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| 1 | TREM-1 multimerization is essential for its activation on monocytes and neutrophils显示文摘The triggering receptor expressed on myeloid cells-1(TREM-1)is a receptor expressed on innate immune cells.By promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptors(TLRs),TREM-1 has been characterized as a major player in the pathophysiology of acute and chronic inflammatory diseases,such as septic shock,myocardial infarction,atherosclerosis,and inflammatory bowel diseases.However,the molecular events leading to the activation of TREM-1 in innate immune cells remain unknown.Here,we show that TREM-1 is activated by multimerization and that the levels of intracellular Ca 2+release,reactive oxygen species,and cytokine production correlate with the degree of TREM-1 aggregation.TREM-1 activation on primary human monocytes by LPS required a two-step process consisting of upregulation followed by clustering of TREM-1 at the cell surface,in contrast to primary human neutrophils,where LPS induced a rapid cell membrane reorganization of TREM-1,which confirmed that TREM-1 is regulated differently in primary human neutrophils and monocytes.In addition,we show that the ectodomain of TREM-1 is able to homooligomerize in a concentration-dependent manner,which suggests that the clustering of TREM-1 on the membrane promotes its oligomerization.We further show that the adapter protein DAP12 stabilizes TREM-1 surface expression and multimerization.TREM-1 multimerization at the cell surface is also mediated by its endogenous ligand,a conclusion supported by the ability of the TREM-1 inhibitor LR12 to limit TREM-1 multimerization.These results provide evidence for ligand-induced,receptor-mediated dimerization of TREM-1.Collectively,our findings uncover the mechanisms necessary for TREM-1 activation in monocytes and neutrophils. | Kevin Carrasco Amir Boufenzer Lucie Jolly Helene Le Cordier Guanbo Wang Albert JR Heck Adelheid Cerwenka Emilie Vinolo Alexis Nazabal Alexandre Kriznik Pierre Launay Sebastien Gibot Marc Derive | 2019 | Cellular & Molecular Immunology2019，16，5： | 13 |
| 2 | Automated Burris gravity meter for single and continuous observation显示文摘The Burris Gravity Meter^(TM) manufactured by ZLS Corporation, Austin/Texas, USA, is based on the invention of L&R(L. LaCoste and A. Romberg): The ZLS(zero-length spring). A digital feedback system(range of about 50 mGal) is used to null the beam. Now, more than 120 gravity meters of this make exist worldwide and are used successfully in exploration, volcanology, geodetic work and surveying.The sensor is made of the well-known(L&R) metal-alloy zero-length spring providing a low drift characteristic. The drifts observed are comparable to L&R gravimeters and are less than 0.3 mGal per month, which is much lower than the drifts known for the fused quartz sensors.The dial is calibrated every 50 mGal over the entire 7000 mGal meter range. Since the gravity value is determined at these points, there are no periodic errors. By a fourth heater circuit temperature effects are totally avoided. The gravity meter is controlled via Bluetooth~ either to a handheld computer(tablet) or a notebook computer.The feedback responds with high stability and accuracy. The nulling of the beam is controlled by the UltraGrav^(TM) control system which incorporates an inherently linear PWM(pulse-width modulated)electrostatic feedback system. In order to improve the handling of the gravimeter we have developed two Windows based programs: AGESfield for single measurements and AGEScont for continuous readings. | Gerhard Jentzsch Richard Schulz Adelheid Weise | 2018 | Geodesy and Geodynamics2018，9，3： | 5 |
| 3 | Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice显示文摘 | Prakash G. Chandak Sascha Obrowsky Branislav Radovic Prakash Doddapattar Elma Aflaki Adelheid Kratzer Lalit S. Doshi Silvia Povoden Helmut Ahammer Gerald Hoefler Sanja Levak-Frank Dagmar Kratky | 2011 | BBA - Molecular and Cell Biology of Lipids2011，，12： | 3 |
| 4 | Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity显示文摘Dear Editor,Next-generation sequencing revealed that the majority of the human genome is transcribed but has no coding function.It is estimated that.30000 long noncoding RNAs(lncRNAs)are expressed in humans,but their functions are largely unknown(Suckau et al.,2009;Rinn and Chang,2012;Poller et al.,2013).Consideration of noncoding genomic elements in pathogenetic studies is warranted and enabled by technological advances allowing comprehensive transcriptome mapping of protein-coding genes as well as small and long ncRNAs. | Martina Gast Blanche Schroen Antje Voigt Jan Haas Uwe Kuehl Dirk Lassner Carsten Skurk Felicitas Escher Xiaomin Wang Adelheid Kratzer Katharina Michalik Anna Papageorgiou Tim Peters Madlen Loebel Sabrina Wilk Nadine Althof Kannanganattu VPrasanth Hugo Katus Benjamin Meder Shinichi Nakagawa Carmen Scheibenbogen Heinz-Peter Schultheiss Ulf Landmesser Stefanie Dimmeler Stephane Heymans Wolfgang Poller | 2016 | Journal of Molecular Cell Biology2016，8，2： | 2 |
| 5 | High temperature( salt melt)corrosion tests with ce- ramic-coated steel 显示文摘 | Adelheid S Martin G Gtinter M | 2015 | Materials Chemistry and Physics2015，，159： | 1 |
| 6 | Comparison of the World HealthOrganization(WHO) Child Growth Standards and the National Center for Health Statistics/WHO international growth reference:Implications for child health programmes显示文摘 | de Onis M Adelheid W O Borghi E | 2006 | Public Health Nutrition2006，9，7： | 1 |
| 7 | Transformation of Dendrobium orchid using particle bombardment of protocorms显示文摘 | Adelheid R. Kuehnle Nellie Sugii | 1992 | Plant Cell Reports1992，，9： | 1 |
| 8 | 一种新型叶绿体表达系统的构建显示文摘针对目前的叶绿体转基因技术存在载体构建步骤繁琐耗时的问题,建立了一种新型的不需自带启动子的叶绿体表达系统,选择模式植物烟草叶绿体中的假基因作为外源基因的插入位点.通过基因枪转化法获得4株独立的叶绿体转化植株.此新技术可实现叶绿体载体构建的时间、技术成本最小化,从而促进转基因叶绿体的应用. | 杨捷 Michele MChampagne A David Hieber Adelheid R Kuehnle | 2010 | 福州大学学报(自然科学版)2010，38，4： | 1 |
| 9 | Comparison of the World Health Organization (WHO) Child Growth Standards and the National Center for Health Statistics/ WHO international growth reference: implications for child health programs显示文摘 | Mercedes de Onis Adelheid WO Elaine B | 2006 | Public Health Nutrition2006，9，7： | 1 |
| 10 | Tansformation of Dendrobium orchid using particle bombardment of protocorms显示文摘 | Adelheid R Kuehnle Nellie S | 1992 | Plant Cell Reports1992，11，9： | 1 |
| 11 | Coronary Neutrophil Extracellular Trap Burden and Deoxyribonuclease Activity in ST-Elevation Acute Coronary Syndrome Are Predictors of ST-Segment Resolution and Infarct Size显示文摘 | Andreas Mangold Sherin Alias Thomas Scherz Thomas Hofbauer Johannes Jakowitsch Adelheid Panzenb?ck Daniel Simon Daniela Laimer Christine Bangert Andreas Kammerlander Julia Mascherbauer Max-Paul Winter Klaus Distelmaier Christopher Adlbrecht Klaus T. Preis | 2015 | Circulation Research2015，，7： | 1 |
| 12 | Twenty Years of Accessibility Improvements:The Case of the Spanish Motorway Building Programme显示文摘 | Adelheid Holl | 2007 | Journal of Transport Geography2007，15，4： | 1 |
| 13 | Natural killer cells, viruses and cancer 显示文摘 | Lewis L Lanier LL | 2001 | Nat Immunol Rev2001，1，： | 1 |
| 14 | Transport Infrastructure, Agglomeration Economies, and Firm Birth: Empirical Evidence from Portugal & Dagger显示文摘 | Adelheid H | 2004 | Journal of Regional Science2004，44，4： | 1 |
| 15 | Twenty Years of Accessibility Improve-ments,The Case of the Spanish Motorway Building Pro-gramme显示文摘 | Adelheid Holl | 2007 | Journal of Transport Geography2007，15，4： | 1 |
| 16 | Everolimus (RAD001)and anti-angiogenic cyclophosphamide show long-term control of gastric cancer growth in vivo显示文摘 | Daniel Cejka Matthias Preusser Adelheid Woehrer Wolfgang Sieghart Sabine Strommer Johannes Werzowa Thorsten Fuereder Volker Wacheck | 2008 | Cancer Biology & Therapy2008，，9： | 1 |
| 17 | Recruitment of bone-marrow-derived cells by skeletal and cardiac muscle in adult dystrophic mdx mice显示文摘 | R. E. Bittner Christian Sch?fer Klara Weipoltshammer Silva Ivanova Berthold Streubel Erwin Hauser Michael Freilinger Harald H?ger Adelheid Elbe-Bürger Franz Wachtler | 1999 | Anatomy and Embryology1999，，5： | 1 |
| 18 | ALK gene translocations and amplifications in brain metastases of non-small cell lung cancer显示文摘 | Matthias Preusser Anna S. Berghoff Ayseguel Ilhan-Mutlu Manuel Magerle Carina Dinhof Georg Widhalm Karin Dieckmann Christine Marosi Adelheid W?hrer Monika Hackl Sabine Z?chbauer-Müller Andreas von Deimling Sebastian F. Schoppmann Christoph C. Zielinski Be | 2013 | Lung Cancer2013，，： | 1 |
| 19 | A phase I trial of intraperitoneal recombinant interleukin 2 in patients with ovarian carcinoma显示文摘 | Paul B. Chapman Jonathan E. Kolitz Thomas B. Hakes Janice L. Gabrilove Karl Welte V. J. Merluzzi Adelheid Engert Edward C. Bradley Michael Konrad Roland Mertelsmann | 1988 | Investigational New Drugs1988，，3： | 1 |
| 20 | The stromelysin-1 5A/6A promoter polymorphism is a disease marker for the extent of coronary heart disease显示文摘 | Adelheid Schwarz Werner Haberbosch Harald Tillmanns Andreas Gardemann | 2002 | Disease Markers2002，，3： | 1 |
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