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| 1 | Isoniazid metabolism and hepatotoxicity显示文摘Isoniazid(INH) is highly effective for the management of tuberculosis.However,it can cause liver injury and even liver failure.INH metabolism has been thought to be associated with INH-induced liver injury.This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury. | Pengcheng Wang Komal Pradhan Xiao-bo Zhong Xiaochao Ma | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 19 |
| 2 | Dual color optogenetic control of neural populations using low-noise,multishank optoelectrodes显示文摘Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings.Genetically-identified classes of neurons are optically manipulated,though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal resolution.We report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in vivo.We describe the design,fabrication,and assembly of low-noise,multisite/multicolor optoelectrodes.Each shank of the four-shank assembly is monolithically integrated with 8 recording sites and a dualcolor waveguide mixer with a 7×30μm cross-section,coupled to 405 nm and 635 nm injection laser diodes(ILDs)via gradient-index(GRIN)lenses to meet optical and thermal design requirements.To better understand noise on the recording channels generated during diode-based activation,we developed a lumped-circuit modeling approach for EMI coupling mechanisms and used it to limit artifacts to amplitudes under 100μV upto an optical output power of 450μW.We implanted the packaged devices into the CA1 pyramidal layer of awake mice,expressing Channelrhodopsin-2 in pyramidal cells and ChrimsonR in paravalbumin-expressing interneurons,and achieved optical excitation of each cell type using sub-mW illumination.We highlight the potential use of this technology for functional dissection of neural circuits. | Komal Kampasi Daniel F.English John Seymour Eran Stark Sam McKenzie Mihály Vöröslakos György Buzsáki Kensall D.Wise Euisik Yoon | 2018 | Microsystems & Nanoengineering2018，4，1： | 8 |
| 3 | Methionine adenosyltransferases in liver health and diseases显示文摘Methionine adenosyltransferases(MATs)are essential for cell survival because they catalyze the biosynthesis of the biological methyl donor S-adenosylmethionine(SAMe)from methionine and adenosine triphosphate(ATP).Mammalian cells express two genes,MAT1A and MAT2A,which encode two MAT catalytic subunits,α1 andα2,respectively.Theα1 subunit organizes into dimers(MATIII)or tetramers(MATI).Theα2 subunit is found in the MATII isoform.A third gene MAT2B,encodes a regulatory subunit b,that regulates the activity of MATII by lowering the inhibition constant(Ki)for SAMe and the Michaelis constant(Km)for methionine.MAT1A expressed mainly in hepatocytes maintains the differentiated state of these cells whereas MAT2A and MAT2B are expressed in non-parenchymal cells of the liver(hepatic stellate cells[HSCs]and Kupffer cells)and extrahepatic tissues.A switch from the liverspecific MAT1A to MAT2A has been observed during conditions of active liver growth and dedifferentiation.Liver injury,fibrosis,and cancer are associated with MAT1A silencing and MAT2A/MAT2B induction.Even though both MAT1A and MAT2A are involved in SAMe biosynthesis,they exhibit distinct molecular interactions in liver cells.This review provides an update on MAT genes and their roles in liver pathologies. | Komal Ramani Shelly C.Lu | 2017 | Liver Research2017，1，2： | 5 |
| 4 | Combinatorial strategies for cancer eradication by silibinin and cytotoxic agents:efficacy and mechanisms显示文摘以开发增加治疗学的功效并且最小化化学疗法的代理人的全身的毒性的有效其他的策略,更多的努力与反癌症药在联合为他们的 synergistic 功效向饮食的补充和另外的 phytotherapeutic 代理人的调查正在被指导。一如此的代理人 issilibinin,它显示出有希望的 chemopreventive 和反癌症完成在在 vitro 并且在 vivo 研究各种各样。现在的评论在前列腺,胸,和肺癌症系统在生长抑制,房间周期规定,和 apoptosis 正式就职上总结 silibinin 和化学疗法的药的联合的效果。一起,当与这些药交上联合时,结果在生长抑制, chemoresistance 的颠倒, apoptosis 正式就职,和 G_2-M 检查点拘捕的猛烈增加上显示 synergistic 效果 ofsilibinin。这些结果关于联合化疗途径是高度重要的,在那里为联合的标准是反应不得不是 synergistic 并且这些药不应该分享抵抗的普通机制并且不在他们的主要副作用重叠。 | Komal RAINA Rajesh AGARWAI | 2007 | Acta Pharmacologica Sinica2007，28，9： | 5 |
| 5 | A high methionine,low folate and vitamin B_6/B_(12) containing diet can be associated with memory loss by epigenetic silencing of netrin-1显示文摘Memory-epigenetics which is the loss of memory due to epigenetic modifications can be due to the silencing of genes involved in cognitive functions and this is the basis of the current study.We hypothesize that a diet containing high methionine and low vitamins can lead to memory impairment by increasing global DNA methylation and therefore,silencing the netrin-1 gene,which encodes the glycoprotein involved in neurogenesis,axonal guidance and maintenance of the synaptic plasticity.Wild type(C57 BL/6 J) mice were fed with a diet containing excess methionine(1.2%),low-folate(0.08 mg/kg),vitamin B_6(0.01 mg/kg),and B_(12)(10.4 mg/kg) for 6 weeks.Mice were examined weekly for the long-term memory function,using a passive avoidance test,which determined loss of fear-motivated long-term memory starting from the fourth week of diet.Similarly,an increase in brain %5-methyl cytosine was observed starting from the 4 th week of diet in mice.Mice fed with a high methionine,low folate and vitamins containing diet showed a decrease in netrin-1 protein expression and an increase in netrin-1 gene promotor methylation,as determined by methylation-sensitive restriction enzyme-polymerase chain reaction analysis.The increase in methylation of netrin-1 gene was validated by high-resolution melting and sequencing analysis.Furthermore,the association of netrin-1 with memory was established by administering netrin that considerably restored long-term fear motivated memory.Taken together,these results suggest that a diet rich in methionine and lacking in folate and vitamin B_6/B_(12) can induce defects in learning and memory.Furthermore,the data indicates that decrease in netrin-1 expression due to hyper-methylation of its gene can be associated with memory loss.The animal procedures were approved by the Institutional Animal Care and Use Committee,University of Louisville,USA(No.A3586-01) on February 2,2018. | Anuradha Kalani Pankaj Chaturvedi Komal Kalani Pradip K.Kamat Poonam Chaturvedi Neetu Tyagi | 2019 | Neural Regeneration Research2019，14，7： | 4 |
| 6 | Silibinin and colorectal cancer chemoprevention:a comprehensive review on mechanisms and efficacy显示文摘Globally,the risk of colorectal cancer(CRC) as well as the incidence of mortality associated with CRC is increasing.Thus,it is imperative that we look at alternative approaches involving intake of non-toxic natural dietary/non-dietary agents,for the prevention of CRC.The ultimate goal of this approach is to reduce the incidence of pre-neoplastic adenomatous polyps and prevent their progression to more advanced forms of CRC,and use these natural agents as a safe intervention strategy during the clinical course of this deadly malignancy.Over the years,pre-clinical studies have shown that silibinin(a flavonolignan isolated from the seeds of milk thistle,Silybum marianum) has strong preventive and therapeutic efficacy against various epithelial cancers,including CRC.The focus of the present review is to provide a comprehensive tabular summary,categorically for an easy accessibility and referencing,pertaining to the efficacy and associated mechanisms of silibinin against CRC growth and progression. | Komal Raina Sushil Kumar Deepanshi Dhar Rajesh Agarwal | 2016 | The Journal of Biomedical Research2016，30，6： | 2 |
| 7 | Monitoring and modeling of urban sprawl through remote sensing and GIS in Kuala Lumpur, Malaysia显示文摘Introduction:Kuala Lumpur is currently experiencing a large-scale urban transformation.This study explores a multi-buffer ring method to investigate the spatial and temporal dynamics of urban growth in the Kuala Lumpur metropolitan area by using Geographical Information Systems(GIS)and remote sensing imageries from1989 to 2014.Methods:The first Landsat images from 1989,2001,and 2014 were classified with maximum likelihood classification to produce land cover maps and identify four types of land cover:urban/built-up,agriculture,forest,and water.Then,the area coverage for all the land use types at different points in time were measured and combined with distance from the city center.Later on,urbanization densities from the city center to the outside for every 1-km distance from 1 to 50 km are calculated.Results:City density on the distance of 5,8,15,20,and 30 km was very high in the years 1989 and 2014.Temporally,urban expansion shows fast and slow growth stages with high-speed growth shifting to the east side of the city.Conclusions:In general,the population,traffic conditions,industrialization,and policy are the major factors thatinfluenced the urban expansion. | Mukesh Singh Boori Maik Netzband Komal Choudhary Vít Voženílek | 2015 | Ecological Processes2015，4，1： | 2 |
| 8 | Preparation of novel antiproliferative emodin derivatives and studies on their cell cycle arrest, caspase dependent apoptosis and DNA binding interaction显示文摘 | T. Narender P. Sukanya Komal Sharma Surendar Reddy Bathula | 2013 | Phytomedicine2013，，： | 2 |
| 9 | Correlation between the proportion of breast volume involved by locally advanced tumors and invasion of the skin and posterior structures显示文摘AIM: To evaluate any differences between the percentages of involved breast volume, pathologic attributes,and tumor marker expression of T3 and T4a-c tumors in locally advanced breast cancers(BC).METHODS: All patients with T3 N > 0 and T4a-c BC without evidence of distant metastasis(M0), presenting to the Breast Clinic from 1980 to 2010, were examinedto determine whether their BC's involved ≥ 50% of their breast volumes, defined by gross replacement of at least one hemisphere. Core needle biopsy or postmastectomy specimens from tumors involving a known percent of breast volume were evaluated for:(1)pathological grades and lympho-vascular invasion(LVI);(2) hormone receptor(ER/PR) expression > 0; and(3)epidermoid growth factor 2(her2) over-expression(3+)by immune-histochemical staining or fluorescent in situ hybridization.RESULTS: The data base included 98 patients with T3N> 0 M0 and 120 with T4a-c, any N disease, M0 disease. T3 tumor masses involved 50% or more of the breast in 23/98(24%), and T4a-c tumors 65/120(54%)(P < 0.001). Only 1% of T3 tumors and 23% of T4a-c tumors presented with total breast replacement. There were no significant differences between the pathological attributes and marker expression of the T3 and T4a-c tumors.CONCLUSION: These data suggest that erosion of the overlying skin or underlying chest wall by some BC may be due to neglect and delay, rather than inherent biological aggressiveness. | Parastoo B Dahi Komal P Dhiran Constantine A Axiotis Jeremy Weedon Mahmoud El-Tamer Gurinder Sidhu Albert S Braverman | 2012 | World Journal of Clinical Oncology2012，3，3： | 2 |
| 10 | The caspase-1 inhibitor VX765 upregulates connexin 43 expression and improves cell-cell communication after myocardial infarction via suppressing the IL-1β/p38 MAPK pathway显示文摘Connexin 43 (Cx43) is the most important protein in the gap junction channel between cardiomyocytes. Abnormalities of Cx43 change the conduction velocity and direction of cardiomyocytes, leading to reentry and conduction block of the myocardium, thereby causing arrhythmia. It has been shown that IL-1β reduces the expression of Cx43 in astrocytes and cardiomyocytes in vitro. However, whether caspase-1 and IL-1β affect connexin 43 after myocardial infarction (MI) is uncertain. In this study we investigated the effects of VX765, a caspase-1 inhibitor, on the expression of Cx43 and cell-to-cell communication after MI. Rats were treated with VX765 (16 mg/kg, i.v.) 1 h before the left anterior descending artery (LAD) ligation, and then once daily for 7 days. The ischemic heart was collected for histochemical analysis and Western blot analysis. We showed that VX765 treatment significantly decreased the infarct area, and alleviated cardiac dysfunction and remodeling by suppressing the NLRP3 inflammasome/caspase-1/IL-1β expression in the heart after MI. In addition, VX765 treatment markedly raised Cx43 levels in the heart after MI. In vitro experiments were conducted in rat cardiac myocytes (RCMs) stimulated with the supernatant from LPS/ATP-treated rat cardiac fibroblasts (RCFs). Pretreatment of the RCFs with VX765 (25 μM) reversed the downregulation of Cx43 expression in RCMs and significantly improved intercellular communication detected using a scrape-loading/dye transfer assay. We revealed that VX765 suppressed the activation of p38 MAPK signaling in the heart tissue after MI as well as in RCMs stimulated with the supernatant from LPS/ATP-treated RCFs. Taken together, these data show that the caspase-1 inhibitor VX765 upregulates Cx43 expression and improves cell-to-cell communication in rat heart after MI via suppressing the IL-1β/p38 MAPK pathway. | Xue-ling Su Shu-hui Wang Sumra Komal Liu-gen Cui Rui-cong Ni Li-rong Zhang Sheng-na Han | 2022 | Acta Pharmacologica Sinica2022，43，9： | 2 |
| 11 | Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12显示文摘 | Birgit Oppmann Robin Lesley Bianca Blom Jackie C Timans Yuming Xu Brisdell Hunte Felix Vega Nancy Yu Jing Wang Komal Singh Francesca Zonin Elena Vaisberg Tatyana Churakova Man-ru Liu Daniel Gorman Janet Wagner Sandra Zurawski Yong-Jun Liu John S Abrams Ke | 2000 | Immunity2000，，5： | 2 |
| 12 | Self nano-emulsifying drug delivery system for Embelin:Design,characterization and in-vitro studies显示文摘CThe objective of the present study was to prepare solid self-nanoemulsifying drug delivery system(S-SNEDDS)containing Capryol-90 as oil phase for the delivery of Embelin,a poorly water soluble herbal active ingredient.Box-Behnken experimental design was employed to optimise the formulation variables,X1(amount of oil;Capryol 90),X2(amount of surfactant;Acrysol EL 135)and X3(amount of co-surfactant;PEG 400).Systems were appraised for visual characteristics for self emulsifying time,globule size and drug release.Optimised liquid formulations were formulated into free flowing granules(S-SNEDDS)by adsorption on the porous materials like Aerosil 200 and Neusilin and thereby compressed into tablet.In vitro dissolution studies of SNEDDS revealed increased in the dissolution rate of the drug.FT-IR data revealed no physicochemical interaction between drug and excipients.Solid state characterization of S-SNEDDS by DSC and Powder XRD confirmed reduction in drug crystallinity which further supports the results of dissolution studies.TEM analysis exhibited spherical globules.Further,the accelerated stability studies for 6 months revealed that S-SNEDDS of Embelin are found to be stable without any significant change in physicochemical properties.Thus,the present studies demonstrated dissolution enhancement potential of porous carrier based S-SNEDDS for poorly water soluble herbal active ingredient,Embelin. | Komal Parmar Jayvadan Patel Navin Sheth | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，5： | 2 |
| 13 | Breast carcinoma with metastasis to the gallbladder:an unusual case report with a short review of literature显示文摘Gallbladder metastases are very rare and usually arise from malignant melanoma, renal cell carcinoma and cervical carcinoma. Breast carcinoma tnetastatic to the gallbladder is extremely rare and only 4 cases have been reported in the English literature. We hereby report a 54-year-old lady who was diagnosed as having breast carcinoma and underwent modified radical mastectomy. One month after the operation, she developed acute abdomenal pain and underwent cholecystectomy after clinical investigation. Histopathological examination revealed metastasis to the gallbladder. Being considered a patient with tnetastatic breast carcinoma she was subjected to taxane and anthracycline-based palliative chemotherapy. Later she had CNS involvement and died of the progressive disease soon after few months. | Dinesh C Doval Komal Bhatia Keechelat Pavithran Jai Bhagwan Sharma Ashok K Vaid Digant Hazarika | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，2： | 2 |
| 14 | 显示文摘 | Sreenivasulu A Sundaram E V Komal Reddy M | 1999 | Indian Journal of Chemical Technology1999，6，5： | 1 |
| 15 | Analysis of Dynamic Characteristic of Micro-drills 显示文摘 | GONG Yong-ping EHMANN Komal F CHENG Lin | 2003 | Journal of Materials Processing Technology2003，141，1： | 1 |
| 16 | Combining Directional Microphone and Single-Channel Noise Reduction Algorithms: A Clinical Evaluation in Difficult Listening Conditions With Cochlear Implant Users显示文摘 | Adam A. Hersbach Komal Arora Stefan J. Mauger Pam W. Dawson | 2012 | Ear and Hearing2012，，4： | 1 |
| 17 | Wireless sensor networks for disaster management 显示文摘 | Kaur H Sawhney RS Komal N | 2012 | International Joumal of Advanced Research in Computer Engineering & Technology2012，1，5： | 1 |
| 18 | Microbial fuel cells for azo dye treatment with electricity generation:A review显示文摘 | Komal S Sindhu S Suddhasatwa B | 2013 | Biore- sour Technol2013，131，： | 1 |
| 19 | Increased HO‐1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21显示文摘 | Terry D. Hinds Komal Sodhi Charles Meadows Larisa Fedorova Nitin Puri Dong Hyun Kim Stephen J. Peterson Joseph Shapiro Nader G. Abraham Attallah Kappas | 2014 | Obesity2014，，3： | 1 |
| 20 | Vascular endothelial growth factor C and vascular endothelial growth factor receptor 2 are related closely to the prognosis of patients with ovarian carcinoma显示文摘 | Nishida N Yano H Komal K | 2004 | Cancer2004，101，6： | 1 |
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