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| 1 | Role of microparticles in endothelial dysfunction and arterial hypertension显示文摘Microparticles are small cell vesicles that can be released by almost all eukaryotic cells during cellular stress and cell activation. Within the last 1-2 decades it has been shown that microparticles are useful blood surrogate markers for different pathological conditions, such as vascular inflammation, coagulation and tumour diseases. Several studies have investigated the abundance of microparticles of different cellular origins in multiple cardiovascular diseases. It thereby has been shown that microparticles released by platelets, leukocytes and endothelial cells can be found in conditions of endothelial dysfunction, acute and chronic vascular inflammation and hypercoagulation. In addition to their function as surrogate markers, several studies indicate that circulating microparticles can fuse with distinct target cells, such as endothelial cells or leukocyte, and thereby deliver cellular components of their parental cells to the target cells. Hence, microparticles are a novel entity of circulating, paracrine, biological vectors which can influence the phenotype, the function and presumably even the transcriptome of their target cells.This review article aims to give a brief overview about the microparticle biology with a focus on endothelial activation and arterial hypertension. More detailed information about the role of microparticles in pathophysiology and disease can be found in already published work. | Thomas Helbing Christoph Olivier Christoph Bode Martin Moser Philipp Diehl | 2014 | World Journal of Cardiology2014，6，11： | 14 |
| 2 | Expression of the oxygen-sensitive transcription factor subunit HIF-1α in patients suffering from secondary Raynaud syndrome显示文摘Anti-ischemic therapy remains a challenge due to the complexity of hypoxia response pathways. Hypoxia-inducible factor (HIF)-1 is a heterodimer tran scription factor con sisti ng of 2 sub units, HIF-1α and HIF-1β. Hypoxia-depe ndent activatio n of HIF-1α regulates cellular 02 homeostasis. Raynaud syndrome (RS), as a comorbidity of the autoimmune disease systemic sclerosis (SS), is characterized by vasospasms that limit blood flow to the limbs, resulting in hypoxia. A single-center randomized study was con ducted to compare prostagla ndin E1 (PgEI) therapy with a treatme nt combi ning PgE1 and an en dotheli n-1 blocker, bosentan. A total of 30 patients suffering from SS with RS were enrolled. We examined the regulation of HIF-1α, its target heme oxygenase-1 (HMOX-1), and the serum levels of the HIF-1α protein in a subset of patients as well as in ten healthy individuals. The expression of HIF-1α and HMOX-1 in monocytes was measured using absolute plasmid-based quantitative real-time PCR, whereas serum HIF-1α levels were measured with ELISA. Samples were taken at the time of randomization and after 24 weeks. We found that HIF-1α and HMOX-1 mRNA expression in monocytes and serum HIF-1α protein levels were significantly higher in the SS/RS patients compared to the healthy control group. Single-drug therapy significantly increased HIF-1α and HMOX-1 mRNA expression in monocytes and serum HIF-1α protein levels in the SS/RS patients compared to those at the time of randomization, whereas combining PgE1 with an en dotheli n-1 blocker preve nted the further in creases in HIF-1α and HMOX-1 expressi on. We propose HIF-1α and HMOX-1 as novel markers for anti-ischemic therapy in RS. | Lukas Andreas Heger Mark Kerber Marcus Hortmann Samuel Robinson Maximilian Mauler Daniela Stallmann Daniel Duerschmied Christoph Bode Christoph Hehrlein Ingo Ahrens | 2019 | Acta Pharmacologica Sinica2019，40，4： | 5 |
| 3 | Chip-based digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction patients显示文摘miRNAs 为尖锐心肌的梗塞(AMI ) 作为潜在的 biomarkers 显示出诺言。然而,当前的使用的量的即时 PCR (qRT-PCR ) 完全为 nucleic 酸的相对表示允许,它产生日常可变性,它限制了把 miRNAs 用作 biomarkers 的有效性。在这研究,我们探索了技术质量和一种新技术的诊断潜力,基于薄片的数字 PCR,在确定在有 AMI 和 ischaemia-reperfusion 损害(I/R ) 的病人的 miRNAs。在合成 C.elegans-miR-39 的一个冲淡系列,基于薄片的数字 PCR 与 qRT-PCR 相比显示了变化(8.9% 对 46.3%) 和察觉(0.2 copies/L 对 1.1 copies/L ) 的更低的限制的一个更低的系数。在从有圣举起心肌的梗塞( STEMI )的 24 个病人和有稳定的冠的动脉疾病( CAD )的 20 个病人镇定的浆液在经皮的冠的干预(一种总线标准)以后的病人,我们使用了 qRT-PCR 和多路的基于薄片的数字 PCR 确定他们在优先的研究在 AMI 被验证了的 miRNA-21 和 miRNA-499 的浆液层次。在 STEMI, I/R 损害经由圣片断分辨率(ST-R ) 的测量被估计。基于薄片的数字 PCR 处于在稳定的 CAD 和 STEMI 组之间的 miR-21 层次的差别揭示了统计意义(118.8 copies/L 对 59 copies/L;P=0.0300 ) ,而 qRT-PCR 是不能的到达意义(136.4 copies/L 对 122.8 copies/L;P=0.2273 ) 。为 miR-499 层次,基于薄片的数字 PCR 和 qRT-PCR 揭示了稳定的 CAD 和 STEMI 组之间的统计上重要的差别(2 copies/L 对 8.5 copies/L, P=0.0011;0 copies/L 对 19.4 copies/L;P < 0.0001 ) 。在 miR-21/499 层次和 ST-R 之间没有协会一种总线标准以后。我们的结果证明基于薄片的数字 PCR 展出优异技术质量和诺言是一个优异方法因为确定的 miRNA 在发行量铺平,它可以为直接确定成为一个更精确、可再现的方法 miRNAs,特别地为在大多中心的使用临床的试用。 | Samuel ROBINSON Marie FOLLO David HAENE Maximilian MAULER Daniela STALLMANN Lukas Andreas HEGER Thomas HELBING Daniel DUERSCHMIED Karlheinz PETER Christoph BODE Ingo AHRENS Marcus HORTMANN | 2018 | Acta Pharmacologica Sinica2018，39，7： | 5 |
| 4 | Steerable Versus Nonsteerable Sheath Technology in Atrial Fibrillation Ablation: A Prospective, Randomized Study显示文摘 | Christopher Piorkowski Charlotte Eitel Sascha Rolf Kerstin Bode Philipp Sommer Thomas Gaspar Simon Kircher Ulrike Wetzel Abdul Shokor Parwani Leif-Hendrik Boldt Meinhard Mende Andreas Bollmann Daniela Husser Nikolaos Dagres Masahiro Esato Arash Arya Wilhe | 2011 | Circulation: Arrhythmia and Electrophysiology2011，，： | 1 |
| 5 | Soil-structure interaction in the time domain using halfspace green's functions 显示文摘 | Christopher Bode Reinhold Hirschauer | 2002 | Soil Dynamics and Earthquake Engineering2002，22，4： | 1 |
| 6 | Rho-Associated Coiled-Coil-Containing Kinase 2 Deficiency in Bone Marrow–Derived Cells Leads to Increased Cholesterol Efflux and Decreased Atherosclerosis显示文摘 | Qian Zhou Yu Mei Takuhito Shoji Xinbing Han Karol Kaminski Goo Taeg Oh Pat P. Ongusaha Kunzhong Zhang Hannah Schmitt Martin Moser Christoph Bode James K. Liao | 2012 | Circulation2012，，18： | 1 |
| 7 | Abciximab, Eptifibatide, and Tirofiban Exhibit Dose-dependent Potencies to Dissolve Platelet Aggregates显示文摘 | Martin Moser Ulf Bertram Karlheinz Peter Christoph Bode Johannes Ruef | 2003 | Journal of Cardiovascular Pharmacology2003，，4： | 1 |
| 8 | Non-invasive imaging in the diagnosis of acute viral myocarditis显示文摘 | Michael Jeserich Stavros Konstantinides Gabor Pavlik Christoph Bode Annette Geibel | 2009 | Clinical Research in Cardiology2009，，12： | 1 |
| 9 | Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME显示文摘 | Patricio Godoy Nicola J. Hewitt Ute Albrecht Melvin E. Andersen Nariman Ansari Sudin Bhattacharya Johannes Georg Bode Jennifer Bolleyn Christoph Borner Jan B?ttger Albert Braeuning Robert A. Budinsky Britta Burkhardt Neil R. Cameron Giovanni Camussi Chong | 2013 | Archives of Toxicology2013，，8： | 1 |
| 10 | Acute results and long-term follow-up of patients with accompanying myocarditis after viral respiratory or gastrointestinal tract infection显示文摘 | Michael Jeserich Manfred Olschewski Simone Kimmel Christoph Bode Annette Geibel | 2014 | International Journal of Cardiology2014，，： | 1 |
| 11 | Pharmacologic cholinesterase inhibition improves survival in experimental sepsis显示文摘 | Stefan Hofer Christoph Eisenbach Ivan K. Lukic Lutz Schneider Konrad Bode Martina Brueckmann Sven Mautner Moritz N. Wente Jens Encke Jens Werner Alexander H. Dalpke Wolfgang Stremmel Peter P. Nawroth Eike Martin Peter H. Krammer Angelika Bierhaus Markus A | 2008 | Critical Care Medicine2008，，2： | 1 |
| 12 | Efficacy and safety of thrombolytic therapy after initially unsuccessful cardiopulmonary resuscitation:a prospective clinical trial显示文摘 | Bernd W Bttoiger Christoph Bode Sabine Kern | 2001 | Lancet2001，357，： | 1 |
| 13 | Land-use proximity as a basis for assessing stream water quality in New York State (USA)显示文摘 | Christopher P. Tran Robert W. Bode Alexander J. Smith Gary S. Kleppel | 2009 | Ecological Indicators2009，，3： | 1 |
| 14 | An empirical examination of supply chain performance along several dimensions of risk显示文摘 | STEPHAN M WAGNER CHRISTOPH BODE | 2008 | Journal of Business Logistics2008，29，1： | 1 |
| 15 | An empirical investigation into supply chain vulnerability显示文摘 | WAGNER STEPHAN M CHRISTOPH BODE | 2006 | Journal of Purchasing&Supply Management2006，12，6： | 1 |
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