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| 1 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 2 | Exploring the Transcriptome Landscape of Pomegranate Fruit Peel for Natural Product Biosynthetic Gene and SSR Marker Discovery显示文摘Pomegranate fruit peel is rich in bioactive plant natural products,such as hydrolyzable tannins and anthocyanins.Despite their documented roles in human nutrition and fruit quality,genes involved in natural product biosynthesis have not been cloned from pomegranate and very little sequence information is available on pomegranate in the public domain.Shotgun transcriptome sequencing of pomegranate fruit peel cDNA was performed using RNA-Seq on the Illumina Genome Analyzer platform.Over 100 million raw sequence reads were obtained and assembled into 9,839 transcriptome assemblies (TAs) (>200 bp).Candidate genes for hydrolyzable tannin,anthocyanin,flavonoid,terpenoid and fatty acid biosynthesis and/or regulation were identified.Three lipid transfer proteins were obtained that may contribute to the previously reported IgE reactivity of pomegranate fruit extracts.In addition,115 SSR markers were identified from the pomegranate fruit peel transcriptome and primers were designed for 77 SSR markers.The pomegranate fruit peel transcriptome set provides a valuable platform for natural product biosynthetic gene and SSR marker discovery in pomegranate.This work also demonstrates that next-generation transcriptome sequencing is an economical and effective approach for investigating natural product biosynthesis,identifying genes controlling important agronomic traits,and discovering molecular markers in non-model specialty crop species. | Nadia Nicole Ono Monica Therese Britton Joseph Nathaniel Fass Charles Meyer Nicolet Dawei Lin Li Tian | 2011 | Journal of Integrative Plant Biology2011，53，10： | 12 |
| 3 | Benign retroperitoneal schwannoma presenting as colitis:A case report显示文摘We report a case of a patient presenting with clinical,radiological and endoscopic features of colitis due to a compressive left para-aortic mass. Total open surgical excision was performed,which resulted in complete resolution of colitis. Histopathology and immunohistochemistry revealed benign retroperitoneal schwannoma. These neural sheath tumors rarely occur in the retroperitoneum. They are usually asymptomatic but as they enlarge they may compress adjacent structures,which leads to a wide spectrum of non-specific symptoms,including lumbar pain,headache,secondary hypertension,abdominal pain and renal colicky pain. CT and MR findings show characteristic features,but none are specific. Schwannoma can be isolated sporadic lesions,or associated with schwannomatosis or neurofibromatosis type Ⅱ (NF2). Although they vary in biological and clinical behavior,their presence is,in nearly every case,due to alterations or absence of the NF2 gene,which is involved in the growth regulation of Schwann cells. Both conditions were excluded by thorough mutation analysis. Diagnosis is based on histopathological examination and immunohistochemistry. Total excision is therapeutic and has a good prognosis. Schwannomatosis and NF2 should be excluded through clinical diagnostic criteria. Genetic testing of NF2 is probably not justified in the presence of a solitary retroperitoneal schwannoma. | Gary Fass Didier Hossey Michel Nyst Dirk Smets Esmail Najar Saligheh Ruth Duttmann Kathleen Claes Pierre Mendes da Costa | 2007 | World Journal of Gastroenterology2007，13，41： | 5 |
| 4 | Effectiveness of proton pump inhibitors in nonerosive reflux disease显示文摘 | Bonnie B. Dean Anacleto D. Gano Kevin Knight Joshua J. Ofman Ronnie Fass | 2004 | Clinical Gastroenterology and Hepatology2004，，8： | 2 |
| 5 | Clinical consequences of silent gastroesophageal reflux disease显示文摘 | Ronnie Fass Ram Dickman | 2006 | Current Gastroenterology Reports2006，，3： | 2 |
| 6 | Erosive esophagitis and nonerosive reflux disease (NERD): comparison of epidemiologic, physiologic, and therapeutic characteristics显示文摘 | Fass R | 2007 | J Clin Gastroenterol2007，41，2： | 1 |
| 7 | Comparative in vitro activities of piperacillin-tazobactam and ticarcillin-clavulanate显示文摘 | Fass RJ Prior RB | 1989 | Antimicrob Agents Chemother1989，33，8： | 1 |
| 8 | Emergence of excitotoxicity in cultured forebrain neurons coincides with larger glutamate-stimulated i increases and NMDA receptor mRNA levels显示文摘 | CHENG C FASS D M REYNOLDS I J | 1999 | Brain Res1999，849，12： | 1 |
| 9 | Fluorodeoxyglucose positron emission tomography and the prognosis of pancreatic carcinoma 显示文摘 | Zimny M Fass J Bares | 2000 | Scand J Gastroenterol2000，35，8： | 1 |
| 10 | Met 3:A Method for Discriminating Metonymy and Metaphor By Computer显示文摘 | Fass D | | 0，，01： | 1 |
| 11 | Erosive esophagitis and nonerosive reflux disease(NERD):comparison of epidemiologic,physiologic,and therapeutic characteristics显示文摘 | Fass R | | 0，，25： | 1 |
| 12 | Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease显示文摘 | Kilgore M Miller CA Fass DM | 2010 | Neuropsychopharmacology2010，35，4： | 1 |
| 13 | Core structure of gp41 from the HIV envelope glycoprotein显示文摘 | Chan DC Fass D Berger JM | 1997 | Cell1997，89，4： | 1 |
| 14 | Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4显示文摘 | Scherz-Shouval R Shvets E Fass E | 2007 | EMBO J2007，26，7： | 1 |
| 15 | Clinical trial : the effects of the proton pump inhibitor dexlansoprazole MR on daytime and nighttime heartburn in patients with non - erosive reflux disease 显示文摘 | Fass R Chey WD Zakko SF | 2009 | Aliment Pharmacol Ther2009，29，： | 1 |
| 16 | The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes 显示文摘 | SHVETS E FASS E SCHERZ-SHOUVAL R | 2008 | Journal of Cell Science2008，121，16： | 1 |
| 17 | Proton pump inhibitor failure--what are the therapeutic options?显示文摘 | FASS R | 2009 | Am J Gastroenterol2009，104，： | 1 |
| 18 | The ome- prazole test is as sensitive as 24-h oesophageal pH moni- toring in diagnosing gastro-oesophageal reflux disease in symptomatic patients with erosive oesophagitis显示文摘 | Fass R OIman JJ Sampliner RE | 2000 | Aliment Pharmacol Ther2000，14，4： | 1 |
| 19 | Nocariac chest pain: epidemiology, natural course and pathogenesis显示文摘 | FASS R ACHEM S R | 2011 | J Neurogastroenterol Motil2011，17，2： | 1 |
| 20 | Antibiotic-impregnated cement and beads for orthopedic infections,显示文摘 | WININGER D A FASS R J | 1996 | Antimicrob Agents Chemother1996，40，12： | 1 |
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