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| 1 | Interleukin-1 beta induces the expression and production of stem cell factor by epithelial cells: crucial involvement of the PI-3K/mTOR pathway and HIF-1 transcription complex显示文摘在发炎和白血球过多症之间的潜在的交叉连接有一段时间被讨论了,但是支持这教义的试验性的证据是少见的。特别地,由煽动性的调停人理解为 proto-oncogenic 生长因素表情的潜在的 upregulation 负责的机制是重要的。这里,我们调查了高度煽动性的 cytokine interleukin-1 贝它的能力(IL-1β) 到导致干细胞因素(SCF ) 的生产,它是在造血的 myeloid 细胞的恶意的转变之上控制尖锐 myeloid 白血球过多症的前进的一个主要造血的生长因素。我们发现了那人的 IL-1β在 MCF-7 人的上皮的乳癌房间和那导致了 SCF 的表示 / 分泌物这个过程取决于组织缺氧可诱导的因素 1 (HIF-1 ) 抄写建筑群。我们也表明了 phosphatidylinositol-3 kinase (PI-3K ) 的一个关键角色 rapamycin (mTOR ) 的 /mammalian 目标在 IL-1β 的小径;导致的 HIF-1α在 MCF-7 房间的累积。重要地, mTOR 也被发现在 IL-1β 起一个作用;导致的 SCF 生产。而且,为 IL-1β 的积极关联的一个趋势;并且在健康人的施主的血浆的 SCF 层次被观察。总的来说,我们的结果表明那 IL-1β,它通常衔接天生、适应的免疫,通过 PI-3K/mTOR 小径和 HIF-1 抄写建筑群导致主要 haematopoietic/proleukaemic 生长因素 SCF 的生产。这些调查结果强烈支持在发炎和尖锐 myeloid 白血球过多症之间的串音。 | Rafal W Wyszynski Bernhard F Gibbs Luca Varani Daniela Iannotta Vadim V Sumbayev | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 2 | The bronchiolar epithelium as a prominent source of pro-inflammatory cytokines after lung irradiation显示文摘 | CLAUDIA E R DANIELA U FALK W | | 0，，05： | 1 |
| 3 | Crystallization of gahnite in CMAS glass forming system - mechanism and process kinetics 显示文摘 | DANIELA H TOMASZ O WIESLAW W | 2010 | Adv Sci Tech2010，68，： | 1 |
| 4 | Mechanical thrombectomy in acute occlusion of the carotid-T : a retrospective single centre study in 51 pa- tients显示文摘 | Daniela F Silke W Miriam I | 2016 | Clin Neumradiol2016，26，1： | 1 |
| 5 | Molecular Analysis of HER2 Signaling in Human Breast Cancer by Functional Protein Pathway Activation Mapping显示文摘 | Julia D W Daniela B Claudia W | | 0，，： | 1 |
| 6 | Increased chromosomal alterations and micronuclei formation in human hepatoma HepG2 cells transfected with the hepatitis B virus HBX gene显示文摘 | Livezey Kristin W Negorev Dmitri Simon Daniela | 2002 | Mutat Res2002，505，12： | 1 |
| 7 | Perspectives of γδ T cells in tumor immunology 显示文摘 | Dieter K Daniela W Wei He | 2007 | Cancer Research2007，67，1： | 1 |
| 8 | Poor responder-high responder:the importance of soluble vascular endothelial growth factor receptor 1 in ovarian stimulation protocols显示文摘 | Joseph N Daniela W Carster H | 2001 | Hum Reprod2001，16，4： | 1 |
| 9 | The effect of low earth orbit atomic oxygen exposure on phenylphosphine oxide-containing polymers 显示文摘 | CONNELL J W DANIELA C S | 2000 | High Performance Polymers2000，12，： | 1 |
| 10 | 'Take it up a NOTCH:' Novel strategies for cancer therapy显示文摘 | STEFANIE L M GREGORY A W DANIELA M D | 2012 | Cell Cycle2012，12，2： | 1 |
| 11 | Effects of a multimodal exercise protocol on functional outcomes,epigenetic modulation and brain-derived neurotrophic factor levels in institutionalized older adults:a quasi-experimental pilot study显示文摘Epigenetic changes have been shown to be associated with both aging process and aging-related diseases.There is evidence regarding the benefits of physical activity on the functionality,cognition,and quality of life of institutionalized older adults,however,the molecular mechanisms involved are not elucidated.The purpose of this pilot study was to investigate the effects of a multimodal exercise intervention on functional outcomes,cognitive performance,quality of life(QOL),epigenetic markers and brain-derived neurotrophic factor(BDNF)levels among institutionalized older adult individuals.Participants(n=8)without dementia who were aged 73.38±11.28 years and predominantly female(87.5%)were included in this quasi-experimental pilot study.A multimodal exercise protocol(cardiovascular capacity,strength,balance/agility andflexibility,perception and cognition)consisted of twice weekly sessions(60 minutes each)over 8 weeks.Balance(Berg Scale),mobility(Timed Up and Go test),functional capacity(Six-Minute Walk test),cognitive function(Mini-Mental State Examination)and QOL(the World Health Organization Quality of Life-BREF Scale questionnaire)were evaluated before and after the intervention.Blood sample(15 mL)was also collected before and after intervention for analysis of biomarkers global histone H3 acetylation and brain-derived neurotrophic factor levels.Significant improvements were observed in cognitive function,balance,mobility,functional capacity and QOL after the intervention.In addition,a tendency toward an increase in global histone H3 acetylation levels was observed,while brain-derived neurotrophic factor level remained unchanged.This study provided evidence that an 8-week multimodal exercise protocol has a significant effect on ameliorating functional outcomes and QOL in institutionalized older adult individuals.In addition,it was also able to promote cognitive improvement,which seems to be partially related to histone hyperacetylation status.The Ethics Research Committee of Centro Universitário Metodista-IPA,Brazil approved the current study on June 6,2019(approval No.3.376.078). | Iasmin Fraga Camila Weber Wériton Baldo Galiano Lucio Iraci Mariana Wohlgemuth Gabriela Morales Camila Cercato Juliana Rodriguez Daniela Pochmann Caroline Dani Pérsia Menz Adriane Dal Bosco Viviane Rostirola Elsner | 2021 | Neural Regeneration Research2021，16，12： | 1 |
| 12 | A novel con formal RFIDenabled module utilizing inkjet-printed anten nas and carbon nanotubes for gas-detection applications显示文摘 | Li Y Zhang R W Staiculescu Daniela | 2009 | IEEE Antennas Wirel Propag Lett2009，8，： | 1 |
| 13 | Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma显示文摘 | Amir Avan Viola Caretti Niccola Funel Elena Galvani Mina Maftouh Richard J. Honeywell Tonny Lagerweij Olaf Van Tellingen Daniela Campani Dieter Fuchs Henk M. Verheul Gerrit-Jan Schuurhuis Ugo Boggi Godefridus J. Peters Thomas Würdinger Elisa Giovannetti | 2013 | Cancer Research2013，，22： | 1 |
| 14 | Study of conductivity of dEPDM rubber and PAni blends显示文摘 | DANIELA A A JOSE C M DEMETRIO A W S | 2007 | Macromolecular Symposia2007，，1： | 1 |
| 15 | Sequencing and Assembly of the 22-Gb Loblolly Pine Genome显示文摘 | Zimin Aleksey Stevens Kristian A Crepeau Marc W Holtz-Morris Ann Koriabine Maxim Mar?ais Guillaume Puiu Daniela Roberts Michael Wegrzyn Jill L de Jong Pieter J Neale David B Salzberg Steven L Yorke James A Langley Charles H | 2014 | Genetics2014，，3： | 1 |
| 16 | Apoearotenoid biosynthesis in arbuseular myeorrhizal roots:Contributions from methylerythritol phosphate pathway isogenes and tools for its manipulation显示文摘 | MICHAEL H W DANIELA S F JOACHIM H | 2007 | Phytochemistry2007，68，： | 1 |
| 17 | The Influence of Proton Pump Inhibitors on the Antiplatelet Potency of Clopidogrel Evaluated by 5 Different Platelet Function Tests显示文摘 | Thomas Gremmel Sabine Steiner Daniela Seidinger Renate Koppensteiner Simon Panzer Christoph W Kopp | 2010 | Journal of Cardiovascular Pharmacology2010，，5： | 1 |
| 18 | NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth显示文摘 | Jaba Irina M Zhuang Zhen W Li Na Jiang Yifeng Martin Kathleen A Sinusas Albert J Papademetris Xenophon Simons Michael Sessa William C Young Lawrence H Tirziu Daniela | 2013 | Journal of Clinical Investigation2013，，4： | 1 |
| 19 | Increased expression of pro-inflammatory cytokines as a cause of lung toxicity after combined treatment with gemcitabine and thoracic irradiation显示文摘 | Claudia E Falk W Daniela Uthe | 2004 | Radiother Oncol2004，72，2： | 1 |
| 20 | Trabectedin has promising antineoplastic activity in high‐grade meningioma显示文摘 | Matthias Preusser Sabine Spiegl‐Kreinecker Daniela L?tsch Adelheid W?hrer Maria Schmook Karin Dieckmann Walter Saringer Christine Marosi Walter Berger | 2012 | Cancer2012，，20： | 1 |
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