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| 1 | 子宫动脉栓塞术后宫腹腔镜联合治疗瘢痕妊娠的临床研究显示文摘目的探讨子宫动脉栓塞术后宫腹腔镜联合治疗在不同分型剖宫产瘢痕妊娠(CSP)中的临床应用价值。方法回顾性分析2008年1月-2014年10月在该院接受治疗的72例CSP患者的临床资料,其中32例行子宫动脉栓塞术(UAE)为UAE组,40例未行UAE为非UAE组;37例行宫腔镜病灶切除术为宫腔镜组,35例行宫腹腔镜联合病灶切除术为联合组;Ⅰ型瘢痕妊娠43例,Ⅱ型瘢痕妊娠28例,Ⅲ型瘢痕妊娠1例。结果 UAE组术中出血量少于非UAE组(P<0.05),住院时间、血β-h CG及月经恢复时间均短于非UAE组(P<0.05),UAE组术后腹痛及发热等不良反应较多、费用较高(P<0.05);UAE组中Ⅱ型瘢痕妊娠行联合手术者术中出血量少于行宫腔镜手术者(P<0.05),住院时间、血β人绒毛膜促性腺激素(β-h CG)恢复至正常的时间、月经恢复时间短于行宫腔镜手术者(P<0.05)。结论 UAE在治疗CSP方面存在一定优势,UAE后宫腹腔镜联合治疗在Ⅱ型瘢痕妊娠治疗中具有创伤小、康复快的优点,值得推广。 | 韩丽萍 胡庆红 Hada Abha 陈岩 | 2016 | 中国妇幼保健2016，31，4： | 43 |
| 2 | 中期妊娠合并卵巢良性肿瘤的腹腔镜手术治疗显示文摘目的探讨腹腔镜手术治疗中期妊娠合并卵巢良性肿瘤的安全性与可行性。方法回顾性分析郑州大学第一附属医院行手术治疗的27例中期妊娠(13~28周)合并卵巢良性肿瘤患者的临床资料(腹腔镜手术13例,开腹手术14例)。结果腹腔镜手术组出血量少于开腹手术组[(16±6)ml vs(39±25)ml,P=0.004],切口疼痛评分、术后肛门排气时间、住院时间及术后盆腔粘连发生率均小于开腹手术组(P〈0.05),两组患者新生儿体重及Apgar评分未见明显差异(P〉0.05)。结论腹腔镜手术治疗中期妊娠合并卵巢良性肿瘤安全可行。 | 韩丽萍 陈岩岩 张会敏 余海洋 Hada Abha | 2016 | 中国妇产科临床杂志2016，17，1： | 14 |
| 3 | Aluminum potassium sulfate and tannic acid sclerotherapy for Goligher Grades Ⅱ and Ⅲ hemorrhoids: Results from a multicenter study显示文摘AIM: To show that aluminum potassium sulfate and tannic acid(ALTA) sclerotherapy has a high success rate for Grade Ⅱ and Ⅲ hemorrhoids.METHODS: This study was based on the clinical data of 604 patients with hemorrhoids who underwent ALTA sclerotherapy between January 2009 and February 2015. The objective of this study was to assess the efficacy of this treatment for Grades Ⅱ and Ⅲ hemorrhoids. Preoperative and postoperative symptoms, complications and success rate were all assessed retrospectively. Follow-up consisted of a simple questionnaire, physical examination and an anoscopy. Patients were followed-up at one day, one week, two weeks, one month, one year, two years, three years, four years and five years after the ALTA sclerotherapy.RESULTS: One hundred and sixty-nine patients were diagnosed with Grade Ⅱ hemorrhoids and 435 patients were diagnosed with Grade Ⅲ hemorrhoids. The one year, three year and five year cumulative success rates of ALTA sclerotherapy for Grades Ⅱ and Ⅲ hemo-rrhoids were 95.9% and 93.1%; 89.3% and 83.7%; and 89.3% and 78.2%, respectively. No significant differences were observed in the cumulative success rates after ALTA sclerotherapy between Grades Ⅱ and Ⅲ hemorrhoids(P = 0.09). There were forty-seven post-operative complications(low grade fever; anal pain; urinary retention; rectal ulcer; and others). No serious or life-threatening complications occurred and all cases improved through conservative treatment. At univariate analysis there were no predictive factors of failure.CONCLUSION: ALTA sclerotherapy has had a high success rate for Grade Ⅱ and Ⅲ hemorrhoids during five years of post-operative treatment. However, additional studies are needed to evaluate the efficacy of this ALTA sclerotherapy in the management of hemorrhoidal disease. | Hidenori Miyamoto Takenori Hada Gentaro Ishiyama Yoshito Ono Hideo Watanabe | 2016 | World Journal of Hepatology2016，8，20： | 10 |
| 4 | Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer显示文摘AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk factors.METHODS:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively.Using clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining analysis.RESULTS:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis.In preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent factors.According to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk groups.CONCLUSION:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively.Among these factors,LI was the most significantly correlated factor. | Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh Yoichi Yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，9： | 8 |
| 5 | Trabeculectomy with Ex-PRESS implant versus Ahmed glaucoma valve implantation-a comparative study显示文摘AIM:To compare the surgical outcomes of trabeculectomy with Ex-PRESS implant and Ahmed glaucoma valve(AGV) implantation. METHODS: Patients who underwent trabeculectomy with Ex-PRESS implants or AGV implantation separately were included in this retrospective chart review.Main outcome measures were surgical failure and complications.Failure was defined as intraocular pressure(IOP) >21 mm Hg or <5 mm Hg on two consecutive visits after 3mo,reoperation for glaucoma,or loss of light perception.Eyes that had not failed were considered as complete success if they did not required supplemental medical therapy.RESULTS: A total of 64 eyes from 57 patients were included: 31 eyes in the Ex-PRESS group and 33 eyes in the AGV group.The mean follow-up time was 2.6 ±1.1y and 3.3±1.6y,respectively.Patients in the AGV group had significantly higher baseline mean IOP(P =0.005),lower baseline mean visual acuity(VA)(P =0.02),and higher proportion of patients with history of previous trabeculectomy(P <0.0001).Crude failure rates were 16.1%,n =5/31 in the Ex-PRESS group and 24.2%,n =8/33 in the AGV group.The cumulative proportion of failure was similar between the groups,P =0.696.The proportion of eyes that experienced postoperative complications was32.3% in the Ex-PRESS group and 60.1% in the AGV group(P =0.0229).CONCLUSION: Trabeculectomy with Ex-PRESS implant and AGV implantation had comparable failure rates.The AGV group had more post-operative complications,but also included more complex cases with higher baselinemean IOP,worse baseline mean VA,and more previous glaucoma surgeries.Therefore,the results are limited to the cohort included in this study. | Michael Waisbourd Naomi Fischer Hadas Shalev Oriel Spierer Elad Ben Artsi Rony Rachmiel Gabi Shemesh Shimon Kurtz | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 6 |
| 6 | MRI图像体视学参数对脑膜瘤良恶性的鉴别诊断显示文摘目的探讨脑膜瘤MRI图像体视学参数与其良恶性之间的关系,以寻找一种临床鉴别脑膜瘤良恶性的方法。方法收集2014年5月~2018年9月我院收治的182例脑膜瘤患者的MRI图像和病理学资料,其中男性39例,女性143例,利用体视学方法测量肿瘤体积(V)及肿瘤表面积密度(Sv)。结果所有患者中,良性组共148例,平均体积36.51 cm3,平均表面积密度4.83;恶性组共34例,平均体积49.09 cm3,平均表面积密度7.06。良恶性组脑膜瘤体积比较,差异无统计学意义(P>0.05);恶性组脑膜瘤表面积密度高于良性组,差异有统计学意义(P<0.05)。恶性组Sv≥6.1827例(27/34);良性组Sv≤5.60127例(127/148)。结论MRI图像体视学方法测定脑膜瘤表面积密度可行,脑膜瘤表面积密度与病理级别有关,Sv≥6.18和Sv≤5.60可以作为鉴别脑膜瘤良恶性的指标。 | 蒋雨锋 胡跃宣 唐青青 Sushant S Hada 马勋泰 | 2020 | 西部医学2020，32，4： | 5 |
| 7 | Alternative Transcription Initiation and the AUG Context Configuration Control Dual-Organellar Targeting and Functional Competence of Arabidopsis Lon 1 Protease显示文摘细胞的动态平衡包括女伴和朊酶依靠蛋白质质量控制的部件。在细菌和 eukaryoticorganelles, Lon 朊酶在移开不能挽回地损坏的蛋白质并且从而阻止 accumulationof 起一个关键作用有害降级抵抗的总数。基因表示,实时房间的成像, immunobiochemical,和功能的 complementationapproaches 为对叶绿体和线粒体双指向的 Lon1 提供最后的证据。Dual-organellar depositionof Lon1 isoforms 经由漏的核糖体 scanningfrom 取决于 transcriptional 规定和其他的翻译开始从最佳 Kozak 一致广泛地背离的第一 8 月顺序上下文。在 Arabidopsis lon1-1 异种的部分互补的细胞器特定的 Lon1 targetingresults,而完整的互补被指向的 dual-organellar 完全完成。两最佳并且 non-optimalAUG 顺序上下文在酵母是功能的并且便于漏的核糖体扫描当 mitochondrial presequence 被使用时,补充 pim1 显型。生物信息的搜索与 Lon1 类型双指向的顺序组织识别了一小部分 Arabidopsis 基因。Lon4, Lon1 的 paralog,模糊 presequence 多半从祖先的象 Lon1 一样基因的成双的 presequences 演变,产生单个双目标的蛋白质 isoform。我们要求那 Lon1 和它的 subfunctional paralog Lon4 发展了 transcriptional 和 posttranscriptional 的互补子集对为 dual-organellar targeting.Key 词的 environmentalcues 应答的规章的部件: | Gerasimos Daras Stamatis Rigas Dikran Tsitsekian Hadas Zur Tamir Tuller Polydefkis Hatzopoulos | 2014 | Molecular Plant2014，7，6： | 4 |
| 8 | Notch signaling regulates expression of Mcl-1 andapoptosis in PPD-treated macrophages显示文摘巨噬细胞是为由细菌和病毒的感染的细胞的目标。感染的巨噬细胞的命运在决定主人免疫者反应的结果起一个关键作用。巨噬细胞的 Apoptotic 房间死亡被认为是消除病原体的保护的主人防卫并且感染房间。在这研究,我们调查了槽口在在与结核菌素对待的巨噬细胞调整 apoptosis 发信号的参与净化的蛋白质衍生物(PPD ) 。导出髓的巨噬细胞(BMM ) 与 PPD 对待或与 Mycobacterium bovis 杆菌 Calmette-Gué 感染了的鼠科的骨头; rin (BCG ) 导致了 Notch1 的 upregulation。这 upregulation 在 transcriptional 和翻译层次两个都与 anti-apoptotic 基因 mcl-1 的 upregulation 相关很好。Notch1 和 Mcl-1 的减少的层次在当一个 gamma secretase 禁止者(GSI ) 禁止处理槽口受体,被使用时,与 PPD 对待的 BMM 被观察。而且,在像巨噬细胞的房间线 RAW264.7 的 silencing Notch1 减少了 Mcl-1 蛋白质表示,建议那 Notch1 为在巨噬细胞的 Mcl-1 表示是批评的。apoptotic 房间的重要增加与车辆控制相比面对 GSI 与 PPD 在 BMM 的处理之上被观察对待的房间。最后,在人和老鼠的 mcl-1 倡导者的分析揭示了保存潜在的 CSL/RBP-Jκ有约束力的地点。与 mcl-1 倡导者一起的 Notch1 的协会被染色质 immunoprecipitation 证实。一起拿,这些结果显示 Notch1 禁止直接控制 mcl-1 倡导者与 PPD 刺激的巨噬细胞的 apoptosis。 | Tanapat P alaga Siriluk Ratanabunyong Thitiporn Pattarakankul Naunpun Sangphech Wipawee Wongchana Yukihiro Hadae Patipark Kueanjinda | 2013 | Cellular & Molecular Immunology2013，10，5： | 4 |
| 9 | 血栓药物对局部麻醉腹股沟疝无张力修补患者的影响显示文摘目的探讨围手术期不停用口服抗血栓药物的腹股沟疝患者行局部麻醉下无张力修补术的临床安全性。方法采用前瞻性队列研究的方法,连续入组2018年9月至2020年3月四川大学华西医院胃肠外科收治的术前长期口服抗血小板药或抗凝药的腹股沟疝患者作为试验组,选取同一时期入院的年龄、性别、身体质量指数(BMI)、腹股沟疝Rutkow分型与试验组相匹配的未服用抗血栓药物的腹股沟疝患者作为对照组。试验组围手术期不停用抗血栓药物治疗,2组患者由同一主刀医生行局部浸润麻醉下无张力疝修补术。对2组患者的手术情况、住院天数和术后30 d内患者切口并发症、出血性及血栓栓塞性并发症发生率进行比较。使用t检验或Mann-Whitney U-检验,卡方检验或Fisher精确检验对结果进行统计分析。结果共纳入148例患者,其中试验组74例(口服华法林14例、口服新型口服抗凝药3例,口服阿司匹林36例口服氯吡格雷13例、口服替格瑞洛1例、联合口服阿司匹林与氯吡格雷7例),对照组74例。试验组与对照组相比年龄、性别、BMI、腹股沟疝Rutkow分型、手术时间、术中出血、住院天数比较,差异无统计学意义(P>0.05),术前凝血酶原时间、部分活化凝血酶原时间、国际标准化比值试验组较对照组明显延长(P<0.05)。试验组术后1例患者出现术区皮下血肿,无需输血及再次手术治疗,4例出现切口愈合不良,1例出现阴囊水肿。对照组术后3例出现切口愈合不良。均保守治疗后愈合,差异无统计学意义(P>0.05)。所有患者围手术期未发现血栓栓塞事件。结论长期口服抗血栓药物的患者可安全地行局部浸润麻醉下腹股沟疝无张力修补术,不中断抗血栓药物治疗与未服用抗血栓药物的患者相比不会增加术中出血及术后出血性事件的发生风险。 | 张森 Gonish hada 简福顺 谢妍妍 宋应寒 雷文章 | 2020 | 中华疝和腹壁外科杂志(电子版)2020，14，5： | 3 |
| 10 | 体视学方法探索脑膜瘤体积、表面积密度、病理类型与瘤周水肿的关系显示文摘目的探讨脑膜瘤体积、表面积密度、部位、病理类型与瘤周水肿之间的关系。方法收集2013年5月至2018年5月经手术和病理证实为脑膜瘤的212例首发患者的脑膜瘤组织病理切片及影像学资料,运用体视学方法计算出肿瘤瘤体体积、表面积密度、瘤周水肿体积及水肿指数,并分析瘤周水肿特点。结果发生瘤周水肿组脑膜瘤瘤体体积、表面积密度明显大于不发生瘤周水肿组(P<0.05);大脑镰旁、前颅窝、中颅窝及蝶骨嵴部位脑膜瘤瘤周水肿发生率明显高于其他部位脑膜瘤(P<0.05);高级别脑膜瘤瘤周水肿发生率明显高于低级别脑膜瘤(P<0.05)。Logistic回归分析显示:脑膜瘤瘤体体积与瘤周水肿的发生密切相关(P<0.05)。结论脑膜瘤瘤体体积、表面积密度及高、低级别与瘤周水肿的发生密切相关,但以瘤体体积相关性更大。 | 唐青青 Sushant S Hada 马勋泰 | 2020 | 成都医学院学报2020，15，1： | 3 |
| 11 | 脑膜瘤侵袭性的体视学特征分析显示文摘目的描述脑膜瘤体视学特征,分析MRI影像上侵袭性脑膜瘤与非侵袭性脑膜瘤体视学参数是否存在差异。方法在2012年7月至2017年5月于我院MRI增强扫描诊断脑膜瘤的患者影像中,以随机等距抽样的方法抽出126例患者影像,统计分析脑膜瘤患者性别、年龄及肿瘤部位分布;选择其中符合纳入标准的37例磁共振增强扫描影像,其中侵袭性24例(男:女=9:15),非侵袭性13例(男:女=2:11),采用体视学方法测定瘤体体积V(cm^3)、全脑体积V(cm^3),求得瘤体体积分数(%)。结果侵袭性脑膜瘤体积介于(3.210~78.630)cm^3,平均体积为26.2002cm^3,平均体积分数为2.246%;非侵袭性脑膜瘤体积介于(1.206~20.336)cm^3,平均体积为8.3638cm^3,平均体积分数为0.732%;侵袭性与非侵袭性脑膜瘤患者瘤体体积与体积分数差异均有统计学意义。结论侵袭性与非侵袭性脑膜瘤瘤体体积、体积分数均存在统计学差异,可以认为侵袭性脑膜瘤瘤体体积及体积分数均大于非侵袭性脑膜瘤;瘤体体积可作为临床医师判断脑膜瘤是否具有侵袭性的依据之一。 | 胡跃宣 马勋泰 Sushant S Hada | 2019 | 四川医学2019，40，8： | 3 |
| 12 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 13 | 青少年腹股沟疝170例手术治疗疗效分析显示文摘目的分析青少年腹股沟疝的临床特点,探讨合理的修补术式。方法回顾性分析2010年1月至2019年1月在四川大学华西医院接受疝修补术的170例14~18岁腹股沟疝病人的临床资料。分析手术方式、麻醉方法、手术时间、医疗费用、复发和并发症发生情况。结果 170例病人中应用传统缝合法行Bassinni手术者16例,应用网塞修补者11例,应用平片法行Lichtenstein手术者3例,行腹腔镜TAPP者3例,应用腹膜前间隙修补法者137例。3例TAPP术式病人采用全麻,5例病人采用持续硬膜外麻醉,162例病人采用局部浸润麻醉,手术时间(28.5±11.6)min。术后中位住院时间1 d,其中日间手术159例,占93.5%。医疗总费用单侧腹股沟疝(7254.8±236.5)元,双侧腹股沟疝(13261.9±543.8)元。随访率为95%,随访时间5~113个月,无复发病人。1例双侧隐睾病人出现生育障碍,2例病人出现慢性疼痛,余未出现严重并发症。结论青少年腹股沟疝应选择个体化治疗方案。 | 宋应寒 张森 简福顺 Gonish Hada 彭雪峰 雷文章 | 2019 | 中国实用外科杂志2019，39，8： | 3 |
| 14 | Liquid marbles containing petroleum and their properties显示文摘Liquid marbles(non-stick droplets) containing crude petroleum are reported.Liquid marbles were obtained by use of fluorinated decyl polyhedral oligomeric silsequioxane(FD-POSS) powder.Marbles containing crude petroleum remained stable on a broad diversity of solid and liquid supports.The effective surface tension of marbles filled with petroleum was established.The mechanism of friction of the marbles is discussed.Actuation of liquid marbles containing crude petroleum with an electric field is presented. | Edward Bormashenko Roman Pogreb Revital Balter Hadas Aharoni Doron Aurbach Vladimir Strelnikov | 2015 | Petroleum Science2015，12，2： | 2 |
| 15 | Sofosbuvir and Ribavirin for Treatment of Compensated Recurrent Hepatitis C Virus Infection After Liver Transplantation显示文摘 | Michael Charlton Edward Gane Michael P. Manns Robert S. Brown Michael P. Curry Paul Y. Kwo Robert J. Fontana Richard Gilroy Lewis Teperman Andrew J. Muir John G. McHutchison William T. Symonds Diana Brainard Brian Kirby Hadas Dvory-Sobol Jill Denning Sara | 2014 | Gastroenterology2014，，： | 2 |
| 16 | Specifc inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss显示文摘Elevated osteoclast(OC)activity is a major contributor to inflammatory bone loss(IBL)during chronic inflammatory diseases.However,the specific OC precursors(OCPs)responding to inflammatory cues and the underlying mechanisms leading to IBL are poorly understood.We identified two distinct OCP subsets:Ly6C^(hi)CD11b^(hi) inflammatory OCPs(iOCPs)induced during chronic inflammation,and homeostatic Ly6C^(hi)CD11b^(lo)OCPs(hOCPs)which remained unchanged.Functional and proteomic characterization revealed that while iOCPs were rare and displayed low osteoclastogenic potential under normal conditions,they expanded during chronic inflammation and generated OCs with enhanced activity.In contrast,hOCPs were abundant and manifested high osteoclastogenic potential under normal conditions but generated OCs with low activity and were unresponsive to the inflammatory environment.Osteoclasts derived from iOCPs expressed higher levels of resorptive and metabolic proteins than those generated from hOCPs,highlighting that different osteoclast populations are formed by distinct precursors.We further identified the TNF-αand S100A8/A9 proteins as key regulators that control the iOCP response during chronic inflammation.Furthermore,we demonstrated that the response of iOCPs but not that of hOCPs was abrogated in tnf-α^(-/-)mice,in correlation with attenuated IBL.Our findings suggest a central role for iOCPs in IBL induction.iOCPs can serve as potential biomarkers for IBL detection and possibly as new therapeutic targets to combat IBL in a wide range of inflammatory conditions. | Yaron Meirow Milena Jovanovic Yuval Zur Juliana Habib Daniele Filippo Colombo Nira Twaik Hadas Ashkenazi-Preiser Kerem Ben-Meir Ivan Mikula Jr. Or Reuven Guy Kariv Leonor Daniel Saja Baraghithy Yehuda Klein Jeroen Krijgsveld Noam Levaot Michal Baniyash | 2022 | Bone Research2022，10，3： | 2 |
| 17 | Clinical characteristics of progressive nonarteritic anterior ischemic optic neuropathy显示文摘AIM:To study whether patients with progressive nonarteritic anterior ischemic optic neuropathy(NAION)present earlier than patients with stable NAION and to describe their clinical characteristics and visual outcome.METHODS:This was a retrospective chart review.All patients with NAION seen during the acute stage from January 2012 to December 2018 were reviewed.Patients were included if they had documented disc edema and follow up of at least 3 mo.Patients with progressive NAION were identified if they worsened in 2 out of 3 parameters:visual acuity≥3 Snellen lines;Color vision≥4 Ishihara plates;the visual field defect involved a new quadrant.The clinical characteristics,time from symptom onset to presentation,systemic risk factors and visual outcome were compared to patients with stable NAION.RESULTS:Totally 122 NAION cases met the inclusion criteria.Mean age was 58.1 y(range 22-74),70%were men.Twenty cases(16.4%)had progressive NAION.Patients with progressive NAION did not differ from stable NAION in their demographics,systemic risk factors or in their initial visual deficit.At last follow up,median visual acuity was 1.0 log MAR(IQR 0.64-1.55)in patients with progressive NAION,vs 0.18(IQR 0.1-0.63)in stable NAION(P<0.001).Median color vision testing was 0 plates correct(IQR 0-2.5%)vs 92%plates correct(IQR 50%-100%)in the stable NAION group(P<0.001).Patients with progressive NAION differed in the time from symptom onset to presentation(median 2 d vs 5 d,P=0.011).CONCLUSION:We find no identifiable risk factors associated with progressive NAION.Progressors arrive earlier for ophthalmological evaluation. | Omer Y.Bialer Hadas Stiebel-Kalish | 2021 | International Journal of Ophthalmology(English edition)2021，14，4： | 2 |
| 18 | Removal of SO x and NO x over activated carbon fibers显示文摘 | Isao Mochida Yozo Korai Masuaki Shirahama Shizuo Kawano Tomohiro Hada Yorimasa Seo Masaaki Yoshikawa Akinori Yasutake | 2000 | Carbon2000，，2： | 2 |
| 19 | Tumor microRNA-29a expression and the risk of recurrence in stage IIcolon cancer显示文摘 | Alina Weissmann-Brenner Michal Kushnir Gila Lithwick Yanai Ranit Aharonov Hadas Gibori Ofer Purim Yulia Kundel Sara Morgenstern Marissa Halperin Yaron Niv Baruch Brenner | 2012 | International Journal of Oncology2012，，： | 2 |
| 20 | Combination immunotherapy with Survivin and luteinizing hormone-releasing hormone fusion protein in murine breast cancer model显示文摘AIM To investigate the therapeutic potential of two recombinant proteins, Survivin and luteinizing hormone-releasing hormone (LHRH) fusion protein [LHRH(6 leu)-LTB] for immunotherapy of breast cancer.METHODS Murine 4 T-1 breast cancer model was used to evaluate the efficacy of recombinant proteins in vivo. Twenty four Balb/c mice were divided into 4 groups of 6 mice each. Recombinant Survivin and LHRH fusion protein, alone or in combination, were administered along with immunomodulator Mycobacterium indicus pranii (MIP) in Balb/c mice. Unimmunized or control group mice were administered with phosphate buffer saline. Each group was then challenged with syngeneic 4 T-1 cells to induce the growth of breast tumor. Tumor growth was monitored to evaluate the efficacy of immune-response in preventing the growth of cancer cells.RESULTS Preventive immunization with 20 μg recombinant Survivin and MIP was effective in suppressing growth of 4 T-1 mouse model of breast cancer (P = 0.04) but 50 μg dose was ineffective in suppressing tumor growth. However, combination of Survivin and LHRH fusion protein was more effective in suppressing tumor growth (P = 0.02) as well as metastasis in vivo in comparison to LHRH fusion protein as vaccine antigen alone.CONCLUSION Recombinant Survivin and MIP suppress tumor growth significantly. Combining LHRH fusion protein with Survivin and MIP enhances tumor suppressive effects marginally which provides evidence for recombinant Survivin and LHRH fusion protein as candidates for translating the combination cancer immunotherapy approaches. | Himani Garg Rohit Singh Hada Jagdish C Gupta G P Talwar Shweta Dubey | 2018 | World Journal of Clinical Oncology2018，9，8： | 2 |
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