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| 1 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 2 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 3 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 4 | Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light. | lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu | 2017 | Science Bulletin2017，62，21： | 6 |
| 5 | Stem cell therapy for chronic skin wounds in the era of personalized medicine:From bench to bedside显示文摘With the significant financial burden of chronic cutaneous wounds on the healthcare system,not to the personal burden mention on those individuals afflicted,it has become increasingly essential to improve our clinical treatments.This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient.The most promising potential treatment options rely on stem cellbased therapies.Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function.Clinical approaches involving stem cells could thus be utilized in some cases to improve a body’s inhibited healing capacity.We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential.Given the current problems and complications presented by chronic wounds,we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care. | Elam Coalson Elliot Bishop Wei Liu Yixiao Feng Mia Spezia Bo Liu Yi Shen Di Wu Scott Du Alexander J.Li Zhenyu Ye Ling Zhao Daigui Cao Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Rex C.Haydon Lewis Shi Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid | 2019 | Genes & Diseases2019，6，4： | 6 |
| 6 | Increased stromal-cell-derived factor 1 enhances the homing of bone marrow derived mesenchymal stem cells in dilated cardiomyopathy in rats显示文摘背景干细胞移植被显示了在扩大心肌症上有有益的效果。然而,为到在扩大心肌症的心脏的织物的干细胞 homing 的机制还没是 elucidated.Methods 间充质的干细胞从老鼠骨头髓被获得,在 vitro 膨胀了,并且用 99mTc 标记 .Cardiomyopathy 模特儿被 doxorubicin 在老鼠劝诱。标记房间的 99mTc 在心肌症和控制老鼠被灌输进左室。在注射以后的十六个小时,动物被牺牲,不同纸巾被收获测量特定的放射性。由即时聚合酶链反应和 immunohistochemistry 的使用,为在心脏的织物的 stromal-cell-derived 因素 1 的 Mrna 和蛋白质表情是把间充质的干细胞的效率标记的 measured.Results (70. | ZHOU Yan-li ZHANG Hai-feng LI Xin-li DI Ruo-min YAO Wen-ming LI Dian-fu FENG Jian-lin HUANG Jun CAO Ke-jiang Michael Fu | 2010 | Chinese Medical Journal2010，，22： | 5 |
| 7 | Notch signaling:Its essential roles in bone and craniofacial development显示文摘Notch is a cellecell signaling pathway that is involved in a host of activities including development,oncogenesis,skeletal homeostasis,and much more.More specifically,recent research has demonstrated the importance of Notch signaling in osteogenic differentiation,bone healing,and in the development of the skeleton.The craniofacial skeleton is complex and understanding its development has remained an important focus in biology.In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton,skull,and face develop.We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system,and what importance it may play in the future. | Mikhail Pakvasa Pranav Haravu Michael Boachie-Mensah Alonzo Jones Elam Coalson Junyi Liao Zongyue Zeng Di Wu Kevin Qin Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Yongtao Zhang Changchun Niu Meng Wu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Michael J.Lee Jennifer Moriatis Wolf Aravind Athiviraham Sherwin S.Ho Tong-Chuan He Kelly Hynes Jason Strelzow Mostafa El Dafrawy Russell R.Reid | 2021 | Genes & Diseases2021，8，1： | 4 |
| 8 | Short-term climatic impacts of afforestation in the East Asian monsoon region显示文摘The influence of changes in vegetation cover on short-term climate over the East Asian monsoon region is simulated using the Community Climate System Model Version 3.5.The results show the annual mean surface air temperature significantly decreases by 0.93°C in response to afforestation over the East Asian monsoon region.Also,surface air temperature decreases by 1.46 and 0.40°C in summer and winter,respectively.The cooling is caused by enhanced evapotranspiration(ET) produced by increased forest cover.Evapotranspiration is greater in summer than in winter,so summer cooling is greater than winter cooling.The annual mean precipitation increases in response to afforestation,with a maximum of 7% in April.Water vapor increases significantly because of greater latent heat flux release.Meanwhile,afforestation leads to higher surface roughness,which decreases surface wind speed and induces an ascending air motion.These factors can produce more clouds and precipitation.Moreover,the surface albedo and the reflective solar radiation are reduced in response to afforestation. | MA Di LIU ZhengYu Lü ShiHua MICHAEL Notaro RONG XinYao CHENG GuangShan WANG FuYao | 2013 | Chinese Science Bulletin2013，58，18： | 3 |
| 9 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 10 | Brain-Gut Axis: From Basic Understanding to Treatment of IBS and Related Disorders显示文摘 | Michael Camilleri Carlo Di Lorenzo | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，4： | 2 |
| 11 | Survival benefit of liver resection for patients with hepatocellular carcinoma across different Barcelona Clinic Liver Cancer stages: a multicentre study显示文摘 | Alessandro Vitale Patrizia Burra Anna Chiara Frigo Franco Trevisani Fabio Farinati Gaya Spolverato Michael Volk Edoardo G. Giannini Francesca Ciccarese Fabio Piscaglia Gian Lodovico Rapaccini Mariella Di Marco Eugenio Caturelli Marco Zoli Franco Borzio Gi | 2014 | Journal of Hepatology2014，，： | 2 |
| 12 | Narrowing the phase window width in prospectively ECG-gated single heart beat 320-detector row coronary CT angiography显示文摘 | Michael L. Steigner Hansel J. Otero Tianxi Cai Dimitrios Mitsouras Leelakrishna Nallamshetty Amanda G. Whitmore Hale Ersoy Noah A. Levit Marcelo F. Di Carli Frank J. Rybicki | 2009 | The International Journal of Cardiovascular Imaging2009，，1： | 2 |
| 13 | Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis显示文摘 | Salvatore Modica Michele Petruzzelli Elena Bellafante Stefania Murzilli Lorena Salvatore Nicola Celli Giuseppe Di Tullio Giuseppe Palasciano Tarek Moustafa Emina Halilbasic Michael Trauner Antonio Moschetta | 2012 | Gastroenterology2012，，2： | 2 |
| 14 | The prevalence and risk factors associated with esophageal varices in subjects with hepatitis C and advanced fibrosis <ce:link locator='fx1'/>显示文摘 | Arun J. Sanyal Robert J. Fontana Adrian M. Di Bisceglie James E. Everhart Michael C. Doherty Gregory T. Everson John A. Donovan Peter F. Malet Savant Mehta Muhammad Y. Sheikh Andrea E. Reid Marc G. Ghany David R. Gretch the HALT-C Trial Group | 2006 | Gastrointestinal Endoscopy2006，，6： | 2 |
| 15 | Estimated cumulative radiation dose from PET/CT in children with malignancies: a 5-year retrospective review显示文摘 | Soni C. Chawla Noah Federman Di Zhang Kristen Nagata Soujanya Nuthakki Michael McNitt-Gray M. Ines Boechat | 2010 | Pediatric Radiology2010，，： | 2 |
| 16 | Molecular biology of microbial ureases显示文摘 | Harryl TM Michael DI Robert PH | 1995 | Microbiol Rev1995，59，3： | 1 |
| 17 | Substance P (SP) and vasoactive intestinal polypeptide (VIP) in the lower uterine segment in first and repeated cesarean sections显示文摘 | Antonio Malvasi Andrea Tinelli Carlo Cavallotti Stefano Bettocchi Gian Carlo Di Renzo Michael Stark | 2010 | Peptides2010，，11： | 1 |
| 18 | Arch replacement and downstream stent grafting in complex aortic dissection: first results of an international registry ☆显示文摘 | Konstantinos Tsagakis Davide Pacini Roberto Di Bartolomeo Jaroslav Benedik Stepan Cerny Michael Gorlitzer Martin Grabenwoger Carlos A. Mestres Heinz Jakob | 2011 | European Journal of Cardio-Thoracic Surgery2011，，1： | 1 |
| 19 | Improved Cardiac Risk Assessment With Noninvasive Measures of Coronary Flow Reserve显示文摘 | Venkatesh L. Murthy Masanao Naya Courtney R. Foster Jon Hainer Mariya Gaber Gilda Di Carli Ron Blankstein Sharmila Dorbala Arkadiusz Sitek Michael J. Pencina Marcelo F. Di Carli | 2011 | Circulation2011，，： | 1 |
| 20 | Impact of gastro- oesophageal reflux on microRNA expression, location and function显示文摘 | Smith CM Michael MZ Watson DI | 2013 | BMC Gastroenterol2013，13，： | 1 |
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