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| 1 | Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats显示文摘BACKGROUND: Post-hepatectomy liver failure as a result of insufficient liver remnant is a feared complication in liver surgery. Efforts have been made to find new strategies to support liver regeneration. The aim of this study was to investigate the effects of terlipressin versus splenectomy on postoperative liver function and liver regeneration in rats undergoing 70%partial hepatectomy. METHODS: Seventy-two male Wistar rats were randomly assigned into three groups(n=24 in each group): 70% partial hepatectomy as control(PHC), 70% partial hepatectomy with splenectomy(PHS) or 70% partial hepatectomy with a micropump for terlipressin administration(PHT). Eight rats in each group were sacrificed on postoperative day(POD) 1,3 and 7. To assess liver regeneration, immunohistochemical analysis of liver tissue using bromodeoxyuridine(BrdU) and Ki-67 labeling was performed. Portal venous pressure, serum concentrations of creatinine, urea, albumin, bilirubin and prothrombin time as well as liver-, body-weight and their ratio were determined on POD 1, 3 and 7.RESULTS: The liver-, body-weight and their ratio were not statistically different among the groups. On POD 1, 3 and 7 portal venous pressure in the intervention groups(PHT:8.13 ±1.55, 10.38±1.30, 6.25±0.89 cm H_2O and PHS: 7.50±0.93,8.88 ±2.42, 5.75±1.04 cm H_2O) was lower compared to the control group(PHC: 8.63±2.06, 10.50±2.45, 6.50±2.67 cmH_2O). Hepatocyte proliferation in the intervention groups was delayed, especially after splenectomy on POD 1(Brd U: PHS vs PHC, 20.85% ±13.05% vs 28.11%±10.10%; Ki-67, 20.14%±14.10% vs 23.96% ±11.69%). However, none of the differences were statistically significant.CONCLUSIONS: Neither the administration of terlipressin nor splenectomy improved liver regeneration after 70% partial hepatectomy in rats. Further studies assessing the regulation of portal venous pressure as well as extended hepatectomy animal models and liver function tests will help to further investigate mechanisms of liver regeneration. | Tom Florian Ulmer Anne Weiland Georg Lurje Christian Klink Anne Andert Hamid Alizai Christoph Heidenhain Ulf Neumann | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，5： | 3 |
| 2 | The β-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke显示文摘 | Christa Th?ne-Reineke Christian Neumann Pawel Namsolleck Kristin Schmerbach Maxim Krikov Jan H Schefe Kristin Lucht Heide H?rtnagl Michael Godes Susanne Müller Kay Rumschüssel Heiko Funke-Kaiser Arno Villringer U Muscha Steckelings Thomas Unger | 2008 | Journal of Hypertension2008，，12： | 2 |
| 3 | Baseline NT-proBNP and biomarkers of inflammation and necrosis in patients with ST-segment elevation myocardial infarction: insights from the APEX-AMI trial显示文摘 | Sean Diepen Matthew Roe Renato Lopes Amanda Stebbins Stefan James L. Newby David Moliterno Franz-Josef Neumann Justin Ezekowitz Kenneth Mahaffey Judith Hochman Christian Hamm Paul Armstrong Pierre Theroux Christopher Granger | 2012 | Journal of Thrombosis and Thrombolysis2012，，1： | 1 |
| 4 | Biomechanical analyses of prosthetic mesh repair in a hiatal hernia model显示文摘 | Patrick Hamid Alizai Sofie Schmid Jens Otto Christian Daniel Klink Anjali Roeth Jochen Nolting Ulf Peter Neumann Uwe Klinge | 2014 | J. Biomed. Mater. Res2014，，7： | 1 |
| 5 | Impact of the Degree of Peri-Interventional Platelet Inhibition After Loading With Clopidogrel on Early Clinical Outcome of Elective Coronary Stent Placement显示文摘 | Willibald Hochholzer Dietmar Trenk Hans-Peter Bestehorn Benjamin Fischer Christian M. Valina Miroslaw Ferenc Michael Gick Angelika Caputo Heinz Joachim Büttner Franz-Josef Neumann | 2006 | Journal of the American College of Cardiology2006，，9： | 1 |
| 6 | Anti-Galectin-3 IgG Autoantibodies in Patients with Crohn’s Disease Characterized by Means of Phage Display Peptide Libraries显示文摘 | Erika Jensen-Jarolim Christian Neumann Georg Oberhuber Regina Gscheidlinger Csilla Neuchrist Walter Reinisch Riaz I. Zuberi Edward Penner Fu-Tong Liu George Boltz-Nitulescu | 2001 | Journal of Clinical Immunology2001，，5： | 1 |
| 7 | Anticancer drugs induce mdr1 gene expression in recurrent ovarian cancer显示文摘 | Stephanie Hille Daniel T. Rein Marion Riffelmann Rainer Neumann Judith Sartorius Andreas Pfützner Christian M. Kurbacher Thomas Sch?ndorf Martina Breidenbach | 2006 | Anti-Cancer Drugs2006，，9： | 1 |
| 8 | Paclitaxel-eluting balloons, paclitaxel-eluting stents, and balloon angioplasty in patients with restenosis after implantation of a drug-eluting stent (ISAR-DESIRE 3): a randomised, open-label trial显示文摘 | Robert A Byrne Franz-Josef Neumann Julinda Mehilli Susanne Pinieck Britta Wolff Klaus Tiroch Stefanie Schulz Massimiliano Fusaro Ilka Ott Tareq Ibrahim J?rg Hausleiter Christian Valina Jürgen Pache Karl-Ludwig Laugwitz Steffen Massberg Adnan Kastrati | 2012 | The Lancet2012，，： | 1 |
| 9 | The globalization of steam coal markets and the role of logistics: An empirical analysis显示文摘 | Aleksandar Zaklan Astrid Cullmann Anne Neumann Christian von Hirschhausen | 2011 | Energy Economics2011，，1： | 1 |
| 10 | Challenges in the Technology Development for Additive Manufacturing in Space显示文摘Instead of foreseeing and preparing for all possible scenarios of machine failures,accidents,and other challenges arising in space missions,it appears logical to take advantage of the flexibility of additive manufacturing for“in-space manufacturing”(ISM).Manned missions into space rely on complicated equipment,and their safe operation is a great challenge.Bearing in mind the absolute distance for manned missions to the Moon and Mars,the supply of spare parts for the repair and replacement of lost equipment via shipment from Earth would require too much time.With the high flexibility in design and the ability to manufacture ready-to-use components directly from a computer-aided model,additive manufacturing technologies appear to be extremely attractive in this context.Moreover,appropriate technologies are required for the manufacture of building habitats for extended stays of astronauts on the Moon and Mars,as well as material/feedstock.The capacities for sending equipment and material into space are not only very limited and costly,but also raise concerns regarding environmental issues on Earth.Accordingly,not all materials can be sent from Earth,and strategies for the use of in-situ resources,i.e.,in-situ resource utilization(ISRU),are being envisioned.For the manufacturing of both complex parts and equipment,as well as for large infrastructure,appropriate technologies for material processing in space need to be developed. | Andrea Zocca Janka Wilbig Anja Waske Jens Günster Martinus Putra Widjaja Christian Neumann Mélanie Clozel Andreas Meyer Jifeng Ding Zuoxin Zhou Xiaoyong Tian | 2022 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2022，1，1： | 1 |
| 11 | Long-Term Contracts and Asset Specificity Revisited: An Empirical Analysis of Producer–Importer Relations in the Natural Gas Industry显示文摘 | Christian Hirschhausen Anne Neumann | 2008 | Review of Industrial Organization2008，，2： | 1 |
| 12 | Cue reactivity and its inhibition in pathological computer game players显示文摘 | Robert C. Lorenz Jenny‐Kathinka Krüger Britta Neumann Bj?rn H. Schott Christian Kaufmann Andreas Heinz Torsten Wüstenberg | 2012 | Addiction Biology2012，，： | 1 |
| 13 | Changing effects of monetary policy in the US - evidence from a time -varying coefficient VAR 显示文摘 | Florian Huppner Christian Melzer and Thorst- en Neumann | 2008 | Applied Economics2008，40，： | 1 |
| 14 | Cryoballoon ablation of paroxysmal atrial fibrillation: 5-year outcome after single procedure and predictors of success显示文摘 | Thomas Neumann Maciej Wójcik Alexander Berkowitsch Damir Erkapic Sergey Zaltsberg Harald Greiss Dimitri Pajitnev Stefan Lehinant J?rn Schmitt Christian W. Hamm Heinz F. Pitschner Malte Kuniss | 2013 | Europace2013，，8： | 1 |
| 15 | Egg viability and worker policing in honeybees显示文摘 | CHRISTIAN W W Pirk PETER Neumann RANDALL Hepburn | 2004 | The National Academy of Sciences of the USA2004，101，23： | 1 |
| 16 | Egg viability and worker policing in honey bees显示文摘 | Christian WW Pirk Peter Neumann Randall Hepburn | 2004 | The National Academy of Sciences of the USA2004，101，23： | 1 |
| 17 | Inflammation and Long-Term Mortality After Non-ST Elevation Acute Coronary Syndrome Treated With a Very Early Invasive Strategy in 1042 Consecutive Patients显示文摘 | Christian Mueller Heinz J. Buettner John M. Hodgson Stephan Marsch André P. Perruchoud Helmut Roskamm Franz-Josef Neumann | 2002 | Circulation: Journal of the American Heart Association2002，，12： | 1 |
| 18 | Clinical relevance and cellular source of elevated soluble urokinase plasminogen activator receptor (su PAR ) in acute liver failure显示文摘 | Alexander Koch Henning W. Zimmermann Nikolaus Gassler Christoph Jochum Ralf Weiskirchen Jan Bruensing Lukas Buendgens Hanna Dückers Tony Bruns Guido Gerken Ulf P. Neumann David H. Adams Christian Trautwein Ali Canbay Frank Tacke | 2014 | Liver Int2014，，9： | 1 |
| 19 | Circumferential Pulmonary Vein Isolation With the Cryoballoon Technique显示文摘 | Thomas Neumann Jürgen Vogt Burghard Schumacher Anja Dorszewski Malte Kuniss Hans Neuser Klaus Kurzidim Alexander Berkowitsch Marcus Koller Johannes Heintze Ursula Scholz Ulrike Wetzel Michael A.E. Schneider Dieter Horstkotte Christian W. Hamm Heinz-Friedr | 2008 | Journal of the American College of Cardiology2008，，4： | 1 |
| 20 | Divestitures in the Electricity Sector: Conceptual Issues and Lessons from International Experiences显示文摘 | Hannes Weigt Anne Neumann Christian von Hirschhausen | 2009 | The Electricity Journal2009，，3： | 1 |
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