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| 1 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 2 | MicroRNA-21 in pancreatic cancer:correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity显示文摘 | Giovannetti E Funel N Peters G J Del Chiaro M Erozenci LA Vasile E | | 0，，： | 1 |
| 3 | Effect of phenolic acids and anthocyanins on growth,viability and malolactic activity of a lactic acid bacterium显示文摘 | Vivas N Lonvaud Funel A Glories Y | 1997 | Food Microbiology1997，14，3： | 1 |
| 4 | Influence of oak wood and grape tannins on the lactic acid bacterium Oenococcus oeni (Leuconostoc oenos 8413) 显示文摘 | Vivas N Augustin M Lonvaud- Funel A | 2000 | Journal of the Science of Food and Agriculture2000，80，11： | 1 |
| 5 | Critical role of lasermicrodissection for genetic,epigenetic and proteomic analysesin pancreatic cancer显示文摘 | Funel N Giovannetti E Pollina LE | 2011 | Expert Rev Mol Diagn2011，11，7： | 1 |
| 6 | MicroRNA-21 in pancreatic cancer:correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity显示文摘 | Giovannetti E Funel N Peters GJ | | 0，，： | 1 |
| 7 | Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma显示文摘 | Esposito I Menicagli M Funel N | 2004 | J Clin Pathol2004，57，6： | 1 |
| 8 | Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma显示文摘 | Esposito l Menicagli M Funel N | 2004 | J Clin Pathol2004，57，6： | 1 |
| 9 | Optimisation of low dose CT with adaptive statistical iterativc reconstruction in total body examination显示文摘 | Romagnoli A Funel V Meschini A | 2012 | Radiol Med2012，117，8： | 1 |
| 10 | Mast Cells Density Positive to Tryptase Correlates with Angiogenesis in Pancreatic Ductal Adenocarcinoma Patients Having Undergone Surgery显示文摘 | Michele Ammendola Rosario Sacco Giuseppe Sammarco Giuseppe Donato Valeria Zuccalà Maria Luposella Rosa Patruno Ilaria Marech Severino Montemurro Nicola Zizzo Cosmo Damiano Gadaleta Girolamo Ranieri Niccola Funel | 2014 | Gastroenterology Research and Practice2014，，： | 1 |
| 11 | The good, the bad and the ugly: A tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms显示文摘 | Caponi S Funel N Frampton AE | 2013 | Ann Oncol2013，24，3： | 1 |
| 12 | Identification and sequence analysis of the region encoding the site-specific integration system from Leuconostoc oenos (OEnococcus oeni) temperate bacteriophage phi 10MC显示文摘 | Torlois S Lonvaud Funel A | 1997 | FEMS Microbiol Lett1997，147，2： | 1 |
| 13 | Vanillin production from simple phenols by wine-associated lactic acid bacteria显示文摘 | Bloem A Bertrand A Lonvaud- Funel A | 2006 | Letters in Applied Microbiology2006，44，1： | 1 |
| 14 | The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms 显示文摘 | Caponi S Funel N Frampton AE | 2013 | Arm Oncol2013，24，3： | 1 |
| 15 | Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma 显示文摘 | Esposito I Menicagli M Funel N | 2004 | J Clin Pathol2004，57，6： | 1 |
| 16 | Tissue microarray-chip featuring computerized immunophenotypical characterization more accurately subtypes ampullary adenocarcinoma than routine histology显示文摘BACKGROUND Ampullary adenocarcinomas(AACs)are heterogeneous tumors currently classified into three important sub-classes(SC):Intestinal(INT),Pancreato-Biliary(PB)and Mixed-Type(MT).The different subgroups have similar clinical presentation and are treated by pancreatoduodenectomy with curative intent.However,they respond differently to chemotherapy and have different prognostic outcomes.The SC are often difficult to identify with conventional histology alone.The clinical outcome of all three remains unclear,particularly for MT.AIM To identify two main subtypes of AACs,using an immunohistochemical(IHC)score based on CDX2,CK7 and CK20.METHODS Tissue samples from 21 patients who had undergone resection of AAC were classified by HE histology and IHC expression of CDX2,CK7 and CK 20.An IHC score was obtained for each marker by counting the number of positive cells(0=no stained cells;1<25%;2<50%and 3>50%)and their intensity(1=weak;2=moderate and 3=strong).A global score(GS)was then obtained by summation of the IHC scores of each marker.The MT tumors were grouped either with the INT or PB group based on the predominant immuno-molecular phenotype,obtaining only two AACs subtypes.The overall survival in INT and PB patients was obtained by Kaplan-Meier methods.RESULTS Histological parameters defined the AACs subtypes as follows:15%INT,45%PB and 40%MT.Using IHC expression and the GS,75%and 25%of MT samples were assigned to either the INT or the PB group.The mean value of the GS was 9.5(range 4-16).All INT samples had a GS above the average,distinct from the PB samples which had a GS score significantly below the average(P=0.0011).The INT samples were identified by high expression of CDX2 and CK20,whereas PB samples exhibited high expression of CK7 and no expression of CK20(P=0.0008).The INT group had a statistically significant higher overall survival than in the PB group(85.7 mo vs 20.3 mo,HR:8.39;95%CI:1.38 to 18.90;P=0.0152).CONCLUSION The combination of histopathological and molecular criteria enables the classification of AACs into two clinically relevant histo-molecular phenotypes,which appear to represent distinct disorders with potentially significant changes to the current therapeutic strategies. | Matteo Palmeri Niccola Funel Gregorio Di Franco Niccolo Furbetta Desiree Gianardi Simone Guadagni Matteo Bianchini Luca E Pollina Claudio Ricci Marco Del Chiaro Giulio Di Candio Luca Morelli | 2020 | World Journal of Gastroenterology2020，26，43： | 1 |
| 17 | Learning To empower patients:the results of a professional education program for diabetes educators显示文摘 | Anderson RM Funell MM Barr PA | | 0，，： | 1 |
| 18 | rpoB gene: A target for identification of LAB cocci by PCR - DGGE and melting curves analyses in real time PCR显示文摘 | Renouf V Claisse O Lonvaud - Funel A | 2006 | J Microbiol Methods2006，67，1： | 1 |
| 19 | MicroRNA profiling of primary pulmonary enteric adenocarcinoma in members from the same family reveals some similarities to pancreatic adenocarcinoma- a step towards personalized therapy 显示文摘 | Garajovd I Funel N Fiorentino M | 2015 | Clin Epigenetics2015，7，： | 1 |
| 20 | Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy显示文摘 | Elisa Giovannetti Paola Pacetti Michele Reni Leticia G Leon Andrea Mambrini Enrico Vasile Michele Ghidini Niccola Funel Matteo Lucchesi Stefano Cereda Godefridus J Peters Maurizio Cantore | 2011 | Pharmacogenomics2011，，12： | 1 |
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