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| 1 | Mast cells as rapid innate sensors of cytomegalovirus by TLR3/TRIF signaling-dependent and -independent mechanisms显示文摘简明比喻, ‘免疫系统装载了 gun' ,被用来在能在需求上几乎立即被释放与侵略者作斗争的能分泌的小粒由于他们大量有势力支持 inflammatory 和抗菌剂调停人的存储描述桅杆房间(MC ) 的角色。在主人环境定位了边界并且与模式识别受体的一个军火库装备了, MC 被注定是渗透 endothelial 和上皮的表面的病原体的快速的天生的传感器。尽管在抗菌剂和 antiparasitic 防卫的 MC 的重要性长被欣赏了,他们在对病毒的感染发出报警的角色仅仅最近被注意了。 cytomegalovirus ( CMV )上的工作在鼠科的模型的感染在在 CMV 的天生、适应的有免疫力的监视之间的新奇串音轴作为播放器揭示了 MC 在 MC ,它与 MC degranulation 和 chemokine CCL5 的版本被联系的那感染,提高保护的 CD8 T 房间的招募到病毒复制的血管外的地点,明确地到肺 interstitium 和牙槽的上皮。这里,我们由响应主人感染为 MC 激活和作为结果的 degranulation 调查条件阐述了这些研究。令人惊讶地,数据揭示了 MC 激活的二个时间地并且机械学地不同的波浪:取决于 TLR3/TRIF 发信号并且由没包含 TLR3/TRIF 发信号的 MC 的直接感染推迟了激活的几乎立刻的间接激活。产出有选择地从 MC 发源的表示 eGFP 记者病毒的房间类型特定的 Cre 再结合识别了是的 MC 一在 vivo 新,生产鼠科的 CMV 感染的第一点击的目标房间。 | Marc Becker Niels AW Lemmermann Stefan Ebert Pamela Baars Angelique Renzaho Jurgen Podlech Michael Stassen Matthias J Reddehase | 2015 | Cellular & Molecular Immunology2015，12，2： | 1 |
| 2 | 18F-FDG PET imaging of rheumatoid knee synovitis correlates with dynamic magnetic resonance and sonographic assessments as well as with the serum level of metalloproteinase-3显示文摘 | Catherine Beckers Xavier Jeukens Clio Ribbens Béatrice André Stefaan Marcelis Philippe Leclercq Marie-Jo?lle Kaiser Jacqueline Foidart Roland Hustinx Michel G. Malaise | 2006 | European Journal of Nuclear Medicine and Molecular Imaging2006，，3： | 1 |
| 3 | Double-oblique free-breathing high resolution three-dimensional coronary magnetic resonance angiography显示文摘 | Matthias Stuber René M. Botnar Peter G. Danias Daniel K. Sodickson Kraig V. Kissinger Marc Van Cauteren Jan De Becker Warren J. Manning | 1999 | Journal of the American College of Cardiology1999，，2： | 1 |
| 4 | Medical history and risk of lymphoma: results of a European case–control study (EPILYMPH)显示文摘 | Nikolaus Becker Joan Fortuny Tomas Alvaro Alexandra Nieters Marc Maynadié Lenka Foretova Anthony Staines Paul Brennan Paolo Boffetta Pier Luigi Cocco Silvia Sanjose | 2009 | Journal of Cancer Research and Clinical Oncology2009，，8： | 1 |
| 5 | Increased Platelet Reactivity and Circulating Monocyte-Platelet Aggregates in Patients With Stable Coronary Artery Disease显示文摘 | Mark I Furman Stephen E Benoit Marc R Barnard C.Robert Valeri Marie L Borbone Richard C Becker Herbert B Hechtman Alan D Michelson | 1998 | Journal of the American College of Cardiology1998，，2： | 1 |
| 6 | Driving factors of the phytoplankton functional groups in a deep Mediterranean reservoir显示文摘 | Vanessa Becker Luciano Caputo Jaime Ordó?ez Rafael Marcé Joan Armengol Luciane O. Crossetti Vera L.M. Huszar | 2010 | Water Research2010，，11： | 1 |
| 7 | Accuracy of 64-Slice Computed Tomography to Classify and Quantify Plaque Volumes in the Proximal Coronary System显示文摘 | Alexander W. Leber Alexander Becker Andreas Knez Franz von Ziegler Marc Sirol Konstantin Nikolaou Bernd Ohnesorge Zahi A. Fayad Christoph R. Becker Maximilian Reiser Gerhard Steinbeck Peter Boekstegers | 2006 | Journal of the American College of Cardiology2006，，： | 1 |
| 8 | Hepatocyte Transplantation in an Acute Liver Failure Due to Mushroom Poisoning显示文摘 | Andrea Schneider Masoumeh Attaran Peter N. Meier Christian Strassburg Michael P. Manns Michael Ott Marc Barthold Lubomir Arseniev Thomas Becker Bernd Panning | 2006 | Transplantation2006，，8： | 1 |
| 9 | Neonatal Cholestatic Jaundice as the First Symptom of a Mutation in the Hepatocyte Nuclear Factor-1β gene (HNF-1β)显示文摘 | Dominique Beckers Christine Bellanné-Chantelot Marc Maes | 2007 | The Journal of Pediatrics2007，，3： | 1 |
| 10 | Classic PCB thermal profiling of the reflow solder process显示文摘 | Andy Becker Marc C Apell | 2001 | Circuits Assembly2001，12，5： | 1 |
| 11 | 激光剥蚀-等离子体质谱技术及其在地球化学宇宙化学和环境研究中的应用(英文)显示文摘激光剥蚀-等离子体质谱(LA-ICPMS)已成为地球化学、宇宙化学和环境研究领域元素和同位素原位分析最重要的技术之一。文章介绍了多种类型的质谱仪及其使用的激光器。用途最广的LA-ICPMS仪器之一是单接收器扇形磁场质谱仪,配有Nd:YAG激光剥蚀系统(激光波长分为193 nm和213 nm两种),MPI Mainz实验室使用的就是这套系统,文章对此作一详细介绍。文中阐述了数据优化技术及其多种校正过程;介绍LA-ICPMS在痕量元素和同位素分析领域的一些应用,包括参考物质的研制,Hawaiian玄武岩、Martian陨石、生物骨针和珊瑚虫中痕量元素分析及熔融包裹体和富钙-铝碳质球粒陨石中的铅和锶同位素测量。 | JOCHUM Klaus Peter STOLL Brigitte FRIEDRICH Jon M AMINI Marghaleray BECKER Stefan DüCKING Marc EBEL Denton S ENZWEILER Jacinta HU Ming-yue KUZMIN Dmitry MERTZ-KRAUS Regina MüLLER Werner E G REGNERY Julia SOBOLEV Alexander WANG Xiao-hong ZHAN Xiu-chun | 2009 | 岩矿测试2009，28，1： | 1 |
| 12 | Patient-controlled thoracic epidural infusion with ropivacaine 0.375% provides comparable pain relief as bupivacaine 0.125% plus sufentanil after major abdominal gynecologic tumor surgery显示文摘 | André Gottschalk Marc Freitag Marc-Alexander Burmeister Cornelia Becker Ernst-Peter Horn Thomas Standl | 2002 | Regional Anesthesia and Pain Medicine2002，，4： | 1 |
| 13 | β受体阻滞剂(普萘洛尔)治疗复杂的面部血管瘤显示文摘【结论】为检测β受体阻滞剂治疗血管瘤远期效果的安全性和有效性,将其与其他药物进行前瞻性对照研究显然是有必要的。采用皮质类固醇治疗复杂的血管瘤,可能无反应或产生有害后遗症,因此,需要把注意力放到非传统疗法上。然而,这并不是对已报道的采用传统治疗标准的成功案例的否定。口服皮质类固醇仍是目前可以接受的药物治疗标准;然而,此类药物既不是完全良性,也不是普遍有效。 | Jugpal S. Arneja Peggy N. Pappas Tor A. Shwayder Marc L. Cullen Cristie J. Becker Fasahat H. Hamzavi John D. Roarty David N. Madgy John D. Baker 魏峰 高景恒 张晨 | 2012 | 中国美容整形外科杂志2012，23，3： | 0 |
| 14 | Last line therapy with sorafenib in colorectal cancer: A retrospective analysis显示文摘AIM: To analyze the efficacy of last line sorafenib treatment in colorectal cancer patients. METHODS: All patients receiving chemotherapy for colorectal cancer in the outpatient clinic of the University of Mainz since 2006 were retrospectively analyzed for last line sorafenib exposure. Charts of identified patients were analyzed for clinic-pathological parameters, like data on gender, age, date of initial diagnosis, UICC stage, number and kind of the pretherapies, therapy start and end of sorafenib, sorafenib mediated treatment cessation, side effects, response rates, time to progression and overall survival. RESULTS: Ten patients with a median of 3.0 prior chemotherapy lines had received a last line sorafenib therapy either alone(10%) or in combination with 5-fluorouracil derivates(90%). All patients suffered from colorectal cancer stage UICC 4 and were routinely seen in 2-wk intervals in the oncology outpatient clinic. Median duration of treatment was 142.0 d. At 8 wk 80% of patients showed stable disease but we did not observe any remissions. Median time to progression was 140.5 d(4.7 mo), while median overall survival reached 176.5 d. One patient ceased treatment due to side effects. Reason for treatment stop was bleeding complication in one case and non-specified sorafenib intolerance in another case. Due to the retrospective approach we did not further quantify side effects.CONCLUSION: This retrospective analysis encourages further investigation of sorafenib in colorectal cancer last line therapy. | Ksenia Martchenko Irene Schmidtmann Thomas Thomaidis Verena Thole Peter R Galle Marc Becker Markus Mohler Thomas C Wehler Carl C Schimanski | 2016 | World Journal of Gastroenterology2016，22，23： | 0 |
| 15 | Identification of fungal fossils and novel azaphilone pigments in ancient carbonised specimens of Hypoxylon fragiforme from forest soils of Chatillon-sur-Seine(Burgundy)显示文摘Fungal stromata were recently discovered in association with charcoal and burnt soil aggregates during an archaeological survey in the Chaˆtillon-sur-Seine forest massif.The wood and soil in the samples were dated to the medieval period(between 738 and 1411 AD).Light microscopy and scanning electron microscopy revealed that a few of the stromatal fragments still contained ascospores.Their macromorphological characters were described and secondary metabolite profiles were generated using high performance liquid chromatography with diode array and mass spectrometric detection(HPLC–DAD/MS).The combination of these two data lines then allowed species identification.Most of the fragments were assigned to Hypoxylon fragiforme,the type species of the Hypoxylaceae(Xylariales).Two further species whose stromata grew on the fossil charcoal could be tentatively identified as Jackrogersella cohaerens and(more tentatively)as Hypoxylon vogesiacum.These three species are still commonly encountered in the forests of Central Europe today.Furthermore,the HPLC-HRMS data of H.fragiforme suggested the presence of unknown azaphilone dimers and of further new pigments.These archaeological compounds were compared to fresh stromata of H.fragiforme collected in Germany and subjected to the same analytical protocol.While the major components in both samples were identified as the known mitorubrin type azaphilones and orsellinic acid,the chemical structures of seven novel complex azaphilone pigments,for which we propose the trivial names rutilins C-D and fragirubrins A-E,were elucidated using spectral methods(NMR and CD spectroscopy,high resolution mass spectrometry).It appears that these pigments had indeed persisted for millennia in the fossil stromata. | Frank Surup Abolfazl Narmani Lucile Wendt Sebastian Pfutze Robin Kretz Kevin Becker Cle ment Menbrives Alain Giosa Michelle Elliott Christophe Petit Manfred Rohde Marc Stadler | 2018 | Fungal Diversity2018，，5： | 0 |
| 16 | A prospective longitudinal study shows putamen volume is associated with moderate amphetamine use and resultant cognitive impairments显示文摘Background:Amphetamine-type stimulants(ATS)have become a critical public health issue.Animal models have indicated a clear neurotoxic potential of ATSs.In humans,chronic use has been associated with cogni-tive deficits and structural brain abnormalities.However,cross-sectional retrospective designs in chronic users cannot truly determine the causal direction of the effects.Objective:To prospectively determine effects of occasional ATS use on cognitive functioning and brain structure.Methods:In a prospective longitudinal study design,cognitive functioning and brain structure were assessed at baseline and at 12-month follow-up in occasional ATS users(cumulative lifetime use<10 units at baseline).Results:Examination of change scores between the initial examination and follow-up revealed declined verbal memory performance and putamen volume in users with high relative to low interim ATS exposure.In the entire sample,interim ATS use,memory decline,and putamen volume reductions were strongly associated.Conclusions:The present findings support the hypothesis that ATS use is associated with deficient dorsal stri-atal morphology that might reflect alterations in dopaminergic pathways.More importantly,these findings strongly suggest that even occasional,low-dose ATS use disrupts striatal integrity and cognitive functioning. | Keith M.Kendrick Joerg Daumann Daniel Wagner Philip Koester Marc Tittgemeyer Qiang Luo Euphrosyne Gouzoulis-Mayfrank Benjamin Becker | 2021 | Psychoradiology2021，1，1： | 0 |
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