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| 1 | Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model显示文摘AIM: To compare different preconditioning strategies to protect the liver from ischemia/reperfusion injury focusing on the expression of pro- and anti-apoptotic proteins. Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by α-lipoic acid (LA). METHODS: Several groups of rats were compared: sham operated animals, non-pretreated animals (nt), animals receiving IP (10 min of ischemia by clamping of the portal triad and 10 min of reperfusion) prior to sustained ischemia, animals receiving selective ischemic preconditioning (IPsel, 10 min of ischemia by selective clamping of the ischemic lobe and 10 min of reperfusion) prior to sustained ichemia, and animals receiving 500 μmol α-LA injected i.v. 15 min prior to the induction of 90 min of selective ischemia. RESULTS: Cellular damage was decreased only in the LA group. TUNEL-positive hepatocytes as well as necrotic hepatocyte injury were also decreased only by LA (19 ± 2 vs 10 ± 1, P < 0.05 and 29 ± 5 vs 12 ± 1, P < 0.05). Whereas caspase 3- activities in liver tissue were unchanged, caspase 9- activity in liver tissue was decreased only by LA pretreatment (3.1 ± 0.3 vs 1.8 ± 0.2, P < 0.05). Survival rate as the endpoint of liver function was increased after IP and LA pretreatment but not after IPsel. Levels of lipid peroxidation (LPO) in liver tissue were decreased in the IP as well as in the LA group compared to the nt group. Determination of pro- and anti-apoptotic proteins showed a shift towardsanti-apoptotic proteins by LA. In contrast, both our IP strategies failed to influence apototic cell death. CONCLUSION: IP, consisting of 10 min of ischemia and 10 min of reperfusion, protects only partly against ischemia/reperfusion injury of the liver prior to 90 min of selective ischemia. IPsel did not influence ischemic tolerance of the liver. LA improved tolerance to ischemia, possibly by downregulation of pro-apoptotic Bax. | Friedrich Duenschede Kirsten Erbes Nina Riegler Patrick Ewald Achim Kircher Stefanie Westermann Arno Schad Imke Miesmer Simon Albrecht-Schck Ines Gockel Alexandra K Kiemer Theodor Junginger | 2007 | World Journal of Gastroenterology2007，13，27： | 8 |
| 2 | Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans显示文摘AIM: To evaluate the protective effects of precondition- ing by α-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS: Twenty-four patients undergoing liver re- section for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge bi- opsy samples were obtained after opening of the abdo- men immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS: Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histo- morphological features of oncosis. We observed TUNEL- positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenu- ated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION: This is the first report on the poten- tial for LA reducing ischemia/reperfusion injury (IRI) of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans. | Fritz Dünschede Kirsten Erbes Achim Kircher Stefanie Westermann Joachim Seifert Arno Schad Kempski Oliver Alexandra K Kiemer Junginger Theodor | 2006 | World Journal of Gastroenterology2006，12，42： | 6 |
| 3 | Neuropathy experienced by colorectal cancer patients receiving oxaliplatin: A qualitative study to validate the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity scale显示文摘BACKGROUND Although oxaliplatin is widely established as a standard treatment in colorectal cancer(CRC),oxaliplatin-induced neuropathy has emerged as a prominent doselimiting side effect associated with quality of life decrements.Ongoing monitoring and management of neuropathy is important for CRC patient quality of life and adherence to treatment.Therefore,a validated self-reported measure of neuropathy would aid in the management and assessment of oxaliplatininduced neuropathy in clinical practice and research.We sought to evaluate the content validity of the 13-item Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity subscale(FACT/GOGNtx)for CRC patients receiving oxaliplatin.AIM To understand the neuropathy experiences of CRC patients and assess content validity of the FACT/GOG-Ntx.METHODS Semi-structured concept elicitation and cognitive debriefing interviews were conducted with 31 CRC patients experiencing peripheral neuropathy from current or previous oxaliplatin treatment.Interview data were analyzed using a constant comparative approach,and data were mapped to the FACT/GOG-Ntx to assess content validity.RESULTS Mean age of the sample was 54(range 34-82).The sample was primarily Caucasian(84%)and consisted of nearly equal numbers of men and women.Participants described 28 unique neuropathy symptoms;hand tingling(experienced by 87%of respondents);feet tingling(81%);hand numbness(68%);and feet numbness(84%)were most frequently mentioned.Neuropathy symptoms occurring on the feet were most often identified as most bothersome by participants.Eleven of the 13 FACT/GOG-Ntx items exhibited moderate to strong evidence of content validity.Two items related to trouble hearing and ringing in the ears had weak support;however,these items represent severe neuropathy and could be useful for a patient reported outcome measure.CONCLUSION The FACT/GOG-Ntx represents the key neuropathy experiences of CRC patients treated with oxaliplatin. | Karen Kaiser Madison Lyleroehr Sara Shaunfield Leilani Lacson Maria Corona Sheetal Kircher Malin Nittve David Cella | 2020 | World Journal of Gastrointestinal Oncology2020，12，2： | 2 |
| 4 | A Short Amino-Terminal Part of Arabidopsis Phytochrome A Induces Constitutive Photomorphogenic Response显示文摘Phytochrome A (phyA ) 是在 Arabidopsis thaliana 察觉到的 far-red 光的主导的光敏电阻器。phyA 在发信号的变白的幼苗,和导致光的 phyA 的细胞质在高水平积累被一个复杂规章的网络调停。这包括光 -- 并且进在 vivo 的原子核的本国的 phyA 的 FHY1/FHL 蛋白质依赖者 translocation。phyA (PHYA406 ) 的短 N 终端碎片对 phenocopy 足够,这也被显示出在 vitro 的这个高度调整的细胞的过程。为了测试这 N 终端的生物活动,在 planta phyA 碎裂,我们生产了表示 PHYA406YFP 的转基因的 phyA-201 植物(黄荧光灯蛋白质) DD, PHYA406YFPDDNLS (原子本地化信号) ,和 PHYA406YFPDDNES (原子出口信号) 熔化蛋白质。这里,我们报导 PHYA406YFPDD 被进口进原子核,而 PHYA406YFPDDNLS 和 PHYA406YFPDDNES 显示期望的组成的本地化模式,这进程部分是轻依赖者的。我们的结果证明这些截断的 phyA 蛋白质是轻马厩的,当局部性时,他们在他们的原子核,和两个都不触发组成的象 photomorphogenic 一样回答导致合适的 phyA 发信号。我们证明在 vitro 并且在 vivo PHYA406, Pfr 和 Pr 绑 COP1, photomorphogenesis 的一个一般抑压者,并且在原子身体与它共同本地化。因此,我们断定在 planta,截断的 PHYA406 蛋白质以一种光无关的方式在原子核使 COP1 失去活性。 | Andra's Viczia'n E'va Ada'm Iris Wolf Ja'nos Bindics Stefan Kircher Marc Heijde Roman Ulm Eberhard Scha'fer Ferenc Nagy | 2012 | Molecular Plant2012，5，3： | 2 |
| 5 | LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of e- sophageal adenocarcinomas with and without Barrett's esophagus 显示文摘 | von Rahden BH Kircher S Lazariotou M | 2011 | J Exp Clin Cancer Res2011，30，： | 1 |
| 6 | Hippocampal proteoglycans brevican and versican are linked to spatial memory of SpragueDawley rats in the morris water maze显示文摘 | Saroja SR Sase A Kircher SG | 2014 | J Neurochem2014，130，6： | 1 |
| 7 | De- velopment of Building Damage Functions for Earth- quake Loss Estimation显示文摘 | KIRCHER C A NASSAR A A KUSTU O | 1997 | Earthquake Spectra1997，13，4： | 1 |
| 8 | Photoactivated phytochrome induces rapid PIF3 phosphorylation prior to proteasome-mediated degradation显示文摘 | Al-Sady B Ni W Kircher S Sch?fer E Quail P H | 2006 | Molecular cell2006，23，3： | 1 |
| 9 | Experimental and nu- merical simulation of a stainless steel coating subjected to ther- mal fatigue显示文摘 | REVEL P KIRCHER D BOGARD V | 2000 | Materials Scienee and Engineering: A2000，290，12： | 1 |
| 10 | Driver Experience and Cognitive Workload in Different Traffic Environments显示文摘 | Patten C J D Kircher A Ostlund J | | 0，，05： | 1 |
| 11 | High-throughput DNA sequencing--concepts and limitations显示文摘 | Kircher M Kelso J | 2010 | Bioessc(vs2010，32，6： | 1 |
| 12 | Phenotype,function and chimaerism of monocyte-derived blood dendritic cells after allogeneic haematopoietic stem cell transplantation显示文摘 | Nachbaur D Kircher B Elisendle K | 2003 | British J Haematology2003，123，1： | 1 |
| 13 | Cell-free DNA comprises an in vivo nucleosome footprint that informs its tissues-of-origin显示文摘 | Snyder MW Kircher M Hill AJ | 2016 | Cell2016，164，： | 1 |
| 14 | Fatigue at sea in Swedish shipping-a field study显示文摘 | LtitzhSft M1 Dahlgren A Kircher A | 2010 | Am J lnd Med2010，53，7： | 1 |
| 15 | The codependence of angiogenesis and chronic inflammation 显示文摘 | Jackson JR Seed MP Kircher CH | 1997 | FASEB J1997，11，6： | 1 |
| 16 | Sleep, sleepiness, and neurobehavioral performance while on watch in a simulated 4 hours on/8 hours off maritime watch system 显示文摘 | van Leeuwen W M Kircher A Dahlgren A | 2013 | Chronobiol Int2013，30，9： | 1 |
| 17 | Steerable Versus Nonsteerable Sheath Technology in Atrial Fibrillation Ablation: A Prospective, Randomized Study显示文摘 | Christopher Piorkowski Charlotte Eitel Sascha Rolf Kerstin Bode Philipp Sommer Thomas Gaspar Simon Kircher Ulrike Wetzel Abdul Shokor Parwani Leif-Hendrik Boldt Meinhard Mende Andreas Bollmann Daniela Husser Nikolaos Dagres Masahiro Esato Arash Arya Wilhe | 2011 | Circulation: Arrhythmia and Electrophysiology2011，，： | 1 |
| 18 | Granzymes A and B serum levels in allo-SCT显示文摘 | Kircher B Schumacber P Nachbaur D | 2009 | Bone Marrow Transplant2009，43，10： | 1 |
| 19 | Effect of age on antibody titer to Myceplasma pneumoniae显示文摘 | Daxbceck F Kircher K Kranse R | 2002 | Scand J Infect Dis2002，34，8： | 1 |
| 20 | Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake显示文摘 | Zhao M Kircher MF Josephson L | 2002 | Bioconjug Chem2002，13，4： | 1 |
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