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| 1 | 三维CT肾盂成像指导经皮肾造口取石术:结石测量、结石显示及肾盂肾盏系统重建的准确性显示文摘对经皮肾造口取石术(PCNL)前的CT肾盂成像检查进行回顾性研究。对20例肾结石病人应用精心设计的方案进行CT肾盂成像。评分并比较横断位、冠状位最大密度投影(MIP)和容积再现(VR)影像上结石的大小、对比剂排泄的一致性及结石和肾盂肾盏系统重建的准确性。注射对比剂后,横断位像可准确显示结石大小,而在冠状位像上常被低估。增强前后测量结果分别平均为14.7mm:14.4mm(横断位)、17.2mm:16.1mm(冠状位)(P=0.11和0.03)。 | U. Patel R.M. Walkden K.R. Ghani K. Anson 闫喆(译) 李威(校) | 2009 | 国际医学放射学杂志2009，32，4： | 42 |
| 2 | 新加坡最大回用水处理厂污水短程硝化厌氧氨氧化脱氮工艺显示文摘总结了新加坡樟宜回用水处理厂4次采样的结果,该厂日处理城市污水80万t.在好氧区很好地实现了部分硝化和亚硝酸盐积累,其中好氧氨氧化率平均为72.2%,亚硝酸盐积累率平均为76.0%.在缺氧区氨氮和亚硝酸盐得到了同步去除(厌氧氨氧化).物料衡算结果表明:初沉池的出水总氮的37.5%是通过自养脱氮去除,27.1%是通过传统的硝化/反硝化脱氮去除,其余部分总氮则存在于活性污泥和出水中.微生物和动力学研究表明:短悬浮或游离的厌氧氨氧化菌可存在于污泥龄较短的污水处理系统.最后从出水氮质量浓度、pH、碱度、曝气能耗及反应器容积等方面,将樟宜回用水处理厂的分段进水活性污泥法工艺与新加坡其他3个回用水处理厂的MEL/LE工艺进行了对比分析. | Cao Yeshi Kwok Bee Hong Yan Zhou Yu Liu He Jianzhong Chua Seng Chye Wah Yuen Long Yahya Ghani | 2015 | 北京工业大学学报2015，41，10： | 32 |
| 3 | 高发心脏性猝死的3型长QT综合征一家系报道显示文摘目的 采用基因检测和电生理功能分析诊断长QT综合征(LQTS)患者,发现有潜在患病风险的家系成员,以提供临床评估与适当的治疗.方法 采集和分析1例LQTS患儿及所在家系成员的临床资料.同时选择200例具有相同种族背景的健康个体作为正常对照.聚合酶链式反应(PCR)扩增LQTS先证者候选基因KCNQ1、KCNH2和SCN5A外显子及附近上下游序列,直接测序并进行分析.如发现突变,进一步采用全细胞膜片钳技术对该突变进行电生理功能分析,并对其家系成员进行特定突变基因筛查,寻找基因变异及评估其发生心脏性猝死风险.结果 先证者12导联常规心电图初步诊断为LQTS.临床上给予美托洛尔(25 mg、2次/d)治疗,患者服药第3天于午饭时猝死.基因检测发现先证者SCN5A基因上存在一个杂合子错义突变(V411M),在正常对照组该位点未发现基因突变.与野生型相比,V411M突变型钠通道表现为峰值钠电流[(230.8±27.6) pA/pF比(101.2±10.9)pA/pF,n=10,P<0.01]及晚钠电流[(156.6±13.6) pA/pF比(95.9±7.9) pA/pF,n=12,P<0.01]增加.测试脉冲电压在-50 mV时,V411M突变型的钠通道激活数目明显多于野生型(85.0%±7.4%比41.5%±2.6%,P<0.01).V411M突变型稳态激活曲线左移,而稳态失活曲线无明显变化.另外,其他家系成员进行SCN5A基因检测发现,先证者母亲、外祖母为无症状突变携带者,给予适当临床评估及长期随访.先证者的同卵双生姐姐及姨妈死于婴儿猝死综合征.结论 首次在国人LQTS患者SCN5A基因上报道一个杂合子错义突变(V411M).V411 M突变导致钠离子通道蛋白的“功能增强”效应,构成3型LQTS的发病基础.基因检测和电生理功能分析有助于明确LQTS患者及其家系成员的疾病诊断,并提供重要临床评估与治疗,预防心脏性猝死的发生. | 周慧 Li Zhang Ali Raza Ghani 朱文根 周琼琼 申阳 谢金燕 曹青 万蓉 胡金柱 洪葵 | 2015 | 中华心血管病杂志2015，43，12： | 8 |
| 4 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 5 | Maintenance Peginterferon Therapy and Other Factors Associated With Hepatocellular Carcinoma in Patients With Advanced Hepatitis C显示文摘 | Anna S. Lok James E. Everhart Elizabeth C. Wright Adrian M. Di Bisceglie Hae–Young Kim Richard K. Sterling Gregory T. Everson Karen L. Lindsay William M. Lee Herbert L. Bonkovsky Jules L. Dienstag Marc G. Ghany Chihiro Morishima Timothy R. Morgan | 2011 | Gastroenterology2011，，3： | 4 |
| 6 | GENETIC PROGRAMMING TO PREDICT SKI-JUMP BUCKET SPILLWAY SCOUR显示文摘Researchers in the past had noticed that application of Artificial Neural Networks (ANN) in place of conventional statistics on the basis of data mining techniques predicts more accurate results in hydraulic predictions. Mostly these works pertained to applications of ANN. Recently, another tool of soft computing, namely, Genetic Programming (GP) has caught the attention of researchers in civil engineering computing. This article examines the usefulness of the GP based approach to predict the relative scour depth downstream of a common type of ski-jump bucket spillway. Actual field measurements were used to develop the GP model. The GP based estimations were found to be equally and more accurate than the ANN based ones, especially, when the underlying cause-effect relationship became more uncertain to model. | AZAMATHULLA H. MD GHANI A. AB ZAKARIA N. A LAI S. H CHANG C. K LEOW C. S ABUHASAN Z | 2008 | Journal of Hydrodynamics2008，20，4： | 4 |
| 7 | Barrett's esophagus:Prevalence and risk factors in patients with chronic GERD in Upper Egypt显示文摘AIM:To determine the prevalence and possible risk factors of Barrett's esophagus(BE) in patients with chronic gastroesophageal reflux disease(GERD) in El Minya and Assuit, Upper Egypt.METHODS:One thousand consecutive patients with chronic GERD symptoms were included in the study over 2 years.They were subjected to history taking including a questionnaire for GERD symptoms, clinical examination and upper digestive tract endoscopy.Endoscopic signs suggestive of columnar-lined esophagus(CLE) were defined as mucosal tongues or an upward shift of the squamocolumnar junction.BE was diagnosed by pathological examination when specialized intestinal metaplasia was detected histologically in suspected CLE.pH was monitored in 40 patients.RESULTS:BE was present in 7.3% of patients with chronic GERD symptoms, with a mean age of 48.3 ± 8.2 years, which was signif icantly higher than patients with GERD without BE(37.4 ± 13.6 years).Adenocarcinomawas detected in eight cases(0.8%), six of them in BE patients.There was no signiflcant difference between patients with BE and GERD regarding sex, smoking, alcohol consumption or symptoms of GERD.Patients with BE had significantly longer esophageal acid exposure time in the supine position, measured by pH monitoring.CONCLUSION:The prevalence of BE in patients with GERD who were referred for endoscopy was 7.3%.BE seems to be associated with older age and more in patients with nocturnal gastroesophageal reflux. | Yasser M Fouad Madiha M Makhlouf Heba M Tawfik Hussein El Amin Wael Abdel Ghany Hisham R El-khayat | 2009 | World Journal of Gastroenterology2009，15，28： | 4 |
| 8 | Incidence of Hepatocellular Carcinoma and Associated Risk Factors in Hepatitis C-Related Advanced Liver Disease显示文摘 | Anna S. Lok Leonard B. Seeff Timothy R. Morgan Adrian M. di Bisceglie Richard K. Sterling Teresa M. Curto Gregory T. Everson Karen L. Lindsay William M. Lee Herbert L. Bonkovsky Jules L. Dienstag Marc G. Ghany Chihiro Morishima Zachary D. Goodman | 2009 | Gastroenterology2009，，1： | 3 |
| 9 | 碳基固体酸催化剂上无溶剂条件下酮和芳香醛交叉羟醛缩合反应显示文摘Aromatic aldehydes undergo cross-aldol condensation with ketones in the presence of carbon-based solid acid under solvent-free conditions to afford the corresponding α,β-unsaturated aldol products in excellent yields. The catalyst is reusable several times without any decrease in the yield of the reactions. | Abbas ZALI Kamal GHANI Arash SHOKROLAHI Mohammad Hossein KESHAVARZ | 2008 | 催化学报2008，29，7： | 3 |
| 10 | The liver diseases of lipodystrophy: The long-term effect of leptin treatment显示文摘 | Elika Safar Zadeh Andreea O. Lungu Elaine K. Cochran Rebecca J. Brown Marc G. Ghany Theo Heller David E. Kleiner Phillip Gorden | 2013 | Journal of Hepatology2013，，1： | 3 |
| 11 | Drug Targets and Molecular Mechanisms of Drug Resistance in Chronic Hepatitis B显示文摘 | Marc Ghany T. Jake Liang | 2007 | Gastroenterology2007，，4： | 3 |
| 12 | Diagnosis, management, and treatment of hepatitis C: An update显示文摘 | Marc G. Ghany Doris B. Strader David L. Thomas Leonard B. Seeff | 2009 | Hepatology2009，，4： | 3 |
| 13 | Central retinal artery resistive index and optical coherence tomography in assessment of glaucoma progression显示文摘AIM: To assess the relation between central retinal artery(CRA) resistive index(RI) and retinal nerve fiber thickness measured by optical coherence tomography(OCT) in assessment of disease progress in cases of open angle glaucoma.METHODS: Twenty-three patients with diagnosed open angle glaucoma were included in this study. They were examined by colored duplex ultrasonography of CRA with estimation of RI of CRA and ophthalmic artery(OA)with estimation of CRA/OA RI ratio as well as OCT measurement of the average retinal nerve fiber layer(RNFL) thickness in order to assess the disease progress.RESULTS: There was strong inverse relation between the increased RI in CRA as well as the increased CRA/OA RI ratio and the decrease in average RNFL thickness in cases of open angle glaucoma.CONCLUSION: Assessment of CRA RI can indirectly assess the vascular changes associated with glaucoma and can assess the degree of retinal atrophy helping in evaluating prognosis thus guiding the choice of treatment. | Ahmed F.Abdel Ghany Samer M.Botros Tamer M.El-Raggal | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 2 |
| 14 | Stable channel analysis with sediment transport for rivers in Malaysia: A case study of the Muda, Kurau, and Langat rivers显示文摘Assessments of a stable channel were done to evaluate the conditions of three rivers in Malaysia,using an analytical method that modifies the stable channel flowchart developed by Chang(1988)and Ariffin(2004).The analytical approach was selected to calculate the suitable dimensions for a stable channel,using equations that describe the physical relation of sediment transport,flow resistance,and dynamic equilibrium.Measured field data were used as the input data for the stable channel program,which then processed the data until the input discharge was equal to the output discharge.However,this method depends on the accuracy of the sediment transport equation that is used in the stable channel design.Existing equations recommended by the Department of Irrigation and Drainage(DID),Malaysia,were found to be unsuitable because of their low discrepancy ratio(DR)values,which were below 42%.These are the equations of Engelund and Hansen(1967)and Yang(1979),as well as existing local equations from Ariffin(2004)and Sinnakaudan et al.(2006).Therefore,revised equations were developed in the current study to increase the accuracy of the total bed material load equations for use in Malaysian rivers.The newly revised Ariffin(2004)and Sinnakaudan et al.(2006)equations yielded better DRs of 66.34 and 64.49%,respectively.River assessments done on the Kurau River(a small river),the Muda River(a medium-size river),and the Langat River(a large river)show that these rivers have experienced different levels of erosion.Only the Kurau River was found to have minimal erosion and sedimentation levels.Conversely,stable channel assessments for the Muda River and the Langat River revealed that both rivers had experienced severe erosion,due to excessive sand mining.Almost all the cross section sampling points on the Muda River and Langat River were deeper than the suggested stable channel heights. | Mohd Afiq Harun Aminuddin Ab Ghani Reza Mohammadpour NgaiWeng Chan | 2020 | International Journal of Sediment Research2020，35，5： | 2 |
| 15 | The prevalence and risk factors associated with esophageal varices in subjects with hepatitis C and advanced fibrosis <ce:link locator='fx1'/>显示文摘 | Arun J. Sanyal Robert J. Fontana Adrian M. Di Bisceglie James E. Everhart Michael C. Doherty Gregory T. Everson John A. Donovan Peter F. Malet Savant Mehta Muhammad Y. Sheikh Andrea E. Reid Marc G. Ghany David R. Gretch the HALT-C Trial Group | 2006 | Gastrointestinal Endoscopy2006，，6： | 2 |
| 16 | Strengths,weaknesses,opportunities,and threats(SWOT)analysis of supercapacitors:A review显示文摘The development of clean and sustainable energy sources has received widespread interest in the past few decades due to the rolling energy demands while extenuating the rising tiers of greenhouse gases and environmental pollution.Due to their intermittent nature,these green and sustainable sources require appropriate energy storage systems.Amongst different energy storage technologies,electrochemical energy storage devices,particularly supercapacitors(SCs),have fascinated global attention for their utilization in electric vehicles,power supports,portable electronics,and many others application requiring electric energy devices for their operation.Thus,the growth of SCs in the commercial market has squeezed requirements,and further developments are obligatory for their effective industrialization.In the meantime,SCs also face technical complications and contests for their introduction in industrial settings because of their low energy density and high Levelized cost.The present study combines core strengths,weaknesses,opportunities,and threats(SWOT)analysis of SCs with new perspectives and recent ideas.The challenges and the future progressive prospects of SCs are also presented in detail.This review will afford consistent direction and new superhighways for the further development of SCs as standalone and complementary energy storage systems. | Pragati A.Shinde Qaisar Abbas Nilesh R.Chodankar Katsuhiko Ariga Mohammad Ali Abdelkareem Abdul Ghani Olabi | 2023 | Journal of Energy Chemistry2023，，4： | 2 |
| 17 | 5-Aminolevulinic acid alleviates herbicide-induced physiological and ultrastructural changes in Brassica napus显示文摘It is well known that application of 5-aminolevulinic acid(ALA) could promote the plant growth under abiotic stress in oilseed rape(Brassica napus L.). However, the specifics of its physiological and ultrastructural regulation under herbicide stress conditions are poorly understood. In the present study, alleviating role of ALA in B. napus was investigated under four levels of herbicide propyl 4-(2-(4,6-dimethoxypyrimidin-2-yloxy) benzylamino) benzoate(ZJ0273)(0, 100, 200 and 500 mg L–1) with or without 1 mg L–1 ALA treated for 48 or 72 h. Results showed that after 48 h of herbicide stress, the growth of rape seedlings was significantly inhibited with the successive increases of the ZJ0273 concentrations from 0 to 500 mg L–1, but this inhibition was obviously alleviated by exogenous application of ALA. However, when treatment time prolonged to 72 h, the recovery effects of ALA could not be evaluated due to the death of plants treated with the highest concentration of ZJ0273(500 mg L-1). Further, the root oxidizability and activities of antioxidant enzymes(superoxide dismutase, peroxidase and ascorbate peroxidase) were dramatically enhanced by the application of 1 mg L–1 ALA under herbicide stress. Therefore, plants treated with ALA dynamically modulated their antioxidant defenses to reduce reactive oxygen species(ROS) accumulation and malondialdehyde(MDA) content induced by herbicide stress. Additionally, exogenously applied ALA improved the ultrastructure's of chloroplast, mitochondria and nucleus, and induced the production of stress proteins. Our results suggest that ALA could be considered as a potential plant growth regulator for the improvement of herbicide tolerance through alleviation of the physiological and ultrastructural changes induced by the herbicide in crop production. | XU Ling Faisal Islam ZHANG Wen-fang Muhammad A Ghani Basharat Ali | 2018 | Journal of Integrative Agriculture2018，17，3： | 2 |
| 18 | Three-dimensional planning of percutaneous renal stone surgery in a horseshoe kidney using 16- slice CT and volume-rendered movies 显示文摘 | Ghani KR Rintoul M Patel U | 2005 | J Endourol2005，19，4： | 1 |
| 19 | Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong显示文摘 | Donnelly C A Ghani A C Leung G M | 2003 | Lancet2003，361，： | 1 |
| 20 | Hot water extractable carbon in soils: A sensitive measurement for determining impacts of fertilization on grazing and cultivation 显示文摘 | Ghani A Dexter M Perrot K W | 2003 | Soil Biology and Biochemistry2003，35，： | 1 |
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