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| 1 | Clinical Validation of Global Coagulation Tests to Guide Blood Component Transfusions in Cirrhosis and ACLF显示文摘Background and Aims:Patients with cirrhosis and acuteon-chronic liver failure(ACLF)may have bleeding complications and need for invasive procedures.Point-of-care(POC)coagulation tests like thromboelastography(TEG)and Sonoclot may be better for guiding patient management than the standard coagulation tests(SCTs),like prothrombin time,platelet count and international normalized ratio.Methods:We prospectively compared and validated the POC tests and SCTs in 70 persons with ACLF and 72 persons with decompensated cirrhosis who had clinical bleeding and checked for episodes of re-bleeding and transfusion requirements.We assessed pre-procedure requirement of blood components when correction was done based on an SCT or POC strategy.Results:Episodes of bleeding were seen in 45%and 28%of ACLF and cirrhosis patient,respectively(p=0.036),with the major site of bleeding being gastrointestinal(31%and 16%,respectively).Platelet counts correlated with TEG-maximum amplitude in cirrhosis(p=0.045)and prothrombin time correlated positively with TEG-reaction(R)time(p=0.032),TEG-Clot kinetics(K)time(p=0.042),Son-activated clotting time(p=0.038)and negatively with clot rate(p=0.043)in ACLF,making these correctable target variables in POC transfusion algorithms.Of 223 procedures,transfusion of fresh frozen plasma and platelet concentrate was reduced by 25%(p=0.035)and 20.8%(p=0.045)by using a POC strategy in 76 patients.Correction of deranged Son-activated clotting time and TEG-reaction time was noted in 68%and 72%after 24 h of fresh frozen plasma transfusion in ACLF and 85%and 80%in cirrhosis,respectively.Conclusions:Our study clinically validates that POC tests can better detect coagulation defects and transfusion thresholds in ACLF and cirrhosis,whereas use of conventional tests appear to be less suitable in patients with clinical bleeding.Trial Registration:NCT04332484. | Madhumita Premkumar Rohit Mehtani Smita Divyaveer Kamal Kajal Anand VKulkarni Syed Ahmed Harmanpreet Kaur Harpreet Kaur Radhakrishna Dhiman Ajay Duseja Arka De | 2021 | Journal of Clinical and Translational Hepatology2021，9，2： | 7 |
| 2 | Pulmonary nocardiosis due to Nocardia otitidiscaviarum in an immunocompetent host-A rare case report显示文摘Nocardiosis is a localized or disseminated infection caused by soil-borne aerobic actinomycetes. Pulmonary nocardiosis is a rare infection mostly occurring in immunocompromised patients.We reported a case of 36 year old immunocompetent non-smoker female patient with no premorbid illness who presented with fever,cough with scanty sputum,hemoptysis,left sided chest pain and exertional dyspnea for two weeks.There was no past history of tuberculosis,diabetes mellitus or steroid therapy.Chest X-ray showed homogenous peripherally based opacity in the left upper zone.Bronchoscopy was done and brushing sent for culture,which showed colonies with features of Nocardia species after 48 hours.Further phenotypic characterization revealed it to be Nocardia otitidiscaviarum.Patient was treated with cotrimaxazole for six months after which complete recovery was evidenced symptomatically and radiologically.We report this case to emphasize the fact that among the Nocardia species,Nocardia otitidiscaviarum as causative agent of pulmonary disease is rarely reported even in immunocompromised individuals. | Kusugodlu Ramamoorthi Baise Chandrappagouda Pruthvi Neeleshwara Radhakrishna Rao Jayaprakash Belle Kiran Chawla | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，5： | 4 |
| 3 | Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial显示文摘 | Somnath Mukherjee Christopher N Hurt John Bridgewater Stephen Falk Sebastian Cummins Harpreet Wasan Tom Crosby Catherine Jephcott Rajarshi Roy Ganesh Radhakrishna Alec McDonald Ruby Ray George Joseph John Staffurth Ross A Abrams Gareth Griffiths Tim Maugh | 2013 | Lancet Oncology2013，，4： | 4 |
| 4 | A Review of Graph Neural Networks and Their Applications in Power Systems显示文摘Deep neural networks have revolutionized many machine learning tasks in power systems,ranging from pattern recognition to signal processing.The data in these tasks are typically represented in Euclidean domains.Nevertheless,there is an increasing number of applications in power systems,where data are collected from non-Euclidean domains and represented as graph-structured data with high-dimensional features and interdependency among nodes.The complexity of graph-structured data has brought significant challenges to the existing deep neural networks defined in Euclidean domains.Recently,many publications generalizing deep neural networks for graph-structured data in power systems have emerged.In this paper,a comprehensive overview of graph neural networks(GNNs)in power systems is proposed.Specifically,several classical paradigms of GNN structures,e.g.,graph convolutional networks,are summarized.Key applications in power systems such as fault scenario application,time-series prediction,power flow calculation,and data generation are reviewed in detail.Furthermore,main issues and some research trends about the applications of GNNs in power systems are discussed. | Wenlong Liao Birgitte Bak-Jensen Jayakrishnan Radhakrishna Pillai Yuelong Wang Yusen Wang | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，2： | 3 |
| 5 | Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: Summary of a symposium显示文摘 | Vishnudutt Purohit J. Christian Bode Christiane Bode David A. Brenner Mashkoor A. Choudhry Frank Hamilton Y. James Kang Ali Keshavarzian Radhakrishna Rao R. Balfour Sartor Christine Swanson Jerrold R. Turner | 2008 | Alcohol2008，，5： | 3 |
| 6 | Thermal Degradation and Decomposition Kinetics of Freeze Dried Cow and Camel Milk as well as Their Constituents显示文摘 | K. V. Sunooj J. George V. A. Sajeev Kumar K. Radhakrishna A. S. Bawa | 2011 | Journal of Food Science and Engineering2011，1，2： | 2 |
| 7 | Response reduction factor of irregular RC buildings in Kathmandu valley显示文摘Most current seismic design includes the nonlinear response of a structure through a response reduction factor(R). This allows the designer to use a linear elastic force-based approach while accounting for nonlinear behavior and deformation limits. In fact, the response reduction factor is used in modern seismic codes to scale down the elastic response of a structure. This study focuses on estimating the actual ‘R' value for engineered design/construction of reinforced concrete(RC) buildings in Kathmandu valley. The ductility and overstrength of representative RC buildings in Kathmandu are investigated. Nonlinear pushover analysis was performed on structural models in order to evaluate the seismic performance of buildings. Twelve representative engineered irregular buildings with a variety of characteristics located in the Kathmandu valley were selected and studied. Furthermore, the effects of overstrength on the ductility factor, beam column capacity ratio on the building ductility, and load path on the response reduction factor, are examined. Finally, the results are further analyzed and compared with different structural parameters of the buildings. | Hemchandra Chaulagain Hugo Rodrigues Enrico Spacone Ramesh Guragain Radhakrishna Mallik Humberto Varum | 2014 | Earthquake Engineering and Engineering Vibration2014，13，3： | 2 |
| 8 | A fiber optic biosensor for the detection of cholesterol levels based on chitosan coated long period grating显示文摘A fiber optic sensor for the measurement of total cholesterol is designed and developed.The developed chitosan coated long period grating(LPG) sensor shows a sensitivity of 5.025×106 pm·m L/g in the measurement range of the sensor.The sensor also shows a linear response in the measured range of cholesterol levels,which is highly desirable for exploitation as a commercial cholesterol sensor. | C.Bobby Mathews T.M.Libish B.Kaushalkumar V.Vivek Radhakrishna Prabhu P.Radhakrishnan | 2016 | Optoelectronics Letters2016，12，1： | 2 |
| 9 | LC method for the determination of as say and purity of sibutra-mine hydrochloride and its enantiomers by chiral chromatogra-phy显示文摘 | Radhakrishna T Lakshmi Narayana C H Sreenivas Rao D | 2000 | Journal of Pharmaceutical and Biomedical Analysis2000，22，4： | 1 |
| 10 | Primary ciliary dyskinesia:a genome-wide linkage analysis reveals extensive locus heterogeneity显示文摘 | Blouin JL Meeks M Radhakrishna U | 2000 | Eur J Hum Genet2000，8，2： | 1 |
| 11 | Induction of apoptosis in human lung cancer cells by curcumin 显示文摘 | Radhakrishna Pillail G Srivastaval AS Hassanein TI Chauhan DP Carrier E | 2004 | Cancer Lett2004，208，2： | 1 |
| 12 | Heat-resistant anti-corrosive paint from epoxy-silicone vehicles显示文摘 | Mathivanan L Radhakrishna S | 1997 | Anti-corrosion Methods and Materials1997，44，6： | 1 |
| 13 | Development of an immunological staging system to prognosticate disese course in malignant overical nepolasia显示文摘 | Balaram P Chidambaram S | 1990 | Gynecoiogic Oncology1990，37，： | 1 |
| 14 | Mutation in GL13 in postaxial polydactyly type A显示文摘 | Radhakrishna U Wild A Gizeschik KH | 1997 | Nature Genet1997，17，3： | 1 |
| 15 | Importance of grouting to enhance the performance of earth energy systems 显示文摘 | Lenarduzzi Frank J Cragg Chris B H Radhakrishna H S | 2000 | ASHRAE Transactions2000，106，： | 1 |
| 16 | Sedimentation history and development of fan system along the continental margins of India显示文摘 | Bastia R Radhakrishna M | 2012 | Developments in Petroleum Science2012，59，： | 1 |
| 17 | SLIC superpixels compared to state - of- the - art superpixel methods 显示文摘 | Radhakrishna A Appu S Kevin S | 2012 | IEEE Transactions on Pattern Analysis & Machine Intelli- gence2012，34，11： | 1 |
| 18 | Volume change characteristics of partially saturated soils显示文摘 | MATYAS E L RADHAKRISHNA H S | 1968 | Geotechnique1968，18，4： | 1 |
| 19 | Inferring Investor Behavior:Evidence from TORQ Data显示文摘 | Lee C.M Radhakrishna B | | 0，，02： | 1 |
| 20 | Induction of apoptosis in human lung cancer cells by curcumin显示文摘 | G Radhakrishna Pillai Anand S Srivastava Tarek I Hassanein Dharam P Chauhan Ewa Carrier | 2004 | Cancer Letters2004，，2： | 1 |
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