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| 1 | Pan-enteric dysmotility,impaired quality of life and alexithymia in a large group of patients meeting ROMEⅡ criteria for irritable bowel syndrome显示文摘AIM:Psychological factors, altered motility and sensation disorders of the intestine can be variably associated with irritable bowel syndrome (IBS). Such aspects have not been investigated simultaneously. The aim of this paper was to evaluate gastrointestinal motility and symptoms, psychological spectrum and quality of life in a large group of IBS patients in southern Italy.METHODS: One hundred IBS patients (F:M=73:27, age 48±2 years, mean±SE) fulfilling ROME Ⅱ criteria matched with 100 healthy subjects (F:M=70:30, 45±2 years). Dyspepsia,bowel habit, alexithymia, psycho-affective profile and quality of life were assessed using specific questionnaires. Basally and postprandially, changes in gallbladder volumes and antral areas after liquid meal and orocaecal transit time (OCTT)were measured respectively by ultrasonography and H2-breath test. Appetite, satiety, fullness, nausea, and epigastric pain/discomfort were monitored using visual-analogue scales.RESULTS: Compared with controls, IBS patients had increased dyspepsia (score 12.6±0.7 VS 5.1±0.2, P<0.0001),weekly bowel movements (12.3±0.4 VS 5.5±0.2, P<0.00001, comparable stool shape), alexithymia (score 59.11.1 VS40.5±1.0, P=0.001), poor quality of life and psychoaffective profile. IBS patients had normal gallbladderemptying, but delayed gastric emptying (T50:35.5±1.0 VS 26.1±0.6 min, P=0.00001) and OCTT (163.0±5.4 VS96.6±1.8min, P=0.00001). Fullness, nausea, and epigastric pain/discomfort were greater in IBS than in controls.CONCLUSION: ROME Ⅱ IBS patients have a pan-enteric dysmotility with frequent dyspepsia, associated with psychological morbidity and greatly impaired quality of life.The presence of alexithymia, a stable trait, is a novel finding of potential interest to detect subgroups of IBS patients with different patterns recoveed after therapy. | Piero Portincasa Antonio Moschetta Giuseppe Baldassarre Donato F. Altomare Giuseppe Palasciano | 2003 | World Journal of Gastroenterology2003，9，10： | 23 |
| 2 | Multi-detector CT features of acute intestinal ischemia and their prognostic correlations显示文摘Acute intestinal ischemia is an abdominal emergency occurring in nearly 1% of patients presenting with acute abdomen. The causes can be occlusive or non occlusive. Early diagnosis is important to improve survival rates. In most cases of late or missed diagnosis, the mortality rate from intestinal infarction is very high, with a reported value ranging from 60% to 90%. Multidetector computed tomography(MDCT) is a fundamental imaging technique that must be promptly performed in all patients with suspected bowel ischemia. Thanks to the new dedicated reconstruction program, its diagnostic potential is much improved compared to the past and currently it is superior to that of any other noninvasive technique. The increased spatial and temporal resolution, high-quality multi-planar reconstructions, maximum intensity projections, vessel probe, surface-shaded volume rending and tissue transition projections make MDCT the gold standard for the diagnosis of intestinal ischemia, with reported sensitivity, specificity, positive and negative predictive values of 64%-93%, 92%-100%, 90%-100% and 94%-98%, respectively. MDCT contributes to appropriate treatment planning and provides important prognostic informationthanks to its ability to define the nature and extent of the disease. The purpose of this review is to examine the diagnostic and prognostic role of MDCT in bowel ischemia with special regard to the state of art new reconstruction software. | Marco Moschetta Michele Telegrafo Leonarda Rella Amato Antonio Stabile Ianora Giuseppe Angelelli | 2014 | World Journal of Radiology2014，6，5： | 8 |
| 3 | Primary sclerosing cholangitis: Updates in diagnosis and therapy显示文摘Primary sclerosing cholangitis (PSC) is a chronic cholestatic syndrome of unknown origin mostly found in males, and characterized by diffuse inflammation and fibrosis of both intra- and extra-hepatic bile ducts. So far, PSC is considered as an autoimmune hepatobiliary disease. In most cases the progression of PSC towards liver cirrhosis and liver failure is slow but irreversible, and liver transplantation is currently the only definitive treatment. In recent years,PSC has been an area of active research worldwide with great interest in etiology, pathogenesis, diagnosis, and therapeutic options such as hydrophilic ursodeoxycholic acid and immunosuppressive agent tacrolimus. Recent updates on clinical and therapeutic aspects of PSC are discussed in the present review. | Piero Portincasa Michele Vacca Antonio Moschetta Michele Petruzzelli Giuseppe Palasciano Karel J.van Erpecum Gerard P.van Berge-Henegouwen | 2005 | World Journal of Gastroenterology2005，11，1： | 7 |
| 4 | Pancreatic trauma: The role of computed tomography for guiding therapeutic approach显示文摘AIM: To evaluate the role of computed tomography(CT) for diagnosing traumatic injuries of the pancreas and guiding the therapeutic approach.METHODS: CT exams of 6740 patients admitted to our Emergency Department between May 2005 and January 2013 for abdominal trauma were retrospectively evaluated. Patients were identified through a search of our electronic archive system by using such terms as 'pancreatic injury', 'pancreatic contusion', 'pancreatic laceration', 'peri-pancreatic fluid', 'pancreatic active bleeding'. All CT examinations were performed before and after the intravenous injection of contrast material using a 16-slice multidetector row computed tomography scanner. The data sets were retrospectively analyzed by two radiologists in consensus searching for specific signs of pancreatic injury(parenchymal fracture and laceration, focal or diffuse pancreatic enlargement/edema, pancreatic hematoma, active bleeding, fluid between splenic vein and pancreas) and non-specific signs(inflammatory changes in peri-pancreatic fat and mesentery, fluid surrounding the superior mesentericartery, thickening of the left anterior renal fascia, pancreatic ductal dilatation, acute pseudocyst formation/peri-pancreatic fluid collection, fluid in the anterior and posterior pararenal spaces, fluid in transverse mesocolon and lesser sac, hemorrhage into peri-pancreatic fat, mesocolon and mesentery, extraperitoneal fluid, intraperitoneal fluid).RESULTS: One hundred and thirty-six/Six thousand seven hundred and forty(2%) patients showed CT signs of pancreatic trauma. Eight/one hundred and thirty-six(6%) patients underwent surgical treatment and the pancreatic injures were confirmed in all cases. Only in 6/8 patients treated with surgical approach, pancreatic duct damage was suggested in the radiological reports and surgically confirmed in all cases. In 128/136(94%) patients who underwent non-operative treatment CT images showed pancreatic edema in 97 patients, hematoma in 31 patients, fluid between splenic vein and pancreas in 113 patients. Non-specific CT signs of pancreatic injuries were represented by peri-pancreatic fat stranding and mesentery fluid in 89% of cases, thickening of the left anterior renal fascia in 65%, pancreatic ductal dilatation in 18%, acute pseudocyst/peri-pancreatic fluid collection in 57%, fluid in the pararenal spaces in 45%, fluid in transverse mesocolon and lesser sac in 29%, hemorrhage into peri-pancreatic fat, mesocolon and mesentery in 66%, extraperitoneal fluid in 66%, intra-peritoneal fluid in 41% cases.CONCLUSION: CT represents an accurate tool for diagnosing pancreatic trauma, provides useful information to plan therapeutic approach with a detection rate of 75% for recognizing ductal lesions. | Marco Moschetta Michele Telegrafo Valeria Malagnino Laura Mappa Amato A Stabile Ianora Dario Dabbicco Antonio Margari Giuseppe Angelelli | 2015 | World Journal of Radiology2015，7，11： | 4 |
| 5 | Therapeutic targeting of the mTOR ‐signalling pathway in cancer: benefits and limitations显示文摘 | M Moschetta A Reale C Marasco A Vacca M R Carratù | 2014 | Br J Pharmacol2014，，： | 2 |
| 6 | Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis显示文摘 | Salvatore Modica Michele Petruzzelli Elena Bellafante Stefania Murzilli Lorena Salvatore Nicola Celli Giuseppe Di Tullio Giuseppe Palasciano Tarek Moustafa Emina Halilbasic Michael Trauner Antonio Moschetta | 2012 | Gastroenterology2012，，2： | 2 |
| 7 | 纳米飞行器概念设计显示文摘纳米飞行器(NAV)指尺寸7.5cm以内、携带载荷2g以上、具有悬停和低速前飞等多种飞行模式的新概念可控无人飞行器,是无人飞行器系统的重要组成部分,可在狭窄空间中探测、侦察、数据中继和释放载荷,具有重要的军事和民用价值.本文阐述了NAV的设计要求、概念研究的最新进展.同时就设计中关键理论和技术进行了评述,主要为:NAV外形选择方法的提出;极低雷诺数空气动力学机理、极低雷诺数下旋翼外形和扑翼外形流场特征的分析;当前极低雷诺数研究方法和研究现状、新材料在NAV设计中应用前景及微推进技术和微电子技术研究进展的综述. | 刘振 徐敏 Jean-Marc Moschetta 杨士斌 | 2010 | 科学通报2010，55，34： | 2 |
| 8 | Gallstone disease: Symptoms and diagnosis of gallbladder stones显示文摘 | Portincasa P Moschetta A Petruzzelli M | 2006 | Best Pract Res Clin Gastroenterol2006，20，6： | 1 |
| 9 | Cholesterol gallstone disease显示文摘 | Portincasa P Moschetta A Palasciano G | 2006 | Lancet2006，368，9531： | 1 |
| 10 | Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis显示文摘 | Inagaki T Choi M Moschetta A | 2005 | Cell Metab2005，2，4： | 1 |
| 11 | Diffuse 3JI lung uptake in bronchiectasis:a potential pitfall in the follow-up of differentiated thyroid carcinoma显示文摘 | Triggiani V Moschetta M Giagulli VA | 2012 | Thyroid2012，22，12： | 1 |
| 12 | Bile acids lower triglyceride levels via a pathway involving FXR,SHP,and SREBP-1c显示文摘 | Watanabe M Houten SM Wang L Moschetta A Mangelsdorf D J Heyman RA | | 0，，： | 1 |
| 13 | Aerodynamic design of micro air vehicles for vertical flight显示文摘 | SHKARAYEV S MOSCHETTA J M BATAILLE B | 2008 | Journal of Aircraft2008，45，5： | 1 |
| 14 | Regulation oi antibacterial defense in the small intestine by the nuclear bile acid receptor显示文摘 | Inagaki T Moschetta A Lee Y K Peng LZhao G Downes M | 2006 | Proc Natl Acad Sci USA2006，103，： | 1 |
| 15 | Cholesterol ga- llstone disease显示文摘 | Portincasa P Moschetta A Palasciano G | 2006 | Lancet2006，368，9531： | 1 |
| 16 | Pathobiology of cholesterol gallstone disease: from equilibrium ternary phase diagram to agents preventing cholesterol crystallization and stone formation 显示文摘 | Portincasa P Moschetta A Calamita G | 2003 | Curr Drug Targets lmnnme Endocr Metabol Disord2003，3，1： | 1 |
| 17 | Cholesterol gallstone disease 显示文摘 | Portincasa P Moschetta A Palasciano G | 2006 | Lancet2006，368，9531： | 1 |
| 18 | The effect of acute oral erythromycin on gallbladder motility and on upper gastrointestinal symptoms in gastrectomized patients with and without gallstones:a randomized,placebo-controlled ultrasonographic study显示文摘 | Portincasa P Altomare DF Moschetta A | 2000 | Am J Gastroenterol2000，95，12： | 1 |
| 19 | Atherosclerosis: lessons from LXR and the intestine 显示文摘 | Bonamassa B Moschetta A | 2012 | Trends Endocrinol Metab2012，24，3： | 1 |
| 20 | Cholesterol gallstone disease显示文摘 | Portincasa P Moschetta A Palasciano G | 2006 | Lancet2006，368，9531： | 1 |
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