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| 1 | Diagnostic criteria for acute liver failure due to Wilson disease显示文摘AIM: To describe the diagnostic criteria for acute liver failure due to Wilson disease (WD), which is an uncommon cause of acute liver failure (ALF). METHODS: We compared findings of patients presenting with ALF due to WD to those with ALF of other etiologies. RESULTS: Previously described criteria, such as low alkaline phosphatase activity, ratio of low alkaline phosphatase to total bilirubin or ratio of high aspartate aminotransferase (AST) to alanine aminotransferase (ALT), failed to identify patients with ALF due to WD. There were significant differences in low ALT and AST activities (53 ± 43 vs 1982 ± 938, P < 0.0001 and 87 ± 44 vs 2756 ± 2941, P = 0.037, respectively), low choline esterase activity (1.79 ± 1.2 vs 4.30 ± 1.2, P = 0.009), high urine copper concentrations (93.4 ± 144.0 vs 3.5 ± 1.8, P = 0.001) and low hemoglobin (7.0 ± 2.2 vs 12.6 ± 1.8, P < 0.0001) in patients with ALF caused by WD as compared with other etiologies. Interestingly, 4 of 7 patients with ALF due to WD survived without liver transplantation. CONCLUSION: In ALF, these criteria can help establish a diagnosis of WD. Where applicable, slit- lamp examination for presence of Kayser-Fleischer rings and liver biopsy for determination of hepatic copper concentration still remain important for the diagnosis of ALF due to WD. The need for liver transplantation should be evaluated carefully as the prognosis is not necessarily fatal. | Christoph Eisenbach Olivia Sieg Wolfgang Stremmel Jens Encke Uta Merle | 2007 | World Journal of Gastroenterology2007，13，11： | 14 |
| 2 | Arabidopsis Coordinates the Diurnal Regulation of Carbon Allocation and Growth across a Wide Range of Photoperiods显示文摘在短光周期,植物在光更快积累淀粉并且降级它更慢慢地在夜里,保证他们的淀粉储备持续直到黎明。为了调查伴随,在预定生长变化, Arabidopsis 在光周期的一个范围被种并且在黎明和黄昏为插座生物资源,光合作用,呼吸,核糖体丰富,装载的 polysome,淀粉,和超过 40 代谢物分析。数据集合被用来在白天和夜里为生长率建模,并且识别与生长相关的代谢物。建模的生长率并且 polysome 装载在白天并且在在长光周期的夜里高,但是在短光周期在夜里减少了。核糖体丰富在所有光周期是类似的。淀粉的数量怎么在轻时期,夜里的长度,和维护费用积累了,被讨论交往在短光周期在夜里抑制生长,并且为优化核糖体使用改变策略。重要关联在在生长率和糖信号 trehalose 6 磷酸盐和氨基酸生合成中介 shikimate 的层次之间的白天和夜里被发现,识别象在协调生长与的一个网络的中心的这些代谢物日报在碳供应的变化。 | Ronan Sulpice Anna Flis Alexander A. Ivakov Federico Apelt Nicole Krohn Beatrice Encke Christin Abel Regina Feil John E. Lunn Mark Stitt | 2014 | Molecular Plant2014，7，1： | 8 |
| 3 | Are heat stroke and physical exhaustion underestimated causes of acute hepatic failure?显示文摘While cardiopulmonary symptoms are common in patients undergoing classical or, due to physical exercise, exertional heat stroke, the failure of other organs is a rarely described phenomenon. Here we present two cases of acute hepatic failure, one due to classic heat shock, while the other occurred while the patient was doing a marathon-type running. Both cases presented with very high transaminases and significantly elevated international normalized ratio (INR). No other causes for liver failure could be identified but physical exhaustion and hyperthermia. | Kilian Weigand Carina Riediger Wolfgang Stremmel Christa Flechtenmacher Jens Encke | 2007 | World Journal of Gastroenterology2007，13，2： | 8 |
| 4 | Placebo responses in patients with gastrointestinal disorders显示文摘Over the last several years there has been a growing interest in placebo, not only as an inert control in clinical trials, but also in the placebo effect as a group effect as well as a reaction in individual subjects. Methodological factors such as regression to the mean and natural history of the disease play a role in the evaluation of a possible placebo effect. In this report, we discuss several factors including Pavlovian conditioning, beliefs outcome, expectations, and other factors as potential mediators of the placebo response. Placebo effects are common in gastrointestinal diseases and there seems to be no clear difference between placebo effects in functional gastrointestinal diseases (functional dyspepsia and irritable bowel syndrome) and organic gastrointestinal disease (duodenal ulcer and inflammatory bowel disease). | Frauke Musial Sibylle Klosterhalfen Paul Enck | 2007 | World Journal of Gastroenterology2007，13，25： | 7 |
| 5 | 生活能自理老人疼痛问题的处理显示文摘老年人的疼痛症状不论其病因,在诊治上都颇费周折。由于老年人特殊的生理变化,例如感知能力减退,对阿片类药物比较敏感,所以对疼痛的处理就不能按一般人对待。本文重点复习有关尚能自理的老年人出现疼痛症状应如何正确对待,尤其对阿片类药物和非类固醇消炎镇痛药的使用作了重点阐述。 | Enck R E 冯新华 孙慧 | 1992 | 国外医学(护理学分册)1992，11，3： | 6 |
| 6 | Treatment of hepatitis C virus infection显示文摘Acute and chronic hepatitis C virus (HCV) infection remains a serious health problem worldwide, however, there has been advancement in the treatment of HCV infection due to standard treatment using pegylated interferon and ribavirin. The literature indicates that therapy for HCV is becoming more individualized. In addition to considering genotype and viral RNA levels before treatment, achievement of an early virologic response (EVR) and a rapid virologic response (RVR) is now possible during therapy. Moreover, problem patients, such as non-responders, relapsers, HIV or HBV co- infected patients, patients with liver cirrhosis, and pre- or post-liver transplantation patients are an increasing fraction of the patients requiring treatment. This article reviews the literature regarding standard treatments and problem patients with acute and chronic HCV infection. It also includes discussion on contraindications and side effects of treatment with interferon and ribavirin, as well as new drug development. | Kilian Weigand Wolfgang Stremmel Jens Encke | 2007 | World Journal of Gastroenterology2007，13，13： | 4 |
| 7 | Irritable bowel syndrome and chronic pelvic pain: A singular or two different clinical syndrome?显示文摘Irritable bowel syndrome (IBS) and chronic pelvic pain (CPP) are both somatoform disorders with a high prevalence within the population in general. The objective was to compare both entities, to fi nd the differences and the similarities related to epidemiology and psychosocial aspects like stressful life events, physical and sexual abuse, illness behaviour and comorbidity. The technical literature was reviewed systematically from 1971 to 2006 and compared. According to literature, IBS and CPP seem to be one rather than two different entities with the same localisation of pain. Both syndromes also are similar concerning prevalence, the coexistence of mental and somatoform disorders, the common history of sexual and physical abuse in the past and their health care utilization. It could be shown that there were many similarities between IBS and CPP. Nevertheless both are traded as different clinical pictures as far. Therefore it seems to be reasonable and necessary to generate a common diagnosis algorithm and to bring gynaecologists and gastroenterologists into dialogue. | Anna Matheis Ute Martens Johannes Kruse Paul Enck | 2007 | World Journal of Gastroenterology2007，13，25： | 2 |
| 8 | Genetic vaccination with Flt3-L and GM-CSF as adjuvants: Enhancement of cellular and humoral mmune responses that results in protective immunity in a murine model of hepatitis C virus infection显示文摘AIM: To investigate whether transfection of plasmid DNA encoding these cytokines enhances both humoral and cellular immune responses to hepatitis C virus (HCV) in a murine model. METHODS: We established a tumor model of HCV infection using syngenic mouse myeloma cells stably transfected with NS5. Co-vaccination of DNA encoding granulocyte macrophage colony-stimulating factor (GM- CSF) and Flt-3 ligand together with a plasmid encoding for the HCV NS5 protein was carried out. Mice were sacrificed 14 d after the last immunization event with collection of spleen cells and serum to determine humoral and cellular immune responses. RESULTS: Co-vaccination of DNA encoding GM-CSF and Flt-3 ligand together with a plasmid encoding for the HCV NS5 protein induced increased antibody responses and CD4+ T cell proliferation to this protein. Vaccination with DNA encoding GM-CSF and Flt-3L promoted protection against tumor formation and/or reduction in mice co- immunized with cytokine-encoding DNA constructs. This suggests this strategy is capable of generating cytotoxic T lymphocyte activity in vivo. Following inoculation withplasmid DNA encoding Flt-3L, no increase in spleen size or in dendritic cell (DC) and natural killer cell numbers was observed. This was in contrast to a dramatic increase of both cell types after administration of recombinant Flt3-L in vivo. This suggests that vaccination with plasmid DNA encoding cytokines that regulate DC generation and mobilization may not promote unwanted side effects, such as autoimmunity, splenic fibrosis or hematopoietic malignancies that may occur with administration of recombinant forms of these proteins. CONCLUSION: Our data support the view that plasmid DNA vaccination is a promising approach for HCV immunization, and may provide a general adjuvant vaccination strategy against malignancies and other pathogens. | Jens Encke Jomo Bernardin Jasmin Geib Gocha Barbakadze Raymond Bujdoso Wolfgang Stremmel | 2006 | World Journal of Gastroenterology2006，12，44： | 2 |
| 9 | Perspectives for gene therapy of Wilson disease 显示文摘 | Merle U Stremmel W Encke J | 2007 | Curr Gene Ther2007，7，3： | 1 |
| 10 | Inhibition of Hepatitis C Virus NS3 Function by Antisense Oligodeoxy Nucleotides and Protease Inhibitor显示文摘 | Encke J Zu Putlitz J | 2001 | J Med Virol2001，65，4： | 1 |
| 11 | Anorectal functional testing:review of collective experience显示文摘 | Azpiroz F Enck P Whitehead WE | 2002 | Am J Gastroenterol2002，97，2： | 1 |
| 12 | Evidence of survival benefit of extended (D2) lymphadenectomy in western patients with gastric cancer based on a new concept:a prospective long-term follow-up study显示文摘 | Roukos DH Lorenz M Encke A | | 0，，： | 1 |
| 13 | Development of a heterologous, multigenotype vaccine against hepatitis C virus infection显示文摘 | Encke J Radunz W Eisenbach C | 2007 | Eur J Clin Invest2007，37，5： | 1 |
| 14 | TaintDroid: An Information- Flow Tracking System for Realtime Privacy Monitoring on Smartphones 显示文摘 | ENCK W GILBERT P | 2014 | ACM Transactions on Computer Systems2014，，2： | 1 |
| 15 | Understanding Android security显示文摘 | Enck W,Ongtang M,McDaniel P | 2009 | IEEE Security2009，7，1： | 1 |
| 16 | Functional Anorectal Disor-ders 显示文摘 | Bharucha AE Wald A Enck P | 2006 | Seminars in Gastrointestinal Disease2006，130，5： | 1 |
| 17 | Perspectives for gene therapy of Wilson disease显示文摘 | Merle U Stremmel W Encke J | 2007 | Curr Gene Ther2007，7，3： | 1 |
| 18 | TaintDroid:An information-flow tracking system for realtime privacy monitoring on smartphones显示文摘 | Enck W Gilbert P Han S | 2014 | ACM Transactions on Computer Systems (TOCS)2014，32，2： | 1 |
| 19 | Understanding Android Security 显示文摘 | Enck W Ongtang M McDaniel P | 2009 | IEEE Security & Privacy2009，7，1： | 1 |
| 20 | Historical evolution of inguinal her- nia repair显示文摘 | Sachs M Datum M Encke A | 1997 | World J Surg1997，21，2： | 1 |
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