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| 1 | Characterisation and risk assessment of venous thromboembolism in gastrointestinal cancers显示文摘AIM To characterise venous thromboembolism(VTE) in gastrointestinal cancer and assess the clinical utility of risk stratification scoring. METHODS We performed a retrospective analysis using electronic patient records of 910 gastro-oesophageal(GO) cancer and 1299 colorectal cancer(CRC) patients referred to a tertiary cancer centre to identify the incidence of VTE, its relationship to chemotherapy and impact on survival.VTE risk scores were calculated using the Khorana index. Patients were classified as low risk(0 points), intermediate risk(1 to 2 points) or high risk(3 points). Data was analysed to determine the sensitivity of the Khorana score to predict VTE. RESULTS The incidence of VTE was 8.9% for CRC patients and 9.7% for GO cancer patients. Pulmonary emboli(PE) were more common in advanced than in localised CRC(50% vs 21% of events respectively) and lower limb deep vein thrombosis(DVT) were more common in localised than in advanced CRC(62% vs 39% of events respectively). The median time to VTE from cancer diagnosis was 8.3 mo for CRC patients compared to 6.7 mo in GO cancer. In localised CRC median time to VTE was 7.1 mo compared with 10.1 mo in advanced CRC. In contrast in GO cancer, the median time to VTE was 12.5 mo in localised disease and 6.8 mo in advanced disease. No survival difference was seen between patients with and without VTE in this cohort. The majority of patients with CRC in whom VTE was diagnosed had low or intermediate Khorana risk score(94% for localised and 97% in advanced CRC). In GO cancer, all patients scored either intermediate or high risk due to the primary site demonstrating a limitation of the risk assessment score in discriminating high and low risk patients with GO cancers. Additional risk factors were identified in this cohort including surgery, chemotherapy or hospital admission. Overall, 81% of patients with CRC and 77% of patients with GO cancer had one or more of these factors within 4 wk prior to diagnosis VTE. These should be factored into clinical risk assessment scores. CONCLUSION The Khorana score has low sensitivity for thrombotic events in CRC and cannot discriminate low risk patients in high risk cancer sites such as GO cancer. | Robert L Metcalf Eamon Al-Hadithi Nicholas Hopley Thomas Henry Clare Hodgson Antony McGurk Wasat Mansoor Jurjees Hasan | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 10 |
| 2 | Induction of entosis by epithelial cadherin expression显示文摘房间吞没典型地从后生动物的纸巾为清理指向死了或死的房间。然而,最近的证据证明实时房间能也被指向并且吞没能引起房间死亡。Entosis 是建议调停的一机制吞没并且由他们的邻居,实时肿瘤房间杀死是经常指的一项活动房间同类相食。这里,我们报导在缺乏上皮的 cadherins 的内长的表示的人的胸肿瘤房间的外长的上皮的 cadherin 蛋白质(E-cadherin) 或 P-cadherin ) 的表示导致 entosis 并且禁止转变生长。cadherin 表示导致的 Entosis 在耳中的房间以内与 Rho 和 Rho-kinase (岩石) 活动的极化的分发被联系,它依赖于 p190A RhoGAP 活动。p190A RhoGAP 表示的岩石抑制或 downregulation 减少 entosis 并且增加上皮的表示 cadherin 肿瘤房间的转变生长。这些数据为 entosis 的学习定义新房间系统,并且作为被上皮的粘附的建立导致并且禁止转变生长的房间同类相食的机制识别 entosis。 | Qiang Sun Edmund S Cibas Hongyan Huang Louis Hodgson Michael Overholtzer | 2014 | Cell Research2014，24，11： | 10 |
| 3 | 大规模开放网络课程在护理教育中的应用显示文摘大规模开放网络课程(massive open online courses,MOOCs)是一种在线课程运营模式,随着北京大学、清华大学、复旦大学、上海交通大学的加入,掀开了MOOCs在我国的本土化元年。MOOCs对教育界带来的震动很大,有人称之为'革命',有人称之为'海啸'。该文介绍了MOOCs与传统教学方式的不同,以及MOOCs在护理教育中的开展形式、运作过程、课程设计及评价方法,并提出在我国护理教育中开展MOOCs所面临的问题。 | 邓寒羽 Nancy Hodgson 刘华平 | 2015 | 中华护理教育2015，12，2： | 8 |
| 4 | Sol-gel derived HA/TiO_2 double coatings on Ti scaffolds for orthopaedic applications显示文摘Hydroxyapatite/titania (HA/TiO2) double layers were coated onto Ti scaffolds throughout for orthopaedic applications by sol-gel method. Differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and X-ray diffractometry (XRD) were used for the characterisation of the phase transformations of the dried gels and coated surface structures. Scanning electron microscope (SEM) equipped with energy dispersive spectrometry (EDS) was used for the observation and evaluation of the morphology and phases of the surface layers and for the assessment of the in vitro tests. The in vitro assessments were performed by soaking the HA/TiO2 double coated samples into the simulated body fluid (SBF) for various periods. The TiO2 dipping-coating method at a speed of 12 cm/min, followed by a heat treatment at 600 ℃ for 20 min. The HA la lyaeyre wr wasa ssu cbosaetqeude bnytl ya dipping-coated on the outer surface at the same speed and then heat-treated at difference temperatures. The results indicat that the HA phase begins to crystallize after a heat treatment at 560 ℃. The crystallinity increases obviously at 760 ℃. SEM observations find no delamination or crack at the interfaces of HA/TiO2 and TiO2/Ti. The HA/TiO2 coated Ti scaffolds displays excellent bone-like apatite forming ability when it is soaked into SBF. Ti scaffolds after HA/TiO2 double coatings can be anticipated as promising implant materials for orthopaedic | XU W HU W Y LI M H MA Q Q P. D. HODGSON WEN C E | 2006 | 中国有色金属学会会刊:英文版2006，16，B01： | 5 |
| 5 | Screening Helicobacter pylori genes induced during infection of mouse stomachs显示文摘AIM:To investigate the effect of in vivo environment on gene expression in Helicobacter pylori(H.pylori) as it relates to its survival in the host.METHODS:In vivo expression technology(IVET) systems are used to identify microbial virulence genes.We modified the IVET-transcriptional fusion vector,pIVET8,which uses antibiotic resistance as the basis for selection of candidate genes in host tissues to develop two unique IVET-promoter-screening vectors,pIVET11 and pIVET12.Our novel IVET systems were developed by the fusion of random Sau3A DNA fragments of H.pylori and a tandem-reporter system of chloramphenicol acetyltransferase and beta-galactosidase.Additionally,each vector contains a kanamycin resistance gene.We used a mouse macrophage cell line,RAW 264.7 and mice,as selective media to identify specific genes that H.pylori expresses in vivo.Gene expression studies were conducted by infecting RAW 264.7 cells with H.pylori.This was followed by real time polymerase chain reaction(PCR) analysis to determine the relative expression levels of in vivo induced genes.RESULTS:In this study,we have identified 31 in vivo induced(ivi) genes in the initial screens.These 31 genes belong to several functional gene families,including several well-known virulence factors that are expressed by the bacterium in infected mouse stomachs.Virulence factors,vacA and cagA,were found in this screen and are known to play important roles in H.pylori infection,colonization and pathogenesis.Their detection validates the efficacy of these screening systems.Some of the identified ivi genes have already been implicated to play an important role in the pathogenesis of H.pylori and other bacterial pathogens such as Escherichia coli and Vibrio cholerae.Transcription profiles of allivi genes were confirmed by real time PCR analysis of H.pylori RNA isolated from H.pylori infected RAW 264.7 macrophages.We compared the expression profile of H.pylori and RAW 264.7 coculture with that of H.pylori only.Some genes such as cag A,vac A,lpx C,mur I,tlp C,trx B,sod B,tnp B,pgi,rbf A and inf B showed a 2-20 fold upregulation.Statistically significant upregulation was obtained for all the above mentioned genes(P < 0.05).tlp C,cag A,vac A,sod B,rbf A,inf B,tnp B,lpx C and mur I were also significantly upregulated(P < 0.01).These data suggest a strong correlation between results obtained in vitro in the macrophage cell line and in the intact animal.CONCLUSION:The positive identification of these genes demonstrates that our IVET systems are powerful tools for studying H.pylori gene expression in the host environment. | Aparna Singh Nathaniel Hodgson Ming Yan Jungsoo Joo Lei Gu Hong Sang Emmalena Gregory-Bryson William G Wood Yisheng Ni Kimberly Smith Sharon H Jackson William G Coleman | 2012 | World Journal of Gastroenterology2012，18，32： | 5 |
| 6 | Protein misfolding in neurodegenerative diseases:implications and strategies显示文摘A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse.Therapeutic options are currently being explored that target different steps in the production and processing of proteins implicated in neurodegenerative disease,including synthesis,chaperone-assisted folding and trafficking,and degradation via the proteasome and autophagy pathways.Other therapies,like mTOR inhibitors and activators of the heat shock response,can rebalance the entire proteostatic network.However,there are major challenges that impact the development of novel therapies,including incomplete knowledge of druggable disease targets and their mechanism of action as well as a lack of biomarkers to monitor disease progression and therapeutic response.A notable development is the creation of collaborative ecosystems that include patients,clinicians,basic and translational researchers,foundations and regulatory agencies to promote scientific rigor and clinical data to accelerate the development of therapies that prevent,reverse or delay the progression of neurodegenerative proteinopathies. | Patrick Sweeney Hyunsun Park Marc Baumann John Dunlop Judith Frydman Ron Kopito Alexander McCampbell Gabrielle Leblanc Anjli Venkateswaran Antti Nurmi Robert Hodgson | 2017 | Translational Neurodegeneration2017，6，1： | 4 |
| 7 | 1998年印度洋珊瑚死亡事件的生态影响和社会经济影响:是ENSO影响和未来变化的警告吗?显示文摘自大约15O年前开始有气温记录以来,1998年是所记录到的最热的一年,20世纪90年代是最热的十年。另外,1998年也是有记录以来厄尔尼诺现象最严重的一年。这一现象产生的结果是,海洋中许多地方的水温很高,尤其是位于热带的印度洋的水温常常比正常年份高3~5℃。该区域内的大量珊瑚脱色并死亡,可能是由于高的水温以及其它气象、气候因子共同作用所致。斯里兰卡、马尔代夫、印度、肯尼亚、坦桑尼亚和塞舌尔群岛的珊瑚礁中珊瑚的死亡率较高,许多浅海区甚至高达90%。在位于印度洋其它地方和距海面20米以下的珊瑚礁中,珊瑚的死亡率通常为50%。因此,1998年珊瑚的死亡情况是空前严重的。印度洋的珊瑚褪色对沿海社区的二级社会经济影响可能是长期的和严重的。除了鱼资源可能减少和对旅游造成不良影响外,侵蚀可能成为一个严重的问题,尤其是在马尔代夫和塞舌尔群岛。如果目前已经发现的全球温度升高的趋势继续下去,那么1998年印度洋珊瑚礁上发生的情况在未来一些年内极有可能加剧并在其它的热带海洋区出现。印度洋的珊瑚礁可能是反映全球气候变化潜在影响的一个重要信号,我们应当对这一警告引起注意。 | Clive Wilkinson OlofLindén Herman Cesar Gregor Hodgson Jaston Rubens Alan E.Strong 李岱青 | 1999 | 人类环境杂志1999，28，2： | 4 |
| 8 | Microstructure and Tensile Properties of a Nb–Mo Microalloyed 6.5Mn Alloy Processed by Intercritical Annealing and Quenching and Partitioning显示文摘The transformation behavior, microstructural evolution and mechanical properties were compared in a coldrolled Nb–Mo microalloyed 6.5Mn alloy after intercritical annealing(IA) and quenching and partitioning(Q & P),respectively. The thermodynamic calculation and theoretical analysis were used to determine the optimal heat treatment parameters. The Q & P samples exhibited relatively higher strength with relatively low ductility, mainly due to the hard martensite matrix, which resulted in continuous yielding behavior upon loading, whereas the IA samples showed the significantly improved ductility, which benefited from the more sufficient transformation-induced plasticity(TRIP) effects and the softer ultrafine ferrite matrix. The dependence of yield point elongation(YPE) of IA samples on grain size demonstrated that the YPE value was in the reverse proportional relationship to the average grain size, which agreed well with theoretical analysis. | Ming-Hui Cai Hong-Shou Huang Hai-Jun Pan Sheng-Hui Sun Hua Ding Peter Hodgson | 2017 | Acta Metallurgica Sinica(English Letters)2017，30，7： | 4 |
| 9 | Elastic modulus and hardness of cortical and trabecular bovine bone measured by nanoindentation显示文摘The elastic modulus and hardness of several microstructure components of dry bovine vertebrae and tibia have been investigated in the longitude and transverse directions using nanoindentation. The elastic modulus for the osteons and the interstitial lamellae in the longitude direction were found to be (24.7±2.5) GPa and (30.1±2.4) GPa. As it's difficult to distinguish osteons from interstitial lamellae in the transverse direction, the average elastic modulus for cortical bovine bone in the transverse direction was (19.8±1.6) GPa. The elastic modulus for trabecular bone in the longitude and transverse direction were (20±2) GPa and (14.7±1.9) GPa respectively. The hardness also varied among the microstructure components in the range of 0.41-0.89 GPa. Analyses of variance show that the values are significantly different. | HODGSON P D | 2006 | 中国有色金属学会会刊:英文版2006，16，B02： | 4 |
| 10 | Hodgkin Lymphoma Across the Age Spectrum: Epidemiology, Therapy, and Late Effects显示文摘 | Angela Punnett Richard W. Tsang David C. Hodgson | 2010 | Seminars in Radiation Oncology2010，，1： | 3 |
| 11 | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial显示文摘 | John Burn Anne-Marie Gerdes Finlay Macrae Jukka-Pekka Mecklin Gabriela Moeslein Sylviane Olschwang Diane Eccles D Gareth Evans Eamonn R Maher Lucio Bertario Marie-Luise Bisgaard Malcolm G Dunlop Judy WC Ho Shirley V Hodgson Annika Lindblom Jan Lubinski Pa | 2011 | The Lancet2011，，9809： | 3 |
| 12 | CYFRA 21-1 as a Prognostic and Predictive Marker in Advanced Non–Small-Cell Lung Cancer in a Prospective Trial: CALGB 150304显示文摘 | Martin J. Edelman Lydia Hodgson Paula Y. Rosenblatt Robert H. Christenson Everett E. Vokes Xiaofei Wang Robert Kratzke | 2012 | Journal of Thoracic Oncology2012，，4： | 3 |
| 13 | ACCF/ACR/AHA/NASCI/SAIP/SCAI/SCCT 2010 Expert Consensus Document on Coronary Computed Tomographic Angiography显示文摘 | Daniel B. Mark Daniel S. Berman Matthew J. Budoff J. Jeffrey Carr Thomas C. Gerber Harvey S. Hecht Mark A. Hlatky John McB. Hodgson Michael S. Lauer Julie M. Miller Richard L. Morin Debabrata Mukherjee Michael Poon Geoffrey D. Rubin Robert S. Schwartz | 2010 | Journal of the American College of Cardiology2010，，23： | 2 |
| 14 | EBUS-TBNA在肺部疾病(包括肺癌分期)中的作用综述显示文摘本综述重点阐述EBUS-TBNA在日常肺部疾病诊疗中的作用。所列举的病例为EBUS-TBNA的常见适应征,包括:①肺癌分期;②确诊胸部恶性淋巴结;③诊断中央型肺部肿块;④诊断肺结节病;⑤诊断炎性/良性胸部淋巴结。这项技术应用广泛,有经验的支气管镜医师经过适当的训练后,该技术将成为支气管镜检查的一部分。 | David FIELDING Farzad BASHIRZADEH Phan NGUYEN Alan HODGSON Daniel JAMES 吴齐 吴楠 | 2010 | 中国肺癌杂志2010，，5： | 2 |
| 15 | Retained austenite characteristics in thermomechanically processed Si-Mn transformation-induced plasticity steels显示文摘 | A. Zarei Hanzaki P. D. Hodgson S. Yue | 1997 | Metallurgical and Materials Transactions A1997，，11： | 2 |
| 16 | Degradation of the strength of porous titanium after alkali and heat treatment显示文摘 | J.G. Lin Y.C. Li C.S. Wong P.D. Hodgson C.E. Wen | 2009 | Journal of Alloys and Compounds2009，，1： | 2 |
| 17 | 老年女性蔬菜硝酸盐的摄入与颈动脉粥样硬化和缺血性脑血管病的相关性显示文摘膳食硝酸盐的短期增加可通过形成一氧化氮和其他氮氧化物来改善血管健康。其是否可降低长期血管疾病风险尚未得到验证,为了明确这一点,Bondonno教授团队调查了植物来源的硝酸盐摄入与老年女性颈总动脉内膜中层厚度(common carotid artery intimamedia thickness,CCA-IMT)、斑块严重程度和缺血性脑血管疾病事件的关系(n=1226),方法:纳入研究对象,确定基线时(1998年)的蔬菜硝酸盐摄入量、生活方式因素和心血管病危险因素。 | 刘莉 叶鹏 Bondonno CP Blekkenhorst LC Prince RL Ivey KL Lewis JR Devine A Woodman RJ Lundberg JO Croft KD Thompson PL Hodgson JM | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 18 | Epitaxial Growth of Multi-structure SnO_2 by Chemical Vapor Deposition显示文摘The nanowire and whisker heterostructures of tin dioxide were fabricated by the chemical vapor deposition technique.It was demonstrated that various structures of tin oxide can be obtained by controlling the thickness of gold layer and the partial pressure of source vapor at growing sites.12.5 and 25 nm thicknesses are preferable for the epitaxial growth of nanowires and heterostructure through vapor–liquid–solid mechanism,respectively.The tin dioxide whiskers with core-shell structure were fabricated by vapor–solid mechanism.Meanwhile,the influences of various factors on the tin dioxide growth are also discussed. | Dong-Ning He Peter Hodgson Wei-Min Gao | 2015 | Acta Metallurgica Sinica(English Letters)2015，28，7： | 2 |
| 19 | 以牲畜摄取行为决定植物种的选择和放牧管理方法显示文摘放牧系统中,在管理决策方面牲畜的摄入和牧草的选择是很重要的.按照牲畜的摄取行为,来决定植物种的选择和放牧方法是成功的农场管理的先决条件. | 翁森红 John Hodgson 李博 | 1996 | 内蒙古大学学报(自然科学版)1996，27，2： | 2 |
| 20 | Darwinism in economics: from analogy to ontology显示文摘 | Geoffrey M. Hodgson | 2002 | Journal of Evolutionary Economics2002，，3： | 2 |
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