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| 1 | Liver hemangioma and vascular liver diseases in patients with systemic lupus erythematosus显示文摘AIM:To investigate whether systemic lupus erythematosus (SLE) is associated with benign focal liver lesions and vascular liver diseases, since these have been occasionally reported in SLE patients. METHODS:Thirty-five consecutive adult patients with SLE and 35 age-and sex-matched healthy controls were evaluated. Hepatic and portal vein patency and presence of focal liver lesions were studied by colour-Doppler ultrasound, computerized tomography and magnetic resonance were used to refine the diagnosis, clinical data of SLE patients were reviewed. RESULTS:Benign hepatic lesions were common in SLE patients (54% vs 14% controls, P < 0.0001), withhemangioma being the most commonly observed lesion in the two groups. SLE was associated with the presence of single hemangioma [odds ratios (OR) 5.05; 95% confidence interval (CI) 1.91-13.38] and multiple hemangiomas (OR 4.13; 95% CI 1.03-16.55). Multiple hemangiomas were associated with a longer duration of SLE (9.9 ± 6.5 vs 5.5 ± 6.4 years; P = 0.04). Imaging prior to SLE onset was available in 9 patients with SLE and hemangioma, showing absence of lesions in 7/9. The clinical data of our patients suggest that SLE pos- sibly plays a role in the development of hemangioma. In addition, a Budd-Chiari syndrome associated with nodular regenerative hyperplasia (NRH), and a NRH associated with hepatic hemangioma were observed, both in patients hospitalized for abdominal symptoms, suggesting that vascular liver diseases should be specifically investigated in this population. CONCLUSION:SLE is associated with 5-fold increased odds of liver hemangiomas, suggesting that these might be considered among the hepatic manifestations of SLE. | Annalisa Berzigotti Marilena Frigato Elena Manfredini Lucia Pierpaoli Rita Mulè Carolina Tiani Paola Zappoli Donatella Magalotti Nazzarena Malavolta Marco Zoli | 2011 | World Journal of Gastroenterology2011，17，40： | 5 |
| 2 | Hepatitis C virus-related B cell subtypes in non Hodgkin's lymphoma显示文摘AIM:To evaluate if indolent B cell-non Hodgkin's lymphoma(B-NHL) and diffuse large B-cell lymphoma(DLBCL) in hepatitis C virus(HCV) positive patients could have different biological and clinical characteristics requiring different management strategies.METHODS:A group of 24 HCV related B-NHL patients(11 indolent,13 DLBCL) in whom the biological and clinical characteristics were described and confronted.Patients with DLBCL were managed with the standard of care of treatment.Patients with indolent HCV-related B-NHL were managed with antiviral treatment pegylated interferon plus ribavirin and their course observed.The outcomes of the different approaches were compared.RESULTS:Patients with DLBCL had a shorter duration of HCV infection and a higher prevalence of HCV genotype 1 compared to patients with indolent B-NHL in which HCV genotype 2 was the more frequent genotype.Five of the 9 patients with indolent HCV-relatedB-NHL treated with only antiviral therapy,achieved a complete response of their onco-haematological disease(55%).Seven of the 13 DLBCL patients treated with immunochemotheraphy obtained a complete response(54%).CONCLUSION:HCV genotypes and duration of HCV infection differed between B-NHL subtypes.Indolent lymphomas can be managed with antiviral treatment,while DLBCL is not affected by the HCV infection. | Adriano M Pellicelli Massimo Marignani Valerio Zoli Mario Romano Aldo Morrone Lorenzo Nosotti Giuseppe Barbaro Antonio Picardi Umberto Vespasiani Gentilucci Daniele Remotti Cecilia D'Ambrosio Caterina Furlan Fabrizio Mecenate Ettore Mazzoni Ignazio Majolino Roberto Villani Arnaldo Andreoli Giorgio Barbarini | 2011 | World Journal of Hepatology2011，3，11： | 4 |
| 3 | Body composition changes after transjugular intrahepatic portosystemic shunt in patients with cirrhosis显示文摘AIM:To investigate the effect of transjugular intra-hepatic porto-systemic shunt (TIPS) on malnutrition in portal hypertensive cirrhotic patients.METHODS: Twenty-one patients with liver cirrhosis and clinical indications for TIPS insertion were investigated before and 1, 4, 12, 52 wk after TIPS. For each patient we assayed body composition parameters [dry lean mass, fat mass, total body water (TBW)], routine liver and kidney function tests, and free fatty acids (FFA). Glucose and insulin were measured for the calculation of the homeostasis model assessment insulin resistance (HOMA-IR); liver function was measured by the galactose elimination capacity (GEC); the severity of liver disease was graded by model for end-stage liver disease (MELD).RESULTS: Porto-systemic gradient decreased after TIPS (6.0±2.1 mmHg vs 15.8±4.8 mmHg, P<0.001). Patients were divided in two groups according to initial body mass index. After TIPS, normal weight patients had an increase in dry lean mass (from 10.9±5.9 kg to 12.7±5.6 kg, P=0.031) and TBW (from 34.5±7.6 L to 40.2±10.8 L,P=0.007), as well as insulin (from 88.9±49.2 pmol/L to 164.7±107.0 pmol/L,P=0.009) and HOMA-IR (from 3.36%±2.18% to 6.18%±4.82%,P=0.023). In overweight patients only FFA increased significantly (from 0.59±0.24 mmol/L to 0.93±0.34 mmol/L, P=0.023).CONCLUSION: TIPS procedure is effective in lowering portal pressure in patients with portal hypertension and improves body composition without significant changes in metabolic parameters. | Jonathan Montomoli Peter Holland-Fischer Giampaolo Bianchi Henning GrФnbk Hendrik Vilstrup Giulio Marchesini Marco Zoli | 2010 | World Journal of Gastroenterology2010，16，3： | 3 |
| 4 | Survival benefit of liver resection for patients with hepatocellular carcinoma across different Barcelona Clinic Liver Cancer stages: a multicentre study显示文摘 | Alessandro Vitale Patrizia Burra Anna Chiara Frigo Franco Trevisani Fabio Farinati Gaya Spolverato Michael Volk Edoardo G. Giannini Francesca Ciccarese Fabio Piscaglia Gian Lodovico Rapaccini Mariella Di Marco Eugenio Caturelli Marco Zoli Franco Borzio Gi | 2014 | Journal of Hepatology2014，，： | 2 |
| 5 | Circulating and stool nucleic acid analysis for colorectal cancer diagnosis显示文摘In recent years,the need to identify molecular markers characterized by high sensitivity and specificity in detecting and monitoring early and colorectal cancer lesions has increased.Up to now,none of the markers or panels of markers analyzed have met the rigorous standards required of a screening program.The important discovery of circulating nucleic acids in biological fluids has aroused intense scientific interest because of their usefulness in malignant and non malignant diseases.Over time,their yield and stability have been identified and compared with other'standard'biomarkers.The analysis of circulating DNA from blood and stool is a relatively simple and non-invasive procedure,representing a very attractive marker to detect genetic and epigenetic mutations and to monitor disease progression.A correlation between blood and stool biomarkers could also help to enhance currently available diagnostic approaches.However,various processing and analytic problems need to be resolved before such an approach can be applied in clinical practice. | Giulia De Maio Claudia Rengucci Wainer Zoli Daniele Calistri | 2014 | World Journal of Gastroenterology2014，20，4： | 2 |
| 6 | The course of inflammatory bowel disease during pregnancy and postpartum: a prospective European ECCO‐EpiCom Study of 209 pregnant women显示文摘 | N. Pedersen A. Bortoli D. Duricova R. D′Inca M. R. Panelli J. P. Gisbert G. Zoli A. López‐Sanromán F. Castiglione G. Riegler V. Annese P. Gionchetti A. Prada E. D. Pont A. Timmer C. Felley M. Shuhaibar E. V. Tsianos C. Dejaco F. J. Baert T. Jess M. Lebech | 2013 | Aliment Pharmacol Ther2013，，5： | 2 |
| 7 | Mortality and cancer incidence in cohorts of Swedish fishermen and fishermen’s wives: Updated findings显示文摘 | Zoli Mikoczy Lars Rylander | 2008 | Chemosphere2008，，7： | 2 |
| 8 | Early Diagnosis and Treatment of Postoperative Endoscopic Recurrence of Crohn’s Disease: Partial Benefit by Infliximab—A Pilot Study显示文摘 | Dario Sorrentino Giovanni Terrosu Alberto Paviotti Marco Geraci Claudio Avellini Giorgio Zoli Walter Fries Silvio Danese Pietro Occhipinti Tiziano Croatto Dimitra Zarifi | 2012 | Digestive Diseases and Sciences2012，，5： | 2 |
| 9 | Barcelona Clinic Liver Cancer staging and transplant survival benefit for patients with hepatocellular carcinoma: a multicentre, cohort study显示文摘 | Alessandro Vitale Rafael Ramirez Morales Giacomo Zanus Fabio Farinati Patrizia Burra Paolo Angeli Anna Chiara Frigo Paolo Del Poggio Gianludovico Rapaccini Maria Anna Di Nolfo Luisa Benvegnù Marco Zoli Franco Borzio Edoardo Giovanni Giannini Eugenio Catur | 2011 | Lancet Oncology2011，，7： | 2 |
| 10 | Metformin in non-alcoholic steatohepatitis显示文摘 | Giulio Marchesini Giampaolo Bianchi Sara Tomassetti Marco Zoli Nazario Melchionda | 2001 | The Lancet2001，，9285： | 2 |
| 11 | Brain nicotinic acetylcholine re- ceptors: native subtypes and their relevance显示文摘 | Gotti C Zoli M Clementi F | 2006 | Trends Phar- macol Sci2006，27，9： | 1 |
| 12 | Characterization of the hypothalamo-pituitary-IGF-I axis in rats made obese by overfeeding显示文摘 | Cattaneo L De Gennaro Colonna V Zoli M | 1996 | J Endocrinol1996，148，2： | 1 |
| 13 | Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens显示文摘 | Flisser A Gauci CG Zoli A | | 0，，09： | 1 |
| 14 | p16INK4A and CDH13 hypermethylation in tumor and serum of non-small eelllung cancer patients 显示文摘 | Ulivi P Zoli W Calistri D | 2006 | J Cell Physiol2006，206，3： | 1 |
| 15 | Natural history of cirrhotic patients with small esophageal varices: a prospective study显示文摘 | Marco Zoli Carlo Merkel Donatella Magalotti Cristina Gueli Michele Grimaldi Angelo Gatta Mauro Bernardi | 2000 | The American Journal of Gastroenterology2000，，2： | 1 |
| 16 | Prognostic indicators in compensated cirrhosis 显示文摘 | Zoli M Cordiani MR Marchesini G | 1991 | Am J Gastroenterol1991，86，10： | 1 |
| 17 | Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries显示文摘 | Laudenbach V Medja F Zoli M | 2002 | FASEB J2002，16，3： | 1 |
| 18 | Efficacy of different sequences of radio-and chemotherapy in experimental models of human melanoma 显示文摘 | Arienti C Zoli W Pignatta S | 2014 | J Cell Physiol2014，，： | 1 |
| 19 | Induction of protection a- gainst porcine cysticercosis by vaccination with recombinant on- cosphere antigens显示文摘 | Flisser A Gauci CG Zoli A | 2004 | Infect Immun2004，72，9： | 1 |
| 20 | Brain nicotinic acetylcholine receptors: Native subtypes and their relevance 显示文摘 | Gotti C Zoli M Clementi F | 2006 | Trends Pharmacol Sci2006，27，9： | 1 |
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