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| 1 | Sex-Dependent Glial Signaling in Pathological Pain:Distinct Roles of Spinal Microglia and Astrocytes显示文摘Increasing evidence suggests that spinal microglia regulate pathological pain in males. In this study, we investigated the effects of several microglial and astroglial modulators on inflammatory and neuropathic pain following intrathecal injection in male and female mice. These modulators were the microglial inhibitors minocycline and ZVEID(a caspase-6 inhibitor) and the astroglial inhibitors L-α-aminoadipate(L-AA, an astroglial toxin) and carbenoxolone(a connexin 43 inhibitor), as well as U0126(an ERK kinase inhibitor) and D-JNKI-1(a c-Jun N-terminal kinase inhibitor). We found that spinal administration of minocycline or ZVEID, or Caspase6 deletion, reduced formalin-induced inflammatory and nerve injury-induced neuropathic pain primarily in male mice. In contrast,intrathecal L-AA reduced neuropathic pain but not inflammatory pain in both sexes. Intrathecal U0126 and D-JNKI-1 reduced neuropathic pain in both sexes. Nerve injury caused spinal upregulation of the astroglial markers GFAP and Connexin 43 in both sexes. Collectively, our data confirmed male-dominant microglial signaling but also revealed sex-independent astroglial signaling in the spinal cord in inflammatory and neuropathic pain. | Gang Chen Xin Luo M.Yawar Qadri Temugin Berta Ru-Rong Ji | 2018 | Neuroscience Bulletin2018，34，1： | 18 |
| 2 | Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7,Species Differences, and Regulation by Paclitaxel显示文摘Voltage-gated sodium channels(Navs) play an important role in human pain sensation. However, the expression and role of Nav subtypes in native human sensory neurons are unclear. To address this issue, we obtained human dorsal root ganglion(hDRG) tissues from healthy donors. PCR analysis of seven DRG-expressed Nav subtypes revealed that the hDRG has higher expression of Nav1.7(~50% of total Nav expression) and lower expression of Nav1.8(~12%), whereas the mouse DRG has higher expression of Nav1.8(~45%) and lower expression of Nav1.7(~18%). To mimic Nav regulation in chronic pain, we treated hDRG neurons in primary cultures with paclitaxel(0.1-1 μmol/L) for 24 h. Paclitaxel increased the Nav 1.7 but not Nav1.8 expression and also increased the transient Na^+ currents and action potential firing frequency in small-diameter(<50 μm) hDRG neurons. Thus, the hDRG provides a translational model in which to study'human pain in a dish' and test new pain therapeutics. | Wonseok Chang Temugin Berta Yong Ho Kim Sanghoon Lee Seok-Yong Lee Ru-Rong Ji | 2018 | Neuroscience Bulletin2018，34，1： | 12 |
| 3 | Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter显示文摘 | Xing-Jun Liu Yanli Zhang Tong LIU Zhen-Zhong Xu Chul-Kyu Park Temugin Berta Dianhua Jiang Ru-Rong Ji | 2014 | Cell Research2014，24，11： | 5 |
| 4 | Neuroprotective effects of meloxicam on transient brain ischemia in rats:the two faces of anti-inflammatory treatments显示文摘The inflammato ry response plays an important role in neuroprotection and regeneration after ischemic insult.The use of non-ste roidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental effects.In this context,the effects of the anti-inflammatory agent meloxicam have been scarcely documented after stro ke,but its ability to inhibit both cyclooxygenase isoforms(1 and 2) could be a promising strategy to modulate postischemic inflammation.This study analyzed the effect of meloxicam in a transient focal cerebral ischemia model in rats,measuring its neuroprotective effect after 48 hours and 7 days of reperfusion and the effects of the treatment on the glial scar and regenerative events such as the generation of new progenitors in the subventricular zone and axonal sprouting at the edge of the damaged area.We show that meloxicam’s neuroprotective effects remained after 7 days of reperfusion even if its administration was restricted to the two first days after ischemia.Moreover,meloxicam treatment modulated glial scar reactivity,which matched with an increase in axonal sprouting.However,this treatment decreased the formation of neuronal progenitor cells.This study discusses the dual role of anti-inflammatory treatments after stro ke and encourages the careful analysis of both the neuroprotective and the regenerative effects in preclinical studies. | Irene Fernández Ugidos Paloma González-Rodríguez María Santos-Galdiano Enrique Font-Belmonte Berta Anuncibay-Soto Diego Pérez-Rodríguez JoséManuel Gonzalo-Orden Arsenio Fernández-López | 2023 | Neural Regeneration Research2023，18，9： | 3 |
| 5 | Neuroprotection by salubrinal treatment in global cerebral ischemia显示文摘Most common cerebrovascular accidents(CVAs)result from the occlusion of a blood vessel and are called ischemic stroke.The interruption of the blood flow reduces the oxygen and glucose levels in the neural parenchyma,which in turn decreases the energy of the cells and compromises their homeostasis.This condition has to be reverted for cell survival.One of the homeostatic processes impaired by cerebral ischemia is protein folding in | Berta Anuncibay-Soto María Santos-Galdiano Arsenio Fernández-López | 2016 | Neural Regeneration Research2016，11，11： | 2 |
| 6 | 瑞典梅拉伦、哈马伦、维纳恩和韦特恩湖外来种的环境影响显示文摘在梅拉伦、维纳恩、韦特恩、和哈马伦湖已经有了20个外来种。有意引入的种类有来自北美洲的鱼类、信号小龙虾、观赏植物以及加拿大大雁。非有意引入的有,随被感染的小龙虾而来的小龙虾瘟疫,随压舱水而来的斑马贻贝和中国绒鳌蟹。病原体、寄生虫,特别是小龙虾瘟疫的引入,给各大湖带来很大的环境和社会经济影响,造成了本地贵重小龙虾的大批死亡。放养起源于不同生物地理区的鳟鱼和大麻哈鱼,使得维纳恩湖残留的本地鱼种类消失了。尽管除了小龙虾瘟疫外由于外来种的引入造成的主要生态系统的破坏没有在瑞典的4大湖发生,但局部问题已时有出现。 | Melanie Josefsson Berta Andersson 康保玲 | 2001 | AMBIO-人类环境杂志2001，30，8： | 2 |
| 7 | Analysis of optic disc damage by optical coherence tomography in terms of therapy in non-arteritic anterior ischemic optic neuropathy显示文摘This study aimed to assess the relationship between the rate of nerve fiber loss in non-arteritic anterior ischemic optic neuropathy(NAION) and time delay before therapy.Total 24 patients received the same treatment within or after 2wk(early and late groups).There were significantly lower level of destruction of nerve fibers(P=0.0014) and significantly better visual field sensitivity(P=0.039) in early group.The results indicate that therapy should be started within 2wk.The degree of ischemic damage due to NAION correlates well with retinal nerve fiber layer thickness and the ischemia-induced decrease in visual field sensitivity. | Zsuzsa Balogh Marta Kasza Julianna Varadai Izabella Reznek Judit Damjanovich Adrienne Csutak Andras Berta Valeria Nagy | 2016 | International Journal of Ophthalmology(English edition)2016，9，9： | 2 |
| 8 | A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif显示文摘 | Berta P Palmer MS | 1990 | Nature1990，346，6218： | 1 |
| 9 | A gene from the human sex determining region encodes a protein with homology to a conserved DNA binding motif显示文摘 | Sinclau AH Berta P Palmer MS | 1990 | Nature1990，346，： | 1 |
| 10 | Use of soft computing methods in risk assessment of electrostatic fire and explosion hazards in industries显示文摘 | Berta I | 2009 | JElectrostatics2009，67，： | 1 |
| 11 | Productionof biologically active tethered tilapia LHβαby the methyl-otrophic yeast Pichia pastoris显示文摘 | HAREL KASUTO BERTA LEVAVI-SIVAN | 2004 | General and Compara-tive Endocrinology2004，140，2005： | 1 |
| 12 | A gene from the human sex-determining region encodes a protein with homology to a conserved DNA binding motif显示文摘 | Sinclair A H Berta P Palmer M S | 1990 | Nature1990，346，： | 1 |
| 13 | A gene from the human sex-determining region encodes aprotein with homology to a conserved DNA-binding motif显示文摘 | Sinclair AH Berta P | 1990 | Nature1990，346，： | 1 |
| 14 | Plant root growth, architecture and function显示文摘 | Hodge A Berta G Doussan C Merchan F Crespi M | 2009 | Plant Soil2009，321，12： | 1 |
| 15 | Serum levels of intedeukin-6, tumor Ilecr06i8 factor and interferon gama in infants with and with- out dengue显示文摘 | Berta NR Diana MI Clam LS | 2008 | Revista da Sociedade Brasileira de Medicina Tropi- cal2008，41，1： | 1 |
| 16 | Improving perception of and response to natural hazards: the need for local education 显示文摘 | Vitek J D Berta S M | 1982 | Journal of Geography1982，81，6： | 1 |
| 17 | Use of near infrared hyperspectral tools for the screening of extractable polyphenols in red grape skins显示文摘 | NOGALES-BUENO J BERTA BACA-BOCANEGRA FRANCISCO JOSE RODR~GUEZ-PULIDO | 2015 | Food Chemistry2015，，172： | 1 |
| 18 | Effect of chemical structure on combustion and thermal behaviour of polyurethane elastomer layered silicate nanocompos- ites显示文摘 | Berta M Lindsay C Pans G | 2006 | Polymer Degradation and Stabil- ity2006，91，5： | 1 |
| 19 | A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif显示文摘 | Sinclair A H Berta P Palmer M S | 1990 | Nature1990，346，： | 1 |
| 20 | Plant root growth, archi- tecture and function 显示文摘 | Hodge A Berta G Doussan C | 2009 | Plant and Soil2009，321，： | 1 |
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