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| 1 | DNMT3A、FLT3-ITD突变与AML患者不良预后的相关性显示文摘目的探讨FLT3-ITD及DNMT3A突变对细胞遗传学中等风险的急性髓系白血病(AML)患者预后评估的价值。方法选取2010—2016年美国俄勒冈州健康与科学大学附属医院收治的AML初诊患者132例,根据细胞遗传学分析结果将患者分为预后良好细胞遗传学组(简称预后良好组)24例、中等风险细胞遗传学组(简称中等风险组)79例、不良风险细胞遗传学组(简称不良风险组)27例,另有细胞遗传学信息不详2例。使用下一代测序(NGS)技术检测与血液系统肿瘤发病相关的42个基因突变。结果 132例AML患者中有120例(91%)至少发生1个基因突变,多基因(≥2)突变占61%。Kaplan-Meier生存曲线显示,在中等风险组中,FLT3-ITD突变阳性组的总体生存期与FLT3-ITD突变阴性组比较,差异有统计学意义(P<0.001)。进一步分析发现,FLT3-ITD突变阳性+DNMT3A突变组的中位生存期明显短于FLT3-ITD突变阴性组(P<0.001),FLT3-ITD突变阳性+DNMT3A野生型组的中位生存期与FLT3-ITD突变阴性组比较,差异无统计学意义(P>0.05)。FLT3-ITD突变阳性+DNMT3A突变组的总生存期明显短于FLT3-ITD突变阴性组(P<0.001)和FLT3-ITD突变阳性+DNMT3A野生型组(P=0.003)。结论在细胞遗传学中等风险的AML患者中,如果同时存在FLT3-ITD及DNMT3A突变,提示预后不良。检测FLT3-ITD及DNMT3A突变状态有助于对AML进行预后评估。 | 马娟 沈立松 Jennifer Dunlap Fan Guang | 2017 | 检验医学2017，32，9： | 6 |
| 2 | 一株抑制黄曲霉毒素的深海微杆菌的分离与鉴定显示文摘从南大西洋深海海水中分离到一株放线菌菌株R104,该菌株的发酵无细胞上清液对黄曲霉毒素合成的抑制率高达96.2%,经16S r DNA序列分析,初步将该菌株鉴定为微杆菌(Microbacterium),这是首次报道深海来源的微杆菌具有抑制黄曲霉毒素合成的能力。 | 徐静静 闫培生 王凯 马瑞 贾文文 Dunlap Christopher A | 2015 | 生物技术进展2015，5，3： | 4 |
| 3 | Uterine biology in pigs and sheep显示文摘There is a dialogue between the developing conceptus (embryo-fetus and associated placental membranes) and maternal uterus which must be established during the peri-implantation period for pregnancy recognition signaling, implantation, regulation of gene expression by uterine epithelial and stromal cells, placentation and exchange of nutrients and gases. The uterus provide a microenvironment in which molecules secreted by uterine epithelia or transported into the uterine lumen represent histotroph required for growth and development of the conceptus and receptivity of the uterus to implantation. Pregnancy recognition signaling mechanisms sustain the functional lifespan of the corpora lutea (CL) which produce progesterone, the hormone of pregnancy essential for uterine functions that support implantation and placentation required for a successful outcome of pregnancy. It is within the peri-implantation period that most embryonic deaths occur due to deficiencies attributed to uterine functions or failure of the conceptus to develop appropriately, signal pregnancy recognition and/or undergo implantation and placentation. With proper placentation, the fetal fluids and fetal membranes each have unique functions to ensure hematotrophic and histotrophic nutrition in support of growth and development of the fetus. The endocrine status of the pregnant female and her nutritional status are critical for successful establishment and maintenance of pregnancy. This review addresses the complexity of key mechanisms that are characteristic of successful reproduction in sheep and pigs and gaps in knowledge that must be the subject of research in order to enhance fertility and reproductive health of livestock species. | Fuller W Bazer Gwonhwa Song Jinyoung Kim Kathrin A Dunlap Michael Carey Satterfield Gregory A Johnson Robert C Burghardt Guoyao Wu | 2012 | Journal of Animal Science and Biotechnology2012，3，3： | 3 |
| 4 | 是,生理节奏的节奏实际上确实影响几乎一切显示文摘 | Jay C Dunlap Jennifer J Loros | 2016 | Cell Research2016，26，7： | 3 |
| 5 | Carbon-13 nuclear magnetic resonance of 5-substituted uracils 显示文摘 | Paul D E Dunlap R B Polllard A L | 1973 | Amer Chem Soc1973，95，13： | 2 |
| 6 | Fruiting and shedding of cotton in relation to light and other limiting factor显示文摘 | DUNLAP A A | 1945 | Taxas Sta Bull1945，10，4： | 1 |
| 7 | Pulsaile hemodynamie effects of candesartan in patients with chronic heart failure:The CHARM Prograrn显示文摘 | Mitchell GF Amold JM Dunlap ME | 2006 | J Heart Fai2006，8，3： | 1 |
| 8 | Environmental Sociology: A Personal Perspective on Its First Quarter Century显示文摘 | DUNLAP R | 2002 | Organization & Environment2002，15，1： | 1 |
| 9 | Radio-frequency dielectric properties of dehydrated carrots application to moisture determination by electrical methods显示文摘 | DUNLAP J R MAKOWER B | 1945 | The Journal of Physical Chemistry1945，49，6： | 1 |
| 10 | Paradigms ,theories ,and the primacy of the HEP-NEP distinction显示文摘 | Catton W R J Dunlap R E | 1978 | The A- merican Sociologist1978，13，4： | 1 |
| 11 | The major form of ADP-glucose pyrophosphorylase in maize endosperm is extra-plastidial显示文摘 | Denyer K Dunlap F Thorbjornsen T | | 0，，： | 1 |
| 12 | Molecular Bases for Circadian Clocks显示文摘 | Jay C Dunlap | 1999 | Cell1999，，2： | 1 |
| 13 | Approximating pearson product-moment correlations from Kendall's Tau and spearman's Rho 显示文摘 | Rupinski TM Dunlap PW | 1996 | Educ Psychol Meas1996，56，： | 1 |
| 14 | Soluble epoxide hydrolase gene deletion reduces survival after cardiac arrest and cardiopulmonary resuscitation 显示文摘 | Hutchens MP Nakano T Dunlap J | 2008 | Resuscitation2008，76，1： | 1 |
| 15 | Eight,drought and heat as factors in cotton boll shedding 显示文摘 | DUNLAP A A | 1944 | Phytopathology1944，34，： | 1 |
| 16 | Timing and kinematics of Caledonian thrusting and extensional collapse,southern Norway:Evidence from 40Ar/ 39Ar thermochronology显示文摘 | Dunlap W J | 1998 | Journal of Structural Geology1998，20，6： | 1 |
| 17 | Are fullerene tubules metallic 显示文摘 | Mintmire J W Dunlap B I White C T | 1992 | Physical Review Letters1992，68，5： | 1 |
| 18 | Antarctic krill (Euphausia superba) acquire a UV- absorbing mycosporine-like aminoacid from dietary algae显示文摘 | NEWMAN S J DUNLAP W C NICOL S | 2000 | Journal of Experimental Marine Biology and Ecology2000，255，： | 1 |
| 19 | Vortex shed- ding as a source of acoustic energy in segmented solid rockets显示文摘 | Brown R S Dunlap R Young S W | 1981 | Journal of Spacecrafts and Rockets1981，18，4： | 1 |
| 20 | Thermosensitive water-dispersible hairy particle-supported Pd nanoparticles for catalysis of hydrogenation in an aqueous/organic biphasic system 显示文摘 | Li D Dunlap J R Zhao B | 2008 | Langmuir2008，24，11： | 1 |
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