|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Targeting LIF/LIFR signaling in cancer显示文摘Leukemia inhibitory factor (LIF), and its receptor (LIFR), are commonly over-expressed in many solid cancers and recent studies have implicated LIF/LIFR axis as a promising clinical target for cancer therapy. LIF/LIFR activate oncogenic signaling pathways including JAK/STAT3 as immediate effectors and MAPK, AKT, mTOR further downstream. LIF/LIFR signaling plays a key role in tumor growth, progression, metastasis, stemness and therapy resistance. Many solid cancers show overexpression of LIF and autocrine stimulation of the LIF/LIFR axis;these are associated with a poorer relapse-free survival. LIF/LIFR signaling also plays a role in modulating multiple immune cell types present in tumor micro environment (TME). Recently, two targeted agents that target LIF (humanized anti-LIF antibody, MSC-1) and LIFR inhibitor (EC359) were under development. Both agents showed effectivity in preclinical models and clinical trials using MSC-1 antibody are in progress. This article reviews the significance of LIF/LIFR pathways and inhibitors that disrupt this process for the treatment of cancer. | Suryavathi Viswanadhapalli Kalarickal V.Dileep Kam Y.J.Zhang Hareesh B.Nair Ratna K.Vadlamudi | 2022 | Genes & Diseases2022，9，4： | 4 |
| 2 | 多壁碳纳米管负载Cu_2O和CuI催化剂上芳醛与2-氨基吡啶氧化酰胺化反应:Cu(I)物种的催化作用(英文)显示文摘采用浸渍法制备了多壁碳纳米管(MWCNT)负载的Cu2O和CuI催化剂,并运用粉末X射线衍射、红外光谱、扫描电镜-能量散射谱、透射电镜和NH3程序升温脱附等技术对催化剂进行了表征.结果表明,催化剂中沉积的Cu2O和CuI分别以立方相和γ相存在于MWCNT上,且表现出由弱到强的拉电子(Lewis酸)性能.将催化剂用于催化芳醛与2-氨基吡啶氧化酰胺化反应合成N-(吡啶-2-基)苯酰胺类化合物,产物选择性为100%,收率为50%–95%.Cu I/MWCNT催化剂上产物分离收率性能好于Cu2O/MWCNT,但后者的循环使用性能更好.与共价的Cu I相比,离子化的Cu2O与极性的酸活化的MWCNT间具有更适宜的相互作用,这种不同的相互作用可显著影响2-氨基吡啶的氨基对芳醛羰基的亲核进攻速率. | H. N. Hareesh K. U. Minchitha N. Nagaraju N. Kathyayini | 2015 | Chinese Journal of Catalysis2015，36，11： | 4 |
| 3 | Causal Effects of Body Mass Index on Cardiometabolic Traits and Events: A Mendelian Randomization Analysis显示文摘 | Michael V. Holmes Leslie A. Lange Tom Palmer Matthew B. Lanktree Kari E. North Berta Almoguera Sarah Buxbaum Hareesh R. Chandrupatla Clara C. Elbers Yiran Guo Ron C. Hoogeveen Jin Li Yun R. Li Daniel I. Swerdlow Mary Cushman Tom S. Price Sean P. Curtis My | 2014 | The American Journal of Human Genetics2014，，2： | 1 |
| 4 | Dynamic fracture of graphite/epoxy composites stiffened by buffer strips: An experimental study显示文摘 | Dongyeon Lee Hareesh Tippur Phillip Bogert | 2012 | Composite Structures2012，，： | 1 |
| 5 | Gelcasting process for Al2 O3-SiC nanocomposites and its creep characteristics显示文摘 | Ananthakumar S Prabhakaran K Hareesh U S | 2004 | Materials Chemistry and Physics2004，85，1： | 1 |
| 6 | Measurement of transient deformationsusing digital image correlation method andhigh-speed photography:application to dynamic fracture显示文摘 | MADHU S KIRUGULIGE HAREESH V TIPPUR THOMAS S DENNEY | 2007 | Applied Optics2007，46，22： | 1 |
| 7 | Processing,compression resiponse and finite element modeling of syntactic foam based interpenetrating phase ccanposite ( IPC )显示文摘 | Rahul Jhaver Hareesh Tippur | 2009 | Materials Science and Engineering A2009，，499： | 1 |
| 8 | Measurement of transient deformations using digital image correlation method and high-speed photography:application to dynamic fracture显示文摘 | MADHU S KIRUGULIGE HAREESH V TIPPUR THOMAS S DENNEY | 2007 | Applied Optics2007，46，22： | 1 |
| 9 | Study and comparison of various image edge detection techniques used in quality inspection and evaluation of agricultural and food products by computer vision显示文摘Edges characterize boundaries and are therefore a problem of fundamental importance in quality assessment of agricultural and food products.Since edge detection is in the forefront of computer vision system for detection of vegetables,fruits and food grains needs to quality inspection and evaluation,it is crucial to have a good understanding of edge detection algorithms.In this paper the comparative analysis of various image edge detection techniques is presented.The software is developed using MATLAB 7.6.It has been shown that the Canny’s edge detection algorithm performs better than all operators(i.e.LoG,Robert,Prewitt and Sobel)under almost all scenarios. | V G Narendra K S Hareesh | 2011 | International Journal of Agricultural and Biological Engineering2011，4，2： | 1 |
| 10 | Electronic warfare: Issues and challenges for emitter classification显示文摘 | Manish G Hareesh G Arvind M | 2011 | Defence Science Journal2011，61，3： | 1 |
| 11 | Prospects of computer vision automated grading and sorting systems in agricultural and food prod- ucts for quality evaluation 显示文摘 | NARENDRA V G HAREESH K S | 2010 | International Journal of Computer Applications2010，1，4： | 1 |
| 12 | Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo显示文摘 | Preetha Anand Hareesh B. Nair Bokyung Sung Ajaikumar B. Kunnumakkara Vivek R. Yadav Rajeshwar R. Tekmal Bharat B. Aggarwal | 2009 | Biochemical Pharmacology2009，，3： | 1 |
| 13 | Achromobacter denitrificans strain SP1 produces an intracellular esterase upon utilizing di(2ethylhexyl)phthalate显示文摘 | Selvanesan Pradeep Moolakkariyil Sarath Josh Erandapurathukadumana Sreedharan Hareesh Sunil Kumar Sailas Benjamin | 2015 | International Biodeterioration & Biodegradation2015，，： | 1 |
| 14 | Dynamic fracture behavior of syntactic epoxy foams:Optical measurements using coherent gradient sensing显示文摘 | Hadek E Medhat A Tippur Hareesh V | 2003 | Optics and Lasers in Engineering2003，40，4： | 1 |
| 15 | Experimental study of dynamic crack growth in unidirectional graphite/epoxy composites using digital image correlation method and high-speed photography显示文摘 | LEE Dongyeon TIPPUR Hareesh V KIRUGULIGE Madhu | 2009 | Journal of Composite Materials2009，43，19： | 1 |
| 16 | Synthesis of thermallystable high surface area anatase-alumina mixed oxides显示文摘 | Kumar S R Pillai S C Hareesh U S | 2000 | Materi-als Letters2000，43，： | 1 |
| 17 | Measurement of mixedmode fracture parameters near cracks in homogeneous and bimaterial beams显示文摘 | Hareesh V Tippur Sreeganesh Ramaswamy | 1993 | International Journal of Fracture1993，61，： | 1 |
| 18 | Measurement of transient deformations using digital image correlation method and high-speed photography: application to dynamic fracture显示文摘 | KIRUGULIGE MADHU S TIPPUR HAREESH V DENNEY THOMAS S | 2007 | Applied Optics2007，46，22： | 1 |
| 19 | Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo显示文摘 | Preetha Anand Hareesh B. Nair Bokyung Sung Ajaikumar B. Kunnumakkara Vivek R. Yadav Rajeshwar R. Tekmal Bharat B. Aggarwal | 2009 | Biochemical Pharmacology2009，，3： | 1 |
| 20 | Adaptive neural net (ANN) models for desulphurization of hot metal and steel显示文摘 | Amlan Datta Mavoori Hareesh | 1994 | Steel Research1994，65，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员