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| 1 | 组织芯片显示文摘 | 周小鸽 张劲松 张小平 张野 Kristian Sandvej Stephen J Hamilton-Dutoit | 2002 | 中华病理学杂志2002，31，1： | 85 |
| 2 | GRADE指南:Ⅵ.证据质量评价--不精确性(随机误差)显示文摘GRADE建议通过检查95%可信区间(CI)为决定不精确性的最佳方法。在指南实际运用中,如果CI的上、下限值代表了真实效应,而临床实际情况与之不符时,必须降低证据质量级别(即对效应估计值的把握度)。除外当效应值很大且可信区间提示效应稳健,而总样本量不大且事件数很少的情况,其他应考虑因不精确性而降低证据质量级别。作此决定时,可计算有足够检验效能的单个试验所需的病例数(定义为'最优信息样本量',即optimal information size,OIS)。对连续型变量,我们建议用类似方法,首先考虑可信区间上、下限值,再计算OIS。系统评价(SR)所需方法略有不同。如果95%CI不包括相对危险度(RR)为1,且总事件发生数或病例数超过OIS标准,则精确性良好。如果95%CI包括了明显获益或危害(我们建议以RR值<0.75或>1.25作粗标准),即使达到OIS要求,因不精确性而降低证据质量级别较恰当。 | Gordon Guyatt Andrew D.Oxman Regina Kunz Jan Brozek Pablo Alonso-Coello David Rind PJ Devereaux Victor M.Montori Bo Freyschuss Gunn Vist Roman Jaeschke John W.Williams Jr. Mohammad Hassan Murad David Sinclairk Yngve Falck-Ytter Joerg Meerpohl Craig Whittington Kristian orlund Je Andrews Holger J.Schünemann 代表GRADE工作组 李幼平 王莉 陈尹 高霑 | 2011 | 中国循证医学杂志2011，11，12： | 43 |
| 3 | 组织芯片技术在检测正常组织和肿瘤组织抗原表达中的应用显示文摘 | 周小鸽 张劲松 张小平 张野 纪小龙 Kristian Sandvej Stephen J.Hamilton-Dutoit | 2002 | 中华病理学杂志2002，31，2： | 32 |
| 4 | Long-term rice-rice-green manure rotation changing the microbial communities in typical red paddy soil in South China显示文摘On the basis of a long-term(30 years) field experiment that involved four rotation systems, rice-rice-winter fallow(RRF), rice-rice-ryegrass(RRG), rice-rice-rape(RRP), and rice-rice-milk vetch(RRV), this study described the effects of green manure on the microbial communities in the red paddy soils using 454 pyrosequencing for the 16 S r RNA gene. The Chao1 richness and non-parametric Shannon's index increased in all soil samples that received green manure treatments. The communities' structures with the green manure applications were significantly dissimilar from that under the winter fallow. Using Metastats tests, many genera in the RRG, RRP and RRV soils were significantly different from those in the RRF soil, including a number of genera that functioned in the nitrogen and sulfur cycles. Analyses of the genera with these functions revealed the shifts in microbial ecosystem functions after long-term green manuring. Changes in the microbial communities increased the ammonium supply and decreased the soil acidification in green-manure-amended soils. Together, these data suggested powerful effects of green manure on both the microbial communities and the biogeochemical cycle driven by the shifts in bacterial functional groups. | GAO Song-juan ZHANG Ren-gang CAO Wei-dong FAN Yuan-yuan GAO Ju-sheng HUANG Jing BAI Jin-shun ZENG Nao-hua CHANG Dan-na Shimizu Katsu-yoshi Kristian Thorup-Kristensen | 2015 | Journal of Integrative Agriculture2015，14，12： | 25 |
| 5 | 预期寿命估计对脊柱转移瘤手术选择与预后预测的临床意义显示文摘背景与目的:目前,临床上对脊柱转移瘤患者是否采取手术治疗以及如何选择手术仍然存在较大的争议。预期寿命的估计是手术选择的决定因素之一。本研究旨在评价Tokuhashi和Tomita评分系统这两种常用的预期寿命估计方法对硬膜外脊柱转移瘤患者手术选择与预后预测的临床价值。方法:对2001年1月至2004年4月丹麦奥胡斯大学医院脊柱外科中心收治的169例硬膜外脊柱转移瘤入组患者,术前用Tokuhashi与Tomita评分系统进行评分以及估计预期寿命,并结合Tomita脊柱肿瘤分型,选择实施手术分级治疗。术后6个月、12个月以及24个月分别进行前瞻性随访观察。对在预期寿命为“3个月内死亡”、“6个月内死亡”以及“12个月内死亡”的患者通过Tokuhashi与Tomita评分系统绘制受试者作业特征曲线(receiveroperatingcharacteristiccurves,ROC曲线),比较两个评分系统对预期寿命估计的准确性。同时采用Kaplan-Meier生存曲线分析法,计算Tokuhashi和Tomita评分系统各分数段患者术后的实际平均生存时间。结果:预期寿命分别为“3个月内死亡”、“6个月内死亡”以及“12个月内死亡”的病例ROC曲线分析显示,Tomita评分系统与Tokuhashi评分系统之间的差异均无显著性(各组P值分别为0.16、0.47与0.38)。Kaplan-Meier生存曲线分析显示,Tomita评分系统在4~7分之间对预后估计过高,Tokuhashi评分系统在0~8分之间对预后估计过低。结论:Tokuhashi和Tomita评分系统均可成功地预测脊柱转移瘤患者术后预后的情况。Tokuhashi评分系统可较为准确地预测生存期较短的患者,从而避免对这类患者做不必要的大手术。 | 邹学农 Anders Grejs 李海声 Kristian Hφy Ebbe S Hansen Cody Bünger | 2006 | 癌症2006，25，11： | 18 |
| 6 | 基于PLPS调研方法的步行和自行车交通规划设计评估显示文摘开展系统性的步行、自行车交通调研和实证分析,对于弥补城市相关基础数据不足、梳理现状问题、指导规划设计、评估实施效果等有重要意义,有助于改善城市步行和自行车出行环境、引导市民绿色出行。首先介绍了PLPS调研的目的及具体方法,包括公共生活和公共空间两部分调研。以重庆市渝中半岛步行交通示范项目实践为例,探讨PLPS方法在项目前评估和制订方案阶段中的应用。以美国纽约和丹麦哥本哈根两市为案例,阐述PLPS调研在步行、自行车交通项目后评估中的应用。最后,总结PLPS调研方法的优势,并针对其在中国的推广和本土化改进提出建议。 | 姜洋 王悦 余军 胡海 Kristian Skovbakke Villadsen | 2011 | 城市交通2011，9，5： | 18 |
| 7 | 2型糖尿病患者服用吡格列酮的膀胱癌风险显示文摘背景
吡格列酮是一种有争议的噻唑烷二酮类口服降糖药物,可以有效降低糖化血红蛋白(HbA1c)浓度,且降低心血管事件的发生风险,但同时也与体重增加和充血性心力衰竭风险的增加有关。尽管目前数据有限,但还是有证据显示它可能还与膀胱癌患病风险的增加有关。 | Laurent Azoulay assistant professor Hui Yin statistician Kristian B Filion assistant professor Jonathan Assayag graduate student 王子贤(编译) | 2012 | 中国处方药2012，10，5： | 17 |
| 8 | 城市传统商业区步行交通系统规划——以重庆市解放碑商圈为例显示文摘中国城市机动化和郊区化进程不断深入,传统商业区正迎来'提档升级'的挑战和机遇。以重庆市解放碑商圈为例,采用PLPS、问卷调查以及商户座谈的方法收集现状数据,据此对商圈步行交通发展条件及主要问题进行分析。提出创建全方位、适应不同特性的步行交通网络,以及具备复合功能、高品质的公共空间系统,进而制定六大规划策略。将步行交通系统网络划分为轨道交通入口广场、核心步行空间、城市道路、慢速道路、街巷等8种类型的公共空间,针对每种类型给出设计指引。最后,确定近期实施示范项目,开展方案设计。 | 姜洋 解建华 余军 Kristian Skovbakke Villadsen | 2014 | 城市交通2014，12，4： | 13 |
| 9 | 世界级城市街道重建策略研究——以上海市黄浦区为例显示文摘长期以来受以车为主导的规划建设理念影响,中国许多城市新建、改建道路存在尺度失衡、品质降低、活力不足等问题。首先介绍纽约、伦敦、哥本哈根、莫斯科、墨尔本等世界级城市街道重建实践经验。以上海市黄浦区为例,采用公共生活—公共空间(PLPS)调研方法,对34处地点进行行人流量调查,并针对5个公共空间进行停留活动统计。由此分析黄浦区现状街道网络的主要问题与诉求,进而提出街道重建的规划设计策略及措施推进时序。以南京东路为示范项目,探讨其现存问题并提出具体改造方案。 | 王悦 姜洋 Kristian Skovbakke Villadsen | 2015 | 城市交通2015，13，1： | 11 |
| 10 | 系统综述与网状Meta分析的PRISMA扩展声明显示文摘PRISMA声明旨在提高系统综述和META分析报告的完整性,该声明已经广泛用于指导系统综述和META分析的报告和发表。原始的PRISMA声明是针对两种干预措施比较的传统的系统综述与META分析而制定的,然而,随着多种干预措施比较的系统综述的发展,实施和报告这一类系统综述面临较大挑战。此时,针对网状META分析的PRISMA扩展声明应运而生,旨在提高网状META分析系统综述的报告质量。PRISMA扩展声明是由专家们通过DELPHI调查、面对面讨论和共识大会而最终确立的。PRISMA扩展声明是在原始PRISMA声明的报告清单的基础上经过修改,最终确定了32个条目,每个条目均与网状META分析报告的内容直接相关。本文对网状META分析的PRISMA扩展声明进行了阐述,对报告清单各条目进行了举例说明,并详细说明了在原始PRISMA声明的基础上新增和修改各条目的理由。此外,PRISMA扩展声明强调了在网状META分析的实际操作中需要重点关注的信息。本文的目标读者包括网状META分析的作者与读者,以及期刊杂志的编辑与同行评审。 | 李志霞 杨俊 叶欣 周凌波 杨智荣 孙凤 詹思延 Brian Hutton Georgia Salanti Deborah M.Caldwell Anna Chaimani Christopher H.Schmid Chris Cameron John P.A.Ioannidis Sharon Straus Kristian Thorlund Jeroen P.Jansen Cynthia Mulrow Ferrán Catalá-López Peter C.Gozsche Kay Dickersin Isabelle Boutron Douglas G.Altman David Moher | 2016 | 中国循证心血管医学杂志2016，8，6： | 11 |
| 11 | Third Universal Definition of Myocardial Infarction显示文摘 | Kristian Thygesen Joseph S. Alpert Allan S. Jaffe Maarten L. Simoons Bernard R. Chaitman Harvey D. White | 2012 | Journal of the American College of Cardiology2012，，16： | 8 |
| 12 | Aerobic bacteria associated with chronic suppurative otitis media in Angola显示文摘Background:Chronic suppurative otitis media(CSOM)is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living conditions.Topical antibiotics combined with aural toilet is the first-hand treatment for CSOM but antimicrobial resistance and limited availability to antibiotics are obstacles in some areas.The goal of this study was to define aerobic pathogens associated with CSOM in Angola with the overall aim to provide a background for local treatment recommendations.Methods:Samples from ear discharge and the nasopharynx were collected and cultured from 152 patients with ear discharge and perforation of the tympanic membrane.Identification of bacterial species was performed with matrix-assisted laser desorption/ionization-time of flight mass spectrometry and pneumococci were serotyped using multiplex polymerase chain reactions.Antimicrobial susceptibility testing was done according to EUCAST.Results:One hundred eighty-four samples from ear discharge and 151 nasopharyngeal swabs were collected and yielded 534 and 289 individual isolates,respectively.In all patients,correspondence rate of isolates from 2 ears in patients with bilateral disease was 27.3%and 9.3%comparing isolates from the nasopharynx and ear discharge,respectively.Proteus spp.(14.7%),Pseudomonas aeruginosa(13.2%)and Enterococcus spp.(8.8%)were dominating pathogens isolated from ear discharge.A large part of the remaining species belonged to Enterobacteriaceae(23.5%).Pneumococci and Staphylococcus aureus were detected in approximately 10%of nasopharyngeal samples.Resistance rates to quinolones exceeded 10%among Enterobacteriaceae and was 30.8%in S.aureus,whereas 6.3%of P.aeruginosa were resistant.Conclusions:The infection of the middle ear in CSOM is highly polymicrobial,and isolates found in nasopharynx do not correspond well with those found in ear discharge.Pathogens associated with CSOM in Angola are dominated by gram-negatives including Enterobacteriaceae and P.aeruginosa,while gram-positive enterococci also are common.Based on the results of antimicrobial susceptibility testing topical quinolones would be the preferred antibiotic therapy of CSOM in Angola.Topical antiseptics such as aluminium acetate,acetic acid or boric acid,however,may be more feasible options due to a possibly emerging antimicrobial resistance. | Fabian Udden Matuba Filipe Ake Reimer Maria Paul Erika Matuschek John Thegerstrom Sven Hammerschmidt Tuula Pelkonen Kristian Riesbeck | 2018 | Infectious Diseases of Poverty2018，7，1： | 6 |
| 13 | Kaposi肉瘤中人疱疹病毒8的检测及其临床病理学意义显示文摘目的 了解Kaposi肉瘤与人疱疹病毒 8(HHV8)或Kaposi肉瘤相关病毒的关系 ;建立适合于临床病理诊断的原位杂交方法。方法 采用地高辛标记的单链HHV8DNA探针 ,辅以增强探测敏感性的信号扩增系统 (tyramidesignalamplification)对 14例甲醛固定石蜡包埋的Kaposi肉瘤组织标本进行了HHV8原位检测 ,为了比较 ,同时也采用了聚合酶链反应 (PCR)检测技术。结果 用原位杂交和PCR两种方法共发现 10例 (71% )Kaposi肉瘤组织中存在HHV8感染。其中 8例在两种技术检测中均呈阳性。HHV8阳性信号见于肿瘤梭形细胞和内皮细胞 ,也见于各期病变 (早中期的斑片和斑块病变 ,晚期的结节病变 ) ,以及原发 ,复发和 (或 )转移病变。所有阴性对照在两种方法中均呈阴性。结论 Kaposi肉瘤与HHV8存在密切关系 ;这种地高辛标记单链DNA探针 。 | 周小鸽 张劲松 张小平 张野 Kristian Sandvej Stephen Hamilton-Dutoit | 2002 | 中华病理学杂志2002，31，4： | 6 |
| 14 | 利用根管法对油菜和冬小麦苗期根系形态的研究显示文摘快速、准确的根系原位观测方法是根系研究中的重要技术,本研究介绍了一种根管盆栽方法,该方法在透明PVC管内种植作物,通过遮光膜保持管内黑暗环境,以实现在作物生长过程中对其根系生长的原位动态观测,且根系生长环境更接近田间实际情况,并可通过改变根管长度、半径等将其应用于田间深根作物的研究中。利用此方法、结合根系扫描技术分析了油菜和冬小麦从发芽到出苗后16 d时的根系生长情况。结果表明,出苗后7和16 d冬小麦根系和地上部干物重均大于油菜,出苗后16 d冬小麦和油菜根冠比分别为0.513和0.372。大部分根系分布在0~16 cm表层土壤中,出苗后16 d冬小麦和油菜表层土壤中的根长在总根长中的比例分别为62.60%和67.76%,根系总表面积、总体积和一级侧根数均为表层土壤中占比最多,在出苗后7 d,总根长、总表面积、总体积和一级侧根数均为冬小麦显著高于油菜,而在出苗后16 d,两种作物的总根长和总表面积差别不大,说明油菜根系生长呈先缓后快趋势。表层土壤中根系平均直径小于底层土壤,油菜根系平均直径小于冬小麦,油菜和冬小麦的根系直径均大部分在0~0.50 mm之间,随着根系生长,较细的侧根逐渐增多,根系平均直径变小。出苗后16 d内的冬小麦根系伸长速率为1.83 cm/d,大于油菜的1.51 cm/d。因此,冬小麦苗期根系生长快于油菜,油菜根系呈先缓后快的生长特性。本研究介绍的根管法是一种原位研究根系的有效方法。 | 高嵩涓 曹卫东 THORUP-KRISTENSEN Kristian | 2017 | 草业学报2017，26，4： | 6 |
| 15 | A review on glass welding by ultra-short laser pulses显示文摘Glass welding by ultra-short pulsed(USP)lasers is a piece of technology that offers high strength joints with hermetic sealing.The joints are typically formed in glass that is transparent to the laser by exploiting nonlinear absorption effects that occur under extreme conditions.Though the temperature reached during the process is on the order of a few 1000°C,the heat affected zone(HAZ)is confined to only tens of micrometers.It is this controlled confinement of the HAZ during the joining process that makes this technology so appealing to a multitude of applications because it allows the foregoing of a subsequent tempering step that is typically essential in other glass joining techniques,thus making it possible to effectively join highly heat sensitive components.In this work,we give an overview on the process,development and applications of glass welding by USP lasers. | Kristian Cvecek Sarah Dehmel Isamu Miyamoto Michael Schmidt | 2019 | International Journal of Extreme Manufacturing2019，1，4： | 5 |
| 16 | Decreasing Risk of Colorectal Cancer in Patients With Inflammatory Bowel Disease Over 30 Years显示文摘 | Tine Jess Jacob Simonsen Kristian Tore J?rgensen Bo Vestergaard Pedersen Nete Munk Nielsen Morten Frisch | 2012 | Gastroenterology2012，，2： | 4 |
| 17 | 一种新螺杆挤压法从6063铝合金和Mg混合颗粒制备Al/Mg复合材料(英文)显示文摘采用一种新的螺杆挤压法以AA6063合金和工业纯Mg混合颗粒为原料制备Al/Mg双金属复合材料。加入铝合金中的镁合量最高可达到12.5%(质量分数)。所制备复合材料由细小晶粒组织组成。其显微组织中除有原料中的物相外,还观察到由γ-Mg17Al12包围的岛状Al2Mg3金属间合物。复合材料的强度随Mg含量的增加逐渐增高。含Mg为10%复合材料的极限抗拉强度最高,超过350 MPa。断裂表面分析结果表明,增加Mg含量导致材料发生较严重的脆性断裂及断裂机制的较小变化。因此,应对挤压工艺条件进行进一步优化。 | Kristian Gr tta SKORPEN Eirik MAUL Oddvin REISO Hans J rgen ROVEN | 2014 | Transactions of Nonferrous Metals Society of China2014，24，12： | 4 |
| 18 | Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties显示文摘 | Monica Bostad Kristian Berg Anders H?gset Ellen Skarpen Harald Stenmark P?l K. Selbo | 2013 | Journal of Controlled Release2013，，3： | 4 |
| 19 | Physicochemical aspects of allanite flotation显示文摘This paper investigated the physicochemical properties of allanite, a RE-silicate, by measuring zeta potential in the absence and presence of three different flotation collectors(benzohydroxamic acid, sodium oleate and dodecylamine). This data was then verified by microflotation experiments and with bubble-particle attachment pictures. The investigated properties of allanite were compared to those of quartz, a common gangue mineral in many RE deposits. The results of this work indicated that only dodecylamine was able to achieve a selective separation of allanite and quartz. This was accomplished by lowering the dodecylamine dosage so that only quartz was recovered by microflotation. | Adam Jordens Chris Marion Olga Kuzmina Kristian E.Waters | 2014 | Journal of Rare Earths2014，32，5： | 3 |
| 20 | FAIR Computational Workflows显示文摘Computational workflows describe the complex multi-step methods that are used for data collection,data preparation,analytics,predictive modelling,and simulation that lead to new data products.They can inherently contribute to the FAIR data principles:by processing data according to established metadata;by creating metadata themselves during the processing of data;and by tracking and recording data provenance.These properties aid data quality assessment and contribute to secondary data usage.Moreover,workflows are digital objects in their own right.This paper argues that FAIR principles for workflows need to address their specific nature in terms of their composition of executable software steps,their provenance,and their development. | Carole Goble Sarah Cohen-Boulakia Stian Soiland-Reyes Daniel Garijo Yolanda Gil Michael R.Crusoe Kristian Peters Daniel Schober | 2020 | Data Intelligence2020，2，1： | 3 |
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