|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cadmium-induced neurotoxicity: still much ado显示文摘Cadmium(Cd) is a highly toxic heavy metal that accumulates in living system and as such is currently one of the most important occupational and environmental pollutants. Cd reaches into the environment by anthropogenic mobilization and it is absorbed from tobacco consumption or ingestion of contaminated substances. Its extremely long biological half-life(approximately 20–30 years in humans) and low rate of excretion from the body cause cadmium storage predominantly in soft tissues(primarily, liver and kidneys) with a diversity of toxic effects such as nephrotoxicity, hepatotoxicity, endocrine and reproductive toxicities. Moreover, a Cd-dependent neurotoxicity has been also related to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, and multiple sclerosis. At the cellular level, Cd affects cell proliferation, differentiation, apoptosis and other cellular activities. Among all these mechanisms, the Cd-dependent interference in DNA repair mechanisms as well as the generation of reactive oxygen species, seem to be the most important causes of its cellular toxicity. Nevertheless, there is still much to find out about its mechanisms of action and ways to reduce health risks. This article gives a brief review of the relevant mechanisms that it would be worth investigating in order to deep inside cadmium toxicity. | Jacopo Junio Valerio Branca Gabriele Morucci Alessandra Pacini | 2018 | Neural Regeneration Research2018，13，11： | 10 |
| 2 | The HEPD particle detector of the CSES satellite mission for investigating seismo-associated perturbations of the Van Allen belts显示文摘CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle environment, for studying the seismo-associated disturbances in the ionosphere-magnetosphere transition zone. The anthropogenic and electromagnetic noise,as well as the natural non-seismic electromagnetic emissions is mainly due to tropospheric activity. In particular, the mission aims to confirming the existence of possible temporal correlations between the occurrence of earthquakes for medium and strong magnitude and the observation in space of electromagnetic perturbations, plasma variations and precipitation of bursts with highenergy charged particles from the inner Van Allen belt. In this framework, the high energy particle detector(HEPD) of the CSES mission has been developed by the Italian LIMADOU Collaboration. HEPD is an advanced detector based on a tower of scintillators and a silicon tracker that provides good energy and angular resolution and a wide angular acceptance, for electrons of 3–100 Me V, protons of 30–200 Me V and light nuclei up to the oxygen. CSES satellite has been launched on February 2^(nd), 2018 from the Jiuquan Satellite Launch Center(China). | AMBROSI Giovanni BARTOCCI Simona BASARA Laurent BATTISTON Roberto BURGER William J. CARFORA Luca CASTELLINI Guido CIPOLLONE Piero CONTI Livio CONTIN Andrea DE DONATO Cinzia DE SANTIS Cristian FOLLEGA Francesco M. GUANDALINI Cristina IONICA Maria IUPPA Roberto LAURENTI Giuliano LAZZIZZERA Ignazio LOLLI Mauro MANEA Christian MARCELLI Laura MASCIANTONIO Giuseppe MERGE Matteo OSTERIA Giuseppe PACINI Lorenzo PALMA Francesco PALMONARI Federico PANICO Beatrice PATRIZII Laura PERFETTO Francesco PICOZZA Piergiorgio POZZATO Michele PUEL Matteo RASHEVSKAYA Irina RICCI Ester RICCI Marco RICCIARINI Sergio Bruno SCOTTI Valentina SOTGIU Alessando SPARVOLI Roberta SPATARO Bruno VITALE Vincenzo | 2018 | Science China(Technological Sciences)2018，61，5： | 6 |
| 3 | Beneficial effect of sulphate-bicarbonate-calcium water on gallstone risk and weight control显示文摘AIM:To investigate the effect of drinking sulphate-bicarbonate-calcium thermal water (TW) on risk factors for atherosclerosis and cholesterol gallstone disease.METHODS:Postmenopausal women with functional dy-spepsia and/or constipation underwent a 12 d cycle of thermal (n=20) or tap (n=20) water controlled drinking.Gallbladder fasting volume at ultrasound,blood vitamin E,oxysterols (7-β-hydroxycholesterol and 7-ketocholesterol),bile acid (BA),triglycerides,total/low density lipoprotein and high density lipoprotein cholesterol were measured at baseline and at the end of the study.Food consumption,stool frequency and body weight were recorded daily.RESULTS:Blood lipids,oxysterols and vitamin E were not affected by either thermal or tap water consumption.Fasting gallbladder volume was significantly (P<0.005) smaller at the end of the study than at baseline in the TW (15.7±1.1 mL vs 20.1±1.7 mL) but not in the tap water group (19.0±1.4 mL vs 19.4±1.5 mL).Total serum BA concentration was significantly (P<0.05) higher at the end of the study than at baseline in the TW (5.83±1.24μmol vs 4.25±1.00μmol) but not in the tap water group (3.41±0.46μmol vs 2.91±0.56μmol).The increased BA concentration after TW consumption was mainly accounted for by glycochenodeoxycholic acid.The number of pasta (P<0.001),meat (P<0.001) and vegetable (P<0.005) portions consumed during the study and of bowel movements per day (P<0.05) were significantly higher in the TW than in the tap water group.Body weight did not change at the end of the study as compared to baseline in both groups.CONCLUSION:Sulphate-bicarbonate-calcium water consumption has a positive effect on lithogenic risk and intestinal transit and allows maintenance of a stable body weight despite a high food intake. | Stefano Ginanni Corradini Flaminia Ferri Michela Mordenti Luigi Iuliano Maria Siciliano Maria Antonella Burza Bruno Sordi Barbara Caciotti Maria Pacini Edoardo Poli Adriano De Santis Aldo Roda Carolina Colliva Patrizia Simoni Adolfo Francesco Attili | 2012 | World Journal of Gastroenterology2012，18，9： | 3 |
| 4 | Successful multidisciplinary clinical approach and molecular characterization by whole transcriptome sequencing of a cardiac myxofibrosarcoma: A case report显示文摘BACKGROUND Cardiac tumors are rare and complex entities.Surgery represents the cornerstone of therapy,while the role of adjuvant treatment remains unclear and,in case of relapse or metastatic disease,the prognosis is very poor.Lack of prospective,randomized clinical trials hinders the generation of high level evidence for the optimal diagnostic workup and multimodal treatment of cardiac sarcomas.Herein,we describe the multidisciplinary clinical management and molecular characterization of a rare case of cardiac myxofibrosarcoma in an elderly woman.CASE SUMMARY A 73-year-old woman presented signs and symptoms of acute left-sided heart failure.Imaging examination revealed a large,left atrial mass.With suspicion of a myxoma,she underwent surgery,and symptoms were promptly relieved.Histology showed a cardiac myxofibrosarcoma,a rare histotype of cardiac sarcoma.Eight months later,disease unfortunately relapsed,and after a multidisciplinary discussion,a chemotherapy with doxorubicin and then gemcitabine was started,achieving partial radiologic and complete metabolic response,which was maintained up to 2 years and is still present.This report is focused on the entire clinical path of our patient from diagnosis to follow-up,through surgery and strategies adopted at relapse.Moreover,due to their rarity,very little is known about the molecular landscape of myxofibrosarcomas.Thus,we also performed and described preliminary genome analysis of the tumor tissue to get further insight on mechanisms involved in tumor growth,and to possibly unveil new clinically actionable targets.CONCLUSION We report a case of cardiac myxofibrosarcoma that achieved a very good prognosis due to an integrated surgical,cardiac and oncologic treatment strategy. | Maristella Saponara Valentina Indio Carmine Pizzi Elena-Daniela Serban Milena Urbini Annalisa Astolfi Pasquale Paolisso Sofia Martin Suarez Margherita Nannini Davide Pacini Valentina Agostini Ornella Leone Valentina Ambrosini Giuseppe Tarantino Stefano Fanti Fabio Niro Francesco Buia Domenico Attinà Maria Abbondanza Pantaleo | 2019 | World Journal of Clinical Cases2019，7，19： | 2 |
| 5 | MINMOD:a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous tolerance test显示文摘 | Bergman RN | 1986 | Comput Methods Programs Biomed1986，23，： | 1 |
| 6 | Insulin resistance as a determinant of platelet activation in obese women显示文摘 | Basili S Pacini G Guagnano MT etal | 2006 | J Am Coll Cardiol2006，48，12： | 1 |
| 7 | Reliability and validity of the Gastrointestinal Symptom Rating Scale(GSRS) and Quality of Life in Re- flux and Dyspepsia (QOLRAD) questionnaire in dyspepsia :a six-country study显示文摘 | Kulich KR Madisch A Pacini F | 2008 | Health Qual Life Outcomes2008，6，： | 1 |
| 8 | Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year 显示文摘 | Ahr6n B Pacini G Foley J E | 2005 | Diabetes Care2005，28，8： | 1 |
| 9 | Identification and purifi- cation of mesodermal progenitor cells from human adult bone marrow 显示文摘 | PETRINI M PACINI S TROMBI L | 2009 | Stem Cells Dev2009，18，6： | 1 |
| 10 | European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium 显示文摘 | Pacini F Schlumberger M Dralle H | 2006 | European Journal of Endocrinology2006，154，6： | 1 |
| 11 | Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up 显示文摘 | Pacini F Castagna MG Brilli L | 2010 | Ann Oncol2010，21，5： | 1 |
| 12 | Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-Ⅳ inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year 显示文摘 | Ahren B Pacini G Foley JE | 2005 | Diabetes Care2005，28，8： | 1 |
| 13 | MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous tolerance test 显示文摘 | Pacini G Bergman RN | 1986 | Comput Methods Programs Biomed1986，23，： | 1 |
| 14 | Pollen hydration status at dis-persal Cytophysiological features and strategies显示文摘 | NepiM Franedii G G Pacini E | 2001 | Protylasnra2001，216，34： | 1 |
| 15 | Rotating Neutron Stars, Pulsars and Supernova Remnants 显示文摘 | PACINI F | 1968 | Nature1968，219，： | 1 |
| 16 | Thyroid microcarcinoma显示文摘 | Pacini F | 2012 | Best Pract Res Clin Endocrinol Metab2012，26，4： | 1 |
| 17 | Increased plasma leptin in gestational diabetes显示文摘 | Kautzky W A Pacini G Tura A | 2001 | Diabetol ogia2001，44，2： | 1 |
| 18 | Post-surgical use of Radioiodine 131I in patients with papillary and follicular thyroid carcinoma and the issue of remnant ablation:a consensus report显示文摘 | Pacini F Schlumberger M Harmer C | 2005 | Eur J Endocrinol2005，153，5： | 1 |
| 19 | Insulin resistance and hyperinsulinemia are already present in patients with incipient renal disease显示文摘 | Fliser D Pacini G Engelleiter R | 1998 | Kidney Int1998，53，5： | 1 |
| 20 | Methods of cerebral protection in surgery of the thoracic aorta 显示文摘 | Pacini D Di Marco L Di Bartolomeo R | 2006 | Expert Rev Card- iovasc Ther2006，4，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员