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		题名	作者	年代	出处	被引量
	1	Rheumatoid arthritis显示文摘	David L Scott Frederick Wolfe Tom WJ Huizinga	2010	The Lancet2010，，9746：	3
	2	Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls.	Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong	2017	World Journal of Gastroenterology2017，23，6：	2
	3	The joint–gut axis in inflammatory bowel diseases显示文摘	Lianne K.P.M. Brakenhoff Désirée M. van der Heijde Daniel W. Hommes Tom W.J. Huizinga Herma H. Fidder	2009	Journal of Crohn’s and Colitis2009，，3：	1
	4	类风湿关节炎管理新进展显示文摘直到20世纪90年代,阿司匹林等非甾体抗炎药才开始被应用于治疗类风湿关节炎(RA)。那个时期,只有疾病进展后才开始应用甲氨蝶呤(MTX)等缓解病情抗风湿药(DMARDs)治疗。	Naomi B Klarenbeek Pit J S M Kerstens Tom W J Huizinga Ben A C Dijkmans Cornelia F Allaart 季兰岚(译) 张卓莉(校)	2011	英国医学杂志中文版2011，14，2：	1
	5	Expression of FOXP3 mRNA is not confined to CD4 + CD25 + T regulatory cells in humans显示文摘	Mary E. Morgan Jolanda H.M. van Bilsen Aleida M. Bakker Bianca Heemskerk Marco W. Schilham Franca C. Hartgers Berendina G. Elferink Linda van der Zanden René R.P. de Vries Tom W.J. Huizinga Tom H.M. Ottenhoff René E.M. Toes	2005	Human Immunology2005，，1：	1
	6	Genetic influence on cytokine production and fatal meningococcal disease显示文摘	Rudi GJ Westendorp Jan AM Langermans Tom WJ Huizinga Abdul H Elouali Cornelis L Verweij Dorret I Boomsma Jan P Vandenbrouke	1997	The Lancet1997，，9046：	1

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