示文摘 | Ana Delia Gisbert Carlos Romero Jose MartineZ-Cal- vo | 2009 | Eu- phytica2009，168，： | 1 |
| 15 | Real-time transient stability assessment based on centre-of-inertia estimation from phasor measurement unit records显示文摘 | JAIME C C JOS] L R DELIA G C | 2014 | IET Gener Transm Distrib2014，8，8： | 1 |
| 16 | Cycloartane triterpenes from Juncus effusus显示文摘 | Marina Delia Greca Antonio Fiorentino Pietromonaco | 1994 | Phytochemistry1994，35，4： | 1 |
| 17 | Post-thoracotomy analgesia: epidural versus intravenous morphine continuous infusion 显示文摘 | Delia RG Coccia C Pompei L | 2002 | Mi- nerva Anesthesiology2002，68，9： | 1 |
| 18 | Hypoxia in the regulation of neural stem cells显示文摘 | De Filippis L Delia D | | 0，，： | 1 |
| 19 | Bcl-2 gene hypomethylation and high level expression in B-cell chronic lymphocytic leukemia显示文摘 | Hanada M Delia D Aiello A | 2013 | {H}Blood2013，，05： | 1 |
| 20 | HOPS: a novel cAMP-dependent shuttling protein involved in protein synthesis regulation显示文摘 | Delia Fazia MA Castelli M Bartoli D | 2005 | J Cell Sci2005，118，14： | 1 |
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