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| 1 | Benefits of Biochars and NPK Fertilizers for Soil Quality and Growth of Cowpea (Vigna unguiculata L. Walp.) in an Acid Arenosol显示文摘Fertilization is required for optimum plant growth, particularly in unfertile soils, while optimizing nutrient use effciency is an alternative to reduce inorganic fertilizer needs and reduce environmental problems caused by nutrient leaching. This study investigated soil properties and cowpea yield responses to biochars(BCs) made from different feedstocks, baby corn peel biochar(BC1), branches of mango tree biochar(BC2), and rice husk biochar(BC3), applied in combination with nitrogen-phosphorus-potassium(NPK) fertilizers.The experiment was conducted in a greenhouse, using an acid sandy soil(Arenosol) that was submitted for 70 d to the following eight treatments: i) control;ii) full dose of NPK(a commercial compound fertilizer(12-24-12 of N-P2O5-K2O)+ urea(46% N));iii) BC1+ half dose of NPK;iv) BC1 + full dose of NPK;v) BC2 + half dose of NPK;vi) BC2 + full dose of NPK;vii) BC3 + half dose of NPK;and viii) BC3 + full dose of NPK. All biochars were applied at a rate of 0.9%(weight/weight), and each type of biochar was combined with half and full doses of NPK fertilizers. Soil pH increased significantly(P < 0.05) in treatments with BC1 and BC2,while cation exchange capacity(CEC) and available P were higher in the treatments with BC1;BC1 and BC2 also induced higher activity of enzymes related to the P cycle and higher cowpea yield. Similar soil properties and cowpea yield parameters were obtained with the full and half doses of NPK fertilizers for each type of biochar used. In conclusion, biochars in the combination with NPK fertilizers improved soil chemistry and enzymatic activities, allowing reduced fertilizer application and food production costs in the acid soil studied. | Rogerio Borguete Alves RAFAEL Maria Luisa FERNANDEZ-MARCOS Stefania COCCO Maria Letizia RUELLO Flavio FORNASIER Giuseppe CORTI | 2019 | Pedosphere2019，29，3： | 6 |
| 2 | Pathogenic role of oxidative and nitrosative stress in primary biliary cirrhosis显示文摘Primary biliary cirrhosis is a multifactor autoimmune disease characterized by hepatic and systemic manifestations,with immune system dysregulation and abnormalities in the hepatic metabolism of bile salts,lipids,and nutrients,as well as destruction of membrane lipids and mitochondrial dysfunction.Both oxidative and nitrosative stress are associated with ongoing manifestations of the disease.In particular,abnormalities in nitric oxide metabolism and thiol oxidation already occur at early stages,thus leading to the hypothesis that these biochemical events play a pathogenic role in primary biliary cirrhosis.Moreover,the association of these metabolic abnormalities with the progression of the disease may indicate some biochemical parameters as early diagnostic markers of disease evolution,and may open up the potential for pharmacological intervention to inhibit intra-and extra-cellular stress events for resuming hepatocellular functions.The following paragraphs summarize the current knowledge by outlining molecular mechanisms of the disease related to these stress events. | Ignazio Grattagliano Giuseppe Calamita Tiziana Cocco David Q-H Wang Piero Portincasa | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 3 | Impaired coagulation,liver dysfunction and COVID-19:Discovering an intriguing relationship显示文摘Coronavirus disease 2019(COVID-19)is,at present,one of the most relevant global health problems.In the literature hepatic alterations have been described in COVID-19 patients,and they are mainly represented by worsening of underlying chronic liver disease leading to hepatic decompensation and liver failure with higher mortality.Several potential mechanisms used by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)to cause liver damage have been hypothesized.COVID-19 primary liver injury is less common than secondary liver injury.Most of the available data demonstrate how liver damage in SARSCo V-2 infection is likely due to systemic inflammation,and it is less likely mediated by a cytopathic effect directed on liver cells.Moreover,liver alterations could be caused by hypoxic injury and drugs(antibiotics and non-steroidal antiinflammatory drugs,remdesivir,tocilizumab,tofacitinib and dexamethasone).SARS-Co V-2 infection can induce multiple vascular district atherothrombosis by affecting simultaneously cerebral,coronary and peripheral vascular beds.Data in the literature highlight how the virus triggers an exaggerated immune response,which added to the cytopathic effect of the virus can induce endothelial damage and a prothrombotic dysregulation of hemostasis.This leads to a higher incidence of symptomatic and confirmed venous thrombosis and of pulmonary embolisms,especially in central,lobar or segmental pulmonary arteries,in COVID-19.There are currently fewer data for arterial thrombosis,while myocardial injury was identified in 7%-17%of patients hospitalized with SARS-Co V-2 infection and 22%-31%in the intensive care unit setting.Available data also revealed a higher occurrence of stroke and more serious forms of peripheral arterial disease in COVID-19 patients.Hemostasis dysregulation is observed during the COVID-19 course.Lower platelet count,mildly increased prothrombin time and increased Ddimer are typical laboratory features of patients with severe SARS-Co V-2 infection,described as“COVID-19 associated coagulopathy.”These alterations are correlated to poor outcomes.Moreover,patients with severe SARS-Co V-2 infection are characterized by high levels of von Willebrand factor with subsequent ADAMTS13 deficiency and impaired fibrinolysis.Platelet hyperreactivity,hypercoagulability and hypofibrinolysis during SARS-Co V-2 infection induce a pathological state named as“immuno-thromboinflammation.”Finally,liver dysfunction and coagulopathy are often observed at the same time in patients with COVID-19.The hypothesis that liver dysfunction could be mediated by microvascular thrombosis has been supported by postmortem findings and extensive vascular portal and sinusoidal thrombosis observation.Other evidence has shown a correlation between coagulation and liver damage in COVID-19,underlined by the transaminase association with coagulopathy,identified through laboratory markers such as prothrombin time,international normalized ratio,fibrinogen,D-dimer,fibrin/fibrinogen degradation products and platelet count.Other possible mechanisms like immunogenesis of COVID-19 damage or massive pericyte activation with consequent vessel wall fibrosis have been suggested. | Damiano D'Ardes Andrea Boccatonda Giulio Cocco Stefano Fabiani Ilaria Rossi Marco Bucci Maria Teresa Guagnano Cosima Schiavone Francesco Cipollone | 2022 | World Journal of Gastroenterology2022，28，11： | 5 |
| 4 | Oct 4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells显示文摘Neuroblastoma (NB ) 联系了 endothelial microvessels (他们) 可以被导出肿瘤的 endothelial 房间(侦探) 衬里,那是遗传上不稳定的并且 chemoresistant。这里,我们由集中于 Octamer 有约束力的抄写因素 4 在 NB 探讨了侦探祖先的鉴定(Oct-4 ) 作为一个通常认为的标记。Oct-4 + 房间在主要 NB 样品被检测(n = 23 ) ,变形骨头髓把发成送气音(n = 10 ) , NB 房间线(n = 4 ) ,并且 orthotopic 肿瘤(n = 10 ) 在 immunodeficient 老鼠由 HTLA-230 NB 房间线形成了。大多数 Oct-4 + 房间显示出 perivascular 分布,与他们中的 5% 个一起在 perinecrotic 区域的 homing。自从他们与恶意的房间分享了 MYCN oncogene 的扩大,所有 Oct-4 + 房间是导出肿瘤的。表示的 Perivascular Oct-4 + 细胞起源房间相关的、神经祖先相关、 NB 相关的标记包括表面 Tenascin C (TNC ) ,那不在 perinecrotic Oct-4 + 细胞和体积肿瘤细胞。在 vitro 区分进在包含脉管的 endothelial 生长因素(VEGF ) 的媒介在文化之上表示 vascular-endothelial-cadherin,前列腺特定的膜抗原和 CD31 的象 endothelial 一样房间的 TNC + 然而并非 TNC − HTLA-230 房间。TNC + 然而并非 TNC − HTLA-230 房间形成了 neurospheres 什么时候在没有浆液的媒介有教养。房间部分是 tumorigenic,但是仅仅肿瘤由包含的他们由侦探衬里的 TNC + 房间形成了。在结论,我们在 NB 肿瘤识别了包含 Oct-4 + 肿瘤房间的二个通常认为的壁龛。Oct-4 +/TNC+ perivascular NB 房间显示了粘性的高度并且用作侦探的祖先。Oct4 +/TNC+ 祖先的治疗学的指向可以抵抗导出 NB 的 EC 的贡献到肿瘤恶化和 chemoresistance。 | Annalisa Pezzolo Federica Parodi Danilo MarimPietri Lizzia Raffaghello Claudia Cocco Angela Pistorio Manuela Mosconi Claudio Gambini Michele Cilli Silvia Deaglio Fabio Malavasi Vito Pistoia | 2011 | Cell Research2011，21，10： | 2 |
| 5 | Do house prices affect consump-tionEvidence from micro data显示文摘 | Campbell J Cocco J | 2007 | Journal of Mone-tary Economics2007，54，： | 1 |
| 6 | Vitamin A deficiency produces spatial learning and memory impairment in rats显示文摘 | Cocco S Diaz G | 2002 | Neuroscience2002，115，2： | 1 |
| 7 | Narrow band imaging and high definition television in the assessment of laryngeal cancer:a propective study on 279 patients显示文摘 | Piazza C Cocco D Benedetto L | 2010 | Eur Arch Otorhinolaryngol2010，267，3： | 1 |
| 8 | B-cell differentiation in EBV-positive Burkitt lymphoma is impaired at posttranscriptional level by miRNA-ahered expression 显示文摘 | Leucci E Onnis A Cocco M | 2010 | Int J Cancer2010，126，6： | 1 |
| 9 | Interleukin-27 and interleukin-23 modulate human plasmacell functions 显示文摘 | Cocco C Morandi F Airoldi I | 2011 | J Leuko lliol2011，89，5： | 1 |
| 10 | Kinetics of amorphization processes by mechanical alloying: a modeling approach 显示文摘 | DELOGU F COCCO G | 2007 | Journal of Alloys and Compounds2007，436，12： | 1 |
| 11 | β-thalassemia and thyroidfailure:is there a role for thyroid autoimmunity显示文摘 | Mariotti S Pigliaru F Cocco MC | 2011 | Pediatr Endo-crinol Rev2011，82，： | 1 |
| 12 | Gap opening in graphene by shear strain 显示文摘 | COCCO G CADELANO E COLOMBO L | 2010 | Physical Review: B2010，81，24： | 1 |
| 13 | Fifteen-year follow-up of thyroid function in lithium patients显示文摘 | Bocchetta A Cocco F Velluzzi F | 2007 | J Endocrinol Invest2007，30，5： | 1 |
| 14 | Spizzichino a coded aperture imaging in X-and Gamma-ray astronomy 显示文摘 | CAROLI E STEPHEN J COCCO G | 1987 | Space Science Reviews1987，45，： | 1 |
| 15 | Nuclear phosphatidylinositol3,4,5-trisphosphate,phosphatidylinositol3-kinase,AKT,and PTEN:emerging key regulators of anti-apoptotic signaling and carcinogenesis显示文摘 | Martelli AM Cocco L Capitani S | 2007 | Eur J Histochem2007，51，1： | 1 |
| 16 | Lending relationships in the interbank market显示文摘 | Jo?o F. Cocco Francisco J. Gomes Nuno C. Martins | 2008 | Journal of Financial Intermediation2008，，1： | 1 |
| 17 | Vitamin A deficiency produces spatial learning and memory impairment in rats 显示文摘 | Cocco S Diaz G | 2002 | Neurescience2002，115，2： | 1 |
| 18 | Portfolio Choice in the Presence of Housing显示文摘 | Cocco JF | 2005 | Review of Financial Studies2005，，2： | 1 |
| 19 | Mechanical alloying processes and reactive milling显示文摘 | COCCO G MULAS G SCHIFFINI L | 1995 | Journal of Metals1995，47，3： | 1 |
| 20 | Coded aperture imaging in X- and Gamma-ray astronomy 显示文摘 | CAROLI E STEPHEN J COCCO G | 1987 | Space Science Reviews1987，45，34： | 1 |
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