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| 1 | Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on peritoneal inflammation and angiogenesis显示文摘 | Zhen Zhang Na Jiang Zhaohui Ni | 2017 | Frontiers of Medicine2017，11，3： | 14 |
| 2 | Risk factors and pain status due to diabetic neuropathy in chronic long-term diabetic patients in a Chinese urban population显示文摘 | JI Na ZHANG Nan REN Zhan-jie JIA Ke-bao WANG Li NI Jia-xiang MA Jun | 2012 | Chinese Medical Journal2012，，23： | 10 |
| 3 | High entropy rare earth hexaborides/tetraborides(HE REB_(6)/HE REB_(4)) composite powders with enhanced electromagnetic wave absorption performance显示文摘The increasing electromagnetic hazards including electromagnetic interference and electromagnetic pollution,which were stemmed from massive usage of electromagnetic technology,have triggered widespread concerns.To cope with this challenge,electromagnetic wave absorbing materials with high performance are greatly needed.Composite construction has been widely applied in electromagnetic(EM)wave absorbing materials to achieve high permittivity,high permeability and impedance matching.However,high-temperature stability,oxidation and corrosion resistance are still unignorable issues.Herein,high entropy hexaborides/tetraborides(HE REB_(6)/HE REB_(4))composites with synergistic dielectric and magnetic losses were designed and successfully synthesized through a one-step boron carbide reduction method.The five as-prepared(Y_(0.2) Nd_(0.2) Sm_(0.2) Eu_(0.2) Er_(0.2))B_(6)/(Y_(0.2) Nd_(0.2) Sm_(0.2) Eu_(0.2) Er_(0.2))B_(4),(Y_(0.2) Nd_(0.2) Sm_(0.2) Er_(0.2) Yb_(0.2))B_(6)/(Y_(0.2) Nd_(0.2) Sm_(0.2) Er_(0.2) Yb_(0.2))B_(4),(Y_(0.2) Nd_(0.2) Eu_(0.2) Er_(0.2) Yb_(0.2))B_(6)/(Y_(0.2) Nd_(0.2) Eu_(0.2) Er_(0.2) Yb_(0.2))B_(4),(Nd_(0.2) Sm_(0.2) Eu_(0.2) Er_(0.2) Yb_(0.2))B_(6)/(Nd_(0.2) Sm_(0.2) Eu_(0.2) Er_(0.2) Yb_(0.2))B_(4) and(Y_(0.2) Sm_(0.2) Eu_(0.2) Er_(0.2) Yb_(0.2))B_(6)/(Y_(0.2) Sm_(0.2) Eu_(0.2) Er_(0.2) Yb_(0.2))B_(4) contain two phases of HE REB_(6) and HE REB_(4).Among them(Y_(0.2) Nd_(0.2) Sm_(0.2) Eu_(0.2) Er_(0.2))B_(6)/(Y_(0.2) Nd_(0.2) Sm_(0.2) Eu_(0.2) Er_(0.2))B_(4)(HE REB_(6)/HE REB_(4)-1)and(Y_(0.2) Nd_(0.2) Sm_(0.2) Er_(0.2) Yb_(0.2))B_(6)/(Y_(0.2) Nd_(0.2) Sm_(0.2) Er_(0.2) Yb_(0.2))B_(4)(HE REB_(6)/HE REB_(4)-2)exhibit excellent EM wave absorption properties.The optimal minimum reflection loss(RL_(m in))and effective absorption bandwidth(E_(AB))of HE REB_(6)/HE REB_(4)-1 and HE REB_(6)/HE REB_(4)-2 are–53.3 dB(at 1.7 mm),4.2 GHz(at 1.5 mm)and–43.5 dB(1.3 mm),4.2 GHz(1.5 mm),respectively.The combination of conducting HE REB_(4) with magnetism into HE REB_(6) as a second phase enhances dielectric and magnetic losses,which lead to enhanced EM wave absorption performance.Considering superior high-temperature stability,oxidation and corrosion resistance of HE REB_(6) and HE REB_(4),HE REB_(6)/HE REB_(4) composite ceramics are promising as a new type of high-performance EM wave absorbing materials. | Weiming Zhang Biao Zhao Na Ni Huimin Xiang Fu-Zhi Dai Shijiang Wu Yanchun Zhou | 2021 | Journal of Materials Science & Technology2021，，28： | 9 |
| 4 | Biodegradation of pendimethalin by Bacillus subtilis Y3显示文摘A bacterium strain Y3,capable of efficiently degrading pendimethalin,was isolated from activated sludge and identified as Bacillus subtilis according to its phenotypic features and 16 S rRNA phylogenetic analysis.This strain could grow on pendimethalin as a sole carbon source and degrade 99.5%of 100 mg/L pendimethalin within 2.5 days in batch liquid culture,demonstrating a greater efficiency than any other reported strains.Three metabolic products,6-aminopendimethalin,5-amino-2-methyl-3-nitroso-4-(pentan-3-ylamino) benzoic acid,and 8-amino-2-ethyl-5-(hydroxymethyl)-1,2-dihydroquinoxaline-6-carboxylic acid,were identified by HPLC-MS/MS,and a new microbial degradation pathway was proposed.A nitroreductase catalyzing nitroreduction of pendimethalin to 6-aminopendimethalin was detected in the cell lysate of strain Y3.The cofactor was nicotinamide adenine dinucleotide phosphate(NADPH) or more preferably nicotinamide adenine dinucleotide(NADH).The optimal temperature and pH for the nitroreductase were 30℃ and 7.5,respectively.Hg^(2+),Ni^(2+),Pb^(2+),Co^(2+),Mn^(2+) Cu^(2+),Ag^+,and EDTA severely inhibited the nitroreductase activity,whereas Fe^(2+),Mg^(2+),and Ca^(2+) enhanced it.This study provides an efficient pendimethalin-degrading microorganism and broadens the knowledge of the microbial degradation pathway of pendimethalin. | Haiyan Ni Li Yao Na Li Qin Cao Chen Dai Jun Zhang Qin He Jian He | 2016 | Journal of Environmental Sciences2016，28，3： | 7 |
| 5 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 6 | Stress field modeling of northwestern South China Sea since 5.3 Ma and its tectonic significance显示文摘Tectonically,the northwestern South China Sea(SCS)is located at the junction between three micro-plates,i.e.,the Indochina,South China and Zhongsha-Xisha micro-plates,and involves three basins,i.e.,the Yinggehai Basin,the Qiongdongnan Basin and Xisha Trough in the east,and the Zhongjiannan Basin in the south.Since the Pliocene(5.3 Ma),the Yinggehai Basin has experienced repeated accelerating subsidence,high thermal fluid,and widely developing mud-rich overpressure chambers,abundant mud diapers and crust-mantle mixed CO2.While a large central canyon was developed in the Qiongdongnan Basin,new rift occurred in the Xisha Trough.These characteristics demonstrate a single tectonic unit for the northwestern SCS,for which we have undertaken stress field modeling to understand its plate deformations and sedimentary responses.Our results demonstrate that an extension tectonic event occurred after 5.3 Ma in the Yinggehai-Qiongdongnan-Xisha trough area,which is characterized by thinner crust(<16 000 m),half-graben or graben structural style and thicker sedimentary sequences(>3 500 m).A new rift system subsequently was developed in this area;this event was mainly driven by the combined effects of different movement velocity and direction of the three micro-plates,and the far-field effect of the continental collision between the Indian Plate and the Tibetan Plateau,and subduction of the Pacific Plate underneath the Eurasian Plate. | YANG Fengli ZHOU Zuyi ZHANG Na LIU Ning NI Bin | 2013 | Acta Oceanologica Sinica2013，32，12： | 5 |
| 7 | β-Arrestin 2 mediates arginine vasopressin-induced IL-6 induction via the ERK1/2-NF-κB signal pathway in murine hearts显示文摘Evidence to date suggests thatβ-arrestins act beyond their role as adapter proteins.Arginine vasopressin(AVP)may be a factor in inflammation and fibrosis in the pathogenesis of heart failure.In the present study we investigated the effect of AVP on inflammatory cytokine IL-6 production in murine hearts and the impact ofβ-arrestin 2-dependent signaling on AVP-induced IL-6 production.We found that administration of AVP(0.5 U/kg,iv)markedly increased the levels of IL-6 mRNA in rat hearts with the maximum level occurred at 6 h.Inβ-arrestin 2 KO mouse hearts,deletion ofβ-arrestin 2 decreased AVP-induced IL-6 mRNA expression.We then performed in vitro experiments in adult rat cardiac fibroblasts(ARCFs).We found that AVP(10?9–10?6 M)dose-dependently increased the expression of IL-6 mRNA and protein,activation of NF-κB signaling and ERK1/2 phosphorylation,whereas knockdown ofβ-arrestin 2 blocked AVP-induced IL-6 increase,NF-κB activation and ERK1/2 phosphorylation.Pharmacological blockade of ERK1/2 using PD98059 diminished AVP-induced NF-κB activation and IL-6 production.The selective V1A receptor antagonist SR49059 effectively blocked AVP-induced NF-κB phosphorylation and activation as well as IL-6 expression in ARCFs.In AVP-treated mice,pre-injection of SR49059(2 mg/kg,iv)abolished AVP-induced NF-κB activation and IL-6 production in hearts.The above results suggest that AVP induces IL-6 induction in murine hearts via the V1A receptor-mediatedβ-arrestin2/ERK1/2/NF-κB pathway,thus reveal a novel mechanism of myocardial inflammation in heart failure involving the V1A/β-arrestin 2/ERK1/2/NF-κB signaling pathway. | Shu-zhen Sun Hong Cao Na Yao Ling-ling Zhao Xiao-fang Zhu Er-an Ni Qi Zhu Wei-zhong Zhu | 2020 | Acta Pharmacologica Sinica2020，41，2： | 5 |
| 8 | The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wires in vitro and in vivo显示文摘Titanium and its alloy are commonly used as surgical staples in the reconstruction of intestinal tract and stomach,however they cannot be absorbed in human body,which may cause a series of complications to influence further diagnosis.Magnesium and its alloy have great potential as surgical staples,because they can be degraded in human body and have good mechanical properties and biocompatibility.In this study,Mg-2Zn-0.5Nd(ZN20)alloy fine wires showed great potential as surgical staples.The ultimate tensile strength and elongation of ZN20 alloy fine wires were 248 MPa and 13%,respectively,which could be benefit for the deformation of the surgical staples from U-shape to B-shape.The bursting pressure of the wire was about 40 kPa,implying that it can supply sufficient mechanical support after anastomosis.Biochemical test and histological analysis illustrated good biocompatibility and biological safety of ZN20 alloy fine wire.The residual tensile stress formed on the outside of ZN20 fine wire during drawing would accelerate the corrosion.The second phase had a negative influence on corrosion property due to galvanic corrosion.The corrosion rate in vitro was faster than that in vivo due to the capsule formed on the surface of ZN20 alloy fine wire. | Ming Gao Di Na Xiangqiao Ni Lihui Song Iniobong PEtim Ke Yang Lili Tan Zheng Ma | 2021 | Bioactive Materials2021，6，1： | 4 |
| 9 | Original article Efficacy and safety of Changfu peritoneal dialysis solution: a multi-center prospective randomized controlled trial显示文摘 | ZHOU Jian-hui NI Zhao-hui MEI Chang-lin YU Xue-qing LIU Fu-you MIAO Li-ning LIU Zhi-hong YUAN Wei-jie ZHANG Ai-ping LIN Hong-li CHEN Meng-hua CHEN Jiang-hua ZHANG Jin-yuan HE Ya-ni CHEN Jian ZHAO Jiu-yang DING Xiao-qiang LI Ying LI Rong-shan XIE Ru-juan LIU Wen-hu XING Chang-ying WANG Rong DENG Yue-yi CAO Xue-ying CAI Guang-yan MOU Shan MAO Zhi-guo YANG Xiao LIU Hong SUN Jing YU Yu-sheng LIU Jun SHI Shu-mei LI Long-kai TIAN Na ZHANG Xiao-hui ZHOU Wei YANG Jie ZHANG Yong SUN Jing-di JI Jun ZHANG Tao YAN Yan LIU Xiao-gang WANG Gang ZHANG Li ZHANG Hong LUO Jian-hua CHEN Xiang-mei | 2013 | Chinese Medical Journal2013，，22： | 4 |
| 10 | Enabling highly efficient and broadband electromagnetic wave absorption by tuning impedance match in high-entropy transition metal diborides (HETMB_(2))显示文摘The advance in communication technology has triggered worldwide concern on electromagnetic wave pollution.To cope with this challenge,exploring high-performance electromagnetic(EM)wave absorbing materials with dielectric and magnetic losses coupling is urgently required.Of the EM wave absorbers,transition metal diborides(TMB2)possess excellent dielectric loss capability.However,akin to other single dielectric materials,poor impedance match leads to inferior performance.High-entropy engineering is expected to be effective in tailoring the balance between dielectric and magnetic losses through compositional design.Herein,three HE TMB2 powders with nominal equimolar TM including HE TMB2-I(TM=Zr,Hf,Nb,Ta),HE TMB2-2(TM=Ti,Zr,Hf,Nb,Ta),and HE TMB2-3(TM=Cr,Zr,Hf,Nb,Ta)have been designed and prepared by one-step boro/carbothermal reduction.As a result of synergistic effects of strong attenuation capability and impedance match,HE TMB2-1 shows much improved performance with the optimal minimum reflection loss(RL_(min))of-59.6 dB(8.48 GHz,2.68 mm)and effective absorption bandwidth(EAB)of 7.6 GHz(2.3 mm).Most impressively,incorporating Cr in HE TMB2-3 greatly improves the impedance match over 1-18 GHz,thus achieving the RLmin of-56.2 dB(8.48 GHz,2.63 mm)and the EAB of 11.0 GHz(2.2 mm),which is superior to most other EM wave absorbing materials.This work reveals that constructing high-entropy compounds,especially by incorporating magnetic elements,is effectual in tailoring the impedance match for highly conductive compounds,i.e.,tuning electrical conductivity and boosting magnetic loss to realize highly efficient and broadband EM wave absorption with dielectric and magnetic coupling in single-phase materials. | Weiming ZHANG Fu-Zhi DAI Huimin XIANG Biao ZHAO Xiaohui WANG Na NI Rajamallu KARRE Shijiang WU Yanchun ZHOU | 2021 | Journal of Advanced Ceramics2021，10，6： | 4 |
| 11 | Notch signaling:Its essential roles in bone and craniofacial development显示文摘Notch is a cellecell signaling pathway that is involved in a host of activities including development,oncogenesis,skeletal homeostasis,and much more.More specifically,recent research has demonstrated the importance of Notch signaling in osteogenic differentiation,bone healing,and in the development of the skeleton.The craniofacial skeleton is complex and understanding its development has remained an important focus in biology.In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton,skull,and face develop.We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system,and what importance it may play in the future. | Mikhail Pakvasa Pranav Haravu Michael Boachie-Mensah Alonzo Jones Elam Coalson Junyi Liao Zongyue Zeng Di Wu Kevin Qin Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Yongtao Zhang Changchun Niu Meng Wu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Michael J.Lee Jennifer Moriatis Wolf Aravind Athiviraham Sherwin S.Ho Tong-Chuan He Kelly Hynes Jason Strelzow Mostafa El Dafrawy Russell R.Reid | 2021 | Genes & Diseases2021，8，1： | 4 |
| 12 | Genetic Characteristics of 2009 Pandemic H1N1 Influenza A Viruses Isolated from China's Mainland显示文摘A total of 100 H1N1 flu real-time-PCR positive throat swabs collected from fever patients in Zhejiang, Hubei and Guangdong between June and November 2009, were provided by local CDC laboratories. After MDCK cell culture, 57 Influenza A Pandemic (H1N1) viruses were isolated and submitted for whole genome sequencing. A total of 39 HA sequences, 52 NA sequences, 36 PB2 sequences, 31 PB1 sequences, 40 PA sequences, 48 NP sequences, 51 MP sequences and 36 NS sequences were obtained, including 20 whole genome sequences. Sequence comparison revealed they shared a high degree of homology (96%~99%) with known epidemic strains (A/California/04/2009(H1N1). Phylogenetic analysis showed that although the sequences were highly conserved, they clustered into a small number of groups with only a few distinct strains. Site analysis revealed three substitutions at loop 220 (221-228) of the HA receptor binding site in the 39 HA sequences: A/Hubei/86/2009 PKVRDQEG→PKVRDQEA, A/Zhejiang/08/2009 PKVRDQEG→PKVRDQER, A/Hubei/75/2009 PKVRDQEG→PKVRDQGG, the A/Hubei/75/2009 was isolated from an acute case, while the other two were from patients with mild symptoms. Other key sites such as 119, 274, 292 and 294 amino acids of NA protein,627 of PB2 protein were conserved. Meanwhile, all the M2 protein sequences possessed the Ser32Asn mutation, suggesting that these viruses were resistant to adamantanes. Comparison of these sequences with other H1N1 viruses collected from the NCBI database provides insight into H1N1 transmission and circulation patterns. | Jiu-ru Zhao Yong-dong Li Li-min Pan Na Zhu Hong-xia Ni Guo-zhang Xu Yong-zhong Jiang Xi-xiang Huo Jun-qiang Xu Han Xia Na Han Shuang Tang Zhong Zhang Zheng Kou Simon Rayner Tian-xian Li | 2011 | Virologica Sinica2011，26，6： | 4 |
| 13 | Response surface methodology to optimize gradient ion chromatographic separation of inorganic anions and organic acids in tobacco leaves显示文摘The separation optimization of nine organic and inorganic anions in tobacco leaves using gradient ion chromatography by response surface methodology was investigated.In order to achieve this goal the usefulness of the chromatographic response function(CRF) for the evaluation of the two different chromatographic performance goals(resolution and analysis time) was tested. The experiments were performed according to a Box-Behnken design response surface experimental design. | Rui Qi Wang Na Ni Wang Jia Jie Zhang Yan Zhu | 2011 | Chinese Chemical Letters2011，22，12： | 3 |
| 14 | Norovirus Infection and Histo-blood Group Antigens in Children Hospitalized with Diarrhea in Lulong and Chenzhou in China显示文摘Norovirus(No V)is a pathogen that commonly causes viral diarrhea in children.Studies indicate that No V recognizes human histo-blood group antigens(HBGAs)as cell attachment factors.In order to explore the correlation between of No V infection and HBGAs,a cross-sectional study was conducted in children less than five years old who were hospitalized with diarrhea in two areas of China between November 2014 and February 2015. | SUN Xiao Man YAN Xiao Feng HE Zhi Gang Li Jing Xin GUO Ni Jun XU Zi Qian JIN Miao LI Dan Di ZHOU Yong Kang XIE Guang Cheng Pang Li Li ZHANG Qing LIU Na DUAN Zhao Jun | 2016 | Biomedical and Environmental Sciences2016，29，4： | 3 |
| 15 | Ambient flash sintering of reduced graphene oxide/zirconia composites:Role of reduced graphene oxide显示文摘Fabrication of graphene/ceramic composites commonly requires a high-temperature sintering step with long times as well as a vacuum or inert atmosphere,which not only results in property degradation but also significant equipment complexity and manufacturing costs.In this work,the ambient flash sintering behavior of reduced graphene oxide/3 mol% yttria-stabilized ZrO_(2)(rGO/3 YSZ) composites utilizing rGO as both a composite component and a conductive additive is reported.When the sintering condition is carefully optimized,a dense and conductive composite can be achieved at room temperature and in the air within 20 s.The role of the rGO in the FS of the rGO/3 YSZ composites is elucidated,especially with the assistance of a separate investigation on the thermal runaway behavior of the rGO.The work suggests a promising fabrication route for rGO/ceramic composites where the vacuum and furnace are not needed,which is of interest in terms of simplifying the fabrication equipment for energy and cost savings. | Weiwei Xiao Na Ni Xiaohui Fan Xiaofeng Zhao Yingzheng Liu Ping Xiao | 2021 | Journal of Materials Science & Technology2021，，1： | 2 |
| 16 | Attachment of tyrosinase on mixed self-assembled monolayers for the construction of electrochemical biosensor显示文摘A 混合了 thioctic 酸(TCOOH ) 的自我装配的单层(SAM ) , thioctic 酸酰胺(TNH2 ) 被用来为制作生物传感器使 tyrosinase 不能调动。结果证明在 1:4 的比率从答案准备的混合 SAM 为在 tyrosinase 和底层之间的酶的反应提供了优秀微型环境。生物传感器为察觉到底层展出了快回答和高敏感。 | Xue Ping Ji Xian Rui Li Na Wang Rui Xing Ni Xiao Hong Liu Hua Ai Xiong | 2010 | Chinese Chemical Letters2010，21，10： | 2 |
| 17 | Differential Gene Expression in Response to Drought Stress in Maize Seedling显示文摘To provide the useful information for the choice of molecular marker used in marker-assisted selection of drought tolerance, it is necessary to find out more candidate genes and fulfill the information gaps in gene expression regulation under drought stress. In this study, we isolated four differentially expressed cDNA fragments from leaves of a droughttolerant inbred line by suppression subtractive hybridization and reverse Northern hybridization, and validated their differential expression patterns among six inbred lines with different drought tolerance in response to drought stress by quantitative real-time PCR. Sequence similarity analysis indicated that two of four differentially expressed cDNA showed homology to gene DegP encoding trypsin-like serine protease, and gene PGAM-i encoding cofactor-independent phosphoglyceromutase, respectively. Expressions of the genes corresponding to four cDNA fragments was decreased at 6 h after drought stress treatment in most of the six inbred lines, and then returned to the control level with further stress in three of the tolerant inbred lines. The expression of the gene PGAM-i and the genes corresponding to fragments E4 and F4 were increased to a high level in tolerant inbred line 81565. In the two drought-sensitive inbred lines (Dan340 and ES40), the expression of these genes was still down-regulated. The probable mechanisms of these genes in response to drought stress were discussed. These results indicated that the drought-tolerant inbred lines upregulated the expression of the drought-tolerant candidate genes, in contrast, drought-sensitive inbred lines downregulated the expression of the genes. | DENG Xiao-feng FU Feng-ling NI Na LI Wan-chen | 2009 | Agricultural Sciences in China2009，8，7： | 2 |
| 18 | A QoE-based cell range expansion scheme in heterogeneous cellular networks显示文摘Deploying low-power nodes(LPNs) overlaid with Macro cells is a promising strategy to improve the coverage and capacity of cellular systems. Meanwhile, cell range expansion(CRE) scheme is proposed to select a proper serving base station(BS) for users between Macro e Node Bs and LPNs, and then offloading of traffic from Macro cell is made. In this paper, first, we introduce the LPNs deployment strategy and its activation criteria in the heterogeneous system. Then, a quality of experience(Qo E)-based CRE scheme to adjust the coverage area of LPNs adaptively is proposed. Different from the existing CRE schemes, the Qo E values for different users with different services are considered when the users try to select an appropriate serving BS. Finally, simulation results demonstrate that the proposed scheme can improve cell edge user experience for various services as well as overall system performance. | YUAN TingTing FEI Ze Song LI Na WANG Ni Wei XING Cheng Wen LIU Jia Kang | 2015 | Science China(Information Sciences)2015，58，8： | 2 |
| 19 | Epigenetic modification contributes to the expression divergence of three T a EXPA 1 homoeologs in hexaploid wheat ( T riticum aestivum )显示文摘 | Zhaorong Hu Zongfu Han Na Song Lingling Chai Yingyin Yao Huiru Peng Zhongfu Ni Qixin Sun | 2013 | New Phytol2013，，4： | 2 |
| 20 | Multiplexed imaging detection of live cell intracellular changes in early apoptosis with aggregation-induced emission fluorogens显示文摘Apoptosis is an important process for maintaining tissue homeostasis and eliminating abnormal cells in multicellular organisms.Abnormality in apoptosis often leads to severe diseases such as cancers. Better understanding of its mechanisms and processes is therefore important. Accompanying molecular biology events of apoptosis is a series of cellular morphology changes: nucleus condensation, cell shrinkage and rounding, cell surface blebbing, dynamic blebbing, apoptotic membrane protrusions and nucleus fragmentations and finally, the formation and release of apoptotic bodies. It is difficult to detect cellular changes in the early phase of apoptosis due to the subtle changes at this phase. In the current study, we induced apoptosis in He La cells with H2 O2 and used nuclear dye Hoechst 33258, mitochondria, lysosome and cytoplasmic protein specific aggregation-induced emission fluorogens(AIEgens), TPE-Ph-In, 2 M-DABS and BSPOTPE to successfully perform live cell multiplexed imaging to investigate early apoptosis cellular events. We showed the gradual dissipation of mitochondria membrane potential until it is nondetectable by TPE-Ph-In. Increased mitophagy detected by TPE-Ph-In and 2 M-DABS, condensed nucleus detected by Hoechst33258, increased permeability and/or reduced integrity of nuclear membrane, and increased intracellular vesicles detected by2 M-DABS are some of the early events of apoptosis. | Yabin Zhou Haixiang Liu Na Zhao Zhiming Wang Michael Z.Michael Ni Xie Ben Zhong Tang Youhong Tang | 2018 | Science China Chemistry2018，61，8： | 2 |
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