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| 1 | Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies显示文摘Background:Because of the increasing life expectancy in our society,aging-related neurodegenerative disorders are one of the main issues in global health.Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline.Among these diseases,Alzheimer’s disease(AD)and dementia with Lewy bodies(DLB)are the most common types of degenerative dementia.Although both show specific features,an important neuropathological and clinical overlap between them hampers their correct diagnosis.In this work,we identified molecular biomarkers aiming to improve the misdiagnosis between both diseases.Methods:Plasma extracellular vesicles(EVs)-from DLB,AD and healthy controls-were isolated using size-exclusion chromatography(SEC)and characterized by flow cytometry,Nanoparticle Tracking Analysis(NTA)and cryo-electron microscopy.Next Generation Sequencing(NGS)and related bibliographic search was performed and a selected group of EV-associated microRNAs(miRNAs)was analysed by qPCR.Results:Results uncovered two miRNAs(hsa-miR-451a and hsa-miR-21-5p)significantly down-regulated in AD samples respect to DLB patients,and a set of four miRNAs(hsa-miR-23a-3p,hsa-miR-126-3p,hsa-let-7i-5p,and hsamiR-151a-3p)significantly decreased in AD respect to controls.The two miRNAs showing decreased expression in AD in comparison to DLB provided area under the curve(AUC)values of 0.9 in ROC curve analysis,thus suggesting their possible use as biomarkers to discriminate between both diseases.Target gene analysis of these miRNAs using prediction online tools showed accumulation of phosphorylation enzymes,presence of proteasome-related proteins and genes involved in cell death among others.Conclusion:Our data suggest that plasma-EV associated miRNAs may reflect a differential profile for a given dementia-related disorder which,once validated in larger cohorts of patients,could help to improve the differential diagnosis of DLB versus AD. | Ana Gámez-Valero Jaume Campdelacreu Dolores Vilas Lourdes Ispierto Ramón Reñé RamiroÁlvarez MPilar Armengol Francesc E.Borràs Katrin Beyer | 2019 | Translational Neurodegeneration2019，8，1： | 4 |
| 2 | 一种环境友好的鞣制工艺显示文摘研制一种新的鞣制工艺(亮湿革),用此工艺可以生产出一种合格的汽车内饰浅色革。此工艺是无铬、无醛、无有机溶剂挥发的绿色工艺。工艺的重点是使用了凯米拉公司提供的无毒、无害、绿色、安全的鞣剂。与传统的铬鞣革和醛鞣革相比,新工艺无论对环境或在经济上考虑都有很大的优势,具体来说,与传统的铬鞣革相比,可使废水中化学需氧量(COD)降低60%,悬浮液体降低61%,氮含量降低65%,此外这种工艺生产出的亮湿革的挥发性化合物比蓝湿革降低43%,比白湿革降低8%,更为重要的是,真正地做到了无铬废水排放。 | Anna Bacardit Stefan vander Burgh Jordi Armengol Luis Ollé 孙海云 金博 | 2014 | 皮革与化工2014，31，4： | 3 |
| 3 | Laparoscopy-assisted versus open colectomy for treatment of colon cancer in the elderly: morbidity and mortality outcomes in 545 patients显示文摘 | Francesc Vallribera Valls Filippo Landi Eloy Espín Basany José Luis Sánchez García Luis Miguel Jiménez Gómez Marc Martí Gallostra Luis Salgado Cruz Manuel Armengol Carrasco | 2014 | Surgical Endoscopy2014，，12： | 2 |
| 4 | Microleakage of class V composite restorations following Er:YAG and Nd:YAP laser irradiation compared to acid-etch: an in vitro study显示文摘 | Armengol V Jean A Enkel B | 2002 | Lasers Med Sci2002，17，2： | 1 |
| 5 | The Explanatory Power of Symbolic Similarity in Case-based Reasoning显示文摘 | Plaza E Armengol E OntaflOn S | 2005 | Artificial Intel ligence Review2005，24，2： | 1 |
| 6 | Thyroid autoimmune disease: demonstration of thyroid anti- gen-specific B cells and recombination-activating gene ex- pression in chemokine-containing active intrathyroidal ger- minal centers 显示文摘 | ARMENGOL M P JUAN M LUCAS-MARTN A | 2001 | The American Journal of Pathology2001，159，3： | 1 |
| 7 | 一种新的环境友好型鞣制方法评价显示文摘研究的目的旨在研发一种新的生产白色革的鞣制方法(我们称之为亮湿皮),以满足汽车革的所有要求。这种新的鞣制方法获得的皮革不含铬、醛、醛前体和有机溶剂。这个新体系应用来自芬兰凯米拉的Tanfor T系统,对人类和环境安全,不属于有害类。目前传统的鞣制方法通常有铬鞣革(蓝湿皮)和醛鞣革(白湿皮),新系统较之具有经济和环保优势。据此,新的方法降低COD非常显著。更具体地说,新系统比铬鞣降低了60%的COD、60%的固体悬浮物、65%的氮,是一种环境友好的方法。此外,亮湿皮减少挥发性物质的量,相对白湿皮43%,相对蓝湿皮8%。更重要的是新系统产生的废水不含铬。 | Anna Bacardit Stefan van der Burgh Jordi Armengol 陈浩 | 2014 | 西部皮革2014，36，16： | 1 |
| 8 | Fault detection and isolation of the three-tank system using the modal interval analysis显示文摘 | Miguel A Sainz Joaquim Armengol Josep Vehf | 2002 | Journal of Process Control2002，，12： | 1 |
| 9 | The explanatory power of symbolic similarity in case-based reasoning显示文摘 | PLAZA E ARMENGOL E TIAGO S | 2005 | Artificial Intelligence Review2005，24，： | 1 |
| 10 | Clinicalutilityofchromosomalmicroarrayanalysisininvasiveprenataldiagnosis显示文摘 | ArmengolL NevadoJ Serra-JuhéC etal | 2012 | HumGenet2012，131，3： | 1 |
| 11 | Quantum communications at ESA: towards a space experiment on the ISS 显示文摘 | Armengol J M P Furch B Matos C J | | Acta Astronautica0，63，14： | 1 |
| 12 | Driving factors of the phytoplankton functional groups in a deep Mediterranean reservoir显示文摘 | Becker V Caputo L Ordoniez J Marc6 R Armengol J Crossetti L O Huszar V L M | 2010 | Water Research2010，44，： | 1 |
| 13 | A Multicenter, Randomized, Clinical Trial of Hormonal Therapy in the Prevention of Rebleeding From Gastrointestinal Angiodysplasia显示文摘 | Félix Junquera Faust Feu Michel Papo Sebastián Videla José Ramón Armengol Josep Mar??a Bordas Esteban Saperas Josep M. Piqué Juan-Ramón Malagelada | 2001 | Gastroenterology2001，，5： | 1 |
| 14 | Effects of Er:YAG and Nd:YAP laser irradiation on the surface roughness and free surface energy of enamel and dentin:an in vitro study显示文摘 | Armengol V Laboux O Weiss P | 2003 | Oper Dent2003，28，1： | 1 |
| 15 | The injection of plasmid DNA in mouse muscle results in lifelong persistence of DNA, gene expression, and humoral response显示文摘 | Armengol G Ruiz L M Orduz S | 2004 | Mol Biotechnol2004，27，2： | 1 |
| 16 | Characterization of root rot disease of kiwifruit in the Black Sea re?gion of Turkey显示文摘 | ERPER I AGUSTí-BRISACH C TUNALI B ARMENGOL J | 2013 | European Journal of Plant Pathology2013，136，2： | 1 |
| 17 | Differential performance of PTSD, ADHD, and a non-clinical control gToup on tests of attention and inhi- bition 显示文摘 | Armengol CG Cavanaugh SA | 2003 | Rebi Espa de Neuropsic2003，5，1： | 1 |
| 18 | Im- pact of the total number of harvested lymph nodes after colon cancer resections on survival in patients without involved lymph node显示文摘 | Rivadulla-Serrano MI Martinez RD Armengol CM | 2010 | Rev Esp Enferm Dig2010，102，5： | 1 |
| 19 | Identification of T-cell epitopes in the structural and non-structural proteins of classical swine fever virus 显示文摘 | Armengol E Wiesmuller K H Wienhold D | 2002 | J Gen Virol2002，83，： | 1 |
| 20 | Immunomodulatory effect of plasmids co-expressing cytokines in classical swine fever virus subunit gp55/E2-DNA vaccination显示文摘 | Wienhold D Armengol E Marquardt A | 2005 | Vet Res2005，36，4： | 1 |
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