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| 1 | 膀胱过度活动症:发病机制及治疗现状显示文摘内容摘要OAB为一类发病率较高的慢性疾病,严重影响患者的生活质量,给个人及社会带来了巨大的经济负担。OAB为基于症候群进行诊断的综合征,定义为“尿急,伴或不伴急迫性尿失禁,常伴有尿频和夜尿症状”。OAB无明确的病因,不包括由急性尿路感染或其他形式的膀胱尿道局部病变所致的症状。OAB的核心症状为尿急,尿急是指一种突发、强烈的排尿欲望,且很难被主观抑制而延迟排尿。 | Nadir I. Osman Altaf Mangera Christopher R. Chapple 廖利民 | 2012 | 中华泌尿外科杂志2012，33，9： | 10 |
| 2 | Tissue engineering in urethral reconstruction--an update显示文摘织物工程的地很快正在进行。许多工作开始了开发纸巾设计尿道的接枝。当前的接枝长,能创造起始的施主地点病态。在这篇文章,我们评估在发现纸巾为人的尿道设计了代用品取得的进步。研究人员们调查了没有房间、播种房间的接枝。我们讨论不同途径到开发这些接枝并且在人的研究考察他们的报导成功。与进一步的工作,织物设计了接枝可以便于要求口头的 mucosa 替换 urethroplasty 的过长的尿道的苛评的管理。 | Altaf Mangera Christopher R Chapple | 2013 | Asian Journal of Andrology2013，15，1： | 8 |
| 3 | Update summarising the conclusions of the international consultation on male lower urinary tract symptoms显示文摘The International Consultation on Urological Disease have recently published comprehensive conclusions, based on evidence reviewed by eight committees, on aspects of male lower urinary tract symptoms(LUTS). In this review, we summarise the conclusions from fourof the committees, namely, the evidence regarding the epidemiology of male LUTS, patient assessment, nocturia and medical management. It is indisputable that with an expanding and ageing global population the prevalence of male LUTS is likely to increase. Therefore symptom prevention and preservation of quality of life(Qo L) feature highly in the guidelines. There are now a number of different medical options, proven to lead to significant improvements in symptom scores, flow rate and Qo L available to men with LUTS. Metaanalyses have shown the benefits for alpha blockers, antimuscarinics, 5-α reductase and phosphodiesterase-5 inhibitors. High level evidence also exists for combinations of all of the above with alpha blockers and so men with concomitant storage symptoms, prostate volume > 30 mL, PSA > 1.4 or erectile dysfunction may be considered for combination treatment of an alpha blocker with an antimuscarinic, 5-α reductase inhibitor or phosphodiesterase-5 inhibitor respectively. In an era of personalised medicine, appropriate patient selection is likely to provide the key to the most effective clinical management strategy. | Altaf Mangera Christopher Chapple | 2015 | World Journal of Clinical Urology2015，4，2： | 7 |
| 4 | A matter of time: Temporal variation in the introduction history and population genetic structuring of an invasive lizard显示文摘 | HalmahMOULE Kirilee CHAPLIN Rebecca D. BRAY Kimberly A. MILLER Michael B. THOMSON David G. CHAPPLE | 2015 | Current Zoology2015，61，3： | 4 |
| 5 | Synthetic Vaginal Tapes for Stress Incontinence: Proposals for Improved Regulation of New Devices in Europe显示文摘 | Paul Abrams Christopher R. Chapple Marcus Drake Suzy El-Neil Susanne Ludgate Anthony R.B. Smith | 2011 | European Urology2011，，： | 3 |
| 6 | Content-based instruction in Hong Kong: student responses to film显示文摘 | Lynda Chapple Andy Curtis | 2000 | System2000，，3： | 2 |
| 7 | The ARABIDOPSIS Accession Pna-10ls a Naturally Occurring sngl Deletion Mutant显示文摘 | XU Li Joy Bergelson Clint Chapple | 2010 | Molecular Plant2010，3，1： | 2 |
| 8 | Downregulation of 4-coumarate: CoAlig-ase(4CL) in arabidopsis effecton lignin composition and implication for the control of monlignol biosynthesis 显示文摘 | Leed Meyer K Chapple C | 1997 | Plant Cell1997，9，： | 1 |
| 9 | 47, XXY ( Klinefelter syndrome) and 47,XYY estimated rates of and indication for postnatal diagnosis with implication for prenatal counseling显示文摘 | Abramsky L Chapple J | 1997 | Prenat Diag1997，17，： | 1 |
| 10 | Effects of hypercholestero-lemia on the microsomalmembrane fluidity of intimal-media versus medial layers of swine aorta:implication for the pathogenesis of vasospasm显示文摘 | Gillies P Robinson C Chapple R | 1987 | J Exp Mol Pathol1987，47，： | 1 |
| 11 | Neuropilins:expression and roles in the epithelium显示文摘 | Wild JR Staton CA Chapple K | 2012 | Int J Exp Pathol2012，93，2： | 1 |
| 12 | Content-based instrution in Hong Kong:Student responses to film显示文摘 | Chapple I Curtis A | 2000 | 2000，，： | 1 |
| 13 | Site-specific alkaline phosphatase levels in gingival crevicular fluid in health and gingivitis:cross-sectional studies显示文摘 | Chapple IL Glenwright HD Matthews JB | 1994 | J Clin Periodontol1994，21，6： | 1 |
| 14 | Selective alpha 1-adrenorceptor antagonists in benign prostatic hyperplasia:rationale and clinical experience 显示文摘 | Chapple CR | 1996 | Eur Urol1996，29，2： | 1 |
| 15 | A comparison of the efficacy and tolerability of solifenacin succinate and extended release tolterodine at treating overactive bladder syndrome:results of the STAR trial显示文摘 | Chapple CR Martinez-Garcia R Selvaggi L | 2005 | Eur Urol2005，48，3： | 1 |
| 16 | Rewriting the Lignin Roadmap 显示文摘 | HUMPHREYS J M CHAPPLE C | 2002 | Curr Opin Plant Biol2002，5，3： | 1 |
| 17 | Association of a vitamin D receptor gene polymorphism with localized early-onset periodontal diseases显示文摘 | Hennig BJ Parkhill JM Chapple IL | 1999 | J Periodontol1999，70，9： | 1 |
| 18 | New routes for lignin biosynthesis defined by biochemical characterization of recombinant ferulate 5-hydroxylase, a multifunctional eytochrome P450 dependent monooxygenase显示文摘 | Humphreys J M Hemm M R Chapple C | 1999 | Proc Natl Acad Sci USA1999，96，10： | 1 |
| 19 | Paracrine cylxygenase-2 mediated signaling by macrophages promotes tumorigenic progreasion of intestinal cells显示文摘 | Chapple KS Hawcrogr G | 2002 | Oncogene2002，21，47： | 1 |
| 20 | Transurethral implantation of silicone polymer for stress incontinence : evaluation of a porcine model and mechanism of action in vivo显示文摘 | Radley SC Chapple CR Lee JA | 2000 | BJU Int2000，85，： | 1 |
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