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    题名 作者 年代 出处 被引量
11994年中国糖尿病患病率及其危险因素显示文摘为调查全国糖尿病及糖耐量低减(IGT)的患病率及糖尿病危险因素,对全国19省市年龄≥25岁的224251人群进行横向普查,根据1985年WHO标准,年龄在25~64岁的213515人群中,糖尿病患病率为2.51%,糖耐量低减患病率为3.20%(按1990年全国人口年龄标化后患病率);新诊断糖尿病的比例(70.33%)明显高于已确诊的糖尿病者。现患病率是10年前的3.0倍左右,其中农村患病率的增长高于城市。经多因素logistic逐步回归分析显示,年龄、体重指数或腰臀围比、糖尿病家族史、高血压、低体力活动、高收入为非胰岛素依赖型糖尿病(NIDDM)的独立危险因素,而且在高收入人群中,低文化程度也为NIDDM的独立危险因素。Pan Xiaoren *, Yang Wenying, Liu Juan, et al. *Department of Endocrinology, China Japan Friendship Hospital, Beijing 100029 1997中华内科杂志1997,36,6:415
2Spatiotemporal characteristics, patterns, and causes of land-use changes in China since the late 1980s显示文摘Land-use/land-cover 变化(LUCC ) 有连接到人和自然相互作用。瓷器 Land-Use/cover 数据集(CLUD ) 从 1980 年代末在 5 年的间隔定期被更新到 2010,与基于 Landsat TMETM+ 图象的标准过程。陆地使用动态区域化方法被建议分析主要陆地使用变换。在国家规模的陆地使用变化的空间与时间的特征,差别,和原因然后被检验。主要调查结果如下被总结。越过中国的陆地使用变化(LUC ) 在最后 20 年(19902010 ) 里在空间、时间的特征显示了一个重要变化。农田变化的区域在南方减少了并且在北方,而是仍然是的全部的区域增加了几乎未改变。回收农田从东北被转移到西北。布满建筑物陆地很快膨胀了,主要在东方被散布,并且逐渐地展开到中央、西方的中国。树林首先减少了,然后增加但是荒芜的区域是反面。草地继续减少。在中国的 LUC 的不同空间模式被发现在之间迟了第 20 世纪并且早第 21 世纪。原版 13 个 LUC 地区在一些地区被边界的变化由 15 个单位代替。包括的这些变化(1 ) 的主要空间特征加速的扩大布满建筑物在 Huang-Huai-Hai 区域,东南的沿海的区域,长江的中流区域,和四川盆登陆;(2 ) 从东北中国和东方内部蒙古在北方转移了陆地开垦到绿洲在西北中国的农业区域;(3 ) 从在到稻的东北中国的喂雨的农田的连续转变回答;并且(4 ) 为在内部蒙古,黄土高原,和西南的多山的区域的南部的农业牧剧的交错群落的格林工程的谷物的有效性。在最后二十年,尽管在北方的气候变化在农田影响了变化,政策规定和经济驱动力仍然是越过中国的 LUC 的主要原因。在第 21 世纪的第一十年期间,在陆地使用模式驾驶了变化的人为的因素从单程的陆地开发转移了强调到开发和保存。动态区域化方法被用来在单位的 zoning 边界,地区的内部特征,和生长和减少的空间模式分析变化。结果揭示了变化过程的模式,也就是 LUC 的过程和在在不同阶段的特征的地区性的差别。地区的生长和减少在这动态 LUC zoning,在统一边界的变化,和在前者和后者十年之间的变化紧张的特征期间被检验。在为在不同类型和陆地使用的不同区域的变化的陆地使用和原因的模式和过程之间的其他的转变的模式被探索。LIU Jiyuan KUANG Wenhui ZHANG Zengxiang XU Xinliang QIN Yuanwei NING Jia ZHOU Wancun ZHANG Shuwen LI Rendong YAN Changzhe WU Shixin SHI Xuezheng JIANG Nan YU Dongsheng PAN Xianzhang CHI Wenfeng 2014Journal of Geographical Sciences2014,24,2:245
3L^p-Boundedness of Marcinkiewicz Integrals with Hardy Space Function KernelsYong Ding Department of Mathematics, Beijing Normal University, Beijing 100875, P. R. China Dashan Fan Department of Mathematics, Anhui University and University of Wisconsin-Milwaukee. MW 53201 USA Yibiao Pan Department of Mathematics, University of Pittsburgh. Pittsburgh. Pennsylvania 15260. USA 2000Acta Mathematica Sinica,English Series2000,16,4:88
4Ferroptosis is an autophagic cell death process显示文摘Ferroptosis 是调整坏死的一种铁依赖者形式。它在各种各样的人的疾病被含有,包括 ischemic 机关损坏和癌症。这里,我们报导 autophagy 的关键角色,特别地细胞的铁存储蛋白质(作为 ferritinophagy 知道的一个过程) 的 autophagic 降级,在 ferroptosis。用 RNAi,屏蔽结合了随后的基因分析,我们作为 ferroptosis 的积极管理者识别了多重 autophagy 相关的基因。Ferroptosis 正式就职导致了 autophagy 激活和 ferritin 和 ferritinophagy 货物受体 NCOA4 的作为结果的降级。一致地,由 autophagy 的阻塞的 ferritinophagy 的抑制或废除的 NCOA4 击倒联系 ferroptosis 的细胞的易变的铁的累积和反应的氧种类,以及最终的 ferroptotic 细胞死亡。因此, ferroptosis 是一个 autophagic 房间死亡过程,并且调停 NCOA4 的 ferritinophagy 由控制细胞的铁动态平衡支持 ferroptosis。Minghui Gao Prashant Monian Qiuhui Pan Wei Zhang Jenny Xiang Xuejun Jiang 2016Cell Research2016,26,9:138
5Heading toward Artificial Intelligence 2.0显示文摘Yunhe Pan 2016Engineering2016,2,4:115
6Latest research advances on magnesium and magnesium alloys worldwide显示文摘In the past two years,significant progresses have been achieved in high-performance cast and wrought magnesium and magnesium alloys,magnesium-based composites,advanced cast technologies,advanced processing technologies,and functional magnesium materials,such as Mg ion batteries,hydrogen storage Mg materials,bio-magnesium alloys,etc.Great contributions to the development of new magnesium alloys and their processing technologies have been made by Chongqing University,Shanghai Jiaotong University,Chinese Academy of Sciences,Helmholtz Zentrum Geesthacht,Queensland University,Brunel University,etc.This review paper is aimed to summarize the latest important advances in cast magnesium alloys,wrought magnesium alloys and functional magnesium materials worldwide in 2018–2019,including both the development of new materials and the innovation of their processing technologies.Based on the issues and challenges identified here,some future research directions are suggested,including further development of high-performance magnesium alloys having high strength and superior plasticity together with high corrosion resistance and low cost,and fundamental research on the phase diagram,diffusion,precipitation,etc.,as well as the development of advanced welding and joining technology.Jiangfeng Song Jia She Daolun Chen Fusheng Pan 2020Journal of Magnesium and Alloys2020,8,1:132
7A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV.Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 2020Military Medical Research2020,7,1:161
8Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears.Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG 2021Science China(Information Sciences)2021,64,1:122
9Magnetostratigraphy of the late Cenozoic Laojunmiao anticline in the northern Qilian Mountains and its implications for the northern Tibetan Plateau uplift显示文摘Cenozoic sediments in the foreland basin--Jiuquan Basin in west Hexi Corridor recorded tectonic uplift information of the Qilian Mountains. High resolution paleomagnetic dating of the Laojunmiao (LJM) section across the central LJM anticline in the southern Jiuquan Basin reveals ages of the Getanggou Member, Niugetao Member in the Shulehe Formation, the Yumen Conglomerate, Jiuquan Conglomerate and Gobi Formation at >13-8.3 Ma, 8.3-4.9 Ma, 3.66-0.93 Ma, 0.84-0.14 Ma and 0.14-0 Ma, respectively. Sedimentary evolution study suggests that the Qilian Mountains should begin to rise gradually since ~8-6.6 Ma, accompanied by sedimentary environments changing from lacustrine mudstones-sandstones to alluvial conglomerates. Rapid uplift of the Qilian Mountains began at ~3.66 Ma, followed by a series of stepwise or intermittent intensive uplifts at about <1.8-1.23 Ma, 0.93-0.84 Ma and 0.14 Ma, which finally resulted in the present high Qilian Mountains.FANG Xiaomin1,2, ZHAO Zhijun3,2, LI Jijun2, YAN Maodu2, PAN Baotian2, SONG Chunhui2 & DAI Shuang2 1. Institute of Tibetan Plateau Research, Chinese Academy of Sciences, Beijing 100085, China 2. Key Laboratory of Western China’s Environmental Systems, Ministry of Education & College of Resources and Environment, Lanzhou University, Lanzhou 730000, China 3. College of Geography, Nanjing Normal University, Nanjing 210097, China 2005Science China Earth Sciences2005,48,7:61
10Association of H.pylori infection with gastric carcinoma:a Meta analysis显示文摘AIM: To follow the principles of evidence based medicine to reach the integrated results of these studies.METHODS: Twenty-one papers of case-control studies were selected, including 11 on gastric cancer, 7 on precancerous lesion of stomach and 3 on lymphoma of stomach: Meta analysis was used to sum up the odds ratios (OR) of these studies.RESULTS: H. Pylori vsgastric cancer (intestinal and diffuse type): the odds ratio from the fixed effect model is 3.0016(95% Cl 2.4197-3.7234, P < 0.001 ). H. Pylori vs precancerous lesion of stomach: a random effect model was used to calculate the summary odds ratio and its value is 2.5635 (95% Cl: 1.8477-3.5566, P < 0.01). H. Pylori vs lymphoma of stomach: though the quantity of literature is too small to make Meta analysis, the data of these 3 studies show that lymphoma of stomach is highly associated with H. Pylori infections.CONCLUSION: Since it had been revealed that H. Pylori infection pre-exists in gastric carcinoma and precancerous lesions, the results of Meta analysis present a strong evidence to support the conclusion that H. Pylori infection is a risk factor for gastric carcinoma.Fu-Bo Xue~1 Yong-Yong Xu~1 Yi Wan~1 Bo-Rong Pan~2 Jun Ren~2 Dai-Ming Fan~3 1 Department of Health Statistics,Department of2 Oncology3 Gastroenterology of XiJing Hospital,the Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China 2001World Journal of Gastroenterology2001,7,6:66
11SIMULATION OF MAXIMUM LIGHT USE EFFICIENCY FOR SOME TYPICAL VEGETATION TYPES IN CHINA显示文摘Maximum light use efficiency (εmax) is a key parameter for the estimation of net primary pro-ductivity (NPP) derived from remote sensing data. There are still many divergences about its value for each vegetation type. The εmax for some typical vegetation types in China is simulated using a modi-fied least squares function based on NOAA/AVHRR remote sensing data and field-observed NPP data. The vegetation classification accuracy is introduced to the process. The sensitivity analysis of εmax to vegetation classification accuracy is also conducted. The results show that the simulated values of εmax are greater than the value used in CASA model, and less than the values simulated with BIOME-BGC model. This is consistent with some other studies. The rela-tive error of εmax resulting from classification accuracy is ?5.5%―8.0%. This indicates that the simulated values of εmax are reliable and stable.ZHU Wenquan PAN Yaozhong HE Hao YU Deyong HU Haibo 2006Chinese Science Bulletin2006,51,4:61
12A new edge recognition technology based on the normalized vertical derivative of the total horizontal derivative for potential field data显示文摘边察觉和改进技术通常在用潜在的域数据认出地质的身体的边被使用。我们在场一种新边识别技术基于有边察觉和改进技术的功能的全部的水平衍生物的规范的垂直衍生物。首先,我们计算潜在地的数据的全部的水平衍生物(THDR ) 然后计算 n 顺序 THDR 的垂直衍生物(VDRn ) 。为 n 顺序垂直衍生物,全部的水平衍生物(PTHDR ) 的山峰价值用比 0 大的阀值价值被获得。这 PTHDR 能被用于边察觉。第二, PTHDR 价值被全部的水平衍生物划分并且由最大的价值使正常化。最后,我们使用了数字模型的不同类型验证新边识别技术的有效性和可靠性。Wang Wanyin Pan Yu Qiu Zhiyun 2009Applied Geophysics2009,6,3:79
13A Review on Casting Magnesium Alloys: Modification of Commercial Alloys and Development of New Alloys显示文摘The research and development status of casting magnesium alloys including the commercial casting alloys and the new types casting alloys are reviewed,with more attention to microstructure and mechanical properties of modified-AZ91,AM60 and WE43 alloys with various additions,and new types of low cost casting alloys and high strength casting alloys.The modification and/or refinement of Mg2 Si phase in Mg–Al–Si based casting alloys by various additions are discussed and new purifying technologies for casting magnesium alloys are introduced to improve the performance.The modified AZ81 alloy with reduced impurities is found to have the tensile strength of 280 ± 6 MPa and elongation of 16% ± 0.7%.The fatigue strength of AZ91 D alloy could be obviously improved by addition of Ce and Nd.The Mg–16Gd–2Ag–0.3Zr alloy exhibits very high tensile and yield strengths(UTS:423 MPa and YS:328 MPa);however,its elongation still needs to be improved.Fusheng Pan Mingbo Yang Xianhua Chen 2016Journal of Materials Science & Technology2016,32,12:78
14晚中生代以来阿尔金断裂的走滑模式显示文摘对阿尔金断裂两侧塔里木和柴达木盆地晚中生代以来沉积特征以及柴达木盆地反“S”型构造演化的研究表明 ,始新世中期以前塔里木盆地和柴达木盆地是一个连通的盆地 ,阿尔金走滑断裂对柴达木盆地内地表新时代的沉积和反“S”型构造形成的控制起始于始新世中期。在阿尔金断裂中段采集的受到走滑变形作用改造的侏罗纪地层和糜棱岩化加里东期花岗岩的样品 ,测出了激光微区4 0 Ar/ 3 9Ar等时线年龄为 89~ 92Ma。这说明阿尔金断裂在晚白垩世开始发生韧性走滑运动 ,而且走滑作用起始于地下深部 ,并伴有低级变质作用。地表的走滑响应明显地滞后于深部的起始走滑 ,说明走滑作用是从深部向地表扩展的。刘永江 葛肖虹 叶慧文 刘俊来 N.Franz J.Genser Pan Hongxun 潘宏勋 任收麦 2001地球学报2001,22,1:76
15Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier显示文摘AIM To investigate whether gut microbiota metabolite sodium butyrate(Na B)is an effective substance for attenuating non-alcoholic fatty liver disease(NAFLD)and the internal mechanisms.METHODS Male C57BL/6J mice were divided into three groups,normal control were fed standard chow and model group were fed a high-fat diet(HFD)for 16 wk,the intervention group were fed HFD for 16 wk and treated with Na B for 8 wk.Gut microbiota from each group were detected at baseline and at 16 wk,liver histology were evaluated and gastrointestinal barrier indicator such as zonula occluden-1(ZO-1)were detected by immunohistochemistry and realtime-PCR,further serum or liver endotoxin were determined by ELISA and inflammation-or metabolism-associated genes were quantified by real-time PCR.RESULTS Na B corrected the HFD-induced gut microbiota imbalance in mice,while it considerably elevated the abundances of the beneficial bacteria Christensenellaceae,Blautia and Lactobacil us.These bacteria can produce butyric acid in what seems like a virtuous circle.And butyrate restored HFD induced intestinal mucosa damage,increased the expression of ZO-1 in small intestine,further decreased the levels of gut endotoxin in serum and liver compared with HF group.Endotoxin-associated genes such as TLR4 and Myd88,pro-inflammation genes such as MCP-1,TNF-α,IL-1,IL-2,IL-6 and IFN-γin liver or epididymal fat were obviously downregulated after Na B intervention.Liver inflammation and fat accumulation were ameliorated,the levels of TG and cholesterol in liver were decreased after Na B intervention,NAS score was significantly decreased,metabolic indices such as FBG and HOMA-IR and liver function indicators ALT and AST were improved compared with HF group.CONCLUSION Na B may restore the dysbiosis of gut microbiota to attenuate steatohepatitis,which is suggested to be a potential gut microbiota modulator and therapeutic substance for NAFLD.Da Zhou Qin Pan Feng-Zhi Xin Rui-Nan Zhang Chong-Xin He Guang-Yu Chen Chang Liu Yuan-Wen Chen Jian-Gao Fan 2017World Journal of Gastroenterology2017,23,1:77
16MICROWAVE-ASSISTED EXTRACTION OF GLYCYRRHIZIC ACID FROM LICORICE ROOT-EFFECT OF THE PROPERTY OF SOLUTION ON EXTRACTION OF GA显示文摘The property of extraction solution is an important factor influencing the extraction efficiency. In the present work, the effect of the property of solution on extraction of GA was studied, which including the concentration of ethanol, ammonia and cation (M+), pH of extraction solution, different kinds of organic solvent etc. The results show that 50%-60%(v/v) ethanol can reach high percentage extraction of GA. If 1% (v/v) ammonia solution was added into 60%(v/v) ethanol, the percentage extraction can be increased from 2.0% to 2.31%. Without ammonia, 50mmol/L [M+] (M+ = K+, NH4+) was added into 60%(v/v) ethanol, percentage extraction of GA can reach about 2.26%. If pH of solution (60% ethanol) was adjust to pH=4.0, it can reach high percentage extraction. If pH of solution (60% ethanol + 50mmol [M+], pH=6.1) was adjust tO PH=4.0, especially M+ is K+ or NH4+, it can reach almost same extraction efficiency as that of 1% ammonia solution + 60% ethanol, and the operation environment can be greatly improved.Pan Xuejun and Liu Huizhou (Young Scienctist Laboratory of Separation Science & Engineering, State Key Laboratory of Biochemical Engineering, Instigate of Chemical Metallurgy, Chinese Academy of Sciepces, Beijing 100080) 2000化工学报2000,51,S1:52
17Restoring urbanization process in China in the 1990s by using non-radiance-calibrated DMSP/OLS nighttime light imagery and statistical data显示文摘Since current administrative unit-based urban land area statistical data in China lack enough spatial information, the urbanization process re- search at large scale cannot be effectively supported. Based on the current administrative unit-based urban land area statistical data in China, a new approach to quickly and cheaply derive urban land information from the non-radiance-calibrated Defense Meteoro- logical Satellite Program/ Operational Linescan Sys- tem (DMSP/OLS) nighttime light imagery is pre- sented in this paper. With the new approach, the ur- ban pattern information in China in 1992, 1996 and 1998 was derived with the urbanization processes in China in the 1990s restored by using the non-ra- diance-calibrated DMSP/OLS nighttime imagery. The accuracy assessment based on the statistical data showed that the relative error between the derived total urban land area and the statistical data at na- tional scale was less than 2% in 1992, and less than 1% in 1996 and 1998, and the maximum relative er- ror at province scale do not exceed 10% with most of the provinces less than 3%. In addition, the urban patterns derived from the high-resolution Landsat TM imagery were compared with those from the DMSP/ OLS data. The results showed that the urban pattern characteristics derived from DMSP/OLS were basi-cally coincident with those from TM imagery with the total accuracy of about 80%. Thus it can be seen that our restored urbanization process in China in the 1990s by using the non-radiance DMSP/OLS night- time imagery can be accepted and can represent the actual urban development in China at that time on the whole.HE Chunyang SHI Peijun LI dinggang CHEN din PAN Yaozhong LI ding ZHUO Li Ichinose Toshiaki 2006Chinese Science Bulletin2006,51,13:55
18Nanog and transcriptional networks in embryonic stem cell pluripotency显示文摘象 LIF, BMP 和 Wnt 那样的几个外来的信号能支持胚胎的茎(ES ) 的 theself 更新和 pluripotency 通过调整的房间“ pluripotentgenes。“一个唯一的 homeobox 抄写因素, Nanog,是这些信号的关键下游的受动器之一。Nanog 的提高的水平能维持老鼠 ES 细胞自强独立人士 ofLIF 并且没有喂入器饲料分送器细胞,启用人的 ES 细胞生长。除了外部信号,小径,象 FoxD3 那样的内在的抄写因素, P53 和 Oct4 也涉及调整 Nanog 的表示。机能上地, Nanog 和象 Oct4 和 Sox2 那样的另外的关键 pluripotentfactors 工作控制在 EScell pluripotency 有重要函数的一套目标基因。这些关键因素形成一个规章的网络支持或限制对方“ sexpression 铺平房间,它维持 ES 的性质。Guangjin Pan James A Thomson 2007Cell Research2007,17,1:51
19U-Pb zircon dating of Early Paleozoic gabbro from the Nantinghe ophiolite in the Changning-Menglian suture zone and its geological implication显示文摘The Nantinghe ophiolite is located in the northern part of the Changning-Menglian suture zone in southeast Tibet. It is composed of meta-peridotite, cumulative gabbro, meta-gabbro, plagioclase amphibolite and meta-basalt. Zircon U-Pb dating of the cumulative gabbro gives concordant ages of 473.0±3.8 Ma and 443.6±4.0 Ma respectively, indicating the early and late episodes of mafic magmatisms during the Paleo-Tethys oceanic rifting. The 16 LA-ICPMS zircon U-Pb analyses of meta-gabbro yield a weight mean age of 439±2.4Ma. The gabbro shows relatively low contents of SiO2 (46.46%-52.11%), TiO2 (0.96%-1.14%) and K2O (0.48%-0.75%). Its trace element distribution patterns are partly similar to those of the mid-ocean ridge basalts, and part is depleted in high field strength elements such as Nb, Ta, Zr, Hf and Ti. These features suggest that the mafic rocks were probably formed in a MORB-like or backarc rift basin setting. The zircon U-Pb age of gabbro is consistent with a late crystallization age of the cumulative gabbro from the Nantinghe ophiolite, suggesting that the Paleo-Tethys oceanic basin was opened during 444-439 Ma, possibly as a backarc basin. It is the first precise age which defines the formation time of the early Paleozoic ophiolite in the Changning-Menglian suture zone. These geochronological and geochemical characteristics of the Nantinghe ophiolite are consistent with those from the Guoganjianianshan and Taoxinghu of the Longmu Co-Shuanghu suture in the Qiangtang region. Thus, we suggest that the both Changning-Menglian and Longmu Co-Shuanghu sutures were probably transformed from the relic oceanic crust of the uniform Paleo-Tethys, which likely represents the original and main Paleo-Tethys oceanic basin.WANG BaoDi WANG LiQuan PAN GuiTang YIN FuGuang WANG DongBing TANG Yuan 2013Chinese Science Bulletin2013,58,8:54
202018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up.Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu 2018Science Bulletin2018,63,23:54
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