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| 1 | Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells显示文摘 | Charles N Ozawa T Squatrito M Bleau AM Brennan CW Hambardzumyan D Holland EC. | 2010 | 中国神经肿瘤杂志2010，8，1： | 24 |
| 2 | 青稞粉添加量对面条加工特性的影响显示文摘为开发新型营养面条,探究青稞粉对面条的物理品质特性的影响,以小麦粉为原料,分别添加45%、60%、75%的青稞粉制作面条,研究不同青稞粉添加量对面条颜色、硬度、弹性、水分分布状态和淀粉凝胶化温度的影响。结果表明,青稞粉的添加量越多,面条的颜色越暗,硬度和弹性越差;青稞粉的加入使面条内部的水分子状态发生了迁移,与大分子物质如淀粉和蛋白质结合更紧密,面条的淀粉凝胶化温度也逐渐升高。75%添加量的面条无法形成完整的面筋网络,不能达到正常面条质地强度要求。综合来看,45%的青稞粉添加量尚能维持面条的基本物理特性,达到面条的弹性和硬度要求,可以制作青稞面条。 | 贾斌 姚亚静 关文强 刘建福 Charles Stephen Brennan | 2019 | 食品研究与开发2019，40，9： | 11 |
| 3 | Factors Influencing FDI Location Choice in China's Inland Areas显示文摘自从 1978,外国直接投资(FDI ) 的体积在中国去了东南的沿海的区域,与仅仅小部分收到的内陆。与在 2000 的西方的发展策略和华中的发射升起在 2004 的策略,投资地点的选择膨胀了到内陆区域。基于从 1999 ~ 2005 盖住 98 个内陆城市的面板数据,这研究为投资在的 FDI 识别地点偏爱变量中国是内陆区域,并且发现象自然资源那样的生长得很好的因素和低劳动费用不是在在中国的内陆以内决定 FDI 地点的重要因素。相反,政策刺激和工业凝块是最重要的因素。现在的学习的调查结果为两个主人乡村当局和跨国的公司有政策含意。 | Laijun Luo Louis Brennan Chang Liu Yuze Luo | 2008 | China & World Economy2008，16，2： | 11 |
| 4 | 梅州金柚柚皮膳食纤维的理化性质分析显示文摘本文采用酶法对金柚中总膳食纤维、水溶性膳食纤维、水不溶性膳食纤维分别进行提取,并对其结构、理化性质以及肠道功能进行评价。结果表明:金柚柚皮中总膳食纤维含量为65.72%,其中可溶性、水不溶性膳食纤维的得率分别为15.13%%和43.21%;总膳食纤维结构为多孔珊瑚状,水溶性膳食纤维表面有多处孔洞,水不溶性膳食纤维结构较平整;三者均含有丰富的葡萄糖、阿拉伯糖、木糖;水不溶性膳食纤维的持水力和膨胀力较好,分别为6.68 g/g和27.61 g/g;在2.5 mg/mL和10 mg/mL的体系中,水溶性膳食纤维抑制葡萄糖扩散效果更好,为0.11mg/(mL·h);水不溶性膳食纤维对α-淀粉酶抑制效果最好,此时α-淀粉酶活性为93.90%;水溶性纤维破坏胆固醇能力最强,分别为7.20%和9.40%。同时,水溶性膳食纤维具有更优越的DPPH·清除能力和铁离子还原能力。通过酶解法制得的柚皮膳食纤维有较好的理化性质,可以作为优良的食品添加剂在食品中应用。 | 曾心悦 黄嘉泳 袁显和 王琴 Charles Brennan 刘袆帆 刘映君 | 2020 | 现代食品科技2020，36，4： | 9 |
| 5 | Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples显示文摘AIM To compare(1) demographics in urea breath test(UBT) vs endoscopy patients; and(2) the molecular detection of antibiotic resistance in stool vs biopsy samples.METHODS Six hundred and sixteen adult patients undergoing endoscopy or a UBT were prospectively recruited to the study. The Geno Type Helico DR assay was used to detect Helicobacter pylori(H. pylori) and antibiotic resistance using biopsy and/or stool samples from CLOpositive endoscopy patients and stool samples from UBT-positive patients. RESULTS Infection rates were significantly higher in patients referred for a UBT than endoscopy(overall rates: 33% vs 19%; treatment-na?ve patients: 33% vs 14.7%, respectively). H. pylori-infected UBT patients were younger than H. pylori-infected endoscopy patients(41.4 vs 48.4 years, respectively, P < 0.005), with a higher percentage of H. pylori-infected males in the endoscopy-compared to the UBT-cohort(52.6% vs 33.3%, P = 0.03). The Geno Type Helico DR assay was more accurate at detecting H. pylori infection using biopsy samples than stool samples [98.2%(n = 54/55) vs 80.3%(n =53/66), P < 0.005]. Subset analysis using stool and biopsy samples from CLO-positive endoscopy patients revealed a higher detection rate ofresistance-associated mutations using stool samples compared to biopsies. The concordance rates between stool and biopsy samples for the detection of H. pylori DNA, clarithromycin and fluoroquinolone resistance were just 85%, 53% and 35%, respectively. CONCLUSION Differences between endoscopy and UBT patients provide a rationale for non-invasive detection of H. pylori antibiotic resistance. However, the Geno Type Helico DR assay is an unsuitable approach. | Denise E Brennan Joseph Omorogbe Mary Hussey Donal Tighe Grainne Holleran Colm O'Morain Sinéad M Smith Deirdre McNamara | 2016 | World Journal of Gastroenterology2016，22，41： | 6 |
| 6 | Clinical Score for Predicting Recurrence After Hepatic Resection for Metastatic Colorectal Cancer: Analysis of 1001 Consecutive Cases显示文摘 | Yuman Fong Joseph Fortner Ruth L. Sun Murray F. Brennan Leslie H. Blumgart | 1999 | Annals of Surgery1999，，3： | 5 |
| 7 | 香菇粉的添加量对面条物理性质的影响显示文摘为了研究香菇粉的添加量对面条物理性质的影响,以小麦粉为原料,加入不同比例的香菇粉(5%、10%和15%),对面条的颜色、质构特性、水分分布状态和热力学性质进行了分析。结果表明,香菇粉的加入导致面条颜色变深,弹性、黏聚性和回复性减小,同时改变了水分分布状态,水分子发生了迁移,与面条中其他大分子物质的结合更紧密,但香菇粉的添加量对面条的糊化温度没有显著的影响。 | 贾斌 王俊生 关文强 刘建福 Charles Stephen Brennan | 2019 | 食品科技2019，44，4： | 5 |
| 8 | Varicella zoster meningitis complicating combined anti-tumor necrosis factor and corticosteroid therapy in Crohn's disease显示文摘Opportunistic viral infections are a well-recognized complication of anti-tumor necrosis factor (TNF) therapy for inflammatory bowel disease (IBD). Cases of severe or atypical varicella zoster virus infection, both primary and latent reactivation, have been described in association with immunosuppression of Crohn's disease (CD) patients. However, central nervous system varicella zoster virus infections have been rarely described, and there are no previous reports of varicella zoster virus meningitis associated with anti-TNF therapy among the CD population. Here, we present the case of a 40-year-old male with severe ileocecal-CD who developed a reactivation of dermatomal herpes zoster after treatment with prednisone and adalimumab. The reactivation presented as debilitating varicella zoster virus meningitis, which was not completely resolved despite aggressive antiviral therapy with prolonged intravenous acyclovir and subsequent oral valacyclovir. This is the first reported case of opportunistic central nervous system varicella zoster infection complicating anti-TNF therapy in the CD population. This paper also reviews the literature on varicella zoster virus infections of immunosuppressed IBD patients and the importance of vaccination prior to initiation of anti-TNF therapy. | Christopher Ma Brennan Walters Richard N Fedorak | 2013 | World Journal of Gastroenterology2013，19，21： | 5 |
| 9 | High-static-low-dynamic-stiffness vibration isolation enhanced by damping nonlinearity显示文摘High-static-low-dynamic-stiffness(HSLDS) nonlinear isolators have proven to have an advantage over linear isolators, because HSLDS nonlinear isolators allow low-frequency vibration isolation without compromising the static stiffness. Previously, these isolators have generally been assumed to have linear viscous damping, degrading the performance of the isolator at high frequencies. An alternative is to use nonlinear damping, where the nonlinear behavior is achieved by configuring linear dampers so they are orthogonally aligned to the excitation direction. This report compares the performances of single-stage and two-stage isolators with this type of damping with the corresponding isolators containing only linear viscous damping. The results show that both isolators with linear viscous damping and nonlinear damping reduce the transmissibility around the resonance frequencies, but the results show that the isolators with nonlinear damping perform better at high frequencies. | LU ZeQi BRENNAN Michael DING Hu CHEN LiQun | 2019 | Science China(Technological Sciences)2019，62，7： | 5 |
| 10 | Two Hundred Gastrointestinal Stromal Tumors: Recurrence Patterns and Prognostic Factors for Survival显示文摘 | Ronald P. DeMatteo Jonathan J. Lewis Denis Leung Satvinder S. Mudan James M. Woodruff Murray F. Brennan | 2000 | Annals of Surgery2000，，1： | 4 |
| 11 | 非线性动力吸振系统动力学分析和优化显示文摘通过圆形钳制薄板的大变形提供非线性动力吸振器的立方非线性刚度,建立圆形薄板与悬臂梁相耦合的非线性动力吸振系统数学模型。结合谐波平衡法与数值计算方法,探讨非线性动力吸振器的动力学特性。与等价线性吸振器相比较,发现非线性是高阶共振峰离开吸振频率往高频移动的诱因,因此非线性动力吸振器在相对较小的质量下具有相对较宽的吸振频带。与此同时,通过对结构响应和吸振性能的灵敏度分析,找出并优化系统的敏感参数。 | 陆泽琦 杨铁军 陈立群 BRENNAN Michael J 刘志刚 | 2016 | 振动工程学报2016，29，5： | 4 |
| 12 | Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?显示文摘AIM To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori(H. pylori)-infected patients in Ireland. METHODS DNA was extracted from antral and corpus biopsies obtained from 165 H. pylori-infected patients. Genotyping for clarithromycin and fluoroquinolone-mediating mutations was performed using the Genotype Helico DR assay. cag A and vac A genotypes were investigated using PCR. RESULTS Primary, secondary and overall resistance rates for clarithromycin were 50.5%(n = 53/105), 78.3%(n = 47/60) and 60.6%(n = 100/165), respectively. Primary, secondary and overall resistance rates for fluoroquinolones were 15.2%(n = 16/105) and 28.3%(n = 17/60) and 20%(n = 33/165), respectively. Resistance to both antibiotics was 12.4%(n = 13/105) in treatment-na?ve patients, 25%(n = 15/60) in those previously treated and 17%(n = 28/165) overall. A cag A-positive genotype was detected in 22.4%(n = 37/165) of patient samples. The dominant vac A genotype was S1/M2 at 44.8%(n = 74/165), followed by S2/M2 at 26.7%(n = 44/165), S1/M1 at 23.6%(n = 39/165) and S2/M1 at 4.8%(n = 8/165). Primary clarithromycin resistance was significantly lower in cag A-positive strains than in cag A-negative strains [32%(n = 8/25) vs 56.3%(n = 45/80); P = 0.03]. Similarly, in patients infected with more virulent H. pylori strains bearing the vac A s1 genotype, primary clarithromycin resistance was significantly lower than in those infected with less virulent strains bearing the vac A s2 genotype, [41%(n = 32/78) vs 77.8%(n = 21/27); P = 0.0001]. No statistically significant association was found between primary fluoroquinolone resistance and virulence factor status.CONCLUSION Genotypic H. pylori clarithromycin resistance is high and cag A-negative strains are dominant in our population. Less virulent(cag A-negative and vac A S2-containing) strains of H. pylori are associated with primary clarithromycin resistance. | Denise E Brennan Colin Dowd Colm O'Morain Deirdre McNamara Sinéad M Smith | 2018 | World Journal of Gastroenterology2018，24，9： | 4 |
| 13 | The burden of IBS: Looking at metrics显示文摘 | Brennan M. R. Spiegel | 2009 | Current Gastroenterology Reports2009，，4： | 4 |
| 14 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 15 | Novel immunosuppressive agents in kidney transplantation显示文摘Excellent outcomes have been achieved in the field of renal transplantation. A significant reduction in acute rejection has been attained at many renal transplant centers using contemporary immunosuppressive, consisting of an induction agent, a calcineurin inhibitor, an antiproliferative agent plus or minus a corticosteroid. Despite improvements with these regimens, chronic allograft injury and adverse events still persist. The perfect immunosuppressive regimen would limit or eliminate calcineurin inhibitors and/or corticosteroid toxicity while providing enhanced allograft outcomes. Potential improvements to the calcineurin inhibitor class include a prolonged release tacrolimus formulation and voclosporin, a cyclosporine analog. Belatacept has shown promise as an agent to replace calcineurin inhibitors. A novel, fully-human anti-CD40 monoclonal antibody, ASKP1240, is currently enrolling patients in phase 2 trials with calcineurin minimization and avoidance regimens. Another future goal of transplant immunosuppression is effective and safe treatment of allograft rejection. Novel treatments for antibody mediated rejection include bortezomib and eculizumab. Several investigational agents are no longer being pursed in transplantation including the induction agents, efalizumab and alefacept, and maintenance agents, sotrastaurin and tofacitinib. The purpose of this review is to consolidate the published evidence of the effectiveness and safety of investigational immunosuppressive agents in renal transplant recipients. | Karen L Hardinger Daniel C Brennan | 2013 | World Journal of Transplantation2013，3，4： | 3 |
| 16 | Colonic stent vs. emergency surgery for management of acute left-sided malignant colonic obstruction: a decision analysis显示文摘 | Laura E. Targownik Brennan M. Spiegel Jonathan Sack Oscar J. Hines Gareth S. Dulai Ian M. Gralnek James J. Farrell | 2004 | Gastrointestinal Endoscopy2004，，6： | 3 |
| 17 | Is Gastric Cancer Different in Korea and the United States? Impact of Tumor Location on Prognosis显示文摘 | Jung Ho Shim Kyo Young Song Hae Myung Jeon Cho Hyun Park Lindsay M. Jacks Mithat Gonen Manish A. Shah Murray F. Brennan Daniel G. Coit Vivian E. Strong | 2014 | Annals of Surgical Oncology2014，，7： | 3 |
| 18 | The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism显示文摘小 GTPase Rap1 经由一条在内外面发信号的小径导致 integrin 激活由交往 Rap1 adaptormolecule (RIAM ) 调停了。堵住这条小径可以压制与活动过度的 integrins.However 有关的肿瘤转移和其它疾病,由 Rap1 的 RIAM 的特定的识别的分子的基础仍然保持大部分未知。此处我们在场在有地岬协会(RA ) 的建筑群的 Rap1 的一个活跃、 GTP 固定的 GTPase 领域的 crystalstructure pleckstrin 相同(PH ) 在 1.65 点的 RIAM 的结构的模块 ? 。结构表明由 Rap1 的 RIAM 的识别被 side-chaininteractions 管理。几方面链在决定这识别的特性是批评的,特别地相对地在另外的地岬 GTPases 与 Glu31/Asp31 残余相比被控告的 Lys31 residuein Rap1。Lys31 形成盐桥 withRIAM 残余 Glu212,使它成为相互作用的关键特性决定因素。我们也在 Rap1 的减小显示出这些 interactionsresults 的那混乱: RIAM 协会,导致共同聚类和房间粘附的损失。我们的调查结果 elucidatethe RIAM 由调停的分子的机制导致 Rap1 的 integrin 激活。水晶结构也由他们的小 GTPasepartners 为 RAPH 包含模块的受动器蛋白质的特定的招募为新 insightinto 提供结构的基础。 | Hao Zhang Yu-Chung Chang Mark L. Brennan Jinhua Wu | 2014 | Journal of Molecular Cell Biology2014，8，2： | 3 |
| 19 | Central pancreatectomy revisited显示文摘 | Kevin K. Roggin M.D. Udo Rudloff M.D. Leslie H. Blumgart M.D. Murray F. Brennan M.D | 2006 | Journal of Gastrointestinal Surgery2006，，6： | 3 |
| 20 | 氙灯试验箱的均匀性研究——旋转鼓式氙灯试验箱和平板式氙灯试验箱的比较显示文摘氙灯测试作为一种加速老化测试方法,在高分子材料的测试中得到了广泛使用。目前,市场上主要有旋转鼓式和平板式两类老化测试设备。在这两类氙灯试验箱中,所有被测样品的测试条件是否一致?是人们比较关心的问题。本文主要研究两种不同类型的氙灯试验箱——旋转鼓式氙灯试验箱和更先进的平板式氙灯试验箱是如何达到均匀的测试条件的。 | Gregory Fedor Patrick Brennan Gerhard Pausch 张恒 | 2007 | 汽车工艺与材料2007，，6： | 3 |
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