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| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | The Role of Synthetic Biology in Atmospheric Greenhouse Gas Reduction: Prospects and Challenges显示文摘The long atmospheric residence time of CO2 creates an urgent need to add atmospheric carbon drawdown to CO2 regulatory strategies.Synthetic and systems biology(SSB),which enables manipulation of cellular phenotypes,offers a powerful approach to amplifying and adding new possibilities to current land management practices aimed at reducing atmospheric carbon.The participants(in attendance:Christina Agapakis,George Annas,Adam Arkin,George Church,Robert Cook-Deegan,Charles DeLisi,Dan Drell,Sheldon Glashow,Steve Hamburg,Henry Jacoby,Henry Kelly,Mark Kon,Todd Kuiken,Mary Lidstrom,Mike MacCracken,June Medford,Jerry Melillo,Ron Milo,Pilar Ossorio,Ari Patrinos,Keith Paustian,Kristala Jones Prather,Kent Redford,David Resnik,John Reilly,Richard J.Roberts,Daniel Segre,Susan Solomon,Elizabeth Strychalski,Chris Voigt,Dominic Woolf,Stan Wullschleger,and Xiaohan Yang)identified a range of possibilities by which SSB might help reduce greenhouse gas concentrations and which might also contribute to environmental sustainability and adaptation.These include,among other possibilities,engineering plants to convert CO2 produced by respiration into a stable carbonate,designing plants with an increased root-to-shoot ratio,and creating plants with the ability to self-fertilize.A number of serious ecological and societal challenges must,however,be confronted and resolved before any such application can be fully assessed,realized,and deployed. | Charles DeLisi Aristides Patrinos Michael MacCracken Dan Drell George Annas Adam Arkin George Church Robert Cook-Deegan Henry Jacoby Mary Lidstrom Jerry Melillo Ron Milo Keith Paustian John Reilly Richard J.Roberts Daniel Segrè Susan Solomon Dominic Woolf Stan D.Wullschleger Xiaohan Yang | 2020 | BioDesign Research2020，，1： | 2 |
| 3 | Radiation Lobectomy: time-dependent analysis of future liver remnant volume in unresectable liver cancer as a bridge to resection显示文摘 | Michael Vouche Robert J. Lewandowski Rohi Atassi Khairuddin Memon Vanessa L. Gates Robert K. Ryu Ron C. Gaba Mary F. Mulcahy Talia Baker Kent Sato Ryan Hickey Daniel Ganger Ahsun Riaz Jonathan Fryer Juan Carlos Caicedo Michael Abecassis Laura Kulik Riad S | 2013 | Journal of Hepatology2013，，： | 2 |
| 4 | Co-occurrence of Cell Lines, Basal Media and Supplementation in the Biomedical Research Literature显示文摘Purpose: The use of in vitro cell culture and experimentation is a cornerstone of biomedical research, however, more attention has recently been given to the potential consequences of using such artificial basal medias and undefined supplements. As a first step towards better understanding and measuring the impact these systems have on experimental results, we use text mining to capture typical research practices and trends around cell culture.Design/methodology/approach: To measure the scale of in vitro cell culture use, we have analyzed a corpus of 94,695 research articles that appear in biomedical research journals published in ScienceDirect from 2000–2018. Central to our investigation is the observation that studies using cell culture describe conditions using the typical sentence structure of cell line, basal media, and supplemented compounds. Here we tag our corpus with a curated list of basal medias and the Cellosaurus ontology using the Aho-Corasick algorithm. We also processed the corpus with Stanford CoreNLP to find nouns that follow the basal media, in an attempt to identify supplements used. Findings: Interestingly, we find that researchers frequently use DMEM even if a cell line's vendor recommends less concentrated media. We see long-tailed distributions for the usage of media and cell lines, with DMEM and RPMI dominating the media, and HEK293, HEK293 T, and HeLa dominating cell lines used. Research limitations: Our analysis was restricted to documents in ScienceDirect, and our text mining method achieved high recall but low precision and mandated manual inspection of many tokens.Practical implications: Our findings document current cell culture practices in the biomedical research community, which can be used as a resource for future experimental design.Originality/value: No other work has taken a text mining approach to surveying cell culture practices in biomedical research. | Jessica Cox Darin McBeath Corey Harper Ron Daniel | 2020 | Journal of Data and Information Science2020，5，3： | 2 |
| 5 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 6 | Demand heterogeneity and technology evolution:implications for product and process innovation显示文摘 | Ron Adner Daniel Levinthal | 2001 | Management science2001，47，5： | 1 |
| 7 | Causal Effects of Body Mass Index on Cardiometabolic Traits and Events: A Mendelian Randomization Analysis显示文摘 | Michael V. Holmes Leslie A. Lange Tom Palmer Matthew B. Lanktree Kari E. North Berta Almoguera Sarah Buxbaum Hareesh R. Chandrupatla Clara C. Elbers Yiran Guo Ron C. Hoogeveen Jin Li Yun R. Li Daniel I. Swerdlow Mary Cushman Tom S. Price Sean P. Curtis My | 2014 | The American Journal of Human Genetics2014，，2： | 1 |
| 8 | Long-term Outcome After Laparoscopic Treatment of Heterotopic Pregnancy: 19 Cases显示文摘 | David Soriano Danielle Vicus Ron Schonman Roy Mashiach David Shashar-Levkovitz Eyal Schiff Daniel S. Seidman Mordechai Goldenberg | 2010 | The Journal of Minimally Invasive Gynecology2010，，3： | 1 |
| 9 | Calculation of Stribeck curves for (water) lubricated journal bearings 显示文摘 | De Kraker Alex Van Ostayen Ron A J Rixen Daniel J | 2007 | Tribology International2007，40，： | 1 |
| 10 | Causal Reasoning and Explanation in Dynamic Economic Systems显示文摘 | Hennie Daniels | 1994 | Journal of Economic Dynamics and Control1994，18，： | 1 |
| 11 | Calculation of Stribeck curves for (water) lubricated journal bearings显示文摘 | Alex de Kraker Ron A.J. van Ostayen Daniel J. Rixen | 2006 | Tribology International2006，，3： | 1 |
| 12 | Demand heterogeneity and technology evolution:implications for product and process innovation显示文摘 | Adner Ron Levinthal Daniel | 2001 | Mangagement Science2001，47，5： | 1 |
| 13 | Combined colposcopy, loop conization, and laser vaporization reduces recurrent abnormal cytology and residual disease in cervical dysplasia 显示文摘 | Bar - Am A Daniel Y Ron IG | 2000 | Gynecol Oncology2000，78，1： | 1 |
| 14 | Demand Heterogeneity and Technology Evolution:Implications for Product and Process Innovation 显示文摘 | Ron Adner Daniel Levinthal | 2001 | Management Science2001，，47： | 1 |
| 15 | Calculation of Stribeck curves for (water) lubricated journal bearings显示文摘 | Alex de Kraker Ron A.J. van Ostayen Daniel J. Rixen | 2006 | Tribology International2006，，3： | 1 |
| 16 | Validation and Potential Mechanisms of Red Cell Distribution Width as a Prognostic Marker in Heart Failure显示文摘 | Larry A. Allen G. Michael Felker Mandeep R. Mehra Jun R. Chiong Stephanie H. Dunlap Jalal K. Ghali Daniel J. Lenihan Ron M. Oren Lynne E. Wagoner Todd A. Schwartz Kirkwood F. Adams | 2010 | Journal of Cardiac Failure2010，，： | 1 |
| 17 | Fiber glass and rock/slag wool exposure of professional and do-it-yourself installers显示文摘 | L Daniel Maxim Walter Eastes John G Hadley Charles M Carter Janis W Reynolds Ron Niebo | 2003 | Regulatory Toxicology and Pharmacology2003，，1： | 1 |
| 18 | Making for the grade with stainless steel tubing显示文摘 | DANIEL S JANIKOWSKL RON ROTH | 2007 | Power Business and Technology for the Global Generation industry2007，151，10： | 1 |
| 19 | <ce:link locator='fx1'/> Sleep Deprivation Is Hyperalgesic in Patients With Gastroesophageal Reflux Disease显示文摘 | Ron Schey Ram Dickman Sairam Parthasarathy Stuart F. Quan Christopher Wendel Jonah Merchant Jeannette Powers Bing Han Daniel van Handel Ronnie Fass | 2007 | Gastroenterology2007，，6： | 1 |
| 20 | Predictors of Subacute Stent Thrombosis: Results of a Systematic Intravascular Ultrasound Study显示文摘 | Edouard Cheneau Laurent Leborgne Gary S. Mintz Jun-ichi Kotani Augusto D. Pichard Lowell F. Satler Daniel Canos Marco Castagna Neil J. Weissman Ron Waksman | 2003 | Circulation2003，，1： | 1 |
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