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| 1 | Interleukin-1 beta induces the expression and production of stem cell factor by epithelial cells: crucial involvement of the PI-3K/mTOR pathway and HIF-1 transcription complex显示文摘在发炎和白血球过多症之间的潜在的交叉连接有一段时间被讨论了,但是支持这教义的试验性的证据是少见的。特别地,由煽动性的调停人理解为 proto-oncogenic 生长因素表情的潜在的 upregulation 负责的机制是重要的。这里,我们调查了高度煽动性的 cytokine interleukin-1 贝它的能力(IL-1β) 到导致干细胞因素(SCF ) 的生产,它是在造血的 myeloid 细胞的恶意的转变之上控制尖锐 myeloid 白血球过多症的前进的一个主要造血的生长因素。我们发现了那人的 IL-1β在 MCF-7 人的上皮的乳癌房间和那导致了 SCF 的表示 / 分泌物这个过程取决于组织缺氧可诱导的因素 1 (HIF-1 ) 抄写建筑群。我们也表明了 phosphatidylinositol-3 kinase (PI-3K ) 的一个关键角色 rapamycin (mTOR ) 的 /mammalian 目标在 IL-1β 的小径;导致的 HIF-1α在 MCF-7 房间的累积。重要地, mTOR 也被发现在 IL-1β 起一个作用;导致的 SCF 生产。而且,为 IL-1β 的积极关联的一个趋势;并且在健康人的施主的血浆的 SCF 层次被观察。总的来说,我们的结果表明那 IL-1β,它通常衔接天生、适应的免疫,通过 PI-3K/mTOR 小径和 HIF-1 抄写建筑群导致主要 haematopoietic/proleukaemic 生长因素 SCF 的生产。这些调查结果强烈支持在发炎和尖锐 myeloid 白血球过多症之间的串音。 | Rafal W Wyszynski Bernhard F Gibbs Luca Varani Daniela Iannotta Vadim V Sumbayev | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 2 | Intracardiac iniection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-KB-dependent hypertrophic gene expression显示文摘 | Daniela S Gaetano S Anna F | 2010 | Hypertension2010，56，4： | 1 |
| 3 | The neural correlates of verb and noun processing: A PET study 显示文摘 | DANIELA PERANI STEFANO F CAPPA | 1999 | Brain1999，122，12： | 1 |
| 4 | Physical interactions in macroporous scaffolds based on poly(e-caprolactone)/chitosan semi- interpenetrating polymer networks 显示文摘 | Dunia M Garcfa C Daniela F | 2009 | Polymer2009，50，9： | 1 |
| 5 | Database techniques for the World Wide Web显示文摘 | DANIELA F ALON L ALBERTO M | 2005 | Sigmod Record2005，32，3： | 1 |
| 6 | Varicocelectomy does not impact pregnancy outcomes following intracytoplasmic sperm injection procedures显示文摘 | Fabio F Daniela P Rita C | 2012 | J Androl2012，33，2： | 1 |
| 7 | Improvements in exercise performance with high-intensity interval training coincide with an increase in skeletal muscle mitochondrial content and function 显示文摘 | Robert AJ Daniela F Thomas CB | 2013 | J Appl Physio12013，115，6： | 1 |
| 8 | Enzyme-catalysed approach to the preparation of the triazole antifungals:synthesis of(-)-genaconazole显示文摘 | Daniela A Elisabetta B Claudio F | 2009 | Tetrahedron:asymmetry2009，20，6： | 1 |
| 9 | Mechanical thrombectomy in acute occlusion of the carotid-T : a retrospective single centre study in 51 pa- tients显示文摘 | Daniela F Silke W Miriam I | 2016 | Clin Neumradiol2016，26，1： | 1 |
| 10 | Polypropylene-polyhedral oligomeric silsesquioxanes (POSS) nanocomposites显示文摘 | Alberto F Daniela T Alberto F | 2005 | Polym2005，46，： | 1 |
| 11 | Rare cause of odynophagia: Giant esophageal ulcer显示文摘Gastrointestinal complications are a frequent cause of morbidity after transplantation and may affect up to 40% of kidney transplant recipients. Here we report a rare case of idiopathic giant esophageal ulcer in a kidney transplant recipient. A 37-year-old female presented with a one-week history of odynophagia and weight loss. Upon admission, the patient presented cold sores, and a quantitative cytomegalovirus polymerase chain reaction was positive(105 copies/ml). An upper endoscopy demonstrated the presence of a giant ulcer. Serological test and tissue biopsies were unable to demonstrate an infectious origin of the ulcer. Immunosuppression was reduced and everolimus was introduced. An empirical i.v. therapy with acyclovir was started, resulting in a dramatic improvement in symptoms and complete healing of the ulcer. Only two cases of idiopathic giant esophageal ulcer in kidney transplant recipients have been reported in the literature; in both cases, steroid therapy was successful without recurrence of symptoms or endoscopic findings. However, this report suggests that correction of immune imbalance is mandatory to treat such a rare complication. | Massimiliano Veroux Giuseppe Aprile Francesca F Amore Daniela Corona Alessia Giaquinta Pierfrancesco Veroux | 2016 | World Journal of Gastroenterology2016，22，14： | 1 |
| 12 | Validation of the personal per- formance (PSP) scale in a german sample of acutely ill patients with schizophrenia 显示文摘 | Georg J Daniela S Nina F | 2008 | Schizophrenia Research2008，，： | 1 |
| 13 | Wavelet Analysis For Wind Fields Estimation显示文摘 | GLADESTON C L DANIELA M U F 6 TIMA N S M | 2010 | Sensors2010，10，： | 1 |
| 14 | The stem cells as a potential treatment for neurodegeneration 显示文摘 | Daniela F Vescovi A L Bottai D | 2007 | Methods Mol Biol2007，399，： | 1 |
| 15 | The High Fre- quency of De novo Promoter Methylation in Synchro- nous Primary Endometrial and Ovarian Carcinomas 显示文摘 | Daniela F Ileana C Barbara M | 2006 | Clinical Cancer Research2006，12，6： | 1 |
| 16 | Man- ufacture of Cheddar cheese from high-pressure-treated whole milk 显示文摘 | Daniela D Voigt John A Donaghy Margaret F Patterson | 2010 | Innovative Food Science and Emerging Technologies2010，，11： | 1 |
| 17 | Microcystin-producing blooms a serious global public health issue显示文摘 | DANIELA R DE F ULISSES M | 2004 | Eeotoxicology and Environmental Safety2004，，59： | 1 |
| 18 | Evaluation of Nonconventional Additives as Fire Retardants on Polya- mide 6,6: Phosphorous-based Master Batch, a-Zirconium Dihydrogen Phosphate, and b-Cyclodextrin Based Nano- sponges显示文摘 | Daniela E Jenny A Alberto F et aI | 2012 | Journal of Applied Polymer Science2012，123，： | 1 |
| 19 | Paper-Based Planar Reaction Arrays for Printed Diagnostics 显示文摘 | Anni M Daniela F Wang S X | 2011 | Sensors and Actuators B: Chemical2011，16，1： | 1 |
| 20 | Improvements in exercise performance with high-intensity interval training coincide with an increase in skeletal muscle mitochondrial content and function显示文摘 | ROBERT A J DANIELA F THOMAS C B | 2013 | J Appl Physiol2013，115，6： | 1 |
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