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| 1 | Helicobacter pylori vac A genotype is a predominant determinant of immune response to Helicobacter pylori CagA显示文摘AIM To evaluate the frequency of Helicobacter pylori(H. pylori) Cag A antibodies in H. pylori infected subjects and to identify potential histopathological and bacterial factors related to H. pylori Cag A-immune response.METHODS Systematic data to H. pylori isolates, blood samples, gastric biopsies for histological and molecular analyses were available from 99 prospectively recruited subjects. Serological profile(anti-H. pylori, anti-Cag A) was correlated with H. pylori isolates(cag A, EPIYA, vac A s/m genotype), histology(Sydney classification) and mucosal interleukin-8(IL-8) m RNA and protein expression. Selected H. pylori strains were assessed for H. pylori Cag A protein expression and IL-8 induction in co-cultivation model with AGS cells.RESULTS Thirty point three percent of microbiologically confirmed H. pylori infected patients were seropositive for Cag A. Majority of H. pylori isolates were cag A gene positive(93.9%) with following vac A polymorphisms: 42.4% vac A s1m1, 23.2% s1m2 and 34.3% s2m2. Anti-Cag AIg G seropositivity was strongly associated with atrophic gastritis, increased mucosal inflammation according to the Sydney score, IL-8 and cag A m RNA expression. V a c A s a n d m p o l y m o r p h i s m s w e r e t h e m a j o r determinants for positive(vac A s1m1) or negative(vac A s2m2) anti-Cag A serological immune response, which also correlated with the in vitro inflammatory potential in AGS cells. In vitro co-cultivation of representative H. pylori strains with AGS cells confirmed functional Cag A translocation, which showed only partial correlation with Cag A seropositivity in patients, supporting vac A as major co-determinant of the immune response.CONCLUSION Serological immune response to H. pylori cag A + strain in H. pylori infected patients is strongly associated with vac A polymorphism, suggesting the crucial role of bacterial factors in immune and clinical phenotype of the infection. | Alexander Link Cosima Langner Wiebke Schirrmeister Wiebke Habendorf Jochen Weigt Marino Venerito Ina Tammer Dirk Schlüter Philipp Schlaermann Thomas F Meyer Thomas Wex Peter Malfertheiner | 2017 | World Journal of Gastroenterology2017，23，26： | 12 |
| 2 | Endoscopic intraductal radiofrequency ablation of remnant intrapapillary mucinous neoplasm with acute hemorrhage after incomplete surgical resection显示文摘 | Jochen Weigt Ane Kandulski Peter Malfertheiner | 2014 | Endoscopy2014，，： | 1 |
| 3 | Germany's wind energy:The potential for fossil capacity replacement and cost saving显示文摘 | Weigt H | 2009 | Applied Energy2009，，10： | 1 |
| 4 | Lepfin is a metabolic signal to the reproductive system显示文摘 | Barash IA Cheung CC Weigte DS | 1996 | Endocfinology1996，137，7： | 1 |
| 5 | Diagnostic and therapeutic impact of double-balloon enteroscopy 显示文摘 | MONKEMULLER K WEIGT J TREIBER G | 2006 | Endoscopy2006，38，1： | 1 |
| 6 | Unsupervised and semi-supervised clustering by message passing: soft-constraint affinity propagation 显示文摘 | Sumedha M L Weigt M | 2008 | The European Physical Journal B-Condensed Matter and Complex Systems2008，66，1： | 1 |
| 7 | Mechanical harvesting for green asparagus 显示文摘 | Kepner R A Cowden R E Weigt G I | 1969 | California Agric1969，23，3： | 1 |
| 8 | Respiratory viral infections in hematopoietic stem cell and solid organ transplant recipients显示文摘 | Weigt SS Gregson AL Deng JC | | 0，，： | 1 |
| 9 | Clustering by soft-constraint affinity propagation: Applications to gene-expression data显示文摘 | Sumedha M L Weigt M | 2007 | Bioinfor matics2007，23，20： | 1 |
| 10 | Clustering by soft- constraint affinity propagation: applications to gene- expression data显示文摘 | Leone M Sumedha Weigt M | 2007 | Bioinformatics2007，23，20： | 1 |
| 11 | Obliterative (constrictive) bronchiolitis 显示文摘 | Lynch J Weigt S S Derhovanessian A | 2012 | Semin Respir Crit Care Med2012，33，5： | 1 |
| 12 | On the properties of small-world network models显示文摘 | A. Barrat M. Weigt | 2000 | The European Physical Journal B - Condensed Matter and Complex Systems2000，，3： | 1 |
| 13 | Effects of estradiol, estrogen receptor subtype-selective agonists and genistein on glucose metabolism in leptin resistant female Zucker diabetic fatty (ZDF) rats显示文摘 | Weigt C Hertrampf T Flenker U | 2015 | J Steroid Biochem Mol Biol2015，154，： | 1 |
| 14 | Molecular effects of ER alpha-and beta-selective agonists on regulation of energy homeostasis in obese female Wistar rats显示文摘 | WEIGT C HERTRAMPFT KLUXEN FM | 2013 | Mol Cell En- docrinol2013，377，1： | 1 |
| 15 | Cournot versus supply functions: What does the data tell us? 显示文摘 | Willems B Rumiantseva I Weigt H | 2009 | Energy Economies2009，31，1： | 1 |
| 16 | Evidence for three major clades within the snapping shrimp genus Alpheus inferred from nuclear and mitochondrial gene sequence data显示文摘 | WILLIAMS S T KNOWLTON N WEIGT L A | 2001 | Mol Phylogenet Evol2001，20，3： | 1 |
| 17 | Clustering by soft- constraint affinity propagation: applications to gene- expression data显示文摘 | Leone M Sumedha Weigt M | 2007 | Bioinformatics2007，23，20： | 1 |
| 18 | The Role of TGF-!3 in the association between primary graft dysfunction and bron- chiolitis obliterans syndrome 显示文摘 | DerHovanessian A Weigt SS Palchevskiy V | 2016 | Am J Transplant2016，16，2： | 1 |
| 19 | Diagnostic and therapeutic impact of double-balloon enteroscopy 显示文摘 | MONKEMULLER K WEIGT J TREIBER G | 2006 | Endoscopy2006，38，1： | 1 |
| 20 | IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome显示文摘 | Keane MP Gomperts BN Weigt S | | 0，，01： | 1 |
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