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| 1 | New challenges in perioperative management of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC)is the fourth leading cause of cancer-related death in the industrialized world.Despite progress in the understanding of the molecular and genetic basis of this disease,the5-year survival rate has remained low and usually does not exceed 5%.Only 20%-25%of patients present with potentially resectable disease and surgery represents the only chance for a cure.After decades of gemcitabine hegemony and limited therapeutic options,more active chemotherapies are emerging in advanced PDAC,like 5-Fluorouracil,folinic acid,irinotecan and oxaliplatin and nab-paclitaxel plus gemcitabine,that have profoundly impacted therapeutic possibilities.PDAC is considered a systemic disease because of the high rate of relapse after curative surgery in patients with resectable disease at diagnosis.Neoadjuvant strategies in resectable,borderline resectable,or locally advanced pancreatic cancer may improve outcomes.Incorporation of tissue biomarker testing and imaging techniques into preoperative strategies should allow clinicians to identify patients who may ultimately achieve curative benefit from surgery.This review summarizes current knowledge of adjuvant and neoadjuvant treatment for PDAC and discusses the rationale for moving from adjuvant to preoperative and perioperative therapeutic strategies in the current era of more active chemotherapies and personalized medicine.We also discuss the integration of good specimen collection,tissue biomarkers,and imaging tools into newly designed preoperative and perioperative strategies. | Francesco Puleo Raphaёl Maréchal Pieter Demetter Maria-Antonietta Bali Annabelle Calomme Jean Closset Jean-Baptiste Bachet Jacques Deviere Jean-Luc Van Laethem | 2015 | World Journal of Gastroenterology2015，21，8： | 4 |
| 2 | TTF-1 positive small cell cancers:Don't think they're always primary pulmonary!显示文摘Thyroid transcription factor 1 (TTF-1) plays a key role in morphogenesis of the lungs and is expressed in up to 90% of pulmonary small cell carcinomas.This explains why this marker is frequently used in the search for the primary origin of metastatic endocrine tumours.Here we report on a TTF-1 expressing mixed endocrine-exocrine carcinoma of the common bile duct in a patient with pulmonary nodules that did not appear to be neoplastic.TTF-1 positivity in pulmonary and extrapulmonary neuroendocrine tumours is reviewed,and we conclude that TTF-1 expression in neuroendocrine tumours of the small-cell type are not uncommon at extrapulmonary locations.Therefore,immunohistochem-istry for TTF-1 in such tumours should be interpreted with caution. | Laurine Verset Marianna Arvanitakis Patricia Loi Jean Closset Myriam Delhaye Myriam Remmelink Pieter Demetter | 2011 | World Journal of Gastrointestinal Oncology2011，3，10： | 2 |
| 3 | Common polymorphism in the PNPLA3 /adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease显示文摘 | Eric Trépo Thierry Gustot Delphine Degré Arnaud Lemmers Laurine Verset Pieter Demetter Romy Ouziel Eric Quertinmont Vincent Vercruysse Leila Amininejad Pierre Deltenre Olivier Le Moine Jacques Devière Denis Franchimont Christophe Moreno | 2011 | Journal of Hepatology2011，，4： | 2 |
| 4 | The proportion of Thl cells, which prevail in gut mucosa, is decreased in inflammatory bowel syndrome 显示文摘 | DAMME NV KEYSER FD DEMETTER P | 2001 | Clin Exp Immunol2001，125，3： | 1 |
| 5 | Focal up-regulation of E-cadherin-catenin complex in inflamed bowel mucosa but reduced expression in ulcer-associated cell lineage显示文摘 | Demetter P De Vos M Van Damme N | 2000 | Am J Clin Pathol2000，114，3： | 1 |
| 6 | Pancreatic neuroendocrine tumor: Added value of fusion of T2-weighted imaging and high b -value diffusion-weighted imaging for tumor detection显示文摘 | Renata Brenner Thierry Metens Maria Bali Pieter Demetter Celso Matos | 2012 | European Journal of Radiology2012，，5： | 1 |
| 7 | High expression of CXCR4 may predict poor survival in resected pancreatic adenocarcinoma 显示文摘 | Marechal R Demetter P Nagy N | 2009 | Br J Cancer2009，100，9： | 1 |
| 8 | High expression of CXCR4may predict poor survival in resected pancreatic adenocarcinoma显示文摘 | Marechal R Demetter P Nagy N | 2009 | Br J Cancer2009，100，9： | 1 |
| 9 | Stromal myo- fibroblasts are drivers of invasive cancer growth 显示文摘 | De Wever O Demetter P Mareel M | 2008 | Int J Cancer2008，123，10： | 1 |
| 10 | Wound healing after paranasal sinus surgery:neutrophilic inflammation influences the outcome显示文摘 | Watelet JB Demetter P Claeys C | 2006 | Histopathology2006，48，6： | 1 |
| 11 | Contribution of CXCR4 and SMAD4 in predicting disease progression pattern and benefit from adjuvant chemotherapy in reseeted pancreatic adenocarcinoma 显示文摘 | Baehet J B Mar~chal R Demetter P | 2012 | Ann Oncol2012，23，9： | 1 |
| 12 | High ex- pression of CXCR4 may predict poor survival in resected pan- creatic adenocarcinoma显示文摘 | MARI:CHAL R DEMETTER P NAGY N | 2009 | British Journal of Cancer2009，100，9： | 1 |
| 13 | S100A2 is a predictive bio- marker of adjuvant therapy benefit in pancreatic adenocarcinoma显示文摘 | Bachet JB Marechal R Demetter P | 2013 | Eur J Cancer2013，49，12： | 1 |
| 14 | Stromal myofibroblasts are drivers of invasive cancer growth 显示文摘 | De-Wever O Demetter P Mareel M | 2008 | Int J Cancer2008，123，10： | 1 |
| 15 | A rare case of a pancreatic mass due to accessory spleen; when EUS-FNA is not enough显示文摘 | Toussaint E Flamen P Demetter P | 2011 | Endoscopy2011，43，2： | 1 |
| 16 | Expression of SGLT1, Bcl-2 and p53 in Primary Pancreatic Cancer Related to Survival显示文摘 | Veerle F. Casneuf Philippe Fonteyne Nancy Van Damme Pieter Demetter Patrick Pauwels Bernard de Hemptinne Martine De Vos Christophe Van de Wiele Marc Peeters | 2008 | Cancer Investigation2008，，8： | 1 |
| 17 | Neutrophil-derived metalloproteinase-9 predicts healing quality after sinus surgery显示文摘 | Watelet JB Demetter P Claeys C | 2005 | Laryngoscope2005，115，1： | 1 |
| 18 | Comparative study of the synovial histology in rheumatoid arthritis, spondy- loarthropathy, and osteoarthritis : influence of disease duration and activity显示文摘 | BAETEN D DEMETTER P CUVELIER C | 2000 | Ann Rheum Dis2000，59，12： | 1 |
| 19 | Impaired blood-brain and blood-spinal cord barriers in mutant SOD1- linked AI_S rat显示文摘 | NICAISE C MITRECIC D DEMETTER P | 2009 | Brain Research2009，1301，： | 1 |
| 20 | Comparative study of the synovial histology in rheumatoid arthritis, spondyloarthropathy, and osteoarthritis : influence of disease duration and activity 显示文摘 | Baeten O Demetter P Cuvelier C etal | 2000 | Ann Rheum Dis2000，59，12： | 1 |
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