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| 1 | Histopathological characteristics and causes of kidney graft failure in the current era of immunosuppression显示文摘BACKGROUND The histopathological findings on the failing kidney allograft in the modern era is not well studied. In this study, we present our experience working with kidney transplant recipients with graft failure within one year of the biopsy.AIM To report the histopathological characteristics of failed kidney allografts in the current era of immunosuppression based on the time after transplant, cause of the end-stage renal disease and induction immunosuppressive medications.METHODS In a single-center observational study, we characterized the histopathological findings of allograft biopsies in kidney transplant recipients with graft failure within one year after the biopsy.RESULTS We identified 329 patients with graft failure that met the selection criteria between January 1, 2006 and December 31, 2016. The three most common biopsy findings were interstitial fibrosis and tubular atrophy(IFTA, 53%), acute rejection (AR, 43%) and transplant glomerulopathy(TG, 33%). Similarly, the three most common causes of graft failure based on the primary diagnosis were AR(40%),TG(17%), and IFTA(13%). Most grafts failed within two years of post-transplant(36%). Subsequently, approximately 10%-15% of grafts failed every two years: >2-4 years(16%), > 4-6 years(13%), > 6-8 years(11%), > 8-10 years(9%) and > 10 years(16%). AR was the most common cause of graft failure in the first six years(48%), whereas TG was the most prevalent cause of graft failure after 6 years(32%) of transplant.CONCLUSION In the current era of immunosuppression, AR is still the most common cause of early graft failure, while TG is the most prevalent cause of late graft failure. | Sandesh Parajuli Fahad Aziz Neetika Garg Sarah E Panzer Emily Joachim Brenda Muth Maha Mohamed Justin Blazel Weixiong Zhong Brad C Astor Didier A Mandelbrot Arjang Djamali | 2019 | World Journal of Transplantation2019，9，6： | 2 |
| 2 | Compartment-specific expression and function of the chemokine IP-10/CXCL10 in a model of renal endothelial microvascular injury显示文摘 | Panzer U Steinmetz O M Reinking R R Meyer T N Fehr S Schneider A | 2006 | J Am Soc Nephrol2006，17，： | 1 |
| 3 | Lupus anticoagulants: strong association with the major histocompatibility complex class II and platelet antibodies显示文摘 | Panzer S Pabinger I Gschwandtner ME | 1997 | Br J Haematol1997，98，： | 1 |
| 4 | Selection of metal oxide charge transport layers for colloidal quantum dot LEDs 显示文摘 | Wood V Panzer M J Halpert J E | 2009 | ACS Nano2009，3，11： | 1 |
| 5 | The influence of team moni- toring on team processes and performance显示文摘 | Marks M A Panzer F J | 2004 | Human Performance2004，17，1： | 1 |
| 6 | Low-voltage operation of a pentacene field-effect transistor with a polymer electrolyte gate dielectric显示文摘 | PANZER M J NEWMAN C R FRISBIE C D | 2005 | Appl Phys Lett2005，86，10： | 1 |
| 7 | Plasma levels of P-se-lectin are determined by platelet turn-over and the P-selectinThr715Pro polymorphism显示文摘 | Panzer S Rosales S Gisslinger H | 2008 | Thromb Res2008，121，： | 1 |
| 8 | Temperature-dependent phonon conduction and nanotube engagement in metalized single wall carbon nanotube films 显示文摘 | PANZER M A DUONG H M OKAWA J | 2010 | Nano Lett2010，10，7： | 1 |
| 9 | Rapid in vivo conversion of effector T ceils into Th2 cells during helminth infection显示文摘 | Panzer M Sitte S Wirth S | 2012 | J Immunol2012，188，2： | 1 |
| 10 | Monoevte ehemoattractant protein-1 and osteopontin differentially regulate monocvtes recruitment in experimental glomerulonephritis显示文摘 | Panzer U Thaiss F Zahner G | 2001 | Kidney lnt2001，59，： | 1 |
| 11 | Comparison of methods to evaluate aspirin-mediated platelet inhibition after percutaneous intervention with stent implantation显示文摘 | Thomas Gremmel Sabine Steiner Daniela Seidinger Renate Koppensteiner Simon Panzer Christoph W. Kopp | 2011 | Platelets2011，，3： | 1 |
| 12 | The immune system and kidney disease: basic concepts and clinical implications显示文摘 | Kurts C Panzer U Anders HJ | 2013 | Nat Rev Immunol2013，13，： | 1 |
| 13 | Evaluation of walking impairment by questionnaire in patients with peripheral arterial disease显示文摘 | Regensteiner JG Steiner JF Panzer RJ | 1990 | J Vasc Med Biol1990，2，2： | 1 |
| 14 | C4-C5 segment finite element model development,validation,and load-sharing investigation显示文摘 | Panzer MB Cronin DS | 2009 | Journal of Biomechanics2009，42，4： | 1 |
| 15 | Alternating current driven electroluminescence l~om ZnSe/ZnS: Mn/ZnS nanocrys- tals 显示文摘 | Wood V Halpert J E Panzer M J | 2009 | Nano Letters2009，9，6： | 1 |
| 16 | Rapid typing for human platelet antigen system-1,-2,-3 and-5 by PCR amplification with sequence-specific primers显示文摘 | Klüter H Fehlau K Panzer S | 1996 | Vox Sang1996，71，： | 1 |
| 17 | Stripping of X-ray brems strahlung spectra up to 300 kV on a desk type com- puter显示文摘 | Seelentag WW Panzer W | 1979 | Phys Med Biol1979，24，4： | 1 |
| 18 | Infrared microscopy thermal characterization of opposing carbon nanotube arrays显示文摘 | Hu X Jack Matthew A Panzer Kenneth E Goodson | 2007 | J Heat Trans2007，129，： | 1 |
| 19 | Combination of intermit tent haemodialysis and high-- volume continuous haemofihration for the treatment of severe metformin induced lactic acedosis 显示文摘 | Panzer Y Kluges Kreymann G | 2004 | Nephrol Dial Translplant2004，19，8： | 1 |
| 20 | Cervical spine model to predict capsular ligament response in rear impact显示文摘 | Fice JB Cronin DS Panzer MB | 2011 | Annals of Biomedi-cal Engineering2011，39，8： | 1 |
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