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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Gastric neuroendocrine tumor: A practical literature review显示文摘Gastric neuroendocrine tumors are gastric neoplasms originating from enterochromaffin type cells and are inserted in a larger group,named gastroenteropancreatic neuroendocrine tumors.They are considered rare and variable in terms of their clinical,morphological and functional characteristics and may be indolent or aggressive.They are classified into types I,II and III,according to their pathophysiology,behavior and treatment.Their diagnosis occurs,in most cases,incidentally during upper digestive endoscopies,presenting as simple gastric polyps.Most cases(type I and type II)are related to hypergastrinemia,can be multiple and are treated by endoscopic resection,whenever possible.The use of somatostatin analogs for tumor control may be one of the options for therapy,in addition to total or subtotal gastrectomy for selected cases.Adjuvant chemotherapy is only reserved for poorly differentiated neuroendocrine carcinomas.Although rare,gastric neuroendocrine tumors have an increasing incidence over the years,therefore deserving more comprehensive studies on its adequate treatment.The present study reviews and updates management recommendations for gastric neuroendocrine tumors. | Gabriel Antonio Roberto Carolina Magalhães Britto Rodrigues Renata D’Alpino Peixoto Riad Naim Younes | 2020 | World Journal of Gastrointestinal Oncology2020，12，8： | 8 |
| 4 | Intensivist-based deep sedation using propofol for pediatric outpatient flexible bronchoscopy显示文摘AIM To evaluate the safety and efficacy of sedating pediatric patients for outpatient flexible bronchoscopy.METHODS A retrospective chart review was conducted for all children, age 17 years or under who underwent flexible bronchoscopy under deep sedation in an outpatient hospital-based setting. Two sedation regimens were used; propofol only or ketamine prior to propofol. Patients were divided into three age groups; infants(less than 12 mo), toddlers(1-3 years) and children(4-17 years). Demographics, indication for bronchoscopy, sedative dosing, sedation and recovery time and adverse events were reviewed.RESULTS Of the total 458 bronchoscopies performed, propofol only regimen was used in 337(74%) while propofol and ketamine was used in 121(26%). About 99% of the procedures were successfully completed. Children in the propofol + ketamine group tend to be youngerand have lower weight compared to the propofol only group. Adverse events including transient hypoxemia and hypotension occurred in 8% and 24% respectively. Median procedure time was 10 min while the median discharge time was 35 min. There were no differences in the indication of the procedure, propofol dose, procedure or recovery time in either sedative regimen. When compared to other age groups, infants had a higher incidence of hypoxemia.CONCLUSION Children can be effectively sedated for outpatient flexible bronchoscopy with high rate of success. This procedure should be performed under vigilance of highly trained providers. | Kamal Abulebda Samer Abu-Sultaneh Sheikh Sohail Ahmed Elizabeth A S Moser Renee C McKinney Riad Lutfi | 2017 | World Journal of Critical Care Medicine2017，6，4： | 8 |
| 5 | The use of hydrogeochemical analyses and multivariate statistics for the characterization of thermal springs in the Constantine area, Northeastern Algeria显示文摘This paper deals with the results of a hydrogeochemistry study on the thermal waters of the Constantine area, Northeastern Algeria, using geochemical and statistical tools. The samples were collected in December2016 from twelve hot springs and were analyzed for physicochemical parameters(electric conductivity, p H,total dissolved solids, temperature, Ca, Mg, Na, K, HCO_3,Cl, SO_4, and SiO_2). The waters of the thermal springs have temperatures varying from 28 to 51 °C and electric conductivity values ranging from 853 to 5630 l S/cm. Q-mode Cluster analysis resulted in the determination of two major water types: a Ca–HCO_3–SO_4 type with a moderate salinity and a Na–K–Cl type with high salinity. The plot of the major ions versus the saturation indices suggested that the hydrogeochemistry of thermal groundwater is mainly controlled by dissolution/precipitation of carbonate minerals, dissolution of evaporite minerals(halite and gypsum), and ion exchange of Ca(and/or Mg) by Na. The Gibbs diagram shows that evaporation is another factor playing a minor role. Principal Component Analysis produced three significant factors which have 88.2% of totalvariance that illustrate the main processes controlling the chemistry of groundwaters, which are respectively: the dissolution of evaporite minerals(halite and gypsum), ion exchange, and dissolution/precipitation of carbonate minerals. The subsurface reservoir temperatures were calculated using different cation and silica geothermometers and gave temperatures ranging between 17 and 279 °C. The Na–K and Na–K-Ca geothermometers provided high temperatures(up to 279 °C), whereas, estimated geotemperatures from K/Mg geothermometers were the lowest(17–53 °C). Silica geothermometers gave the most reasonable temperature estimate of the subsurface waters overlap between 20 and 58 °C, which indicate possible mixing with cooler Mg groundwaters indicated by the Na–K–Mg plot in the immature water field and in silica and chloride mixing models. The results of stable isotope analyses(δ^(18) O and δ~2 H) suggest that the origin of thermal water recharge is precipitation, which recharged from a higher altitude(600–1200 m) and infiltrated through deep faults and fractures in carbonate formations. They circulate at an estimated depth that does not exceed 2 km and are heated by a high conductive heat flow before rising to the surface through faults that acted as hydrothermal conduits.During their ascent to the surface, they are subjected to various physical and chemical changes such as cooling by conduction and change in their chemical constituents due to the mixing with cold groundwaters. | Riad Kouadra Abdeslam Demdoum Nabil Chabour Rebiha Benchikh | 2019 | Acta Geochimica2019，38，2： | 3 |
| 6 | Primary and overall success rates for clinical outcomes after laparoscopic, endoscopic, and open pancreatic cystgastrostomy for pancreatic pseudocysts显示文摘 | Lora Melman Riad Azar Kathleen Beddow L. Michael Brunt Valerie J. Halpin J. Christopher Eagon Margaret M. Frisella Steven Edmundowicz Sreenivasa Jonnalagadda Brent D. Matthews | 2009 | Surgical Endoscopy2009，，2： | 3 |
| 7 | Association of gene variants with susceptibility to type 2 diabetes among Omanis显示文摘AIM:To investigate the association of 10 known common gene variants with susceptibility to type 2diabetes mellitus(T2D)among Omanis.METHODS:Using case-control design,a total of992 diabetic patients and 294 normoglycemic Omani Arabs were genotyped,by an allelic discrimination assay-by-design TaqMan method on fast real time polymerase chain reaction system,for the following gene variants:KCNJ11(rs5219),TCF7L2(rs7903146),CDKAL1(rs10946398),CDKN2A/B(rs10811661),FTO(rs9939609 and rs8050136),IGF2BP2(rs4402960),SLC30A8(rs13266634)CAPN10(rs3792267)and HHEX(rs1111875).T2D patients were recruited from the Diabetes Clinic(n=243)and inpatients(n=749)at Sultan Qaboos Univesity Hospital(SQUH),Muscat,Oman.Adult control participants(n=294)were volunteers from the community and from those visiting Family Medicine Clinic at SQU,for regular medical checkup.The difficulty in recruiting Omani participants with no family history of diabetes was the main reason behind the small number of control participants in this study.Almost all volunteers questioned had a relativewith diabetes mellitus.Inspite of the small number of normoglycemic controls in this study,this sample was sufficient for detection of genes and loci for common alleles influencing T2D with an odds ratio of≥1.3reaching at least 80%power.Data was collected from June 2010 to February 2012.RESULTS:Using binary logistic regression analysis,four gene variants showed significant association with T2D risk:KCNJ11(rs5219,P=5.8×10^(-6),OR=1.74),TCF7L2(rs7903146,P=0.001,OR=1.46),CDKAL1(rs10946398,P=0.002,OR=1.44)and CDKN2A/B(rs10811661,P=0.020,OR=1.40).The fixation index analysis of these four gene variants indicated significant genetic differentiation between diabetics and controls{[KCNJ11(rs5219),P<0.001],[TCF7L2(rs7903146),P<0.001],[CDKAL1(rs10946398),P<0.05],[CDKN2A/B(rs10811661),P<0.05]}.The highest genotype variation%between diabetics and controls was found at KCNJ11(2.07%)and TCF7L2(1.62%).This study was not able to detect an association of T2D risk with gene variants of IGF2BP2(rs4402960),SLC30A8(rs13266634),CAPN10(rs3792267)and HHEX(rs1111875).Moreover,no association was found between FTO gene variants(rs9939609 and rs8050136)and T2D risk.However,T2D risk was found to be significantly associated with obesity(P=0.002,OR=2.22);and with the Waist-to-Hip ratio(n=532,P=1.9×10^(-7),OR=2.4),[among males(n=234,P=1.2×10^(-4),OR=2.0)and females(n=298,P=0.001,OR=6.3)].CONCLUSION:Results confirmed the association of KCNJ11(rs5219),TCF7L2(rs7903146),CDKAL1(rs10946398)and CDKN2A/B(rs10811661)gene variants with susceptibility to T2D among Omani Arabs. | Sawsan Al-Sinani Nicolas Woodhouse Ali Al-Mamari Omaima Al-Shafie Mohammed Al-Shafaee Said Al-Yahyaee Mohammed Hassan Deepali Jaju Khamis Al-Hashmi Mohammed Al-Abri Khalid Al-Rassadi Syed Rizvi Yengo Loic Philippe Froguel Riad Bayoumi | 2015 | World Journal of Diabetes2015，6，2： | 3 |
| 8 | Increased Quality of Life Among Hepatocellular Carcinoma Patients Treated with Radioembolization, Compared with Chemoembolization显示文摘 | Riad Salem Margaret Gilbertsen Zeeshan Butt Khairuddin Memon Michael Vouche Ryan Hickey Talia Baker Michael M. Abecassis Rohi Atassi Ahsun Riaz David Cella James L. Burns Daniel Ganger Al B. Benson Mary F. Mulcahy Laura Kulik Robert Lewandowski | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 9 | Treatment of Unresectable Primary and Metastatic Liver Cancer with Yttrium-90 Microspheres (TheraSphere?): Assessment of Hepatic Arterial Embolization显示文摘 | Kent Sato Robert J. Lewandowski James T. Bui Reed Omary Russell D. Hunter Laura Kulik Mary Mulcahy David Liu Howard Chrisman Scott Resnick Albert A. Nemcek Robert Vogelzang Riad Salem | 2006 | CardioVascular and Interventional Radiology2006，，4： | 2 |
| 10 | Yttrium-90 microspheres for the treatment of hepatocellular carcinoma显示文摘 | Jean Francois H. Geschwind Riad Salem Brian I. Carr Michael C. Soulen Kenneth G. Thurston Kathleen A. Goin Mark van Buskirk Carol A. Roberts James E. Goin | 2004 | Gastroenterology2004，，： | 2 |
| 11 | Study and performaned evaluation of two iterative frequency-domain deconvolution techniques显示文摘 | B Parruck S M Riad | 1994 | IEEE Trans1994，43，2： | 2 |
| 12 | Incidence of Sedation-Related Complications With Propofol Use During Advanced Endoscopic Procedures显示文摘 | Gregory A. Coté Robert M. Hovis Michael A. Ansstas Lawrence Waldbaum Riad R. Azar Dayna S. Early Steven A. Edmundowicz Daniel K. Mullady Sreenivasa S. Jonnalagadda | 2010 | Clinical Gastroenterology and Hepatology2010，，2： | 2 |
| 13 | Recommendations for Radioembolization of Hepatic Malignancies Using Yttrium-90 Microsphere Brachytherapy: A Consensus Panel Report from the Radioembolization Brachytherapy Oncology Consortium显示文摘 | Andrew Kennedy Subir Nag Riad Salem Ravi Murthy Alexander J. McEwan Charles Nutting Al Benson Joseph Espat Jose Ignacio Bilbao Ricky A. Sharma James P. Thomas Douglas Coldwell | 2007 | International Journal of Radiation Oncology, Biology, Physics2007，，： | 2 |
| 14 | the 20GD Superfamily: Emerging Functions in Plant Epigenetics and Hormone Metabolism显示文摘 | Riad Nadi Eduardo Mateo-Bonmati Lucia Juan-Vicente Jose Luis Micol | 2018 | Molecular Plant2018，11，10： | 2 |
| 15 | The role of microstructure of nickel–aluminium–bronze alloy on its cavitation corrosion behavior in natural seawater显示文摘 | A Al-Hashem W Riad | 2002 | Materials Characterization2002，，1： | 2 |
| 16 | Radiation Lobectomy: time-dependent analysis of future liver remnant volume in unresectable liver cancer as a bridge to resection显示文摘 | Michael Vouche Robert J. Lewandowski Rohi Atassi Khairuddin Memon Vanessa L. Gates Robert K. Ryu Ron C. Gaba Mary F. Mulcahy Talia Baker Kent Sato Ryan Hickey Daniel Ganger Ahsun Riaz Jonathan Fryer Juan Carlos Caicedo Michael Abecassis Laura Kulik Riad S | 2013 | Journal of Hepatology2013，，： | 2 |
| 17 | Hydrogeochemical characteristics of groundwater and quality assessment for the purposes of drinking and irrigation in Bougaa area,Northeastern Algeria显示文摘In the northern part of Algeria,the intensive exploitation of groundwater resources and pollution has considerably affected the aquifer water quality,especially in rural areas where groundwater is the main source of water supply for most uses.This study was performed to evaluate the groundwater quality and its suitability for drinking and irrigation purposes through the hydrogeochemical study on the groundwater in Bougaa region(Northeastern Algeria).Fourteen groundwater samples were collected and analyzed for p H,T,EC,TDS,and major ions.Most samples are suitable for drinking based on the permissible limits of the Bureau of Indian standards(Indian standard specification for drinking water(IS 10500:2012),but only 35%of the samples are good enough for drinking purposes based on the water quality index of the groundwater.Assessment of groundwater samples from various parameters and methods such as'Electrical conductivity,Sodium adsorption ratio,Soluble sodium percentage,Magnesium adsorption ratio,Residual sodium carbonate,Permeability index,Kelly’s ratio,Wilcox’s diagram,and US salinity laboratory classification'showed that groundwater in the area is chemically suitable for irrigation uses.The Piper trilinear diagram suggests that the groundwater mainly belongs to the hydrochemical facies Ca–Mg–Cl and Na–Cl.The combination of ionic ratios,Gibbs plots,and saturation indices show that water–rock interaction,particularly the dissolution of carbonate,evaporation minerals,and ion exchange processes affects hydrogeochemistry of the area.Additional processes such as evaporation and anthropogenic pollution from various sources can also have major impacts on groundwater salinity. | Riad Kouadra Abdeslam Demdoum | 2020 | Acta Geochimica2020，39，5： | 2 |
| 18 | Biotechnical system based on fuzzy logic prediction for surgical risk classification using analysis of current-voltage characteristics of acupuncture points显示文摘Objective:This study aimed to develop expert fuzzy logic model to assist physicians in the prediction of postoperative complications of prostatic hyperplasia before surgery.Methods:A method for classification of surgical risks was developed.The effect of rotation of the current–voltage characteristics at biologically active points(acupuncture points)was used for the formation of classifier descriptors.The effect determined reversible and non-reversible changes in electrical resistance at acupuncture points with periodic exposure to a sawtooth probe current.Then,the developed method was tested on the prediction of the success of surgical treatment of benign prostatic hyperplasia.Results:Input descriptors were obtained from collected data including current-voltage characteristics of 5 acupuncture points and composed of 27 arrays feeding in the model.The maximum diagnostic sensitivity of the classifier for the success of a surgical operation in the control sample was 88%and for testing data set prediction accuracy was 97%.Conclusion:The use of tuples of current-voltage characteristic descriptors of acupuncture points in the classifiers could be used to predict the success of surgical treatment with satisfactory accuracy.The model can be a valuable tool to support physicians’diagnosis. | Sergey Filist Riad Taha Al-Kasasbeh Olga Shatalova Nikolay Korenevskiy Ashraf Shaqadan Zeinab Protasova Maksim Ilyash Mikhail Lukashov | 2022 | Journal of Integrative Medicine2022，20，3： | 2 |
| 19 | Phase transformation and mechanical behavior in annealed 2205 duplex stainless steel welds 显示文摘 | Riad Badji Mabrouk Bouabdallah Brigitte Baeroix ect | 2007 | Materials characterization2007，3，4： | 1 |
| 20 | Renin inhibition improves cardiac function and remodeling after myocardial infarction inde- pendent of blood pressure 显示文摘 | Westemmnn D Riad A Lettau O | 2008 | Hypertension2008，52，6： | 1 |
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