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| 1 | Effect of biofilm formation by clinical isolates of Helicobacter pylori on the efflux-mediated resistance to commonly used antibiotics显示文摘AIM To evaluate the role of biofilm formation on the resistance of Helicobacter pylori(H. pylori) to commonly prescribed antibiotics, the expression rates of resistance genes in biofilm-forming and planktonic cells were compared.METHODS A collection of 33 H. pylori isolates from children and adult patients with chronic infection were taken for the present study. The isolates were screened for biofilm formation ability, as well as for polymerase chain reaction(PCR) reaction with HP1165 and hp1165 efflux pump genes. Susceptibilities of the selected strains to antibiotic and differences between susceptibilities of planktonic and biofilm-forming cell populations were determined. Quantitative real-time PCR(qP CR) analysis was performed using 16 S r RNA gene as a H. pylori-specific primer, and two efflux pumps-specific primers, hp1165 and hefA.RESULTS The strains were resistant to amoxicillin, metronidazole, and erythromycin, except for one strain, but they were all susceptible to tetracycline. Minimum bactericidalconcentrations of antibiotics in the biofilm-forming cells were significantly higher than those of planktonic cells. qP CR demonstrated that the expression of efflux pump genes was significantly higher in the biofilm-forming cells as compared to the planktonic ones.CONCLUSION The present work demonstrated an association between H. pylori biofilm formation and decreased susceptibility to all the antibiotics tested. This decreased susceptibility to antibiotics was associated with enhanced functional activity of two efflux pumps: hp1165 and hefA. | Bahareh Attaran Tahereh Falsafi Nassim Ghorbanmehr | 2017 | World Journal of Gastroenterology2017，23，7： | 12 |
| 2 | Immunogenicity and protective efficacy of recombinant M2e.Hsp70c(Hsp70_(359–610)) fusion protein against influenza virus infection in mice显示文摘New strategies in vaccine development are urgently needed to combat emerging influenza viruses and to reduce the risk of pandemic disease surfacing. Being conserved, the M2 e protein, is a potential candidate for universal vaccine development against influenza A viruses. Mycobacterium tuberculosis Hsp70(mHsp70) is known to cultivate the function of immunogenic antigen-presenting cells, stimulate a strong cytotoxic T lymphocyte(CTL) response, and stop the induction of tolerance. Thus, in this study, a recombinant protein from the extracellular domain of influenza A virus matrix protein 2(M2e), was fused to the C-terminus of Mycobacterium tuberculosis Hsp70(Hsp70c), to generate a vaccine candidate. Humoral immune responses, IFN-γ-producing lymphocyte, and strong CTL activity were all induced to confirm the immunogenicity of M2 e.Hsp70c(Hsp70359–610). And challenge tests showed protection against H1N1 and H9N2 strains in vaccinated groups. Finally these results demonstrates M2 e.Hsp70c fusion protein can be a candidate for a universal influenza A vaccine. | Hamidreza Attaran Hassan Nili Majid Tebianian | 2014 | Virologica Sinica2014，29，4： | 2 |
| 3 | The Long-Sought-After Salicylic Acid Receptors显示文摘The plant hormone salicylic acid (SA) plays a prominent role in modulating plant immune responses against diverse pathogens.SA also influences other physiological processes in plants,such as senescence-associated gene expression,basal thermogenesis,and seed germination (Vlot et al.,2009).Because of the critical role of SA in regulating plant immunity,growth,and development,there has been immense research about SA,which has resulted in the discovery of numerous plant genes involved in SA biosynthesis or signal transduction.One of the most notable findings was the identification of NPR1 (non-expressor of pathogenesis protein 1) (Cao et al.,1994;Delaney et al.,1995),a gene that encodes a master regulatory protein of SA-dependent defense responses and is a transcriptional co-activator of the TGA clade of bZIP transcription factors (transcription factors that contain basic region/leucine zipper motif).NPR1 exists in at least two forms in the cell.When the SA level is low in the cell (e.g.in the absence of pathogen infection),NPR1 is localized in the cytoplasm as an oligomer through intermolecular disulphide bonds.However,when the SA level is high (e.g.after pathogen infection),redox changes in the cytosol trigger the reduction of disulphide bonds,and monomeric NPR1 enters the nucleus and functions as a transcriptional co-activator at the target gene promoter (Mou et al.,2003).The npr1 mutant could not initiate the SA-associated global transcriptional response program and is defective inall major SA-dependent defense responses,suggesting a central role in SA signal transduction (Cao et al.,1994;Delaney et al.,1995).Despite these impressive advances,however,one of the most fundamental questions-the identity of the SA receptor-has remained unanswered. | Elham Attaran ShengYang He | 2012 | Molecular Plant2012，5，5： | 2 |
| 4 | Exploring the Relationship between lnfommtion Technology and Business Process Reengineering 显示文摘 | M Attaran | 2004 | Information & Management2004，41，5： | 1 |
| 5 | Ovarian function preservation in the cancer patient显示文摘 | Falcone T Attaran M Bedaiwy MA | 2004 | Fertil Steril2004，81，2： | 1 |
| 6 | Ovarian function preservation in the cancer patient 显示文摘 | Falcone T Attaran M Mohamed AB | 2004 | Fertil Steril2004，81，2： | 1 |
| 7 | Why Does Reengineering Fail? A Practical Guide for Successful Implementation显示文摘 | Attaran M | 2000 | Journal of Management Development2000，19，9： | 1 |
| 8 | Is coronary artery bypass grafting an acceptable alternative to myotomy for the treatment of myocardial bridging?显示文摘 | Attaran S Moscarelli M Athanasiou T | 2013 | Interact Cardiovasc Thorac Surg2013，16，3： | 1 |
| 9 | Brain natriuretic peptide a predictivemarker in cardiac surgery显示文摘 | Attaran S Sherwood R Desai J | 2009 | Interact Cardiovasc Thorac Surg2009，9，4： | 1 |
| 10 | Brain natriuretic peptide a predictive marker in cardiac surgery 显示文摘 | Attaran S Sherwood R Desai J | 2009 | Interact Cardiovasc Thorac Surg2009，9，4： | 1 |
| 11 | Ovarian function preservation in the cancer patient 显示文摘 | Falcone T Attaran M Bedaiwy MA | 2004 | Fertil Steril2004，81，2： | 1 |
| 12 | Vitamin C and vitamin E supplementation reduce oxidative stress-induced embryo toxicity and improve the blastocyst development rate显示文摘 | Wang X Falcone T Attaran M | 2002 | Fer- til Steril2002，78，6： | 1 |
| 13 | Ovarian function preservation in the cancer patient显示文摘 | Falcone T Attaran M Bedaiwy MA | 2004 | Fertil Steril2004，81，2： | 1 |
| 14 | Exploring the Relationship between Information Technology and Business Process Reengineering显示文摘 | Attaran M | 2004 | Information and Management2004，41，5： | 1 |
| 15 | Performance review of high-quality-factor, low-noise and wideband radio- frequency LC-VCO for wireless communication显示文摘 | Moghavvemi A Attaran A | 2011 | IEEE Microwave Magazine2011，12，4： | 1 |
| 16 | Lymphatic mapping and sentinel node biopsy in squamous cell carcinoma of the vulva : systematic review and meta-analysis of the literature 显示文摘 | Hassanzade M Attaran M Treglia G | 2013 | Gynecol Oncol2013，130，1： | 1 |
| 17 | Vitamin C and vitamin E supplementation reduce oxidative stress–induced embryo toxicity and improve the blastocyst development rate显示文摘 | Xia Wang Tommaso Falcone Marjan Attaran Jeffrey M Goldberg Ashok Agarwal Rakesh K Sharma | 2002 | Fertility and Sterility2002，，6： | 1 |
| 18 | The effect of follicular fluid reactive oxygen species on the outcome of in vitro fertilization 显示文摘 | Attaran M Pasqualotto E Falcone T | 2000 | International journal of fertility and women''s medicine2000，45，5： | 1 |
| 19 | Exploring the relationship between information technology and business process reengineering显示文摘 | Mohsen Attaran | 2003 | Information & Management2003，，5： | 1 |
| 20 | Intraportal infusion of ^99mtechnetium-macroaggregrated albumin particles and hepatocytes in rabbits : assessment of shunting and portal hemodynamic changes显示文摘 | Schneider A Attaran M Gratz KF | 2003 | Transplantation2003，75，3： | 1 |
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