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| 1 | Expression of the oxygen-sensitive transcription factor subunit HIF-1α in patients suffering from secondary Raynaud syndrome显示文摘Anti-ischemic therapy remains a challenge due to the complexity of hypoxia response pathways. Hypoxia-inducible factor (HIF)-1 is a heterodimer tran scription factor con sisti ng of 2 sub units, HIF-1α and HIF-1β. Hypoxia-depe ndent activatio n of HIF-1α regulates cellular 02 homeostasis. Raynaud syndrome (RS), as a comorbidity of the autoimmune disease systemic sclerosis (SS), is characterized by vasospasms that limit blood flow to the limbs, resulting in hypoxia. A single-center randomized study was con ducted to compare prostagla ndin E1 (PgEI) therapy with a treatme nt combi ning PgE1 and an en dotheli n-1 blocker, bosentan. A total of 30 patients suffering from SS with RS were enrolled. We examined the regulation of HIF-1α, its target heme oxygenase-1 (HMOX-1), and the serum levels of the HIF-1α protein in a subset of patients as well as in ten healthy individuals. The expression of HIF-1α and HMOX-1 in monocytes was measured using absolute plasmid-based quantitative real-time PCR, whereas serum HIF-1α levels were measured with ELISA. Samples were taken at the time of randomization and after 24 weeks. We found that HIF-1α and HMOX-1 mRNA expression in monocytes and serum HIF-1α protein levels were significantly higher in the SS/RS patients compared to the healthy control group. Single-drug therapy significantly increased HIF-1α and HMOX-1 mRNA expression in monocytes and serum HIF-1α protein levels in the SS/RS patients compared to those at the time of randomization, whereas combining PgE1 with an en dotheli n-1 blocker preve nted the further in creases in HIF-1α and HMOX-1 expressi on. We propose HIF-1α and HMOX-1 as novel markers for anti-ischemic therapy in RS. | Lukas Andreas Heger Mark Kerber Marcus Hortmann Samuel Robinson Maximilian Mauler Daniela Stallmann Daniel Duerschmied Christoph Bode Christoph Hehrlein Ingo Ahrens | 2019 | Acta Pharmacologica Sinica2019，40，4： | 5 |
| 2 | Chip-based digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction patients显示文摘miRNAs 为尖锐心肌的梗塞(AMI ) 作为潜在的 biomarkers 显示出诺言。然而,当前的使用的量的即时 PCR (qRT-PCR ) 完全为 nucleic 酸的相对表示允许,它产生日常可变性,它限制了把 miRNAs 用作 biomarkers 的有效性。在这研究,我们探索了技术质量和一种新技术的诊断潜力,基于薄片的数字 PCR,在确定在有 AMI 和 ischaemia-reperfusion 损害(I/R ) 的病人的 miRNAs。在合成 C.elegans-miR-39 的一个冲淡系列,基于薄片的数字 PCR 与 qRT-PCR 相比显示了变化(8.9% 对 46.3%) 和察觉(0.2 copies/L 对 1.1 copies/L ) 的更低的限制的一个更低的系数。在从有圣举起心肌的梗塞( STEMI )的 24 个病人和有稳定的冠的动脉疾病( CAD )的 20 个病人镇定的浆液在经皮的冠的干预(一种总线标准)以后的病人,我们使用了 qRT-PCR 和多路的基于薄片的数字 PCR 确定他们在优先的研究在 AMI 被验证了的 miRNA-21 和 miRNA-499 的浆液层次。在 STEMI, I/R 损害经由圣片断分辨率(ST-R ) 的测量被估计。基于薄片的数字 PCR 处于在稳定的 CAD 和 STEMI 组之间的 miR-21 层次的差别揭示了统计意义(118.8 copies/L 对 59 copies/L;P=0.0300 ) ,而 qRT-PCR 是不能的到达意义(136.4 copies/L 对 122.8 copies/L;P=0.2273 ) 。为 miR-499 层次,基于薄片的数字 PCR 和 qRT-PCR 揭示了稳定的 CAD 和 STEMI 组之间的统计上重要的差别(2 copies/L 对 8.5 copies/L, P=0.0011;0 copies/L 对 19.4 copies/L;P < 0.0001 ) 。在 miR-21/499 层次和 ST-R 之间没有协会一种总线标准以后。我们的结果证明基于薄片的数字 PCR 展出优异技术质量和诺言是一个优异方法因为确定的 miRNA 在发行量铺平,它可以为直接确定成为一个更精确、可再现的方法 miRNAs,特别地为在大多中心的使用临床的试用。 | Samuel ROBINSON Marie FOLLO David HAENE Maximilian MAULER Daniela STALLMANN Lukas Andreas HEGER Thomas HELBING Daniel DUERSCHMIED Karlheinz PETER Christoph BODE Ingo AHRENS Marcus HORTMANN | 2018 | Acta Pharmacologica Sinica2018，39，7： | 5 |
| 3 | Interactions of hydrogen,CO,oxygen,and water with molybdenum-modified Pt(111)显示文摘 | Robinson A M Montemore M M Samuel A | 2013 | J Phys Chem C2013，117，26： | 1 |
| 4 | Identification and treatment of individuals with attentiondeficit/ hyperactivity disorder and substance use disorder: An expert consensus statement显示文摘Attention-deficit/hyperactivity disorder(ADHD)often co-occurs with substance use(SU)and/or substance use disorder(SUD).Individuals with concurrent ADHD and SU/SUD can have complex presentations that may complicate diagnosis and treatment.This can be further complicated by the context in which services are delivered.Also,when working with young people and adults with co-existing ADHD and SU/SUD,there is uncertainty among healthcare practitioners on how best to meet their needs.In February 2022,the United Kingdom ADHD Partnership hosted a meeting attended by multidisciplinary experts to address these issues.Following presentations providing attendees with an overview of the literature,group discussions were held synthesizing research evidence and clinical experience.Topics included:(1)A review of substances and reasons for use/misuse;(2)identification,assessment and treatment of illicit SU/SUD in young people and adults with ADHD presenting in community services;and(3)identification,assessment and treatment of ADHD in adults presenting in SU/SUD community and inpatient services.Discussions highlighted inter-service barriers and fragmentation of care.It was concluded that a multimodal and multi-agency approach is needed.The consensus group generated a table of practice recommendations providing guidance on:identification and assessment;pharmacological and psychological treatment;and multi-agency interventions. | Susan Young Cyrus Abbasian Zainab Al-Attar Polly Branney Bill Colley Samuele Cortese Sally Cubbin Quinton Deeley Gisli Hannes Gudjonsson Peter Hill Jack Hollingdale Steve Jenden Joe Johnson Deborah Judge Alexandra Lewis Peter Mason Raja Mukherjee David Nutt Jane Roberts Fiona Robinson Emma Woodhouse Kelly Cocallis | 2023 | World Journal of Psychiatry2023，13，3： | 1 |
| 5 | Ex-ome sequencing identifies GRIN2A as frequently muta-ted in melanoma显示文摘 | Wei X Walia V Lin J C Teer J K Prickett T D Gartner J Davis S NISC Comparative Sequencing Program Stemke-Hale K Davies M A Gershenwald J E Rob-inson W Robinson S Rosenberg S A Samuels Y | | 0，，： | 1 |
| 6 | Van- detanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial 显示文摘 | Wells Samuel A Robinson Bruce G Gagel Robert F | 2012 | J Clin Onco12012，30，2： | 1 |
| 7 | Value of peripheral vascular endothelial function in the detection of relative myocardial ischemia in asymptomatic type 2 diabetic patients who underwent myocardial perfusion imaging显示文摘 | Georgios I. Papaioannou Christos Kasapis Richard L. Seip Neil J. Grey Deborah Katten Frans J. Th. Wackers Silvio E. Inzucchi Samuel Engel Amy Taylor Lawrence H. Young Deborah A. Chyun Janice A. Davey Ami E. Iskandrian Robert E. Ratner Evelyn C. Robinson S | 2006 | Journal of Nuclear Cardiology2006，，3： | 1 |
| 8 | Depression, introversion and mortality following stroke显示文摘 | Morris PLP Robinson RG Samuels J | 1993 | Aust N Z J Psychiatry1993，27，3： | 1 |
| 9 | Comprehensive Characterization of Natural Cissus quadrangularis Stem Fiber Composites as an Alternate for Conventional FRP Composites显示文摘 | Suyambulingam Indran Robinson Dhas Edwin Raj Brainerd Samuel Sundar Daniel Joseph Selvi Binoj | 2018 | Journal of Bionic Engineering2018，15，5： | 1 |
| 10 | Mochi: Composing Data Services for High-Performance Computing Environments显示文摘Technology enhancements and the growing breadth of application workflows running on high-performance computing(HPC)platforms drive the development of new data services that provide high performance on these new platforms,provide capable and productive interfaces and abstractions for a variety of applications,and are readily adapted when new technologies are deployed.The Mochi framework enables composition of specialized distributed data services from a collection of connectable modules and subservices.Rather than forcing all applications to use a one-size-fits-all data staging and I/O software configuration,Mochi allows each application to use a data service specialized to its needs and access patterns.This paper introduces the Mochi framework and methodology.The Mochi core components and microservices are described.Examples of the application of the Mochi methodology to the development of four specialized services are detailed.Finally,a performance evaluation of a Mochi core component,a Mochi microservice,and a composed service providing an object model is performed.The paper concludes by positioning Mochi relative to related work in the HPC space and indicating directions for future work. | Robert BRoss George Amvrosiadis Philip Carns Charles DCranor Matthieu Dorier Kevin Harms Greg Ganger Garth Gibson Samuel KGutierrez Robert Latham Bob Robey Dana Robinson Bradley Settlemyer Galen Shipman Shane Snyder Jerome Soumagne Qing Zheng | 2020 | Journal of Computer Science & Technology2020，35，1： | 0 |
| 11 | Challenges with non-descriptive compliance labeling of end-stage renal disease patients in accessibility for renal transplantation显示文摘Non-descriptive and convenient labels are uninformative and unfairly project blame onto patients.The language clinicians use in the Electronic Medical Record,research,and clinical settings shapes biases and subsequent behaviors of all providers involved in the enterprise of transplantation.Terminology such as noncompliant and nonadherent serve as a reason for waitlist inactivation and limit access to life-saving transplantation.These labels fail to capture all the circum-stances surrounding a patient’s inability to follow their care regimen,trivialize social determinants of health variables,and bring unsubstantiated subjectivity into decisions regarding organ allocation.Furthermore,insufficient Medicare coverage has forced patients to ration or stop taking medication,leading to allograft failure and their subsequent diagnosis of noncompliant.We argue that perpetuating non-descriptive language adds little substantive information,in-creases subjectivity to the organ allocation process,and plays a major role in reduced access to transplantation.For patients with existing barriers to care,such as racial/ethnic minorities,these effects may be even more drastic.Transplant committees must ensure thorough documentation to correctly encapsulate the entirety of a patient’s position and give voice to an already vulnerable population. | Benjamin Peticca Tomas M Prudencio Samuel G Robinson Sunil S Karhadkar | 2024 | World Journal of Nephrology2024，13，1： | 0 |
| 12 | 告别“失落的十年”欧元区经济正在回暖显示文摘欧洲到处都是令人沮丧的消息:英国脱欧谈判陷入僵局、加泰罗尼亚与西班牙中央政府的宪法对峙、东欧的反移民敌意。但好消息也有一条:欧洲已不再是世界经济中的“病人”了。经济学家们表示,有19个成员的欧元区已经出现了十年内最强劲的经济增长,也没有任何通胀迹象, | Jana Randow Samuel Potter Cormac Mullen Blaise Robinson 融汐 | 2017 | 商业周刊(中文版)2017，0，24： | 0 |
| 13 | Cancer screening and management in the transgender population:Review of literature and special considerations for gender affirmation surgery显示文摘BACKGROUND Literature focused on cancer screening and management is lacking in the transgender population.AIM To action to increase contributions to the scientific literature that drives the creation of cancer screening and management protocols for transgender and gender nonconforming(TGNC)patients.METHODS We performed a systematic search of PubMed on January 5th,2022,with the following terms:“TGNC”,OR“transgender”,OR“gender non-conforming”,OR“gender nonbinary”AND“cancer screening”,AND“breast cancer”,AND“cervical cancer”,AND“uterine cancer”,AND“ovarian cancer”,AND“prostate cancer”,AND“testicular cancer”,AND“surveillance”,AND“follow-up”,AND“management”.70 unique publications were used.The findings are discussed under“Screening”and“Management”categories.RESULTS Screening:Current cancer screening recommendations default to cis-gender protocols.However,long-term genderaffirming hormone therapy and loss to follow-up from the gender-specific specialties contribute to a higher risk for cancer development and possible delayed detection.The only known screening guidelines made specifically for this population are from the American College of Radiology for breast cancer.Management:Prior to undergoing Gender Affirmation Surgery(GAS),discussion should address cancer screening and management in the organs remaining in situ.Cancer treatment in this population requires consideration for chemotherapy,radiation,surgery and/or reconstruction.Modification of hormone therapy is decided on a case-by-case basis.The use of prophylactic vs aesthetic techniques in surgery is still debated.CONCLUSION When assessing transgender individuals for GAS,a discussion on the future oncologic risk of the sex-specific organs remaining in situ is essential.Cancer management in this population requires a multidisciplinary approach while the care should be highly individualized with considerations to social,medical,surgical and gender affirming surgery related specifications.Special considerations have to be made during planning for GAS as surgery will alter the anatomy and may render the organ difficult to sample for screening purposes.A discussion with the patient regarding the oncologic risk of remaining organs is imperative prior to GAS.Other special considerations to screening such as the conscious or unconscious will to unassociated with their remaining organs is also a key point to address.We currently lack high quality studies pertinent to the cancer topic in the gender affirmation literature.Further research is required to ensure more comprehensive and individualized care for this population. | Juliet C Panichella Sthefano Araya Siddhartha Nannapaneni Samuel G Robinson Susan You Sarah M Gubara Maria T Gebreyesus Theresa Webster Sameer A Patel Alireza Hamidian Jahromi | 2023 | World Journal of Clinical Oncology2023，14，7： | 0 |
| 14 | Microwave remediation of oil contaminated soils显示文摘 | Samuel W. Kingman Colin E. Snape John P. Robinson | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
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