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| 1 | Clinical Validation of Global Coagulation Tests to Guide Blood Component Transfusions in Cirrhosis and ACLF显示文摘Background and Aims:Patients with cirrhosis and acuteon-chronic liver failure(ACLF)may have bleeding complications and need for invasive procedures.Point-of-care(POC)coagulation tests like thromboelastography(TEG)and Sonoclot may be better for guiding patient management than the standard coagulation tests(SCTs),like prothrombin time,platelet count and international normalized ratio.Methods:We prospectively compared and validated the POC tests and SCTs in 70 persons with ACLF and 72 persons with decompensated cirrhosis who had clinical bleeding and checked for episodes of re-bleeding and transfusion requirements.We assessed pre-procedure requirement of blood components when correction was done based on an SCT or POC strategy.Results:Episodes of bleeding were seen in 45%and 28%of ACLF and cirrhosis patient,respectively(p=0.036),with the major site of bleeding being gastrointestinal(31%and 16%,respectively).Platelet counts correlated with TEG-maximum amplitude in cirrhosis(p=0.045)and prothrombin time correlated positively with TEG-reaction(R)time(p=0.032),TEG-Clot kinetics(K)time(p=0.042),Son-activated clotting time(p=0.038)and negatively with clot rate(p=0.043)in ACLF,making these correctable target variables in POC transfusion algorithms.Of 223 procedures,transfusion of fresh frozen plasma and platelet concentrate was reduced by 25%(p=0.035)and 20.8%(p=0.045)by using a POC strategy in 76 patients.Correction of deranged Son-activated clotting time and TEG-reaction time was noted in 68%and 72%after 24 h of fresh frozen plasma transfusion in ACLF and 85%and 80%in cirrhosis,respectively.Conclusions:Our study clinically validates that POC tests can better detect coagulation defects and transfusion thresholds in ACLF and cirrhosis,whereas use of conventional tests appear to be less suitable in patients with clinical bleeding.Trial Registration:NCT04332484. | Madhumita Premkumar Rohit Mehtani Smita Divyaveer Kamal Kajal Anand VKulkarni Syed Ahmed Harmanpreet Kaur Harpreet Kaur Radhakrishna Dhiman Ajay Duseja Arka De | 2021 | Journal of Clinical and Translational Hepatology2021，9，2： | 7 |
| 2 | Immunotherapy and therapeutic vaccines in prostate cancer: an update on current strategies and clinical implications显示文摘在最近的年里,免疫疗法为前列腺癌症的治疗作为可行、吸引人的策略出现了。当有指向免疫系统的多重方法时,治疗学的癌症疫苗和有免疫力的检查点禁止者在迟了阶段的临床的试用是很成功的。为无征状或最低限度地征兆的变形前列腺癌症的 sipuleucel-T 的里程碑食物药品管理局赞同与癌症疫苗 PSA 得信佳和有免疫力的检查点禁止者 ipilimumab 为进行中的阶段 III 试用作准备。没有短期的变化,这些基于免疫者的治疗的一个普通特征是改进全面幸存的外观。这类效果看起来由于肿瘤生长率动力学,激活的免疫系统在施加减缓网络肿瘤生长的经常的 immunologic 压力的调整。新兴的数据建议为癌症疫苗的临床的试用的理想的人口是有更低的肿瘤体积和更少的好攻击的疾病的病人。把免疫疗法与标准治疗相结合的联合策略被显示了扩充有免疫力的反应和临床的利益。 | B Harpreet Singh James L Gulley | 2014 | Asian Journal of Andrology2014，16，3： | 6 |
| 3 | Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial显示文摘 | Somnath Mukherjee Christopher N Hurt John Bridgewater Stephen Falk Sebastian Cummins Harpreet Wasan Tom Crosby Catherine Jephcott Rajarshi Roy Ganesh Radhakrishna Alec McDonald Ruby Ray George Joseph John Staffurth Ross A Abrams Gareth Griffiths Tim Maugh | 2013 | Lancet Oncology2013，，4： | 4 |
| 4 | Review of materials used in laser-aided additive manufacturing processes to produce metallic products显示文摘Rapid prototyping (RP) or layered manufacturing (LM) technologies have been extensively used to manufacture prototypes composed mainly of plastics, polymers, paper, and wax due to the short product development time and low costs of these technologies. However, such technologies, with the exception of selective laser melting and sintering, are not used to fabricate metallic products because of the resulting poor life, short cycle, poor surface finish, and low structural integrity of the fabricated parts. The properties endowed by these parts do not match those of functional parts. Therefore, extensive research has been conducted to develop new additive manufacturing (AM) technologies by extending existing RP technologies. Several AM technologies have been developed for the fabrication of metallic objects. These technologies utilize materials, such as Ni-, A1-, and Ti-based alloys and stainless steel powders, to fabricate high-quality functional components. The present work reviews the type of materials used in laserbased AM processes for the manufacture of metallic products. The advantages and disadvantages of processes and different materials are summarized, and future research directions are discussed in the final section. This review can help experts select the ideal type of process or technology for the manufacturing of elements composed of a given alloy or material (Ni, Ti, Al, Pb, and stainless steel). | Xiaodong NIU Surinder SINGH Akhil GARG Harpreet SINGH Biranchi PANDA Xiongbin PENG Qiujuan ZHANG | 2019 | Frontiers of Mechanical Engineering2019，14，3： | 4 |
| 5 | Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study显示文摘 | Hedy L Kindler Tatsuya Ioka Dirk J Richel Jaafar Bennouna Richard Létourneau Takuji Okusaka Akihiro Funakoshi Junji Furuse Young Suk Park Shinichi Ohkawa Gregory M Springett Harpreet S Wasan Peter C Trask Paul Bycott Alejandro D Ricart Sinil Kim Eric Van | 2011 | Lancet Oncology2011，，3： | 4 |
| 6 | Enhanced photocatalytic activity of electrochemically synthesized aluminum oxide nanoparticles显示文摘In this study, aluminum oxide(Al_2O_3) nanoparticles(NPs) were synthesized via an electrochemical method. The effects of reaction parameters such as supporting electrolytes, solvent, current and electrolysis time on the shape and size of the resulting NPs were investigated. The Al_2O_3 NPs were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy, thermogravimetric analysis/differential thermal analysis, energy-dispersive X-ray analysis, and ultraviolet–visible spectroscopy. Moreover, the Al_2O_3 NPs were explored for photocatalytic degradation of malachite green(MG) dye under sunlight irradiation via two processes: adsorption followed by photocatalysis; coupled adsorption and photocatalysis. The coupled process exhibited a higher photodegradation efficiency(45%) compared to adsorption followed by photocatalysis(32%). The obtained kinetic data was well fitted using a pseudo-first-order model for MG degradation. | Deepak Pathania Rishu Katwal Harpreet Kaur | 2016 | International Journal of Minerals,Metallurgy and Materials2016，23，3： | 3 |
| 7 | Representative Elementary Volume(REV) in Spatio-Temporal Domain: A Method to Find REVfor Dynamic Pores显示文摘One of the potential risks associated with subsurface storage of CO_2 is the seepage of CO_2 through existing faults and fractures. There have been a number of studies devoted to this topic. Some of these studies show that geochemistry, especially mineralization, plays an important role in rendering the faults as conduits for CO_2 movement while others show that mineralization due to CO_2 injection can result in seep migration and flow diversion. Therefore, understanding the changes in reservoir properties due to pore alterations is important to ensure safe long term CO_2 storage in the subsurface. We study the changes in the Representative Elementary Volume(REV) of a rock due to reactive kinetics over a time, using a statistical approach and pore-scale CO_2-rock interactiondata.The goal of this study is to obtain the REV of a rock property that accounts for pore-scale changes over time due to reactive kinetics, and we call this as spatiotemporal REV. Scale-up results suggest that the REV changes with time when CO_2-rock interaction is considered. It is hypothesized that the alteration in pore structure introduces more heterogeneity in the rock, and because of this the magnitude of REV increases. It is possible that these noticeable changes in REV at pore-scale may have an impact when analyzed at the reservoir scale. | Harpreet Singh | 2017 | Journal of Earth Science2017，28，2： | 3 |
| 8 | Utility of Pulse Oximetry Screening for Hepatopulmonary Syndrome显示文摘 | Miguel R. Arguedas Harpreet Singh Dorothy K. Faulk Michael B. Fallon | 2007 | Clinical Gastroenterology and Hepatology2007，，6： | 2 |
| 9 | Magnesium as a biodegradable and bioabsorbable material for medical implants显示文摘 | Harpreet S. Brar Manu O. Platt Malisa Sarntinoranont Peter I. Martin Michele V. Manuel | 2009 | JOM2009，，9： | 2 |
| 10 | Stress-rupture measurements of cast magnesium strengthened by in-situ production of ceramic particles显示文摘We have introduced a polymer precursor into molten magnesium and then in-situ pyrolyzed to produce castings of metal matrix composites(P-MMCs)containing silicon-carbonitride(SiCNO)ceramic particles.Stress-rupture measurements of as-cast P-MMCs was performed at 350 ℃(0.69TM)to 450 ℃(0.78TM)under dead load condition corresponding to tensile stress of 2.5 MPa to 20 MPa.The time-to-fracture data were analyzed using the classical Monkman–Grant equation.The time-to-fracture is thermally activated and follows a power-law stress exponent exhibiting dislocation creep.Fractography analysis revealed that while pure magnesium appears to fracture by dislocation slip,the P-MMCs fail from the nucleation and growth of voids at the grain boundaries. | Nagaraj M.Chelliah Sudarshan Lisa Kraemer Harpreet Singh M.K.Surappa Rishi Raj | 2017 | Journal of Magnesium and Alloys2017，5，2： | 2 |
| 11 | Interconversion of two commonly used performance tools: An analysis of 5844 paired assessments in 1501 lung cancer patients显示文摘AIM To establish the Karnofsky performance status(KPS) categories which would facilitate the interconversion of the KPS scale to the Eastern Cooperative Oncology Group(ECOG) performance status(PS) scale.METHODS This was a retrospective analysis of all patients attending the lung cancer clinic at a tertiary care center over a 5-year period(September 2009 to August 2014). All patients were assessed with both KPS and ECOG PS scales at each visit. Correlation between KPS and ECOG PS was assessed using Spearman's correlation coefficient. KPS categories equivalent to ECOG PS scores were compared using hit rate and weighted kappa(κw).RESULTS A total of 1501 patients were assessed over the study period, providing 5844 paired KPS and ECOG PS assessments. The study cohort had a mean(standard deviation; SD) age of 58.4(10.8) years, with the majority being current or ex-smokers(76.9%) and males(82.3%). Non-small cell lung cancer was the most common histological type(n = 1196, 79.7%) with the majority having advanced(stage ⅢB/Ⅳ) disease(83.4%). Mean baseline KPS and ECOG PS scores were 77.6(SD = 14.4) and 1.5(SD = 1) respectively. The most frequent KPS score was 80(29%), and the most frequent ECOG PS score was 1(43%). The overall correlation between KPS and ECOG PS was good(Spearman r =-0.84, P < 0.0001) but ranged from-0.727 to-0.972 between visits. KPS categories derived from our cohort [10-40(ECOG 4), 50-60(ECOG 3), 70(ECOG 2), 80-90(ECOG 1), 100(ECOG 0)] performed better [hit rate 78.1%, κw = 0.749(0.736-0.762) P < 0.0001] than those suggested in the past literature.CONCLUSION The current study provides the largest set of paired KPS-ECOG assessments to date. We suggest that the KPS categories 10-40, 50-60, 70, 80-90, and 100 are equivalent to ECOG PS categories of 4, 3, 2, 1, and 0 respectively. | Kuruswamy Thurai Prasad Harpreet Kaur Valliappan Muthu Ashutosh Nath Aggarwal Digambar Behera Navneet Singh | 2018 | World Journal of Clinical Oncology2018，9，7： | 2 |
| 12 | Enhanced cavitation erosion resistance of a friction stir processed high entropy alloy显示文摘Friction stir processing of an Al0.1CoCrFeNi high entropy alloy(HEA)was performed at controlled cooling conditions(ambient and liquid submerged).Microstructural and mechanical characterization of the processed and as-cast HEAs was evaluated using electron backscatter diffraction,micro-hardness testing and nanoindentation.HEA under the submerged cooling condition showed elongated grains(10μm)with fine equiaxed grains(2μm)along the boundary compared to the coarser grain(~2 mm)of as-cast HEA.The hardness showed remarkable improvements with four(submerged cooling condition)and three(ambient cooling condition)times that of as-cast HEA(HV^150).The enhanced hardness is attributed to the significant grain refinement in the processed HEAs.Cavitation erosion behavior was observed for samples using an ultrasonication method.All of the HEAs showed better cavitation erosion resistance than the stainless steel 316L.The sample processed under a submerged liquid condition showed approximately 20 and 2 times greater erosion resistance than stainless steel 316L and ascast HEA,respectively.The enhanced erosion resistances of the processed HEAs correlate to their increased hardness,resistance to plasticity,and better yield strength than the as-cast HEA.The surface of the tested samples showed nucleation and pit growth,and plastic deformation of the material followed by fatigue-controlled disintegration as the primary material removal mechanism. | Rakesh B.Nair H.S.Arora Harpreet Singh Grewal | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，10： | 2 |
| 13 | Microstructural evolution of die-cast and homogenized AZ91 Mg-alloys during dry sliding condition显示文摘Received 16 July 2016;revised 24 January 2017;accepted 7 February 2017 Available online 22 February 2017 Abstract Microstructural evolution of die-cast and homogenized AZ91 Mg-alloys was investigated during dry sliding wear condition.Tribological tests were performed using a pin-on-disc(EN8 steel)configuration with a normal load of 50 N at a constant sliding speed of 2.5 ms^(−1) under ambient environment.Delamination was recognized as a predominant wear mechanism in both of these materials.The die-cast AZ91 Mg-alloy exhibits lower coefficient of friction and higher wear rate.This can be ascribed to increase in the intensity of load bearing capacity of hardβ-Mg_(17)Al_(12) phase,and crack formation/de-cohesion at the interface between primaryα-Mg and discontinuousβ-Mg_(17)Al_(12) phases.On the contrary,the homogenized AZ91 Mg-alloy experiences higher coefficient of friction and lower wear rate.The friction-induced microstructural evolution(supersaturatedα-Mg to eutectic(α+β-Mg_(17)Al_(12)))tending to minimize the wear rate by providing barrier to material removal in the near surface region of homogenized AZ91 Mg-alloy.Therefore,experimental observation revealed that an inverse relationship exists between wear rate and coefficient of friction for the investigated materials.The analysis of worn surfaces and subsurfaces by electron microscopy provided evidence to delamination wear and microstructural evolution. | Nagaraj M.Chelliah Ram Kumar Harpreet Singh M.K.Surappa | 2017 | Journal of Magnesium and Alloys2017，5，1： | 2 |
| 14 | Molecular modulation of autophagy: New venture to target resistant cancer stem cells显示文摘Autophagy is a highly regulated catabolic process in which superfluous,damaged organelles and other cytoplasmic constituents are delivered to the lysosome for clearance and the generation of macromolecule substrates during basal or stressed conditions.Autophagy is a bimodal process with a context dependent role in the initiation and the development of cancers.For instance,autophagy provides an adaptive response to cancer stem cells to survive metabolic stresses,by influencing disease propagation via modulation of essential signaling pathways or by promoting resistance to chemotherapeutics.Autophagy has been implicated in a cross talk with apoptosis.Understanding the complex interactions provides an opportunity to improve cancer therapy and the clinical outcome for the cancer patients.In this review,we provide a comprehensive view on the current knowledge on autophagy and its role in cancer cells with a particular focus on cancer stem cell homeostasis. | Harpreet K Mandhair Miroslav Arambasic Urban Novak Ramin Radpour | 2020 | World Journal of Stem Cells2020，12，5： | 2 |
| 15 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 16 | Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: a case report显示文摘 | Stephen J Wroe Suvankar Pal Durrenajaf Siddique Harpreet Hyare Rebecca Macfarlane Susan Joiner Jacqueline M Linehan Sebastian Brandner Jonathan DF Wadsworth Patricia Hewitt John Collinge | 2006 | The Lancet2006，，9552： | 1 |
| 17 | Epigenetic regulation of autophagy: A key modification in cancer cells and cancer stem cells显示文摘Aberrant epigenetic alterations play a decisive role in cancer initiation and propagation via the regulation of key tumor suppressor genes and oncogenes or by modulation of essential signaling pathways.Autophagy is a highly regulated mechanism required for the recycling and degradation of surplus and damaged cytoplasmic constituents in a lysosome dependent manner.In cancer,autophagy has a divergent role.For instance,autophagy elicits tumor promoting functions by facilitating metabolic adaption and plasticity in cancer stem cells(CSCs)and cancer cells.Moreover,autophagy exerts pro-survival mechanisms to these cancerous cells by influencing survival,dormancy,immunosurveillance,invasion,metastasis,and resistance to anti-cancer therapies.In addition,recent studies have demonstrated that various tumor suppressor genes and oncogenes involved in autophagy,are tightly regulated via different epigenetic modifications,such as DNA methylation,histone modifications and non-coding RNAs.The impact of epigenetic regulation of autophagy in cancer cells and CSCs is not wellunderstood.Therefore,uncovering the complex mechanism of epigenetic regulation of autophagy provides an opportunity to improve and discover novel cancer therapeutics.Subsequently,this would aid in improving clinical outcome for cancer patients.In this review,we provide a comprehensive overview of the existing knowledge available on epigenetic regulation of autophagy and its importance in the maintenance and homeostasis of CSCs and cancer cells. | Harpreet K Mandhair Urban Novak Ramin Radpour | 2021 | World Journal of Stem Cells2021，13，6： | 1 |
| 18 | Query by image and video content: The QBIC system显示文摘 | FLICKNER M HARPREET SAWHNEY WAYNE NIBLACK JONATHAN ASHLEY | 1995 | IEEE Computer1995，28，： | 1 |
| 19 | Infrared heating in food processing: an overview显示文摘 | Kathiravan K Harpreet K K Soojin J | 2008 | Comprehensive Reviews in Food Science and Food Safety2008，7，1： | 1 |
| 20 | Aerial Video Surveillance and Exploitation显示文摘 | Rakesh Kumar Harpreet Sawhney Supun Samarasekera | 2001 | Proceedings of The IEEE2001，89，10： | 1 |
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