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| 1 | Role of potassium in acid secretion显示文摘Potassium (K+) ions are critical for the activation and catalytic cycle of the gastric H+,K+-ATPase, resulting in the secretion of hydrochloric acid into the parietal cell canaliculus. As both symptom, severity and esophageal mucosal damage in gastro-esophageal reflux disease (GERD) are related to the degree of acid exposure, K+ is a logical target for approaches to inhibit acid production.The probable K+ binding site on the gastric H+,K+-ATPase has recently been described and studies are elucidating how K+ activates the enzyme. K+ channels in the apical membrane of the parietal cell are implicated in the recycling of K+ and, to date, three potential K+ channels (KCNQ1, Kir2.1 and Kir4.1) have been identified. The channels represent theoretical sites for agents to control acid secretion but it will be difficult to develop selective blockers. An alternative strategy is to prevent K+ from activating gastric H+,K+-ATPase; the potassiumcompetitive acid blocker (P-CAB) class inhibits acidsecretion by binding at or near the K+ binding site.Ongoing research is further defining the role of K+ in the functioning of the gastric H+,K+-ATPase, as well as determining the clinical utility of agents directed toward this important cation. | John P Geibel | 2005 | World Journal of Gastroenterology2005，11，34： | 6 |
| 2 | Role of calcium and other trace elements in the gastrointestinal physiology显示文摘钙是在海洋、陆上的有机体的一个必要离子,在它在从骨骼的形成和维护到神经元功能的规定的过程起一个关键作用的地方。Ca (2+) 平衡被三个机关系统维持,包括胃肠道,骨头和肾。因为第一在 1993 正在被克隆,察觉到受体的 Ca (2+) 沿着全部胃肠道被表示了,直到现在准确功能仅仅部分被阐明。如果察觉到受体的 Ca (2+) 涉及钙由胃肠道处理,这个日期,它尚待坚定。然而,有很少研究,显示出在冒号在胃的酸分泌物和液体运输上察觉到受体的 Ca (2+) 的生理的效果。另外, polyamines 和氨基酸被显示了激活察觉到受体的 Ca (2+) 并且也充当紧密相联的位的修饰词表明滋养的可获得性到肠的上皮细胞。察觉到受体的结肠的 Ca (2+) 的激活能废除在修改象霍乱一样的能分泌的腹泻建议受体的一个角色的周期的调停核苷酸的液体分泌物。为在细胞外的 Ca (2+) 的许多房间类型变化,集中能从增长交换细胞的行为到终端区别或静止。当癌症主要仍然是在增长,结束和 apoptosis 之间的混乱平衡的疾病,在察觉到受体的 Ca (2+) 的功能的混乱可以贡献肿瘤的疾病的前进。压制提高的细胞外的 Ca (2+) 的效果的生长的损失在冒号癌被表明了,并且在 CaSR 表示的水平与变化被相关。 | P Kirchhoff JP Geibel | 2006 | World Journal of Gastroenterology2006，12，20： | 2 |
| 3 | Functions and roles of the-extracellular Ca^2 + -sensing receptor in the gastrointestinal tract显示文摘 | Hebert SC Cheng S Geibel J | 2004 | Cell Calcium2004，35，3： | 1 |
| 4 | Prognostic value of the ECG on admission in patients with acute major pulmonary embolism显示文摘 | Geibel A Zehender M Kasper W | 2005 | Eur Respir J2005，25，： | 1 |
| 5 | Association between thrombolitic treatment and the prognosis of hempdynamically stable patients with major pulmonary embolism显示文摘 | Konstantinides S Geibel A Olschewski M | 1997 | Circulation1997，96，： | 1 |
| 6 | Management strategies and determinants of outcome in acute major pulmonary embolism:results of a multicenter registry显示文摘 | Kasper W Konstantinides S Geibel A | 1997 | J Am Coll Cardiol1997，30，5： | 1 |
| 7 | Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism显示文摘 | Konstantinides S Geibel A Heusel G | 2002 | N Engl J Med2002，347，15： | 1 |
| 8 | Importance of cardiac troponins I and T in risk stratification of patients with pulmonary embolism显示文摘 | Konstantinides S Geibel A Olschewski M | 2002 | Circulation2002，106，10： | 1 |
| 9 | Managemen strategies and determinants of outcome in acute major pulmonaryembol-ism:results of a multecenter regisuy显示文摘 | Kasper W Konstantinides S Geibel A | 1997 | Am Coll Cardiol1997，30，5： | 1 |
| 10 | Prognostic value of the ECG on admission in patients with acute major pulmonary embolism显示文摘 | Geibel A Zehender M Kasper W | 2005 | Eur Respir J2005，25，： | 1 |
| 11 | SVM learning with the Schur-Hadamard inner product for graplas显示文摘 | Jain B J Geibel P Wysotzki F | 2005 | Neuro- computing2005，64，： | 1 |
| 12 | Estimates of the size of key populations at risk for HIV infection:men who have sex with men,female sex workers and injecting drug users in Nairobi,Kenya显示文摘 | Okal J Geibel S Muraguri N | 2013 | Sexually transmitted infections2013，89，5： | 1 |
| 13 | L-type amino acids stimulate gastric acid secretion by activation of the calcium- sensing receptor in parietal cells 显示文摘 | Busque S M Kerstetter J E Geibel J P | 2005 | Am J Physiol Gastrointest Liver Physiol2005，289，4： | 1 |
| 14 | Management strategies and determinants of outcome in acute major pulmonary embolism:results of a multicenter registry显示文摘 | Kasper W Konstantinides S Geibel A | 1997 | J Am Coll Cardiol1997，30，5： | 1 |
| 15 | Intragastric injection of botulinum toxin A for the treatment of obesity显示文摘 | Mittermair R Keller C Geibel J | | 0，，： | 1 |
| 16 | Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism显示文摘 | Konstantinides S Geibel A Olschewski M | 2002 | Circulation2002，106，10： | 1 |
| 17 | Plasma spray forming:an alternate route for manufacturing free-standing components显示文摘 | FROYEN L DELAEY L | 1996 | Journal of Thermal Spray Technology1996，5，4： | 1 |
| 18 | A comparison of surgical and medical therapy for atrial septal defect in adults显示文摘 | Konstantinides S Geibel A Olschewsky M | 1995 | N Engl J Med1995，333，： | 1 |
| 19 | Heparin plus alte- plase compared with heparin alone in patients with submassive pulmonary embolism 显示文摘 | Konstantinides S Geibel A Heusel G | 2002 | N Engl J Med2002，347，15： | 1 |
| 20 | Heparin plus alteplase compared with heparin alone in patients with submassive pulmona- ry embolism显示文摘 | Konstantinides S Geibel A Heusel G | 2002 | N Engl J Med2002，347，15： | 1 |
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