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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Lymphocyte subsets in alcoholic liver disease显示文摘AIM:To compare lymphocyte subsets between healthy controls and alcoholics with liver disease.METHODS:The patient cohort for this study included individuals who were suspected to have alcoholic liver disease(ALD) and who had undergone liver biopsy(for disease grading and staging,doubts about diagnosis,or concurrent liver disease;n = 56).Normal controls included patients who were admitted for elective cholecystectomy due to non-complicated gallstones(n = 27).Formalin-fixed,paraffin-embedded liver biopsy specimens were sectioned and stained with hematoxylin and eosin and Perls' Prussian blue.The non-alcoholic steatohepatitis score was used to assess markers of ALD.Lymphocyte population subsets were determined by flow cytometry.T lymphocytes were identified(CD3+),and then further subdivided into CD4+ or CD8+ populations.B lymphocytes(CD19+) and natural killer(NK) cell numbers were also measured.In addition to assessing lymphocyte subpopulation differences between ALD patients and controls,we also compared subsets of alcoholic patients without cirrhosis or abstinent cirrhotic patients to normal controls.RESULTS:The patient cohort primarily consisted of older men.Active alcoholism was present in 66.1%.Reported average daily alcohol intake was 164.9 g and the average lifetime cumulative intake was 2211.6 kg.Cirrhosis was present in 39.3% of the patients and 66.1% had significant fibrosis(perisinusoidal and portal/periportal fibrosis,bridging fibrosis,or cirrhosis) in their liver samples.The average Mayo end-stage liver disease score was 7.6.No hereditary hemochromatosis genotypes were found.ALD patients(n = 56) presented with significant lymphopenia(1.5 × 109/L ± 0.5 × 109/L vs 2.1 × 109/L ± 0.5 × 109/L,P < 0.0001),due to a decrease in all lymphocyte subpopulations,except for NK lymphocytes:CD3+(1013.0 ± 406.2/mm3 vs 1523.0 ± 364.6/mm3,P < 0.0001),CD4+(713.5 ± 284.7/mm3 vs 992.4 ± 274.7/mm3,P < 0.0001),CD8+(262.3 ± 140.4/mm3 vs 478.9 ± 164.6/mm3,P < 0.0001),and CD19+(120.6 ± 76.1/mm3 vs 264.6 ± 88.0/mm3,P < 0.0001).CD8+ lymphocytes suffered the greatest reduction,as evidenced by an increase in the CD4+/CD8+ ratio(3.1 ± 1.3 vs 2.3 ± 0.9,P = 0.013).This ratio was associated with the stage of fibrosis on liver biopsy(rs = 0.342,P = 0.01) and with Child-Pugh score(rs = 0.482,P = 0.02).The number of CD8+ lymphocytes also had a positive association with serum ferritin levels(rs = 0.345,P = 0.009).Considering only patients with active alcoholism but not cirrhosis(n = 27),we found similar reductions in total lymphocyte counts(1.8 × 109/L ± 0.3 × 109/L vs 2.1 × 109/L ± 0.5 × 109/L,P = 0.018),and in populations of CD3+(1164.7 ± 376.6/mm3 vs 1523.0 ± 364.6/mm3,P = 0.001),CD4+(759.8 ± 265.0/mm3 vs 992.4 ± 274.7/mm3,P = 0.003),CD8+(330.9 ± 156.3/mm3 vs 478.9 ± 164.6/mm3,P = 0.002),and CD19+(108.8 ± 64.2/mm3 vs 264.6 ± 88.0/mm3,P < 0.0001).In these patients,the CD4+/CD8+ ratio and the number of NK lymphocytes was not significantly different,compared to controls.Comparing patients with liver cirrhosis but without active alcohol consumption(n = 11),we also found significant lymphopenia(1.3 × 109/L ± 0.6 × 109/L vs 2.1 × 109/L ± 0.5 × 109/L,P < 0.0001) and decreases in populations of CD3+(945.5 ± 547.4/mm3 vs 1523.0 ± 364.6/mm3,P = 0.003),CD4+(745.2 ± 389.0/mm3 vs 992.4 ± 274.7/mm3,P = 0.032),CD8+(233.9 ± 120.0/mm3 vs 478.9 ± 164.6/mm3,P < 0.0001),and CD19+(150.8 ± 76.1/mm3 vs 264.6 ± 88.0/mm3,P = 0.001).The NK lymphocyte count was not significantly different,but,in this group,there was a significant increase in the CD4+/CD8+ ratio(3.5 ± 1.3 vs 2.3 ± 0.9,P = 0.01).CONCLUSION:All patient subsets presented with decreased lymphocyte counts,but only patients with advanced fibrosis presented with a significant increase in the CD4+/CD8+ ratio. | Luís Costa Matos Paulo Batista Nuno Monteiro Joo Ribeiro Maria A Cipriano Pedro Henriques Fernando Giro Armando Carvalho | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 3 | 青少年和年轻成人先天性心脏病的心理社会远期转归显示文摘目的先天性心脏病(CHD)是一种在全球范围内高发的慢性疾病,通常在出生时或出生前确诊。由于诊断以及早期药物和手术治疗的条件较好,患者的生存率达到90%,并且生存时间不断延长,面临着生活中的各种挑战。该研究探讨了不同人口统计学、临床和心理社会变量对CHD青少年和年轻成人患者的生活质量(QOL)感知、心理社会适应和精神障碍患病率的影响,评估CHD青少年和年轻成人患者的生活质量、心理社会适应和精神障碍发病率,确定哪些变量(人口统计学、临床和心理社会变量)对缓解压力、促进恢复起到积极作用,哪些变量起到不良作用。方法该研究入组了150名CHD患者(男87例,女63例),年龄12~26岁(平均年龄:17.45±3.373岁)。对参与者进行了关于社会支持、家庭教育方式、自我形象、人口统计信息和生理限制等方面的访谈。他们对标准化精神病学访谈(SADS-L)中的问题进行了回答,并填写了自我报告问卷,以进行生活质量(WHOQOL-BREF)和心理社会适应(YSR/ASR)的评估。结果所有参与者精神障碍的终身患病率为18.7%(女性25.4%,男性13.8%)。57.1%的参与者有过留级(平均1.53±0.804年)。与整体葡萄牙人相比,CHD患者的生活质量感知在社会关系、环境、身体和总体方面较好。而女性、学习成绩差、较少的社会支持、复杂性CHD、紫绀型CHD、中重度残留病灶、接受过手术和有生理限制患者生活质量感知较差。除了紫绀,所有这些变量也会引起较差的心理社会适应。结论女性CHD患者及学习成绩差且获得社会支持少的CHD患者的心理社会适应和生活质量较差。 | Maria Emlha Gulmaraes Arelas Catarina I. Pinto Patricia F. Vieira Flavio Teixeira Rosalia. Coelho Isabela Freitas Samantha Matos Marta Castro Sofia Sarmento Victor Viana Jorge Quintas Jose C. Areias | 2013 | 中国当代儿科杂志2013，15，10： | 3 |
| 4 | Parenteral fish oil as a pharmacological agent to modulate post-operative immune response: A randomized, double-blind, and controlled clinical trial in patients with gastrointestinal cancer显示文摘 | Raquel Susana Matos de Miranda Torrinhas Raquel Santana Thaís Garcia Maria Fernanda Cury-Boaventura Maria Mirtes Sales Rui Curi Dan Linetzky Waitzberg | 2013 | Clinical Nutrition2013，，4： | 3 |
| 5 | Understanding bottom-up continuous hydrothermal synthesis of nanoparticles using empirical measurement and computational simulation显示文摘连续热水的合成为 nanoparticles 的生产作为一种创新技术在最近的评论被加亮。在最近的年里,是大量 nanomaterials 的合成的合适的反应媒介被显示了。许多单个、复杂的 nanomaterials 象金属,金属氧化物,做的氧化物,碳酸盐,硫化物,氢氧化物,磷酸盐,和金属那样器官的框架能用连续热水的合成技术被形成。这个工作介绍方法论试验性地并且数字地描绘连续热水的流动系统,并且为大规模生产决定一个相反当前的 supercritical 水反应堆的可伸缩性(> 1,000 T 敳 ? 潰整瑮慩??? ?? 湯敳 ? 猯'T? 漠 ?? 代嘠愠摮挠瑡污瑹捩挠牵敲瑮搠湥楳祴漠 ????? 湡 ? | Jose Sierra-Pallarest Thomas Huddle Juan Garcia-Serna Esther Alonso Fidel Mato Igor Shvets Olaf Luebben Maria Jose Cocero Edward Lester | 2016 | Nano Research2016，9，11： | 2 |
| 6 | Grain-size end-members and environmentally sensitive grain-size components: A comparative study in the mud shelf depocenters off southern Brazil显示文摘The current study aims to do a comparative analysis of the results obtained with two End-Member(EM)grain-size modeling techniques(AnalySize and BasEMMA)and the Environmental Sensitive Grain-Size(ESGS)modeling for sediment samples collected in the mudbelts of the southern Brazilian shelf.The methods were compared using grain-size data from the south Brazilian shelf,and the results are discussed here.It is the first time that the concept of ESGS,in its present form,is utilized outside China.The results show that despite its relative ease of use,the ESGS is not fully comparable to the EM analyses,and only two grain-size ESGS classes were recognized as analogous to EMs.The comparison of the AnalySize and BasEMMA procedures also revealed significant differences between the techniques.A comparative analysis between the two EM techniques revealed advantages in the BasEMMA,especially in the better correlation of the end-members with the original grain size distribution.The analysis of the geographical distribution of the EM abundances allowed point sources of sandy populations to be recognized as well as the contribution of the Rio de la Plata as a source of silty sediments to be inferred. | Michel Michaelovitch de Mahiques Samara Cazzoli y Goya Maria Carolina da Silva Nogueira de Matos Rodrigo Augusto Udenal de Oliveira Bianca Sung Mi Kim Paulo Alves de Lima Ferreira Rubens Cesar Lopes Figueira Marcia Caruso Bícego | 2021 | International Journal of Sediment Research2021，36，2： | 2 |
| 7 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 8 | Integrated Platform for Production and Purification of Human Pluripotent Stem Cell-Derived Neural Precursors显示文摘 | Gon?alo M. C. Rodrigues Andreia F. S. Matos Tiago G. Fernandes Carlos A. V. Rodrigues Michael Peitz Simone Haupt Maria Margarida Diogo Oliver Brüstle Joaquim M. S. Cabral | 2014 | Stem Cell Reviews and Reports2014，，2： | 1 |
| 9 | Effectiveness of rotavirus vaccine against hospitalized rotavirus diarrhea: A case–control study显示文摘 | Maria Y.T. Ichihara Laura C. Rodrigues Carlos A.S. Teles Santos Maria da Gloria L.C. Teixeira Sandra R. De Jesus Sheila M. Alvim De Matos Jose P. Gagliardi Leite Mauricio L. Barreto | 2014 | Vaccine2014，，： | 1 |
| 10 | Age and years in practice as factors associated with needlestick and sharps injuries among health care workers in a Portuguese hospital显示文摘 | Artur Martins Ana C. Coelho Manuela Vieira Manuela Matos Maria L. Pinto | 2012 | Accident Analysis and Prevention2012，，： | 1 |
| 11 | High-Frequency Ultrasound Imaging for Longitudinal Evaluation of Non-Alcoholic Fatty Liver Disease Progression in Mice显示文摘 | Itziar Fernández-Domínguez J. Javier Echevarria-Uraga Nieves Gómez Zigmund Luka Conrad Wagner Shelly C. Lu José M. Mato Maria L. Martínez-Chantar Juan Rodríguez-Cuesta | 2011 | Ultrasound in Medicine & Biology2011，，7： | 1 |
| 12 | Genetic polymorphisms involved in folate metabolism and concentrations of methylmalonic acid and folate on plasma homocysteine and risk of coronary artery disease显示文摘 | Patrícia Matos Biselli Alexandre Rodrigues Guerzoni Moacir Fernandes Godoy Marcos Nogueira Eberlin Renato Haddad Valdemir Melechco Carvalho Hélio Vannucchi érika Cristina Pavarino-Bertelli Eny Maria Goloni-Bertollo | 2010 | Journal of Thrombosis and Thrombolysis2010，，1： | 1 |
| 13 | Pancreatic neuroendocrine tumor: Added value of fusion of T2-weighted imaging and high b -value diffusion-weighted imaging for tumor detection显示文摘 | Renata Brenner Thierry Metens Maria Bali Pieter Demetter Celso Matos | 2012 | European Journal of Radiology2012，，5： | 1 |
| 14 | Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)显示文摘 | Ant?nio Talvane Torres Oliveira Céline Pinheiro Adhemar Longatto-Filho Maria Jose Brito Olga Martinho Delcio Matos André Lopes Carvalho Vinícius Lima Vazquez Thiago Buosi Silva Cristovam Scapulatempo Sarhan Sydney Saad Rui Manuel Reis Fátima Baltazar | 2012 | Journal of Bioenergetics and Biomembranes2012，，1： | 1 |
| 15 | Evaluation and determination of chloride in crude oil based on the counterions Na, Ca, Mg, Sr and Fe, quantified via ICP-OES in the crude oil aqueous extract显示文摘 | Murilo de Oliveira Souza Maria Aparecida Ribeiro Maria Tereza Weitzel Dias Carneiro Geisamanda Pedrini Brand?o Athayde Eustáquio Vinícius Ribeiro de Castro Francisco Luan Fonseca da Silva Wladiana Oliveira Matos Rafael de Queiroz Ferreira | 2015 | Fuel2015，，： | 1 |
| 16 | Genetic polymorphisms involved in folate metabolism and concentrations of methylmalonic acid and folate on plasma homocysteine and risk of coronary artery disease显示文摘 | Patrícia Matos Biselli Alexandre Rodrigues Guerzoni Moacir Fernandes Godoy Marcos Nogueira Eberlin Renato Haddad Valdemir Melechco Carvalho Hélio Vannucchi érika Cristina Pavarino-Bertelli Eny Maria Goloni-Bertollo | 2010 | Journal of Thrombosis and Thrombolysis2010，，1： | 1 |
| 17 | Determination of synthetic food dyes in commercial soft drinks by TLC and ion-pair HPLC显示文摘 | Francisca Ivani de Andrade Maria Izabel Florindo Guedes ícaro Gusm?o Pinto Vieira Francisca Noélia Pereira Mendes Paula Alves Salmito Rodrigues Carla Soraya Costa Maia Maria Marlene Marques ávila Luzara de Matos Ribeiro | 2014 | Food Chemistry2014，，： | 1 |
| 18 | Synthesis and degradation of poly-b-hydroxybutyrate in a sequencing batch biofilm reactor显示文摘 | Regina Nogueira Cláudia Alves Maria Matos António G Brito | 2009 | Bioresource Technology2009，100，： | 1 |
| 19 | Endoscopic and histological evaluations of a newly designed ingui- nal hernia mesh implant: Experimental studies on porcine animal model and human cadaver 显示文摘 | Fabrizio Panaro Aria Maria Matos -Azevedo Jos Antonio Fatas | 2015 | Annals of Medicine and Surgery2015，4，2： | 1 |
| 20 | Mechanism of uranium (VI) removal by two anaerobic bacterial communities显示文摘 | Mónica Martins Maria Leonor Faleiro Ana M. Rosa da Costa Sandra Chaves Rogério Tenreiro António Pedro Matos Maria Clara Costa | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
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