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| 1 | 优化施肥和传统施肥对夏玉米生长发育及产量的影响显示文摘中国农业大学和德国霍恩海姆大学(HohenheimUniversityofGermany)中德合作项目“华北平原作物高产高生产力条件下环境可承受的持续农业研究”2000~2001年度北京试验基地研究结果的一部分。试验结果表明,优化施肥和秸秆还田优化施肥夏玉米株高、基部节间直径、同一时期叶面积指数、干物质积累量、穗部基本性状,如穗长、穗粗、秃尖长、产量结构及产量与传统施肥无显著性差异,而氮肥利用率显著提高。在优化施肥条件下,夏玉米棒三叶总叶面积略微减少,生育后期穗位叶叶绿素含量下降稍快,吐丝至收获干物质积累量略有下降。秸秆还田有利于改善夏玉米的生育状况和提高产量。 | 李志勇 王璞 Marion Boening-Zilkens W.Claupein | 2003 | 玉米科学2003，11，3： | 42 |
| 2 | 不同施肥条件下夏玉米的干物质积累、产量及氮肥利用效率显示文摘针对我国华北地区夏玉米生产中所面临的氮素污染和秸秆资源严重浪费等问题,中国农业大学和德国霍恩海姆大学(HohenheimUniversityofGermany)自1999以来开展了中德国际合作项目'华北平原作物高产高生产力条件下环境可承受的持续农业研究'。研究表明:在同一时期,优化施肥、秸秆还田优化施肥与传统施肥夏玉米干物质积累量无显著性差异。拔节到吐丝,优化施肥的干物质日增长量和干物质积累量并不低于传统施肥,吐丝到灌浆,略低于传统施肥;秸秆还田优化施肥两阶段的干物质日增长量和干物质积累量最高。3处理间夏玉米产量无显著性差异。优化施肥和秸秆还田优化施肥条件下,氮肥当季利用率显著高于传统施肥。 | 李志勇 王璞 魏亚萍 Marion Boening-Zilkens | 2003 | 华北农学报2003，18，4： | 47 |
| 3 | 中国成人的卷烟需求及影响因素研究显示文摘本文全面讨论了我国成人对卷烟的需求状况及其影响因素 ,测算了总体居民的卷烟需求的价格弹性 (- 0 5 13)和不同收入群体的价格弹性 :贫困组为 - 1 90 6 ,低收入组为 - 0 774 ,高收入组为- 0 5 0 7;男性组为 - 0 4 5 ,女性组为 - 0 6 9。 | 毛正中 杨功焕 马继民 Jon Samet Marion Ceraso | 2003 | 卫生软科学2003，17，2： | 28 |
| 4 | Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease显示文摘AIM: To determine characteristics and prognosticpredictors of patients with hepatocellular carcinoma(HCC) in association with non-alcoholic fatty liver disease(NAFLD).METHODS: We reviewed the records of all patients with NAFLD associated HCC between 2000 and 2012. Data collected included demographics; histology; presence or absence of cirrhosis, size and number of HCC, alpha-fetoprotein, body mass index(BMI), and the presence of diabetes, hypertension, or dyslipidaemia.RESULTS: Fifty-four patients with NAFLD associated HCC were identified. Mean age was 64 years with 87% male. Fifteen percent(8/54) were not cirrhotic. 11%, 24% and 50% had a BMI of < 25 kg/m2, 25-29 kg/m2 and ≥ 30 kg/m2 respectively. Fifty-nine percent were diabetic, 44% hypertensive and 26% hyperlipidaemic. Thirty-four percent of the patients had ≤ 1 of these risk factors. Non-cirrhotics had a significantly larger mean tumour diameter at diagnosis than cirrhotics(P = 0.041). Multivariate analysis did not identify any other patient characteristics that predicted the size or number of HCC.CONCLUSION: HCC can develop in NAFLD without cirrhosis. At diagnosis such tumours are larger than those in cirrhotics, conferring a poorer prognosis. | Christopher Leung Sern Wei Yeoh Desmond Patrick Shara Ket Kaye Marion Paul Gow Peter W Angus | 2015 | World Journal of Gastroenterology2015，21，4： | 24 |
| 5 | IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treat- ment of Cancer Brain Tumor Group显示文摘 | van den Bent M J Dubbink HJ Marie Y Brandes AA Taphoorn MJ Wesseling P Frenay M Tijssen CC Lacombe D ldbaih A van Marion R Kros JM Dinjens WN Gorlia T. Sanson M. | 2010 | 中国神经肿瘤杂志2010，8，1： | 22 |
| 6 | 几种水氮模式处理下冬小麦冠层结构的差异显示文摘为了给冬小麦水氮管理提供理论依据,以京冬8号为试验材料,采用随机区组设计,研究了4种水氮模式处理下冬小麦冠层结构的差异。结果表明,与传统水肥相比,传统灌溉-优化施肥的冬小麦株型较紧凑,植株高度相近,基部节间缩短,上3叶变短、变厚,总面积减少11.6%,叶倾角大,各层透光率高;优化灌溉-传统施肥的冬小麦株型松散,植株高度增加,基部节间差异小,上3叶变长、变薄,总面积增加14.1%,叶倾角小,各层透光率低;优化水肥与秸秆还田优化水肥株型稍松散,高度有所增加,基部节间缩短,上3叶长度有所增加,宽度有所减少,总面积分别减少2.3%和1.7%,叶倾角略减小,各层透光率略下降。与优化水肥相比,秸秆还田优化水肥有利于改善冬小麦冠层结构和光分布,但效果不明显。 | 李志勇 郭永新 王璞 翟志席 MARION Boening Zilkens | 2007 | 麦类作物学报2007，27，6： | 19 |
| 7 | 优化灌溉与施肥对冬小麦冠层结构的影响研究显示文摘试验研究优化灌溉与施肥对冬小麦冠层结构的影响结果表明,与限量灌溉处理相比,优化灌溉和传统灌溉处理小麦最上部3个节间明显伸长,导致株高增高10cm,旗叶叶面积减小7%,但倒2叶和倒3叶叶面积分别增加7%和20%;优化灌溉处理小麦旗叶茎叶夹角明显减小。与未施N肥处理相比,施用N肥有增大小麦株高、叶面积和茎叶夹角的趋势,且传统施N比优化施N更加明显。优化水N管理麦田各层次透光率与传统处理差异较小,但它们均显著低于限量灌溉和未施N处理。 | 范仲学 王璞 梁振兴 MARION Boening Zilkens WILHELM Claupein | 2005 | 中国生态农业学报2005，13，3： | 17 |
| 8 | PTEN in liver diseases and cancer显示文摘The phosphoinositide 3-kinase (PI3K)/phosphatase and tensin homolog (PTEN)/Akt axis is a key signal transduction node that regulates crucial cellular functions, including insulin and other growth factors signaling, lipid and glucose metabolism, as well as cell survival and apoptosis. In this pathway, PTEN acts as a phosphoinositide phosphatase, which terminates PI3Kpropagated signaling by dephosphorylating PtdIns(3,4)P2 and PtdIns(3,4,5)P3. However, the role of PTEN does not appear to be restricted only to PI3K signaling antagonism, and new functions have been recently discovered for this protein. In addition to the well-established role of PTEN as a tumor suppressor, increasing evidence now suggests that a dysregulated PTEN expression and/or activity is also linked to the development of several hepatic pathologies. Dysregulated PTEN expression/activity is observed with obesity, insulin resistance, diabetes, hepatitis B virus/hepatitis C virus infections, and abusive alcohol consumption, whereas mutations/deletions have also been associated with the occurrence of hepatocellular carcinoma. Thus, it appears that alterations of PTEN expression and activity in hepatocytes are common and recurrent molecular events associated with liver disorders of various etiologies. These recent f indings suggest that PTEN might represent a potential common therapeutic target for a number of liver pathologies. | Marion Peyrou Lucie Bourgoin Michelangelo Foti | 2010 | World Journal of Gastroenterology2010，16，37： | 16 |
| 9 | Endoscopic and histologic characteristics of serrated lesions显示文摘In recent years , a second pathway for colonic carcinogenesis , distinct from the adenomatous pathway, has been explored. This is referred to as serrated pathway and includes three types of polyp,characterised by a serrated appearance of the crypts:hyperplastic polyps(HP),sessile serrated adenomas(SSA)or lesions,and traditional serrated adenomas.Each lesion has its own genetic,as well as macroscopic and microscopic morphological features.Because of their flat aspect,their detection is easier with chromoendoscopy(carmin indigo or narrow-band imaging).However,as we show in this review,the distinction between SSA and HP is quite difficult.It is now recommended to resect in one piece as it is possible the serrated polyps with a control in a delay depending on the presence or not of dysplasia.These different types of lesion are described in detail in the present review in general population,in polyposis and in inflammatory bowel diseases patients.This review highlights the need to improve characterization and understanding of this way of colorectal cancerogenesis. | Driffa Moussata Gilles Boschetti Marion Chauvenet Karine Stroeymeyt Stéphane Nancey Franoise Berger Thierry Lecomte Bernard Flourié | 2015 | World Journal of Gastroenterology2015，21，10： | 14 |
| 10 | S-acylation-dependent association of the calcium sensor CBL2 with the vacuolar membrane is essential for proper abscisic acid responses显示文摘Calcineurin 象 B 一样(CBL ) 蛋白质贡献由与交往 CBL 蛋白质 kinases (CIPK ) 交往译码钙信号。当前,几乎仍然功能和在 vacuolar 膜是局部性的 CBL 蛋白质的特定的指向机制没有信息。在这研究,我们集中于 CBL2,丰富的 vacuolar 从 Arabidopsis thaliana 的未知功能的膜局部性的钙传感器。我们证明 CBL2 指向的 vacuolar 被三半胱氨酸残余的 S-acylation 明确地在它的 N 终点和那 CBL2 S-acylation 引起并且指向由一条 Brefeldin A 感觉迟钝的小径发生。CBL2 功能的损失在种子萌芽期间并且仅仅充分使植物变为过分敏感到植物激素 abscisic 酸(骆驼毛的织物) S-acylated 和适当地指向 vacuolar 的 CBL2 蛋白质能补充这变异的显型。这些调查结果定义为蛋白质指向小径的 S-acylation-dependent vacuolar 膜并且揭开在骆驼毛的织物回答的 vacuolar 钙传感器的一个关键角色。 | Oliver Batistic Marion Rehers Amir Akerman Kathrin Schlucking Leonie Steinhorst Shaul Yalovsky Jorg Kudla | 2012 | Cell Research2012，22，7： | 12 |
| 11 | The Medicago truncatula Sucrose Transporter Family: Characterization and Implication of Key Members in Carbon Partitioning towards Arbuscular Mycorrhizal Fungi显示文摘我们识别了在模型向水池机关从光合的来源叶子涉及蔗糖的长途的运输的 de novo 蔗糖 transporter (SUT ) 基因豆科的种类 Medicago truncatula。鉴定和糖 transporters 的功能的分析在位于碳在 plantmicroorganism 相互作用划分下面的机制上提供关键信息。因为 M 的全身的序列。truncatula SUT (MtSUT ) 家庭被检索, MtSUT 成员的生物化学的描述被 heterologous 表示在酵母执行。MtSUT 家庭现在包括在双子叶的 clades 之中散布的六基因。MtSUT1-1 和 MtSUT4-1 是关于他们在来源叶子和水池根的表示侧面的关键成员并且作为功能的 H+/sucrose transporters 被描绘。对由 arbuscular mycorrhizal 真菌(AMF ) 的磷供应和接种的生理、分子的回答血管球 intraradices 被基因表示和糖 quantification 分析学习。蔗糖在 M 代表主要的糖运输形式。truncatula 和 MtSUT1-1, MtSUT2,和 MtSUT4-1 的表示侧面向真菌的共生者为有益的糖流动加亮一条调整规定。一起拿,这些结果在植物并且在 biotrophic 相互作用从 SUT1, SUT2,和 SUT4 clades 为蛋白质建议不同功能。 | Joan Doidy Diederik van Tuinen Olivier Lamotte Marion Corneillat Gerard Alcaraz Daniel Wipf | 2012 | Molecular Plant2012，5，6： | 9 |
| 12 | 全国青少年的卷烟需求及影响因素显示文摘 | 毛正中 杨功焕 马继民 Jon Samet Marion Ceraso | 2002 | 中国公共卫生2002，18，8： | 9 |
| 13 | Improvement of quantitative testing of liver function in patients with chronic hepatitis C after installment of antiviral therapy显示文摘AIM: To investigate if and to what extent antiviral therapy influenced a broad panel of quantitative testing of liver function (QTLF).METHODS: Fifty patients with chronic hepatitis C were either treated with interferon (n = 8), interferon/ribavirin (n = 19) or peg-interferon/ribavirin (n = 23). Quantitative testing of liver function, including aminopyrine breath test (ABT), galactose elimination capacity (GEC), sorbitol clearance (SCI) and indocyanine green clearance (ICG)was performed before and 3 mo after initiation of antiviral therapy.RESULTS: After 3 mo of antiviral treatment, 36 patients showed normal transaminases and were negative for HCV-RNA, 14 patients did not respond to therapy. ABT and GEC as parameters of microsomal and cytosolic liver function were reduced in all patients before therapy initiation and returned to normal values in the 36 therapy responders after 3 mo. Parameters of liver perfusion (SCI and ICG) were not affected by antiviral therapy. In the 14 non-responders,no changes in QTLF values were observed during the treatment period.CONCLUSION: ICG and SCI remained unaffected in patients with chronic hepatitis C, while ABT and GEC were significantly compromised. ABT and GEC normalized in responders to antiviral therapy. Early determination of ABT and GEC may differentiate responders from non-responders to antivJral treatment in hepatitis C. | Matthias Ocker Marion Ganslmayer Steffen Zopf Susanne Gahr Christopher Janson Eckhart G. Hahn Christoph Herold | 2005 | World Journal of Gastroenterology2005，11，35： | 8 |
| 14 | 几种水氮模式处理下冬小麦根系生长的差异显示文摘为了给冬小麦水氮管理提供理论依据,以京冬8号为试验材料,采用随机区组设计,研究了4种水氮模式(优化灌溉-传统施肥、传统水肥、秸秆还田-优化水肥、优化水肥、传统灌溉-优化施肥)处理下冬小麦根系生长的差异。结果表明,不同处理间冬小麦0~120cm土层单位面积的根量有差异。与传统水肥相比,传统灌溉-优化施肥0~60cm土层的根系长度有所减少,60~90和90~120cm土层的根系长度分别增加14.62%和73.72%(P〈0.05),总根量略增加;优化灌溉-传统施肥0~30cm土层的根系长度明显增加(P〈0.05),30~60、60~90和90~120cm土层的根系长度分别减少3.52%、6.65%和18.21%,总根量增加;优化水肥和秸秆还田-优化水肥各土层的根量增加。与优化水肥相比,秸秆还田-优化水肥0~60cm土层的根量有所增加,60~120cm土层有所减少。各处理冬小麦根系密度随土层加深而递减的速度大小为优化灌溉-传统施肥〉传统水肥〉秸秆还田-优化水肥〉优化水肥〉传统灌溉-优化施肥。 | 李志勇 陈明灿 王璞 翟志席 MARION Boening Zilkens | 2008 | 麦类作物学报2008，28，6： | 6 |
| 15 | Phosphorus mobility in dam reservoir affected by redox oscillations:An experimental study显示文摘The internal sedimentary phosphorus(P) load of aquatic systems is able to support eutrophication, especially in dam–reservoir systems where sedimentary P stock is high and where temporary anaerobic conditions occur. The aim of this study therefore is to examine the response of sedimentary P exposed to redox oscillations. Surface sediments collected in the Champsanglard dam–reservoir(on the Creuse River, France) were subjected to two aerobic phases(10 and 12 days) alternated with two anaerobic periods(21 and 27 days)through batch incubations. The studied sediment contained 77 ± 3 μmol/g DW of P, mainly associated with the ascorbate fraction(amorphous Fe/Mn oxyhydroxides). The used sediment was rich in organic matter(OM)(21% ± 1%) with primarily allochthone signature.Our results showed that redox oscillations enhance dissolved inorganic phosphorus release at sediment/water interface. During the first anaerobic stage, the P release was mainly controlled by the dissolution/precipitation of iron minerals. The more pronounced increase of P release during the second anaerobic stage(44%) was due to various mechanisms related to the change in quality of dissolved organic matter(DOM), namely a higher SUVA254 and humification indices. The release of more refractory DOM(rDOM) served to lower the microbial metabolism activity, possibly favored iron oxyhydroxide aggregation and thus limiting iron reduction. In addition, rDOM is able to compete for mineral P sorption sites,leading to a greater P release. In reservoir with predominant allochthone OM input, the release of more aromatic DOM therefore plays an important role in P mobility. | Anne Rapin Malgorzata Grybos Marion Rabiet Brice Mourier Véronique Deluchat | 2019 | Journal of Environmental Sciences2019，31，3： | 6 |
| 16 | Gastric emptying evaluation by ultrasound prior colonoscopy:An easy tool following bowel preparation显示文摘AIM: To investigate the gastric emptying after bowel preparation to allow general anaesthesia. METHODS: A prospective, non-comparative, and nonrandomized trial was performed and registered on Eudra CT database(2011-002953-80) and on www.trial.gov(NCT01398098). All patients had a validated indication for colonoscopy and a preparation using sodium phosphate(NaP) tablets. The day of the procedure, patients took 4 tablets with 250 mL of water every 15 min, three times. The gastric volume wasestimated every 15 min from computed antral surfaces and weight according to the formula of Perlas et al(Anesthesiology, 2009). Colonoscopy was performed within the 6 h following the last intake.RESULTS: Thirty patients were prospectively included in the study from November 2011 to May 2012. The maximum volume of the antrum was 212 mL, achieved 15 min after the last intake. 24%, 67% and 92% of subjects had an antral volume below 20 mL at 60, 120 and 150 min, respectively. 81% of patients had a Boston score equal to 2 or 3 in each colonic segment. No adverse events leading to treatment discontinuation were reported.CONCLUSION: Gastric volume evaluation appeared to be a simple and reliable method for the assessment of gastric emptying. Data allow considering the NaP tablets bowel preparation in the morning of the procedure and confirming that gastric emptying is achieved after two hours, allowing general anaesthesia. | Romain Coriat Vanessa Polin Ammar Oudjit Franck Henri Marion Dhooge Sarah Leblanc Chantal Delchambre Anouk Esch Tessa Tabouret Maximilien Barret Frédéric Prat Stanislas Chaussade | 2014 | World Journal of Gastroenterology2014，20，37： | 6 |
| 17 | 金属标准物质中杂质的辉光放电质谱法溯源分析显示文摘标准物质定值分析的溯源性要求比常规分析高很多。在常规分析中,有证标准物质(CRM)可用于校准以及建立可溯源性。尽管与标准物质生产和认定相关的ISO导则并没有十分明确地提到校准,但众多标准物质生产者在定值分析时却不接受基准标准物质用于校准。这些要求制约了标准物质定值方法的使用,因为这些方法可以采用已知高纯度的标准物质、化学计量法及已知高纯度标准物质的混合物进行校准。有效的固体取样技术,例如通常使用的块状标准物质进行校准的辉光放电质谱法(GD-MS)或火花源发射光谱法(spark-OES),似乎不太适合定值分析。尤其是固体样品中痕量元素分析测定的有力工具辉光放电质谱法,除金属杂质外,使用特定气体混合物,这种方法也可以分析相关的非金属杂质如硫和磷。我们开发了一种可以使用已知高纯度的标准物质混合物和化学计量法的校准方法,这种校准方法同样可用于辉光放电质谱法。与溶液中基体匹配技术类似,此校准方法基于掺杂的粉末压片。本文还结合铜和钢标准物质的定值分析结果进行了陈述。 | RECKNAGEL Sebastian KIPPHARDT Heinrich LANGE Britta HOPPE Marion | 2012 | 冶金分析2012，32，2： | 6 |
| 18 | Temporomandibular joint damage in K/BxN arthritic mice显示文摘Rheumatoid arthritis(RA) is an autoimmune disease affecting 1% of the world population and is characterized by chronic inflammation of the joints sometimes accompanied by extra-articular manifestations. K/Bx N mice, originally described in 1996 as a model of polyarthritis, exhibit knee joint alterations. The aim of this study was to describe temporomandibular joint(TMJ)inflammation and damage in these mice. We used relevant imaging modalities, such as micro-magnetic resonance imaging(μMRI)and micro-computed tomography(μCT), as well as histology and immunofluorescence techniques to detect TMJ alterations in this mouse model. Histology and immunofluorescence for Col-I, Col-II, and aggrecan showed cartilage damage in the TMJ of K/Bx N animals, which was also evidenced by μCT but was less pronounced than that seen in the knee joints. μMRI observations suggested an increased volume of the upper articular cavity, an indicator of an inflammatory process. Fibroblast-like synoviocytes(FLSs)isolated from the TMJ of K/Bx N mice secreted inflammatory cytokines(IL-6 and IL-1β) and expressed degradative mediators such as matrix metalloproteinases(MMPs). K/Bx N mice represent an attractive model for describing and investigating spontaneous damage to the TMJ, a painful disorder in humans with an etiology that is still poorly understood. | Sabine Kuchler-Bopp Alexandre Mariotte Marion Strub Chrystelle Po Aurore De Cauwer Georg Schulz Xavier Van Bellinghen Florence Fioretti Francois Clauss Philippe Georgel Nadia Benkirane-Jessel Fabien Bornert | 2020 | International Journal of Oral Science2020，12，1： | 6 |
| 19 | Cyclin A2:At the crossroads of cell cycle and cell invasion显示文摘Cyclin A2 is an essential regulator of the cell division cycle through the activation of kinases that participate to the regulation of S phase as well as the mitotic entry. However,whereas its degradation by the proteasome in mid mitosis was thought to be essential for mitosis to proceed,recent observations show that a small fraction of cyclin A2 persists beyond metaphase and is degraded by autophagy. Its implication in the control of cytoskeletal dynamics and cell movement has unveiled its role in the modulation of Rho A activity. Since this GTPase is involved in both cell rounding early in mitosis and later,in the formation of the cleavage furrow,this suggests that cyclin A2 is a novel actor in cytokinesis. Taken together,these data point to this cyclin as a potential mediator of cell-niche interactions whose dysregulation could be taken as a hallmark of metastasis. | Abdelhalim Loukil Caroline T Cheung Nawal Bendris Bénédicte Lemmers Marion Peter Jean Marie Blanchard | 2015 | World Journal of Biological Chemistry2015，6，4： | 6 |
| 20 | Negative effects of Phaeocystis globosa on microalgae显示文摘The potential allelopathic effects of the microalga,Phaeocystis globosa Scherffel,on three harmful bloom algae,Prorocentrum donghaiense Lu,Chattonella marina(Subrahmanyan) Hara et Chihara and Chattonella ovata Hara et Chihara were studied.The growth of C.marina and C.ovata was markedly reduced when the organisms were co-cultured with P.globosa or cultured in cell-free spent medium.Haemolytic extracts from P.globosa cells in the senescence phase had a similar inhibitory effect on the three harmful bloom algae.However,P.globosa had less influence on the brine shrimp,Artemia salina.These results indicate that P.globosa may have an allelopathic effect on microalgae,which would explain the superior competitive abilities of P.globosa.Because the addition of the haemolytic toxins from P.globosa had similar effects on algae as spent media,these compounds may be involved in the allelopathic action of P.globosa. | 刘洁生 VAN RIJSSEL Marion 杨维东 彭喜春 吕颂辉 王艳 陈菊芳 王朝晖 齐雨藻 | 2010 | Chinese Journal of Oceanology and Limnology2010，28，4： | 6 |
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