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| 1 | Different antibiotic susceptibility between antrum and corpus of the stomach,a possible reason for treatment failure of Helicobacter pylori infection显示文摘AIM:To assess whether antibiotic resistance varies between the antrum and corpus of the stomach of patients that are either Helicobacter pylori(H.pylori)therapy-naive or pre-treated.METHODS:H.pylori strains were isolated from antrum and corpus biopsies from 66 patients that received a diagnostic gastroduodenoscopy for variant clinical indications.Antimicrobial susceptibility to amoxicillin,clarithromycin,tetracycline,metronidazole,levofloxacin and rifabutin was tested with the E-test method on IsoSensitest agar with 10 vol%defibrinated horse blood.In patients with a different antibiotic susceptibility pattern between the isolates from the antrum and corpus,DNA fingerprinting via random amplified polymorphic DNA analysis was performed to detect differences among DNA patterns of H.pylori isolates.RESULTS:Primary,secondary and tertiary resistance to clarithromycin was 6.9%,53.8%and 83.3%,retrospectively.Metronidazole and levofloxacin resistance also increased according to the number of previous treatments(17.2%,69.2%,83.3%;13.8%,23.1%,33.3%).Tertiary resistance to rifabutin was detected in12.5%of patients.In none of the 66 patients a resistance against amoxicillin or tetracycline was detectable.Discordant antibiotic susceptibility between antrum and corpus isolates for different antibiotics was seen in 15.2%(10/66)of the patients.Two out of those ten patients were naive to any H.pylori antibiotic treatment.The remaining eight patients previously received at least one eradication therapy.DNA fingerprinting analysis revealed no substantial differences among DNA patterns between antrum and corpus isolates in the majority of patients suggesting an infection with a single H.pylori strain.CONCLUSION:Different antibiotic susceptibility between antrum and corpus biopsies is a common phenomenon and a possible explanation for treatment failure.Resistant H.pylori strains may be missed if just one biopsy from one anatomic site of the stomach is taken for H.pylori susceptibility testing. | Michael Selgrad Ina Tammer Cosima Langner Jan Bornschein Julia Mei?le Arne Kandulski Mariya Varbanova Thomas Wex Dirk Schlüter Peter Malfertheiner | 2014 | World Journal of Gastroenterology2014，20，43： | 10 |
| 2 | Fiber-enriched diet helps to control symptoms and improves esophageal motility in patients with non-erosive gastroesophageal reflux disease显示文摘AIM To investigate the effect of dietary fiber on symptoms and esophageal function testing parameters in nonerosive gastroesophageal reflux disease(GERD)(NERD) patients.METHODS Thirty-six NERD patients with low(< 20 g/d) dietary fiber intake were enrolled in the study. They were examined with the use of symptom questionnaire(GERD-Q), highresolution esophageal manometry, 24-h esophageal p Himpedance examinations, and food frequency questionnaire before and after 10 d of usual diet supplemented by psyllium 5.0 g TID. Complete data of 30 patients were available to the final analysis. The obtained results were analyzed with the use of non-parametric statistics(Wilcoxon matched pairs test). RESULTS The number of patients experiencing heartburn was less(93.3% at baseline vs 40% at the end of the study, P < 0.001) and the GERD-Q score decreased(mean ± SD: 10.9 ± 1.7 vs 6.0 ± 2.3, P < 0.001) after the treatment period. Minimal resting lower esophageal sphincter(LES) pressure increased from 5.41 ± 10.1 to 11.3 ± 9.4 mm Hg(P = 0.023), but no change in residual LES pressure and mean resting pressure was found. Total number of gastroesophageal refluxes(GER) decreased from 67.9 ± 17.7 to 42.4 ± 13.5(P < 0.001) predominantly by acid and weak acid types of GERs. No significant change in mean esophageal p H and % of time p H < 4 was registered. Maximal reflux time decreased from 10.6 ± 12.0 min to 5.3 ± 3.7 min(P < 0.05). CONCLUSION Fiber-enriched diet led to a significant increase of minimal lower esophageal sphincter resting pressure, a decrease of number of gastroesophageal refluxes, and a decrease of heartburn frequency per week in NERD. | Sergey Morozov Vasily Isakov Mariya Konovalova | 2018 | World Journal of Gastroenterology2018，24，21： | 9 |
| 3 | Modification of titanium surface via Ag-,Sr-and Si-containing micro-arc calcium phosphate coating显示文摘The current research is devoted to the study of the modification of the titanium implants by the micro-arc oxidation with bioactive calcium phosphate coatings containing Ag or Sr and Si elements.The coatings’microstructure,phase composition,morphology,physicochemical and biological properties were examined by scanning electron microscopy(SEM),transmission electron microscopy(TEM),energy-dispersive X-ray spectroscopy(EDX)and X-ray diffraction(XRD).Ag-containing and Sr-Si-incorporated coatings were formed in alkaline and acid electrolytes,respectively.The formation of the coatings occurred at different ranges of the applied voltages,which led to the significant difference in the coatings properties.The trace elements Ag,Sr and Si participated intensively in the plasma-chemical reactions of the micro-arc coatings formation.Ag-containing coatings demonstrated strong antibacterial effect against Staphylococcus aureus AТСС6538-P.MTT in vitro test with 3T3-L1 fibroblasts showed no cytotoxicity appearance on Sr-Si-incorporated coatings. | Mariya B.Sedelnikova Ekaterina G.Komarova Yurii P.Sharkeev Anna V.Ugodchikova Tatiana V.Tolkacheva Julietta V.Rau Evgeny E.Buyko Vladimir V.Ivanov Vladimir V.Sheikin | 2019 | Bioactive Materials2019，4，1： | 6 |
| 4 | 下颌角肥大整形术相关解剖显示文摘目的精细解剖下颌角周围软组织结构及下颌神经管,为下颌角肥大整形术提供解剖学参考。方法20例大体标本,观察及测量面动静脉、面神经下颌缘支及咬肌区的血管和神经。据下颌骨表面骨性标志定位5条径线,测量该5条径线上下颌神经管在下颌骨中的位置。计算各软组织结构和下颌神经管的安全范围。结果面动脉距下颌角点为23. 18~36. 28 mm,距咬肌前缘为-9. 51~9. 27 mm。面静脉距离下颌角点为17. 79~32. 03mm。面神经下颌缘支贴近下颌角部及下颌骨下缘走行,距离下颌角点为-8. 57~10. 70 mm,而咬肌前缘下颌缘支距下颌骨下缘为-8. 83~11. 06 mm。咬肌的血供主要有面动脉咬肌支、颈外动脉咬肌支、上颌动脉咬肌支及面横动脉咬肌支这四大来源。咬肌神经多与咬肌动脉伴行进入咬肌。下颌神经管在5个截面中距离下颌骨外侧点分别大于10. 50 mm、14. 72 mm、15. 60 mm、8. 53 mm、6. 74 mm。结论在剥离下颌角区软组织时,注意对咬肌前缘面动脉、面神经下颌缘支及下颌角点附近面神经下颌缘支的保护。去除咬肌的最佳层次为咬肌深层中份最厚点及中下份。而在截骨或劈骨时,根据下颌神经管的安全范围,可在下颌骨颊侧骨板快速画出一条指导性的安全线。 | 陈卡娜 邵正仁 范华 李理 MARIYA M.El Akka wi 颜玲 | 2018 | 解剖学报2018，49，5： | 4 |
| 5 | Intracellular trafficking of transforming growth factor β receptors显示文摘转变生长因素(TGF ) 家庭成员经由类型的 heterotetrameric 建筑群发信号我(TRI ) 并且类型 II (TRII ) 双特性 kinase 受体。房间表面上的受体的可获得性被几机制控制。最新综合的 TRI 和 TRII 经由分开的线路从 Golgi 仪器被送到房间表面。在房间表面上, TGF 受体在血浆膜的不同 microdomains 之间被散布并且能经由调停 clathrin 、调停 caveolae 的 endocytic 机制被使内在化。尽管受体 endocytosis 不为 TGF 是必要的发信号,早内涵体上的激活的受体建筑群的本地化支持导致 TGF 的 Smad 激活。调停 Caveolae 的 endocytosis,广泛地被认为是便于 TGF 受体的降级的机制,被显示了为经由 non-Smad 小径发信号的 TGF 被要求。TGF 受体的合适的控制的重要性细胞内部的 trafficking 被临床的数据强调,,受体的错误本地化与几人的疾病相关被描述了。因此,和他们的表示, posttranslational 修正和下面规定的规定 TGF 受体的细胞内部的 trafficking 控制,保证 TGF 发信号的合适的规定。 | Ihor Yakymovych Mariya Yakymovych CarI-Henrik Heldin | 2018 | Acta Biochimica et Biophysica Sinica2018，50，1： | 4 |
| 6 | A simple scoring system to estimate perioperative mortality following liver resection for primary liver malignancy-the Hepatectomy Risk Score(HeRS)显示文摘Background:Selection of the optimal treatment modality for primary liver cancers remains complex,balancing patient condition,liver function,and extent of disease.In individuals with preserved liver function,liver resection remains the primary approach for treatment with curative intent but may be associated with significant mortality.The purpose of this study was to establish a simple scoring system based on Model for End-stage Liver Disease(MELD)and extent of resection to guide risk assessment for liver resections.Methods:The 2005-2015 NSQIP database was queried for patients undergoing liver resection for primary liver malignancy.We first developed a model that incorporated the extent of resection(1 point for major hepatectomy)and a MELD-Na score category of low(MELD-Na=6,1 point),medium(MELD-Na=7-10,2 points)or high(MELD-Na>10,3 points)with a score range of 1-4,called the Hepatic Resection Risk Score(HeRS).We tested the predictive value of this model on the dataset using logistic regression.We next developed an optimal multivariable model using backwards sequential selection of variables under logistic regression.We performed K-fold cross validation on both models.Receiver operating characteristics were plotted and the optimal sensitivity and specificity for each model were calculated to obtain positive and negative predictive values.Results:A total of 4,510 patients were included.HeRS was associated with increased odds of 30-day mortality[HeRS=2:OR=3.23(1.16-8.99),P=0.025;HeRS=3:OR=6.54(2.39-17.90),P<0.001;HeRS=4:OR=13.69(4.90-38.22),P<0.001].The AUC for this model was 0.66.The AUC for the optimal multivariable model was higher at 0.76.Under K-fold cross validation,the positive predictive value(PPV)and negative predictive value(NPV)of these two models were similar at PPV=6.4%and NPV=97.7%for the HeRS only model and PPV=8.4%and NPV=98.1%for the optimal multivariable model.Conclusions:The HeRS offers a simple heuristic for estimating 30-day mortality after resection of primary liver malignancy.More complicated models offer better performance but at the expense of being more difficult to integrate into clinical practice. | Dimitrios Moris Brian I.Shaw Cecilia Ong Ashton Connor Mariya L.Samoylova Samuel J.Kesseli Nader Abraham Jared Gloria Robin Schmitz Zachary W.Fitch Bryan M.Clary Andrew S.Barbas | 2021 | Hepatobiliary Surgery and Nutrition2021，10，3： | 2 |
| 7 | 俄罗斯及青藏高原野生雁类在禽流感病毒传播中的作用(英文)显示文摘雁形目和鸻形目鸟类是低致病性禽流感病毒(正粘病毒科)的自然宿主。水禽中野生雁类(雁形目)的迁徙距离达数千公里。从野生雁类中分离出禽流感病毒的成功率很低。本研究旨在检测俄罗斯境内以及青藏高原营巢繁殖的不同野生雁类的禽流感病毒,分析所得数据后进一步明确这些鸟类在病原体传播中的作用。我们检测了来自俄罗斯境内9个地区以及青藏高原(西藏自治区)的3245份样品,未发现禽流感病毒。这表明,野生雁类在长距离迁徙过程中对禽流感的传播并没未起到明显作用。因此,野生雁类可能不是主要的禽流感病毒的自然宿主,但野生雁类种群中禽流感病毒的状况仍需进一步探究。对野生雁类与禽流感病毒的生态学研究有助于我们掌握更多的病原与宿主间关系的信息,以便更好地维持野生雁类种群数量。 | Mariya V.SIVAY Nikita Y.SILKO Kirill A.SHARSHOV Aleksander V.PROKUDIN 李来兴 杨敏 操胜 Aleksander M.SHESTOPALOV | 2011 | Chinese Birds2011，，3： | 2 |
| 8 | Embedding physics domain knowledge into a Bayesian network enables layer-by-layer process innovation for photovoltaics显示文摘Process optimization of photovoltaic devices is a time-intensive,trial-and-error endeavor,which lacks full transparency of the underlying physics and relies on user-imposed constraints that may or may not lead to a global optimum.Herein,we demonstrate that embedding physics domain knowledge into a Bayesian network enables an optimization approach for gallium arsenide(GaAs)solar cells that identifies the root cause(s)of underperformance with layer-by-layer resolution and reveals alternative optimal process windows beyond traditional black-box optimization.Our Bayesian network approach links a key GaAs process variable(growth temperature)to material descriptors(bulk and interface properties,e.g.,bulk lifetime,doping,and surface recombination)and device performance parameters(e.g.,cell efficiency).For this purpose,we combine a Bayesian inference framework with a neural network surrogate device-physics model that is 100×faster than numerical solvers.With the trained surrogate model and only a small number of experimental samples,our approach reduces significantly the time-consuming intervention and characterization required by the experimentalist.As a demonstration of our method,in only five metal organic chemical vapor depositions,we identify a superior growth temperature profile for the window,bulk,and back surface field layer of a GaAs solar cell,without any secondary measurements,and demonstrate a 6.5%relative AM1.5G efficiency improvement above traditional grid search methods. | Zekun Ren Felipe Oviedo Maung Thway Siyu I.P.Tian Yue Wang Hansong Xue Jose Dario Perea Mariya Layurova Thomas Heumueller Erik Birgersson Armin G.Aberle Christoph J.Brabec Rolf Stangl Qianxiao Li Shijing Sun Fen Lin Ian Marius Peters Tonio Buonassisi | 2020 | npj Computational Materials2020，，1： | 2 |
| 9 | Correlation of tetracycline and sulfonamide antibiotics with corresponding resistance genes and resistant bacteria in a conventional municipal wastewater treatment plant显示文摘 | Pin Gao Mariya Munir Irene Xagoraraki | 2012 | Science of the Total Environment2012，，： | 2 |
| 10 | Release of antibiotic resistant bacteria and genes in the effluent and biosolids of five wastewater utilities in Michigan显示文摘 | Mariya Munir Kelvin Wong Irene Xagoraraki | 2010 | Water Research2010，，2： | 2 |
| 11 | Characterizationof OXA-25, OXA-26, and OXA-27, Molecular class D p-Lactamases associated with carbapenem resistance in clin-ical isolates of Acinetobacter baumannii显示文摘 | Mariya A S Woodford N David M L | 2001 | Antimicrobi-al Agents and Chemotherapy2001，45，2： | 1 |
| 12 | mTORC1/C2 and pan-HDAC inhibitors synergistically impair breast cancer growth by convergent AKT and polysome inhibiting mechanisms显示文摘 | Kathleen A. Wilson-Edell Mariya A. Yevtushenko Daniel E. Rothschild Aric N. Rogers Christopher C. Benz | 2014 | Breast Cancer Research and Treatment2014，，： | 1 |
| 13 | Determination of 2-methylimidazole, 4-methylimidazole and 2-acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole in caramel colours and cola using LC/MS/MS显示文摘 | Claudia Schlee Mariya Markova Julia Schrank Fanette Laplagne Rüdiger Schneider Dirk W. Lachenmeier | 2012 | Journal of Chromatography B2012，，： | 1 |
| 14 | 圈养猞猁多雄交配雄性的成功繁殖(英文)显示文摘研究了笼养猞猁多雄交配的结果以及雄性的成功繁殖。雄兽与发情雌兽随机配对,其繁殖成功(所产生的后代数量)不取决于与雌兽的交配顺序、交配次数与持续时间、遗传关系或雄兽的行为特征,但似乎取决于精子质量,特别是取决于形态正常精子的百分率。繁殖成功的雄兽比其竞争对手具有更多的形态正常的精子,似乎更能成功地诱发交配雌兽的排卵。证实了4窝(占总窝数的20%)幼兽的双重父亲身份。在所有情形下, 2雄1雌的交配间隔为24h 。 | Sergey NAIDENKO Mariya EROFEEVA Frank GOERITZ Katrin NEUBAUER Joerns FICKEL Katarina JEWGENOW | 2007 | 动物学报2007，53，3： | 1 |
| 15 | Characterization of OXA-25, OXA-26, and OXA-27, Molecular Class Dβ-Lactamases Associated with Carbapenem Resistance in Clinical Isolates of Acinetobacter baumannii显示文摘 | Mariya AS Woodford N David ML | 2001 | Antimierobial Agents and Chemotherapy2001，45，58： | 1 |
| 16 | Improved Cardiac Risk Assessment With Noninvasive Measures of Coronary Flow Reserve显示文摘 | Venkatesh L. Murthy Masanao Naya Courtney R. Foster Jon Hainer Mariya Gaber Gilda Di Carli Ron Blankstein Sharmila Dorbala Arkadiusz Sitek Michael J. Pencina Marcelo F. Di Carli | 2011 | Circulation2011，，： | 1 |
| 17 | DNA transfer within forensic exhibit packa?ging: Potential for DNA loss and relocation显示文摘 | Mariya G | 2011 | 10: 10162011，10，： | 1 |
| 18 | The effect of folate-related SNPs on clinicopathological features, response to neoadjuvant treatment and survival in pre- and postmenopausal breast cancer patients显示文摘 | Nataliya Babyshkina Elena Malinovskaya Mariya Nazarenko Mariya Koval Polina Gervas Olga Potapova Elena Slonimskaya Nadejda Cherdyntseva | 2013 | Gene2013，，： | 1 |
| 19 | Correlation of tetracycline and sulfonamide antibiotics with corresponding resistance genes and resistant bacteria in a conventional municipal wastewater treatment plant显示文摘 | Gao P Mariya M Irene X | | 0，，： | 1 |
| 20 | Hydraulic similarityin the temperature fluctuation phenomena of non-isothermal coaxial jets显示文摘 | MARIYA S OHSHIMA I | 1990 | Nucl Eng Des1990，120，23： | 1 |
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