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| 1 | Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs显示文摘Objective:To evaluate in ritro antimicrobial activities of selected 58 ethno-medicinal plant extracts with a view to assess their therapeutic potential.Methods:A total of 58 traditional Chinese medicinal plants were carefully selected based on the literature review and their traditional use.The antimicrobial activities of ethanol extracts of these medicinal plants were tested against fungi(Aspergillus funigaius),yeast(Candida albicans),gram-negative(Acirelobacter haumannii and Pseudornnruis aeruginosa)and gram-positive bacteria(Staphglococcus aureus).The activities were tested at three different concentrations of 1.00,0.10 and 0.01 mg/mL.The data was analysed using Gene data Screener program.Results:The measured antimicrobial activities indicated that out of the 58 plant extracts,15 extracts showed anti-fungal activity and 23 extracts exhibited anti-bacterial activity.Eight plant extracts have exhibited both anti-bacterial and anti-fungal activities.For instance,Eucommia ulmoides,Pohgonum cuspidcrtum,Poria cocas and Uncaria rhineophylla showed activity against both bacterial and fungal strains,indicating their broad spectrum of activity.Conclusions:The results revealed that the ethanol extracts of 30 plants out of the selected 58 possess significant antimicrobial activities.It is interesting to note that the findings from the current study are consistent with the traditional use.A clear correlation has also been found between the antimicrobial activity and the flavonoid content of the plant extracts which is in agreement with the literature.Hence.the results presented here can be used to guide the selection of potential plant species for the isolation and structure elucidation of novel antimicrobial compounds in order to establish the structure-activity relationship.This in turn is expected to lead the way to the discovery of novel antimicrobial agents for therapeutic use. | Lin Zhang Anjaneya S.Ravipati Sundar R Koyyalamudi Sang Chul Jeong Narsimha Reddy John Bartlett Paul T.Smith Mercedes de la Cruz Maria Cndida Monteiro ngeles Melguizo Ester Jimnez Francisca Vicente | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，9： | 23 |
| 2 | Extrinsic and intrinsic mechanisms of axon regeneration:the need for spinal cord injury treatment strategies to address both显示文摘Spinal cord injury(SCI)causes disturbances in motor and sensory functions leading to paralysis,the severity of which depends on the spinal level of the injury.Traumatic lesions of spinal cord axon projection tracts are untreatable in human patients,although numerous research | Christina Francisca Vogelaar | 2016 | Neural Regeneration Research2016，11，4： | 5 |
| 3 | Finding the solution for incomplete small bowel capsule endoscopy显示文摘AIM:To evaluate whether the use of real time viewer(RTV)and administration of domperidone to patients with delayed gastric passage of the capsule could reduce the rate of incomplete examinations(IE)and improve the diagnostic yield of small bowel capsule endoscopy(SBCE).METHODS:Prospective single center interventional study,from June 2012 to February 2013.Capsule location was systematically checked one hour after ingestion using RTV.If it remained in the stomach,the patient received 10 mg domperidone per os and the location of the capsule was rechecked after 30 min.If the capsule remained in the stomach a second dose of10 mg of domperidone was administered orally.After another 30 min the position was rechecked and if the capsule remained in the stomach,it was passed into the duodenum by upper gastrointestinal(GI)endoscopy.The rate of IE and diagnostic yield of SBCE were compared with those of examinations performed before the use of RTV or domperidone in our Department(control group,January 2009-May 2012).RESULTS:Both groups were similar regarding age,sex,indication,inpatient status and surgical history.The control group included 307 patients,with 48(15.6%)IE.The RTV group included 82 patients,with3(3.7%)IE,P=0.003.In the control group,average gastric time was significantly longer in patients with IE than in patients with complete examination of the small bowel(77 min vs 26 min,P=0.003).In the RTV group,the capsule remained in the stomach one hour after ingestion in 14/82 patients(17.0%)vs 48/307(15.6%)in the control group,P=0.736.Domperidone did not significantly affect small bowel transit time(260min vs 297 min,P=0.229).The capsule detected positive findings in 39%of patients in the control group and 49%in the RTV group(P=0.081).CONCLUSION:The use of RTV and selective administration of domperidone to patients with delayed gastric passage of the capsule significantly reduces incomplete examinations,with no effect on small bowel transit time or diagnostic yield. | José Cotter Francisca Dias de Castro Joana Magalhes Maria Joo Moreira Bruno Rosa | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，12： | 4 |
| 4 | Essential role of small bowel capsule endoscopy in reclassification of colonic inflammatory bowel disease type unclassified显示文摘AIM To evaluate the role of small bowel capsule endoscopy(SBCE) on the reclassification of colonic inflammatory bowel disease type unclassified(IBDU).METHODS We performed a multicenter, retrospective study including patients with IBDU undergoing SBCE, between 2002 and 2014. SBCE studies were reviewed and the inflammatory activity was evaluated by determining the Lewis score(LS). Inflammatory activity was considered significant and consistent with Crohn's disease(CD) when the LS ≥ 135. The definitive diagnosis during follow-up(minimum 12 mo following SBCE) was based on the combination of clinical, analytical, imaging, endoscopic and histological elements.RESULTS Thirty-six patients were included, 21 females(58%) with mean age at diagnosis of 33 ± 13(15-64) years. The mean follow-up time after the SBCE was 52 ± 41(12-156) mo. The SBCE revealed findings consistent with significant inflammatory activity in the small bowel(LS ≥ 135) in 9 patients(25%); in all of them the diagnosis of CD was confirmed during follow-up. In 27 patients(75%), the SBCE revealed no significant inflammatory activity(LS < 135); among these patients, the diagnosis of Ulcerative Colitis(UC) was established in 16 cases(59.3%), CD in 1 case(3.7%) and 10 patients(37%) maintained a diagnosis of IBDU during follow-up. A LS ≥ 135 at SBCE had a sensitivity = 90%, specificity = 100%, positive predictive value = 100% and negative predictive value = 94% for the diagnosis of CD.CONCLUSION SBCE proved to be fundamental in the reclassification of patients with IBDU. Absence of significant inflammatory activity in the small intestine allowed exclusion of CD in 94% of cases. | Sara Monteiro Francisca Dias de Castro Pedro Boal Carvalho Bruno Rosa Maria Joao Moreira Rolando Pinho Miguel Mascarenhas Saraiva José Cotter | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，1： | 3 |
| 5 | PillCam~ SB3 capsule: Does the increased frame rate eliminate the risk of missing lesions?显示文摘Since its emergence in 2000, small bowel capsule endoscopy(SBCE) has assumed a pivotal role as an investigation method for small bowel diseases. The PillCam SB2-ex offers 12 h of battery time, 4 more than the previous version(SB2). Rahman et al recently found that the PillCam SB2-ex has a significantly increased completion rate, although without higher diagnostic yield, compared with the SB2. We would like to discuss these somewhat surprising results and the new potentialities of the PillCam SB3 regarding the diagnostic yield of small bowel studies. PillCam SB3 offers improved image resolution and faster adaptable frame rate over previous versions of SBCE. We recently compared the major duodenal papilla detection rate obtained with PillCam SB3 and SB2 as a surrogate indicator of diagnostic yield in the proximal small bowel. The PillCam SB3 had a significantly higher major duodenal papilla detection rate than the PillCam SB2(42.7% vs 24%, P = 0.015). Thus, the most recent version of the PillCam capsule, SB3, may increase diagnostic yield, particularly in the proximal segments of the small bowel. | Sara Monteiro Francisca Dias de Castro Pedro Boal Carvalho Maria Joao Moreira Bruno Rosa José Cotter | 2016 | World Journal of Gastroenterology2016，22，10： | 2 |
| 6 | Utilization of autoclaved and fermented sesame(Sesamum indicum L.) seed meal in diets for Til-aqua natural male tilapia显示文摘Current research emphasis has been on the reduction of feed cost by incorporating processed sesame seed meal in the diet of tilapia. Raw sesame(Sesamum indicum) seed was soaked and subjected to either autoclaving or fermentation, after which their oil contents were mechanically extracted. Graded levels of autoclaved(71.2,165,5 and 296.3 g/kg designated as diets 1, 2 and 3, respectively) and fermented(71.0,164.3 and 292,2 g/kg designated as diets 4, 5 and 6, respectively) sesame seed meal were included into fishmeal based diets for Til-aqua natural male tilapia(NMT) fry(initial weight,1.69 ± 0.02 g), A diet without sesame seed meal served as the control. Diets were approximately iso-nitrogenous(35% crude protein). Fish were fed 5 times their maintenance requirement, which was 3.2 x 5 x [fish weight(g)/1,000]^(0.8) daily for 56 days. Processing improved the nutritional profile of raw sesame seed meal in terms of its crude protein and antinutrient compositions. Growth performance of fish was similar(P> 0.05) in the control and dietary treatments. The group fed diet 3 exhibited significantly poorer feed conversion ratio(1.14), protein efficiency ratio(2.77) and economic conversion ratio(US$1.38/kg) relative to the group that received diet 5. Apparent digestibility coefficients for protein, lipid and energy in diet 3 were similar(P > 0.05) to those in diet 6 but significantly lower(P < 0.05) than those of the control and other dietary groups. The sesame seed meals processed with different methods did not significantly affect crude protein, crude lipid and gross energy compositions in the fish carcass. The study demonstrated that71.2 g/kg of autoclaved and 164.3 g/kg of fermented sesame seed meal could be incorporated in the diet of Til-aqua NMT with cost benefit. | Oluwagbenga Olude Francisca George Wilfred Alegbeleye | 2016 | Animal Nutrition2016，，4： | 2 |
| 7 | A prospective cancer chemo-immunotherapy approach mediated by synergistic CD326 targeted porous silicon nanovectors显示文摘经由 nanoparticulate 系统的联合治疗已经为癌症治疗作为一条 synergistic 途径被建议了。此处, undecylenic 酸热地修改了多孔的硅 nanoparticles (UnTHCPSi NP ) 与 sorafenib 装载了的 hydrocarbonized,有 anti-CD326 抗体(Ab ) 的 surface-biofunctionalized 在 MCF-7 和 MDA-MB-231 乳癌房间为癌症 chemo 免疫疗法被开发。cytocompatibility 学习没在比 200 g 低的集中为赤裸、结合抗体的 UnTHCPSi (Un-Ab ) NP 显示出重要毒性 ? 浩汰楹杮愠搠 ' 糖锚?湩琠敨漠潸桰汩捩瑩 ? 景琠敨猠牵慦散倠 ? 瑡浯吗? | Mohammad-Ali Shahbazi Neha Shrestha Ermei Makila Francisca Araujo Alexandra Correia Tomas Ramos Bruno Sarmento Jarno Salonen Jouni Hirvonen Helder A. Santos | 2015 | Nano Research2015，8，5： | 2 |
| 8 | COVID-19 and neurologic manifestations:a synthesis from the child neurologist’s corner显示文摘Background Since December 2019,the SARS-CoV-2 virus has been a global health issue.The main clinical presentation of this virus is a flu-like disease;however,patients with diverse neurologic manifestations have also been reported.In this review,we attempt to summarize,discuss and update the knowledge of the neurologic manifestations in the pediatric population affected by SARS-CoV-2 infection and the pandemic’s effects in children with neurologic diseases.Data sources This review analyzes studies found on the PubMed database using the following keywords:Neurologic manifestations COVID-19,Neurological COVID-19,coronavirus,SARS-CoV-2,pediatric COVID-19,COVID-19 in children,MIS-C,Pediatric Inflammatory Multisystem Syndrome,Guillain BarréSyndrome,Stroke,ADEM,and Anti-NMDA encephalitis.All studies cited were published between 2004 and 2022,and represent the most relevant articles in the field.The World Health Organization COVID-19 online dashboard was assessed to obtain updated epidemiological data.Results The most common neurologic symptoms in the pediatric population are headache,seizures,encephalopathy,and muscle weakness.These can be present during COVID-19 or weeks after recovering from it.Children who presented with multi-system inflammatory syndrome had a higher incidence of neurologic manifestations,which conferred a greater risk of morbidity and mortality.Several neuro-pathophysiological mechanisms have been proposed,including direct virus invasion,hyper-inflammatory reactions,multi-systemic failure,prothrombotic states,and immune-mediated processes.On the other hand,the COVID-19 pandemic has affected patients with neurologic diseases,making it challenging to access controls,treatment,and therapies.Conclusions Various neurologic manifestations have been associated with children’s SARS-CoV-2 infection.It is important to identify and give them proper and opportune treatment because they can be potentially grave and life-threatening;some can lead to long-lasting sequelae.Different neuro-pathophysiological mechanisms have been proposed,however,a causal relationship between SARS-CoV-2 infection and neurologic manifestations remains to be proven.Patients with neurologic diseases are especially affected by COVID-19,not only by the disease itself but also by its complications and pandemic management measures. | Carolina Valderas Gastón Méndez Alejandra Echeverría Nelson Suarez Katherin Julio Francisca Sandoval | 2022 | World Journal of Pediatrics2022，18，6： | 2 |
| 9 | Kinetics of the Anti-oxidant Response to Salinity in the Halophyte Cakile maritima显示文摘在抗氧化剂酶(超级氧化物 dismutase ,过氧化氢酶(猫),过氧化物酶(邮政部门), ascorbate 过氧化物酶( APX ), monodehydroascorbate reductase , dehydroascorbate reductase ( DHAR ),和 glutathionereductase ( GR ))的活动的 NaCI 应力的效果,抗氧化剂分子( ascorbate 和谷胱甘肽),并且氧化应力( malondialdehyde ( MDA ),电解质漏,和 H_2O_2 集中)的参数在 Cakilemaritima 被调查,沿着突尼斯的海岸经常的盐土植物。幼苗面对盐(100, 200,和 400 mmol/L NaCI ) 被种。植物在 20 天周期性地被收获。生长面对 0-100 mmol/L NaCI 是最大的。在 400 mmol/L NaCI,生长显著地减少了。C 的 Thesalt 忍耐。在中等咸度, maritima 与氧化应力的最低价值 oftheparameters 陈述语气被联系,也就是,邮政部门,猫, APX, DHAR, andGR 和高织物的最高的活动 ascorbate 和谷胱甘肽满足。然而,延长了暴露到高咸度在 anti-oxidantactivities 和高 MDA 导致了减少内容,电解质漏,和 H_2O_2 集中。这些结果建议 anti-oxidantsystems 参予 C 的忍耐。maritima 将节制咸度。 | Nader Ben Amor Ana Jimenez Wided Megdiche Marianne Lundqvist Francisca Sevilla Chedly Abdelly | 2007 | Journal of Integrative Plant Biology2007，49，7： | 2 |
| 10 | Aortic valve stenosis provides complementary information to bleeding risk scores in non-valvular atrial fibrillation patients initiating anticoagulation显示文摘Background The identification of modifiable bleeding risk factors may be of relevance.The aim is to evaluate if aortic stenosis(AS)provides additional information to bleeding risk scores for predicting major bleeding(MB)in non-valvular atrial fibrillation(AF).Methods We designed a retrospective multi-center study including 2880 consecutive non-valvular AF patients initiating oral anticoagulation between January 2013 and December 2016.AS was defined as moderate or severe according to European echocardiography guidelines criteria.HASBLED,ATRIA and ORBIT scores were used to evaluate the bleeding risk.MB was defined according to the International Society on Thrombosis and Haemostasia criteria and registered at 18 months of follow-up.Results 168(5.8%)patients had AS.Patients with AS had higher risk for MB compared to those without AS(HR=2.13,95%CI:1.40-3.23,P<0.001).Patients without AS and low-intermediate bleeding risk(0 points)showed the lowest MB rate,whereas the MB rate observed among patients with AS and high bleeding risk(2 points)was the highest one.Discrimination and reclassification analyses showed that AS provided additional information to bleeding risk scores for predicting MB at 18 months of follow-up.Conclusions In this population,AS was associated with an increased risk for MB at midterm follow-up.The three scoring systems showed a moderate discriminatory ability for MB.Moreover,the addition of AS was associated with a significant improvement in their predictive accuracy.We suggest that the presence of this valvulopathy should be taken into account for bleeding risk assessment. | Gines Elvira-Ruiz Cesar Caro-Martinez Pedro JoseFlores-Blanco Juan JoseCerezo-Manchado Helena Albendin-Iglesias Alejandro Lova-Navarro Francisco Arregui-Montoya Francisca Maria Munoz-Franco Natalia Garcia-Iniesta Arcadio Garcia-Alberola JoseLuis Bailen-Lorenzo Domingo Andres Pascual-Figal Sergio Manzano-Fernández | 2020 | Journal of Geriatric Cardiology2020，17，3： | 2 |
| 11 | Endogenous cannabinoids: A new system involved in the homeostasis of arterial pressure in experimental cirrhosis in the rat显示文摘 | Josefa Ros Joan Clària Jordi To-Figueras Anna Planagumà Pilar Cejudo-Martin Guillermo Fernandez-Varo Raul Martín-Ruiz Vicente Arroyo Francisca Rivera Juan Rodés Wladimiro Jimenez | 2002 | Gastroenterology2002，，1： | 2 |
| 12 | Diversity, frequency, and geographic distribution of facultative bacterial endosymbionts in introduced aphid pests显示文摘在昆虫的容许的细菌的 endosymbionts 在最后年期间在强烈学习下面。Endosymbionts 能修改昆虫显型,授与在环境应力下面的适应优点。,这为一组全球农业的蚜虫害虫似乎特别地相关 endosymbionts 修改关键健康相关的特点包括主人植物使用,对生来的敌人和热忍耐的保护。试图在介绍蚜虫害虫,分发和许多的成功上理解容许的 endosymbionts 的角色 5 容许的 endosymbionts ( Hamiltonella defensa , Regiella insecticola , Serratia symbiotica ,立克次休属微生物和 Spiroplasma )在 4 个谷物蚜虫被学习并且比较( Sitobion avenae , Diuraphis noxia , Metopolophium dirhodum 和 Schizaphis graminium )并且在从在智利的 2 个 agroclimatic 地区的豌豆蚜虫 Acyrthosiphon pisum 建筑群。总的来说,有容许的 endosymbionts 的感染展出了取决于蚜虫种类 / 主人赛跑和地理地区的一个高度可变、典型的模式,它能在他们的介绍以后解释蚜虫害虫人口的成功。当时 S。symbiotica 和 H。defensa 是 A 带的最经常的 endosymbionts。pisum 豌豆赛跑和 A。分别地,最经常的容许的 endosymbiont 由所有谷物蚜虫带了的 pisum 苜蓿赛跑蚜虫是 R。insecticola。有趣地, endosymbionts 的一篇高度可变的作文由 S 带了。avenae 也在 agroclimatic 地区之间被观察,建议 endosymbionts 正在回答到不能生活的变量(温度和猛冲) 的差别。另外,我们的调查结果在以前没屏蔽的谷物蚜虫种类组成细菌的 endosymbionts 的第一份报告,并且也,第一在智利蚜虫 endosymbionts 报导。 | Daniela A. Sepulvedat Francisca Zepeda-Paulo Claudio C. Ramfrez Bias Lavandero Christian C. Figueroa | 2017 | Insect Science2017，24，3： | 2 |
| 13 | A Model of Strategic Change:Universities and Dynamic Capabilities显示文摘 | Jose Ruiz Navarro Francisca Orihuela Gallardo | 2003 | Higher Education Poficy2003，，16： | 1 |
| 14 | Spatial variability of agricultural soil parameters in southern Spain显示文摘 | Francisca López-Granados Montserrat Jurado-Expósito Silvia Atenciano Alfonso García-Ferrer Manuel Sánchez de la Orden Luis García-Torres | 2002 | Plant and Soil2002，，1： | 1 |
| 15 | Human Schistosome Infection and Allergic Sensitisation显示文摘 | Nadine Rujeni David W. Taylor Francisca Mutapi Maria Ilma Araujo | 2012 | Journal of Parasitology Research2012，，： | 1 |
| 16 | Hypoxia induces H2O2production and activates antioxidant defence system in grapevine buds through mediation of H2O2and ethylene显示文摘 | Ricardo V Francisca P Sebastián R | 2012 | Experimental Botany2012，63，11： | 1 |
| 17 | Transmission of a live Eimeria acervulina vaccine strain and response to infection in vaccinated and contact-vaccinated broilers显示文摘 | Francisca C V Annemarie B Arjan S J | 2012 | Vaccine2012，30，2： | 1 |
| 18 | Growth and yield responses of spring and winter triticale cultivated under Mediterranean conditions 显示文摘 | Francisca S Conxita R Romagosa I | 2004 | European Journal of Agronomy2004，20，： | 1 |
| 19 | Short communication : Influence of microbial inoculation and co - composting material on the evolution of humic - like substances during composting of horticultural wastes 显示文摘 | Vargas - Garcia M adel Carmen Suarez - Estrella F Francisca Lopez M a Jose | 2006 | Process Biochemistry2006，41，6： | 1 |
| 20 | Inducing α-synuclein compaction: a new strategy for inhibiting α-synuclein aggregation?显示文摘Proteins might misfold during translation and folding or even once they are in their native states, due to stochastic fluctuations, destabilizing mutations or cellular stress. Aberrant protein species are usually detected and either refolded or cleared by the protein quality control machinery (Ciechanover and Kwon, 2015). When misfolded protein conformers cannot be degraded, they tend to self-assemble to form aggregates, a characteristic of many neurodegenerative diseases. | Francisca Pinheiro Salvador Ventura | 2019 | Neural Regeneration Research2019，14，11： | 1 |
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