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| 1 | Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of liver-related morbidity and mortality. It can develop secondary to numerous causes but a great majority of NAFLD cases occur in patients who are obese or present with other components of metabolic syndrome (hypertension, dyslipidemia, diabetes). This is called primary NAFLD and insulin resistance plays a key role in its pathogenesis. Obesity is characterized by expanded adipose tissue, which is under a state of chronic inflammation. This disturbs the normal storage and endocrine functions of adipose tissue. In obesity, the secretome (adipokines, cytokines, free fatty acids and other lipid moieties) of fatty tissue is amplified, which through its autocrine, paracrine actions in fat tissue and systemic effects especially in the liver leads to an altered metabolic state with insulin resistance (IR). IR leads to hyperglycemia and reactive hyperinsulinemia, which stimulates lipid-accumulating processes and impairs hepatic lipid metabolism. IR enhances free fatty acid delivery to liver from the adipose tissue storage due to uninhibited lipolysis. These changes result in hepatic abnormal fat accumulation, which may initiate the hepatic IR and further aggravate the altered metabolic state of whole body. Hepatic steatosis can also be explained by the fact that there is enhanced dietary fat delivery and physical inactivity. IR and NAFLD are also seen in various lipodystrophic states in contrary to popular belief that these problems only occur due to excessive adiposity in obesity. Hence, altered physiology of adipose tissue is central to development of IR, metabolic syndrome and NAFLD. | Kamran Qureshi Gary A Abrams | 2007 | World Journal of Gastroenterology2007，13，26： | 52 |
| 2 | Early osmotic adjustment responses in drought-resistant and drought-sensitive oilseed rape显示文摘The impact of osmotic stress on growth, physiology, and metabolism of winter oilseed rape(Brassica napus L.)was investigated by detailed analysis of biomass traits,hormone metabolites and osmolytes in two genetically unrelated drought-tolerant genotypes and two unrelated drought-sensitive genotypes. Seedlings were grown in vitro under controlled conditions and osmotic stress was simulated by applying a gradual treatment with polyethylene glycol(PEG6000), followed by hypo-osmotic treatment of variants used for metabolite determination. The results provide a basis for the identification of reliable selection criteria for drought resistance in oilseed rape. The in vitro cultivation system established during this study enabled effective discrimination of early osmotic stress responses between drought-resistant and -susceptible oilseed rape genotypes that also show large differences in relative seed yield under drought conditions in the field. Clear physiological and metabolic differences were observed between the drought-resistant and drought-sensitive genotypes, suggesting that osmotic adjustment is a key component of drought response in oilseed rape. Unexpected ly, however, the drought-resistant genotypes did not show typical hormonal adjustment and osmolyte accumulation suggesting that they possess alternative physiological mech anisms enabling avoidance of stress symptoms. | Sarah Hatzig L.Irina Zaharia Suzanne Abrams Marie Hohmann Laurie Legoahec Alain Bouchereau Nathalie Nesi Rod J.Snowdon | 2014 | Journal of Integrative Plant Biology2014，56，8： | 5 |
| 3 | Resected adenocarcinoma of the pancreas— 616 patients: Results, outcomes, and prognostic indicators显示文摘 | Taylor A. Sohn M.D. Charles J. Yeo M.D. Jokn L. Cameron M.D. Leonidas Koniaris M.D. Sunjay Kaushal M.D. Ross A. Abrams M.D. Patricia K. Sauter A.C.N.P. JoAnn Coleman A.C.N.P. Ralph H. Hruban M.D. Keith D. Lillemoe M.D | 2000 | Journal of Gastrointestinal Surgery2000，，6： | 4 |
| 4 | Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial显示文摘 | Somnath Mukherjee Christopher N Hurt John Bridgewater Stephen Falk Sebastian Cummins Harpreet Wasan Tom Crosby Catherine Jephcott Rajarshi Roy Ganesh Radhakrishna Alec McDonald Ruby Ray George Joseph John Staffurth Ross A Abrams Gareth Griffiths Tim Maugh | 2013 | Lancet Oncology2013，，4： | 4 |
| 5 | 乌尔逊凹陷苏仁诺尔CO_(2)气藏主控因素分析显示文摘乌尔逊凹陷苏仁诺尔走滑断裂带西部南屯组发育天然CO_(2)气藏。利用测井、地震、岩心、生产数据等资料,采用序贯高斯模拟方法,建立苏仁诺尔气田南屯组三维地质模型,包括构造模型(地层、断裂带)、岩性模型、物性模型,分析乌尔逊凹陷南屯组的地层格架、断裂分布,以及砂岩储层和物性的三维空间展布特征。结果表明:乌尔逊凹陷苏仁诺尔气田南屯组储层具有低孔隙度、低渗透率的特点,CO_(2)气藏主要分布于断裂活动带构造高点。苏仁诺尔走滑断裂带作为运移通道,对CO_(2)气藏分布起决定性作用;储层岩性和物性在控制CO_(2)气藏聚集和分布中起次要作用。该结果对寻找研究区CO_(2)气藏及后期勘探开发具有指导意义。 | 齐宁 薛海涛 卢双舫 杨金秀 卢明月 夏萦 曹怿昕 MUHAMMAD Saqib RAYON Abrams | 2021 | 东北石油大学学报2021，45，3： | 3 |
| 6 | Fulminant myocarditis in adults: a narrative review显示文摘Fulminant myocarditis(FM)is an uncommon syndrome characterized by sudden and severe hemodynamic compromise secondary to acute myocardial inflammation,often presenting as profound cardiogenic shock,life-threatening ventricular arrhythmias and/or electrical storm.FM may be refractory to conventional therapies and require mechanical circulatory support(MCS).The immune system has been recognized as playing a pivotal role in the pathophysiology of myocarditis,leading to an increased focus on immunosuppressive treatment strategies.Recent data have highlighted not only the fact that FM has significantly worse outcomes than non-FM,but that prognosis and management strategies of FM are heavily dependent on histological subtype,placing greater emphasis on the role of endomyocardial biopsy in diagnosis.The impact of subtype on severity and prognosis will likewise influence how aggressively the myocarditis is managed,including whether MCS is warranted.Many patients with refractory cardiogenic shock secondary to FM end up requiring MCS,with venoarterial extracorporeal membrane oxygenation demonstrating favorable survival rates,particularly when initiated prior to the development of multiorgan failure.Among the challenges facing the field are the need to more precisely identify immunopathophysiological pathways in order to develop targeted therapies,and the need to better optimize the timing and management of MCS to minimize complications and maximize outcomes. | Santiago Montero Darryl Abrams Enrico Ammirati Florent Huang Dirk WDonker Guillaume Hekimian Cosme García-García Antoni Bayes-Genis Alain Combes Matthieu Schmidt | 2022 | Journal of Geriatric Cardiology2022，19，2： | 3 |
| 7 | Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance显示文摘 | James A. McCubrey Linda S. Steelman William H. Chappell Stephen L. Abrams Ellis W.T. Wong Fumin Chang Brian Lehmann David M. Terrian Michele Milella Agostino Tafuri Franca Stivala Massimo Libra Jorg Basecke Camilla Evangelisti Alberto M. Martelli Richard | 2006 | BBA - Molecular Cell Research2006，，8： | 3 |
| 8 | Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway显示文摘BACKGROUND Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common and causes more than one million deaths annually.Fibrosis develops from recurrent liver injury but the molecular mechanisms are not fully understood.Recently,the TLR4-MyD88 signaling pathway has been reported to contribute to fibrosis.Extracellular histones are ligands of TLR4 but their roles in liver fibrosis have not been investigated.AIM To investigate the roles and potential mechanisms of extracellular histones in liver fibrosis.METHODS In vitro,LX2 human hepatic stellate cells(HSCs)were treated with histones in the presence or absence of non-anticoagulant heparin(NAHP)for neutralizing histones or TLR4-blocking antibody.The resultant cellular expression of collagen I was detected using western blotting and immunofluorescent staining.In vivo,the CCl4-induced liver fibrosis model was generated in male 6-week-old ICR mice and in TLR4 or MyD88 knockout and parental mice.Circulating histones were detected and the effect of NAHP was evaluated.RESULTS Extracellular histones strongly stimulated LX2 cells to produce collagen I.Histone-enhanced collagen expression was significantly reduced by NAHP and TLR4-blocking antibody.In CCl4-treated wild type mice,circulating histones were dramatically increased and maintained high levels during the duration of fibrosisinduction.Injection of NAHP not only reduced alanine aminotransferase and liver injury scores,but also significantly reduced fibrogenesis.Since the TLR4-blocking antibody reduced histone-enhanced collagen I production in HSC,the CCl4 model with TLR4 and MyD88 knockout mice was used to demonstrate the roles of the TLR4-MyD88 signaling pathway in CCl4-induced liver fibrosis.The levels of liver fibrosis were indeed significantly reduced in knockout mice compared to wild type parental mice.CONCLUSION Extracellular histones potentially enhance fibrogenesis via the TLR4–MyD88 signaling pathway and NAHP has therapeutic potential by detoxifying extracellular histones. | Zhi Wang Zhen-Xing Cheng Simon T Abrams Zi-Qi Lin ED Yates Qian Yu Wei-Ping Yu Ping-Sheng Chen Cheng-Hock Toh Guo-Zheng Wang | 2020 | World Journal of Gastroenterology2020，26，47： | 3 |
| 9 | Synthetic Vaginal Tapes for Stress Incontinence: Proposals for Improved Regulation of New Devices in Europe显示文摘 | Paul Abrams Christopher R. Chapple Marcus Drake Suzy El-Neil Susanne Ludgate Anthony R.B. Smith | 2011 | European Urology2011，，： | 3 |
| 10 | Cholangiocarcinoma: A Spectrum of Intrahepatic, Perihilar, and Distal Tumors显示文摘 | Attila Nakeeb Henry A. Pitt Taylor A. Sohn JoAnn Coleman Ross A. Abrams Steven Piantadosi Ralph H. Hruban Keith D. Lillemoe Charles J. Yeo John L. Cameron | 1996 | Annals of Surgery1996，，4： | 3 |
| 11 | A RANDOMIZED TRIAL COMPARING TRANSURETHRAL RESECTION OF THE PROSTATE, LASER THERAPY AND CONSERVATIVE TREATMENT OF MEN WITH SYMPTOMS ASSOCIATED WITH BENIGN PROSTATIC ENLARGEMENT: THE CLasP STUDY显示文摘 | JENNY L. DONOVAN TIM J. PETERS DAVID E. NEAL SARA T. BROOKES SANDEEP GUJRAL K. NINAN CHACKO MARK WRIGHT L. GAIL KENNEDY PAUL ABRAMS | 2000 | The Journal of Urology2000，，1： | 3 |
| 12 | Colorectal cancer prevention in ulcerative colitis: a case‐control study显示文摘 | Eaden Abrams Ekbom Jackson Mayberry | 2001 | Aliment Pharmacol Ther2001，，2： | 2 |
| 13 | Prospective Quality Initiative to Maximize Dysphagia Screening Reduces Hospital-Acquired Pneumonia Prevalence in Patients With Stroke显示文摘 | W. Lee Titsworth Justine Abram Amy Fullerton Jeannette Hester Peggy Guin Michael F. Waters J Mocco | 2013 | Stroke2013，，11： | 2 |
| 14 | A Lethally Irradiated Allogeneic Granulocyte-Macrophage Colony Stimulating Factor-Secreting Tumor Vaccine for Pancreatic Adenocarcinoma: A Phase II Trial of Safety, Efficacy, and Immune Activation显示文摘 | Lutz Eric Charles J. Yeo Keith D. Lillemoe Barbara Biedrzycki Barry Kobrin Joseph Herman Elizabeth Sugar Steven Piantadosi John L. Cameron Sara Solt Beth Onners Irena Tartakovsky Miri Choi Rajni Sharma Peter B. Illei Hruban Ralph H. Ross A. Abrams Dung Le | 2011 | Annals of Surgery2011，，2： | 2 |
| 15 | Pulmonary Dysfunction in Chronic Liver Disease显示文摘 | Michael B Fallon Gary A Abrams | 2000 | Hepatology2000，，4： | 2 |
| 16 | Soil phosphorus as a potential non-point source for elevated strean phosphorus levels显示文摘 | ABRAMS MM etal | 1995 | Environment Qualyty1995，24，1： | 2 |
| 17 | Direct detection of activated platelets and platelet-derived microparticles in humans显示文摘 | Abrams CS Ellison N Budzynski AZ | 1990 | Blood1990，75，： | 2 |
| 18 | The Influence of Total Nodes Examined, Number of Positive Nodes, and Lymph Node Ratio on Survival After Surgical Resection and Adjuvant Chemoradiation for Pancreatic Cancer: A Secondary Analysis of RTOG 9704显示文摘 | Timothy N. Showalter Kathryn A. Winter Adam C. Berger William F. Regine Ross A. Abrams Howard Safran John P. Hoffman Al B. Benson John S. MacDonald Christopher G. Willett | 2011 | International Journal of Radiation Oncology Biology Physics2011，，5： | 2 |
| 19 | Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12显示文摘 | Birgit Oppmann Robin Lesley Bianca Blom Jackie C Timans Yuming Xu Brisdell Hunte Felix Vega Nancy Yu Jing Wang Komal Singh Francesca Zonin Elena Vaisberg Tatyana Churakova Man-ru Liu Daniel Gorman Janet Wagner Sandra Zurawski Yong-Jun Liu John S Abrams Ke | 2000 | Immunity2000，，5： | 2 |
| 20 | Inability of interferon and aminogunidine to alter Cryptosporidium parvum infection in mice with severe combined immunodeficiency显示文摘 | Kuhls T L Mosier D A Abrams V L | 1994 | Journal of Parasitology1994，80，3： | 2 |
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