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| 1 | Colorectal cancer screening:20 years of development and recent progress显示文摘Colorectal cancer(CRC)is the second most common cancer in Europe and its incidence is steadily increasing.This trend could be reversed through timely secondary prevention(screening).In the last twenty years,CRC screening programs across Europe have experienced considerable improvements(fecal occult blood testing;transition from opportunistic to population based program settings).The Czech Republic is a typical example of a country with a long history of nationwide CRC screening programs in the face of very high CRC incidence and mortality rates.Each year,approximately 8000 people are diagnosed with CRC and some 4000 die from this malignancy.Twenty years ago,the first pilot studies on CRC screening led to the introduction of the opportunistic Czech National Colorectal Cancer Screening Program in 2000.Originally,this program was based on the guaiac fecal occult blood test(FOBT)offered by general practitioners,followed by colonoscopy in cases of FOBT positivity.The program has continuously evolved,namely with the implementation of immunochemical FOBTs and screening colonoscopy,as well as the involvement of gynecologists.Since the establishment of the Czech CRC Screening Registry in 2006,2405850 FOBTs have been performed and 104565 preventive colonoscopies recorded within the screening program.The overall program expanded to cover 25.0%of the target population by 2011.However,stagnation in the annual number of performed FOBTs lately has led to switching to the option of a population-based program with personal invitation,which is currently being prepared. | Miroslav Zavoral Stepan Suchanek Ondrej Majek Premysl Fric Petra Minarikova Marek Minarik Bohumil Seifert Ladislav Dusek | 2014 | World Journal of Gastroenterology2014，20，14： | 16 |
| 2 | How significant is the association between metabolic syndrome and prevalence of colorectal neoplasia?显示文摘The incidence and prevalence of metabolic syndrome(MS) and colorectal cancer(CRC) has been rising in developed countries. The association between these two diseases has been widely studied and reported. Less evidence is available about the relationship between MS and CRC precancerous lesions(adenomatous polyps, adenomas). The aim of this paper is to present an overview of our scientific understanding of that topic and its implication in clinical practice. One of the principal goals of current CRC secondary prevention efforts is to detect and remove the precancerous lesions in individuals with an average CRC risk to prevent the development of invasive cancer. MS is not currently considered a high-risk CRC factor and is therefore not included in the guidelines of organized screening programs. However, in light of growing scientific evidence, the approach to patients with MS should be changed. Metabolic risk factors for the development of adenomas and cancers are the same- obesity, impaired glucose tolerance, dyslipidemia, hypertension, cardiovascular diseases and diabetes mellitus type 2. Therefore, the key issue in the near future is the development of a simple scoring system, easy to use in clinical practice, which would identify individuals with high metabolic risk of colorectal neoplasia and would be used for individual CRC secondary prevention strategies. Currently, such scoring systems have been published based on Asian(Asia-Pacific Colorectal Screening Score; APCS) and Polish populations. | Stepan Suchanek Tomas Grega Ondrej Ngo Gabriela Vojtechova Ondrej Majek Petra Minarikova Nagyija Brogyuk Bohus Bunganic Bohumil Seifert Ladislav Dusek Miroslav Zavoral | 2016 | World Journal of Gastroenterology2016，22，36： | 10 |
| 3 | Colorectal cancer screening in Europe显示文摘Colorectal cancer(CRC)is the second most frequent malignant disease in Europe.Every year,412 000people are diagnosed with this condition,and 207 000patients die of it.In 2003,recommendations forscreening programs were issued by the Council of the European Union(EU),and these currently serve as thebasis for the preparation of European guidelines forCRC screening.The manner in which CRC screening iscarried out varies significantly from country to countrywithin the EU,both in terms of organization and thescreening test chosen.A screening program of onesort or another has been implemented in 19 of 27 EUcountries.The most frequently applied method is testing stool for occult bleeding(fecal occult blood test,FOBT).In recent years,a screening colonoscopy hasbeen introduced,either as the only method(Poland)orthe method of choice(Germany,Czech Republic). | Miroslav Zavoral Stepan Suchanek Filip Zavada Ladislav Dusek Jan Muzik Bohumil Seifert Premysl Fric | 2009 | World Journal of Gastroenterology2009，15，47： | 8 |
| 4 | Longitudinal molecular characterization of endoscopic specimens from colorectal lesions显示文摘AIM: To compare molecular profiles of proximal colon, distal colon and rectum in large adenomas, early and late carcinomas. To assess feasibility of testing directed at molecular markers from this study in routine clinical practice. METHODS: A prospective 3-year study has resulted in the acquisition of samples from 159 large adenomas and 138 carcinomas along with associated clinical parameters including localization, grade and histological type for adenomas and localization and stage for carcinomas. A complex molecular phenotyping has been performed using multiplex ligation-dependent probe amplification technique for the evaluation of Cp G-islandmethylator phenotype(CIMP), PCR fragment analysis for detection of microsatellite instability and denaturing capillary electrophoresis for sensitive detection of somatic mutations in KRAS, BRAF, TP53 and APC genes.RESULTS: Molecular types according to previously introduced Jass classification have been evaluated for large adenomas and early and late carcinomas. An increase in CIMP+ type, eventually accompanied with KRAS mutations, was notable between large adenomas and early carcinomas. As expected, the longitudinal observations revealed a correlation of the CIMP+/BRAF + type with proximal location. CONCLUSION: Prospective molecular classification of tissue specimens is feasible in routine endoscopy practice. Increased frequency of some molecular types corresponds to the developmental stages of colorectal tumors. As expected, a clear distinction is notable for tumors located in proximal colon supposedly arising from the serrated(methylation) pathway. | Petra Minarikova Lucie Benesova Tereza Halkova Barbora Belsanova Stepan Suchanek Jiri Cyrany Inna Tuckova Jan Bures Miroslav Zavoral Marek Minarik | 2016 | World Journal of Gastroenterology2016，22，20： | 2 |
| 5 | 菊芋不同种植密度比较试验显示文摘通过对科尔沁菊芋进行不同密度种植研究发现,宽窄行距相间的种植模式比等行距种植的效果显著,平均块茎产量增产18.7%。因此,在内蒙古中部地区实施宽窄行小株距的密度栽培是提高菊芋产量的有效途径,对发展菊芋规模生产、促进农牧民增效增收具有积极的意义。 | 张宇 stepan kiru 刘俊 门果桃 鲍红春 natalia anushkevich natalia lebedeva 赵胜利 | 2017 | 当代畜禽养殖业2017，0，10： | 2 |
| 6 | Calcitonin load test to assess the efficacy of salmon calcitonin显示文摘 | Stepan JJ Zikan V | 2003 | Clin Chim Acta2003，336，12： | 1 |
| 7 | Chatter Stability of Milling in Frequency and Discrete Time Domain 显示文摘 | ALTINTAS Y STEPAN G MERDOL D | 2008 | CIRP Journal of Manufacturing Science and Technology2008，1，1： | 1 |
| 8 | Morphology and fracture behavior of POM modified epoxy matrices and their carbon fiber composites显示文摘 | Mohammadali Aravand Stepan V Lomov Larissa Gorbatikh | 2015 | Composites Science and Technology2015，110，： | 1 |
| 9 | Circulatory solubleedog- lin and its predice value for preeclampsia in second--trimester pregnancies with abnorm aluterine 显示文摘 | Stepan H Geipel A Schwarz F | 2008 | Am J Obstet Gynecol2008，198，2： | 1 |
| 10 | Glycine-extened gastrin exerts growth-promoting effects on human colon cancer cells 显示文摘 | Stepan VM Sawada M Toodisco A | 1999 | Mol Med1999，59，3： | 1 |
| 11 | Micafungin versus fluconasole for prophylaxis against invasive fungal infections 显示文摘 | van Burik JA Ratanatharathorn V Stepan DE | 2004 | Clin Infect Dis2004，，： | 1 |
| 12 | Positive Homoclinic Solutions for a Class of Second Order Differential Equations显示文摘 | Minhós Feliz Stepan Tersian | 1999 | J Math Anal Appl1999，240，1： | 1 |
| 13 | A minimax theorem and applications to nonresonance problems for semilinear equations显示文摘 | Stepan A Tersian | 1986 | Nonlinear A-nal TMA1986，10，65： | 1 |
| 14 | Serum levels of adipocyteacid binding protein are increased in gestational diabetes mellitus显示文摘 | Kralisch S Stepan H Kratzsch i | 2009 | Eur J Endocrinol2009，160，1： | 1 |
| 15 | Using A Double-Pass Solar Drier For Jerky Drying显示文摘 | Jan Banout Iva Kucerova Stepan Marek | 2012 | Energy Procedia2012，，： | 1 |
| 16 | Serum levels of adipocyte fatty acid binding protein are increased in gestafional diabetes mellitus 显示文摘 | Kralisch S Stepan H Kratzsch J | 2009 | Eur J Endocrinol2009，160，1： | 1 |
| 17 | Arch replacement and downstream stent grafting in complex aortic dissection: first results of an international registry ☆显示文摘 | Konstantinos Tsagakis Davide Pacini Roberto Di Bartolomeo Jaroslav Benedik Stepan Cerny Michael Gorlitzer Martin Grabenwoger Carlos A. Mestres Heinz Jakob | 2011 | European Journal of Cardio-Thoracic Surgery2011，，1： | 1 |
| 18 | Predictive value of maternal angiogenic factors in second trimester pregnancies with abnormal uterine perfusion显示文摘 | Stepan H Unversucht A Wessel N | 2007 | Hypertension2007，49，4： | 1 |
| 19 | Micafungin versus fluconazole against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation显示文摘 | van Burik JAH Ratanatharathorn V Stepan DE | 2004 | Clin Infect Dis2004，39，10： | 1 |
| 20 | Delay, Parametric Excitation, and the Nonlinear Dynamics of Cutting Processes 显示文摘 | GABOR STEPAN* TAMAS INSPERGERtand ROBERT SZALAI | 2005 | International Journal of Bifurcation and Chaos2005，15，39： | 1 |
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