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| 1 | 《国际功能、残疾和健康分类》:对康复策略进行统一概念描述的模式显示文摘成功开展康复实践和研究工作的重要基础是将其作为健康策略来全面地描述康复概念,而一个被广泛接受的概念模式与人类功能概念和分类则是健康策略的基础。2001年,世界卫生大会批准了《国际功能、残疾和健康分类》(ICF),并在2005年召开的世界卫生大会上通过关于ICF的《残疾,包括预防、管理和康复》的决议,因此,我们可以依据一种被广泛接受的概念模式解决相关的残疾与康复问题。我们应抓住机遇,及时发展基于ICF的概念描述,它可以作为类似领域概念描述的基础,并根据专业的定义在人类功能与康复研究的不同科学领域中运用康复策略。目前,通过与欧洲医学联盟(UEMS)物理和康复医学(PRM)专业委员会的专家和其专业委员会的紧密合作,笔者已经完成了第一个基于ICF的概念描述的版本,用简短的文字描述康复的定义。PRM专业委员会、卫生部门和其他行业的专业人士共同将该定义应用于服务人群,其目的是让那些健康状况处于残疾或可能会有残疾的人在与环境的交互作用中实现和保持最佳功能。 | Gerold STUCKI Alarcos CIEZA John MELVIN 祝捷(译) 李智玲(译) 邱卓英(审校) 李建军(审校) | 2008 | 中国康复理论与实践2008，14，12： | 31 |
| 2 | Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients显示文摘AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy subjects.CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology. | Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel Jan Knol Kaouther Ben-Amor Louis MA Akkermans | 2009 | World Journal of Gastroenterology2009，15，23： | 33 |
| 3 | 《国际功能、残疾和健康分类》:对物理和康复医学进行统一概念描述的模式显示文摘需要发展一个当代为国际上广泛接受的物理和康复医学(PRM)的概念描述。建立这种新的概念依赖于统一的概念模型和《国际功能、残疾和健康分类》(ICF)的分类体系。这种基于ICF的康复概念描述是将康复作为一种健康策略。欧盟医学专家委员会(UEMS)的康复专家正在致力于将ICF作为物理和康复医学的统一概念的模型,并依据此建立基于ICF的概念描述并给PRM下定义。根据此项目标,作者通过与欧盟物理和康复医学专业实践委员会成员的合作,对于属于医学专业的PRM作了一个简明的定义。物理和康复医学是基于功能评估的医学专业,包含健康状况的诊断和治疗,实施、应用生物医学并结合其它更为广泛的干预方法,使残疾人或者可能经历残疾的人达到功能最佳化的目标。 | Gerold STUCKI John MELVIN 卢雯(译) 李智玲(译) 邱卓英(审校) 王斌(审校) | 2008 | 中国康复理论与实践2008，14，12： | 28 |
| 4 | ICF发展应用:康复学科知识体系与临床工具构建显示文摘WHO-FIC-FDRG专家委员会Stucki博士于2008年5月13日访问了中国康复研究中心康复信息研究所,并与WHO-FIC-FDRG专家邱卓英博士及其同事做了广泛交流。Stucki博士就ICF应用于康复科学体系建设以及开发基于ICF核心分类模板相关事宜做了专题讲座。作为《Journal of Rehabilitation Medicine》杂志编委,Stucki博士欣然接受本刊邀请成为本刊的国际编委,并代表德国国际分类家族WHO合作中心—ICF研究分中心(ICF Research Branch of WHO Collaborating Center for the Family of International Classifications,Germany(DMIDI))与中国康复信息研究所建立有关ICF研究国际合作,建立了《Journal of Rehabilitation Medicine》和《中国康复理论与实践》杂志间的学术联系。本专题的英文文章发表于《Journal of Rehabilitation Medicine》,由Stucki教授授权《中国康复理论与实践》杂志以中文形式独家发表。第一篇是由中外专家专门为本刊撰写的特稿。本专题的文章是在相关专家组织下翻译的,内容涉及基于ICF的康复学科体系的建立,面向功能的整合性康复学科体系的发展,从细胞到社会的功能结构分类摸板,基于ICF重新定义康复医学、康复科学和康复服务,以及开发应用于不同康复医疗领域的ICF核心分类等内容。这些研究反应了国际最新的理论和应用发展成果,对于依据ICF这一国际性的功能残疾模式和知识分类标准,建立符合科学发展规律和社会发展要求的学科体系以及实践领域具有十分重要的理论和实践意义。通过出版本专题,希望能使广大康复科技工作者关注国际相关发展,更新有关观念和方法,推动康复科学学科建设和发展,扩大国际合作与交流。鉴于ICF理论与方法相对较新,本专题中很多文章从科学学和方法论角度探讨学科建设和知识体系的构建,有的内容涉及到专业性很强的测量学方法,这些对于专题译校团队的专家学者也是一种挑战。作为当前国际康复界研究发展的热点领域,文章作者、译校者也衷心希望专家和读者就有关问题开展广泛讨论,促进残疾和康复科学发展。本研究相关研究是国家科技部科技基础性工作和社会公益研究专项项目:中国残疾分类系统和评定标准平台研究(2003DIB1J063);国家科技部科技基础性工作和社会公益研究专项项目:中国残疾人功能和健康评定研究(2004DIB5J183)和首都医学发展科研基金:基于ICF架构的功能、残疾和健康评定和研究(2007-3132)支持研究项目。 | Gunnar GRIMBY John MELVIN Gerold STUCKI 邱卓英 张爱民(译) 吴弦光(审校) | 2008 | 中国康复理论与实践2008，14，12： | 22 |
| 5 | Nitrous oxide emission by denitrifying phosphorus removal culture using polyhydroxyalkanoates as carbon source显示文摘Nitrous oxide(N2O) emission has been reported to be enhanced during denitrification when internally-stored compounds are used as carbon sources.However,negligible N2O emissions have been detected in the few studies where polyhydroxyalkanoates(PHA) were specifically used.This study investigated and compared the potential enhancement of N2O production,based on utilization of an internally-stored polymer and external carbon(acetate) by a denitrifying phosphorus removal culture.Results indicated that at relatively low chemical oxygen demand-to-nitrogen(COD/N) ratios,more nitrite was reduced to N2O in the presence of an external carbon source as compared to an internal carbon source(PHA).At relatively higher COD/N ratios,similar N2O reduction rates were obtained in all cases regardless of the type of carbon source available.N2O reduction rates were,however,generally higher in the presence of an internal carbon source.Results from the study imply that when the presence of an external carbon source is not sufficient to support denitrification,it is likely competitively utilized by different metabolic pathways of denitrifying polyphosphate accumulating organisms(DPAOs) and other ordinary denitrifiers.This study also reveals that the consumption of PHA is potentially the rate-limiting step for N2O reduction during denitrification. | Yan Zhou Melvin Lim Soekendro Harjono Wun Jern Ng | 2012 | Journal of Environmental Sciences2012，24，9： | 17 |
| 6 | 脂肪抽吸及术后并发脂肪栓塞的临床分析显示文摘采用真空抽吸器反复抽拉行脂肪抽吸术,使脂肪组织破碎为团状脂肪小球、破碎的脂肪细胞和中性脂肪。脂肪抽吸过程中,血管管腔产生裂隙,为脂肪酸进入血液循环系统提供途径。在肺血管脂肪栓塞中,由于脂肪球具有流动性和可变形性,其并未完全阻塞毛细血管血流,因此其栓塞是暂时的或不完全的。脂肪栓塞的初始症状可能是由于一些脂肪球的体积过大不能通过毛细血管,而机械性的阻塞多条血管造成的。肺细胞可以游离脂肪酸,以降低阻塞肺循环的中性脂肪,但游离脂肪酸可对肺实质形成损伤,造成成人呼吸窘迫综合征(ARDS)。脂肪栓塞综合征(FES)表现为:急性低氧血症,呼吸窘迫,中枢神经系统功能障碍,以及头、颈、前胸或腋窝处瘀斑。对肺脂肪栓塞的诊断,主要依靠以上典型症状和体征。而治疗方式多采用支持治疗。 | Melvin A Shiffman 魏峰(译) 高景恒(译) | 2010 | 中国美容整形外科杂志2010，21，7： | 15 |
| 7 | Metabolomic Profiling in Selaginella lepidophylla at Various Hydration States Provides New Insights into the Mechanistic Basis of Desiccation Tolerance显示文摘Selaginella lepidophylla 是仅仅一些之一发展了干燥忍耐(DT ) 或从一个 air-dried 状态复兴的能力的尖铁苔藓(Selaginellaceae ) 的种类。以便理解 DT 的新陈代谢的基础, S。lepidophylla 受到一五阶段, rehydration/dehydration 周期,然后分析了使用基于 GC/MS 和 UHLC/MS/MS2 平台介绍技术的非偏导的、全球 metabolomics。包括 167 说出的 251 代谢物(66.5%) 的一个总数并且 84 (33.4%) 未命名的混合物被描绘。仅仅 42 (16.7%) 并且(29.5%) 74 混合物显示出显著地增加或减少的丰富分别地,显示大多数混合物组成地被生产包括高度丰富的 trehalose,蔗糖,和葡萄糖。几 glycolysis/gluconeogenesis 和 tricarboxylic 酸(TCA ) 周期中介在 100% 亲戚水内容(RWC ) 和 50% RWC 显示出增加的丰富。Vanillate,一种有势力抗氧化剂,也更充满含水的状态。许多不同的糖白酒和糖酸更充满含水的状态。这些 polyols 多半速度率在水和期间在弄干的过程以及慢水吸收期间浇损失,稳定蛋白质,并且清除反应的氧种类(ROS ) 。相反,充满氮并且 -glutamyl 氨基酸,瓜氨酸,和核苷酸分解代谢产品(例如 allantoin ) 更充满干燥状态,建议这些混合物可能在水和期间或在清除的 ROS 在氮动员起重要作用。紫外保护的混合物象 3-(3-hydroxyphenyl ) 那样 propionate, apigenin,和 naringenin,更充满干燥状态。大多数类脂化合物组成地被生产,与胆碱磷酸盐的例外,它更充满干燥状态并且多半在膜水和和稳定起一个作用。相反,几多元不堡和丰满的酸更充满含水的状态,建议这些混合物多半帮助在脱水期间维持膜流动性。最后, S。lepidophylla 包含了显示了双重或更大的丰富在的七未命名的混合物干燥或 rehydrating 状态,建议这些混合物可能在 DT 起适应作用。 | Abou Yobi Bernard W.M. Wone Wenxin Xu Danny C. Alexander Lining Guo John A. Ryals Melvin J. Oliver John C. Cushman | 2013 | Molecular Plant2013，6，2： | 9 |
| 8 | Carcinogenesis of nasopharyngeal carcinoma:an alternate hypothetical mechanism显示文摘Current proposed mechanisms implicate both early and latent Epstein-Barr virus(EBV)infection in the carcinogenic cascade,whereas epidemiological studies have always associated nasopharyngeal carcinoma(NPC)with early childhood EBV infection and with chronic ear,nose,and sinus conditions.Moreover,most patients with NPC present with IgA antibody titers to EBV capsid antigen(VCA-lgA),which can precede actual tumor presentation by several years.If early childhood EBV infection indeed constitutes a key event in NPC carcinogenesis,one would have to explain the inability to detect the virus in normal nasopharyngeal epithelium of patients at a high risk for EBV infection.It is perhaps possible that EBV resides within the salivary glands,instead of the epithelium,during latency.This claim is indirectly supported by observations that the East Asian phenotype shares the characteristics of an increased susceptibility to NPC and immature salivary gland morphogenesis,the latter of which is influenced by the association of salivary gland morphogenesis with an evolutionary variant of the human ectodysplasin receptor gene(EDAR),EDARV370A.Whether the immature salivary gland represents a more favorable nidus for EBV is uncertain,but in patients with infectious mononucleosis,EBV has been isolated in this anatomical organ.The presence of EBV-induced lymphoepitheliomas in the salivary glands and lungs further addresses the possibility of submucosal spread of the virus.Adding to the fact that the fossa of Rosen Muller contains a transformative zone active only in the first decade of life,one might be tempted to speculate the possibility of an alternative carcinogenic cascade for NPC that is perhaps not dissimilar to the model of human papillomavirus and cervical cancer. | Sharon Shuxian Poh Melvin Lee Kiang Chua Joseph T.S.Wee | 2016 | Chinese Journal of Cancer2016，35，1： | 8 |
| 9 | 东亚唐棣组织培养体系显示文摘以东亚唐棣带芽茎段为外植体,研究了不同消毒方法对于无菌体系建立的影响、不同类型的芽对于诱导萌发的影响、不同基本培养基以及激素组合对于增殖与生根的影响。结果表明:较为适合东亚唐棣消毒的方法为75%酒精消毒30 s,0.1%Hg Cl2消毒8 min,萌发率为16.7%;带有一侧芽的顶芽为较为合适的外植体,萌发率可达87.6%;最适增殖培养基为MS+6-BA 3.0 mg·L-1+NAA 0.1 mg·L-1,增殖系数可达4.8;最适生根培养基为1/4MS+NAA 0.1 mg·L-1。 | 尹鹏先 蔡靖 李厚华 Melvin T T 姜在民 | 2015 | 东北林业大学学报2015，43，1： | 6 |
| 10 | Surgery as an alternative to radiotherapy in early-stage nasopharyngeal carcinoma:innovation at the expense of uncertainty显示文摘Radiotherapy(RT)has an unassailable track record as the backbone of treatment in nasopharyngeal carcinoma(NPC).Several reasons explain its dominance.Likewise to human papilloma virus-associated oropharyngeal squamous cell carcinoma,Epstein-Barr virus(EBV)-associated NPC is exquisitely sensitive to RT.Thus,huge leaps with technological advances in RT delivery over the past decades have led to substantial improvements in tumor control,while reducing debilitating late RT-induced complications[1,2].Innovations in this space continue to drive the enhancement of the therapeutic ratio of RT,with the goal of enhancing the quality of life(QoL)among long-term survivors[3].Therefore,there has not been any compelling reason to disrupt this timehonored convention of employing RT as the standard of care in NPC. | Luo Huang Melvin L.K.Chua | 2020 | Cancer Communications2020，40，2： | 5 |
| 11 | Natural-orifice transgastric endoscopic peritoneoscopy in humans: Initial clinical trial显示文摘 | Jeffrey W. Hazey Vimal K. Narula David B. Renton Kevin M. Reavis Christopher M. Paul Kristen E. Hinshaw Peter Muscarella E. Christopher Ellison W. Scott Melvin | 2008 | Surgical Endoscopy2008，，1： | 4 |
| 12 | 儿茶酚胺介导的多形性室速患者家系CASQ2基因F189L突变的基因分析显示文摘目的在27例儿茶酚胺介导的多形性室速患者及家庭成员中寻找CASQ2基因突变。方法应用直接DNA序列分析对临床诊断为家族性多形性室速27例患者及家庭成员进行进行基因突变分析。应用Taqman基因分型检测在以1400名正常人群中确定CASQ2变异的频率。结果在一个多形性室速家系中发现了1个新的杂合子改变F189L。通过与多种生物比对,证实该改变发生于在第2结构域一个高度保守的氨基酸上,位于第5外显子的F189L的改变,使编码蛋白的第189位氨基酸由苯丙氨酸改变为亮氨酸。应用Taqman SNP genotyping assay分析方法证实正常人群1400名中未发现同样改变。在CASQ2基因中未发现其他引起疾病的基因突变。结论发现了CASQ2基因的1个新F189L突变。 | 刘茜蓓 Carlos Oberti 张贤钦 柯铁 张腾 Melvin Scheinman 胡大一 王擎 | 2008 | 中华医学遗传学杂志2008，25，3： | 4 |
| 13 | 以整体观念发展人体功能和康复研究显示文摘WHO发布的《国际功能、残疾与健康分类》,为全面理解将损伤的生物医学观点与残疾的社会模式整合在一起的人体功能与康复研究奠定了基础。它提出了在提高研究能力方面面临的一系列新旧挑战。本文将从三个方面概述应对这些挑战的方法:建立深入到不同科学领域的人体功能与康复研究的组织;发展合适的学术培训项目;建立大学研究中心和合作网络。 | Gerold Stucki, MD, MS Jan Dietrich Reinhardt, PhD Gunnar Grimby, MD, PhD John Melvin, MD, MMSc 李露(译) 卫小梅(译) 郭铁成(校) | 2008 | 中华物理医学与康复杂志2008，30，1： | 4 |
| 14 | C-reactive protein levels during a relapse of Crohn’s disease are associated with the clinical course of the disease显示文摘AIM: To explore if C-reactive protein (CRP) levels might serve as a prognostic factor with respect to the clinical course of Crohn's disease and might be useful for classification.METHODS: In this retrospective cohort study we enrolled 94 patients from the inflammatory bowel disease (IBD) database of the University Medical Centre Utrecht. CRP levels during relapse were correlated with the number of relapses per year. Severity of relapses was based on endoscopic reports and prednisone use. Furthermore, patients were categorized in a low or high CRP group based on their CRP response during relapse and demographic and clinical features were compared.RESULTS: Overall, a positive correlation between CRP levels, number of relapses, and severity of relapse was found (respectively rs = 0.31, P < 0.01 and rs = 0.50, P < 0.001). Employing a cut-off level of 15 mg/L, the index CRP level was found to discriminate patients with respect to the number of relapses per year, as well as for severity of relapses (respectively 0.25 ± 0.16 vs 0.36 ± 0.24, P < 0.05 and 4.4 ± 1.2 vs 3.2 ± 1.1 on a 10-point visual analogue scale, P < 0.001 for the high CRP and low CRP groups respectively). In addition, the high CRP group showed more cumulative days of prednisone use per year (107 ± 95 vs 58 ± 48, P < 0.05), as well as a better response to infliximab (93 % vs 33 %, P = 0.06).CONCLUSION: A higher CRP level during relapse seems to be associated with a more severe clinical course of disease. | Chantal L Koelewijn Matthijs P Schwartz Melvin Samsom Bas Oldenburg | 2008 | World Journal of Gastroenterology2008，14，1： | 4 |
| 15 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 16 | Extraintestinal Manifestations of Inflammatory Bowel Disease显示文摘 | Folashade A Jose Melvin B Heyman | 2008 | Journal of Pediatric Gastroenterology and Nutrition2008，，2： | 3 |
| 17 | The evolution of Epstein-Barr virus detection in nasopharyngeal carcinoma显示文摘The detection of Epstein-Barr virus(EBV)in nasopharyngeal carcinoma(NPC)has evolved over the last40 years,transitioning from simple serological tests of latent viral infection to extremely sensitive measurements of | You Quan Li Ni Sann Khin Melvin L.K.Chua | 2018 | Cancer Biology & Medicine2018，15，1： | 3 |
| 18 | Sedation-risk-free colonoscopy for minimizing the burden of colorectal cancer screening显示文摘Unsedated colonoscopy is available worldwide,but is not a routine option in the United States(US).We conducted a literature review supplemented by our experience and expert commentaries to provide data to support the use of unsedated colonoscopy for colorectal cancer screening.Medline data from 1966 to 2009 were searched to identify relevant articles on the subject.Data were summarized and co-authors provided critiques as well as accounts of unsedated colonoscopy for screening and surveillance.Diagnostic colonoscopy was initially dev eloped as an unsedated procedure.Procedure-re lated discomfort led to wide adoption of sedation in the US,although unsedated colonoscopy remains the usual practice elsewhere.The increased use of colonoscopy for colorectal cancer screening in healthy,asymptomatic individuals suggests a reass-essment of the burden of sedation in colonoscopy for screening is appropriate in the US for lowering costs and minimizing complications for patients.A water method developed to minimize discomfort has shown promise to enhance outcomes of unsedated colonoscopy.The use of scheduled,unsedated colono scopy in the US appears to be feasible for colorectal cancer screening.Studies to assess its applicability in diverse practice settings deserve to be conducted and supported. | Felix W Leung Abdulrahman M Aljebreen Emilio Brocchi Eugene B Chang Wei-Chih Liao Takeshi Mizukami Melvin Schapiro Konstantinos Triantafyllou | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，3： | 3 |
| 19 | Clinical outcomes of coronavirus disease 2019 (COVID-19) in cancer patients with prior exposure to immune checkpoint inhibitors显示文摘Dear Editor,The coronavirus disease 2019(COVID-19)pandemic has affected over 6,000,000 people globally[1].Patients with COVID-19 manifest with symptoms of fever,dry cough,dyspnea,and present with radiological changes that are consistent with atypical pneumonia[2].Pathogenetic mechanisms for these abnormalities involve the systemic immune response that is associated with the hyperactivation of peripheral CD8+and CD4+T cells,and a cytokine storm[3].Globally,the reported prevalence of patients with COVID-19 and cancer ranges from 0.5%to 6.0%in the different case series[4]. | Qiuji Wu Qian Chu Hongyan Zhang Bin Yang Xudong He Yahua Zhong Xianglin Yuan Melvin L.K.Chua Conghua Xie | 2020 | Cancer Communications2020，40，8： | 3 |
| 20 | Microstructure Transition and Grain Refinement Mechanism of Undercooled Alloys显示文摘The solidification microstructures of undercooled Ni90Cu10 alloys under different undercoolings were studied systematically by means of melt coating and cyclic superheating.In the obtained undercooling range,the solidification structures of the two undercooled alloys have similar transformation processes,and there are two kinds of grain refinement structures under the conditions of low undercooling and high undercooling,respectively.The microstructures of the two grain refinement processes were analyzed in more detail by electronic backscattering diffraction technique.Under the condition of small undercooling,dendrite remelting is considered to be the main reason of grain refinement.However,under the condition of high undercooling,the existence of annealing twins and obvious migration of grain boundary are important evidences for the occurrence of recrystallization process. | 李洪涛 Nancy Julius Siambun Bih-Lii Chuab Melvin Gan Jet Hong 安红恩 | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，6： | 3 |
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