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| 1 | Attributable Causes of Breast Cancer and Ovarian Cancer in China:Reproductive Factors,Oral Contraceptives and Hormone Replacement Therapy显示文摘Objective:To provide an evidence-based,consistent assessment of the burden of breast cancer attributable to reproductive factors(RFs,including nulliparity,mean number of children,age at first birth and breastfeeding),use of oral contraceptives(OCs,restricted to the age group of 15-49 years),and hormone replacement therapy(HRT),as well as of the burden of ovarian cancer attributable to the mean number of children in China in 2005.Methods:We derived the prevalence of these risk factors and the relative risk of breast and ovarian cancer from national surveys or large-scale studies conducted in China.In the case of RFs,we compared the exposure distributions in 2001 and counterfactual exposure.Results:Exposure of RFs in 2001 was found to account for 6.74% of breast cancer,corresponding to 9,617 cases and 2,769 deaths,and for 2.78% of ovarian cancer(711 cases,294 deaths).The decrease in mean number of children alone was responsible for 1.47% of breast cancer and 2.78% of ovarian cancer.The prevalence of OC use was 1.74% and the population attributable fraction(PAF) of breast cancer was 0.71%,corresponding to 310 cases and 90 deaths.The PAF of breast cancer due to HRT was 0.31%,resulting in 297 cases and 85 deaths.Conclusion: RFs changes in China contributed to a sizable fraction of breast and ovarian cancer incidence and mortality, whereas HRT and OCs accounted for relatively low incidence of breast cancer in China. | Li Li Jia JI Jian-bing Wang Mayineur Niyazi You-lin Qiao Paolo Boffettas | 2012 | Chinese Journal of Cancer Research2012，24，1： | 38 |
| 2 | Attributable Causes of Cancer in China:Fruit and Vegetable显示文摘Objective:To provide an evidence-based and consistent assessment of the burden of cancer attributable to inadequate fruit and vegetable intake in China in 2005.Methods:The proportions of cancers attributable to low consumption of vegetable and fruit were calculated separately to estimate the burden of related cancers for the year 2005 in China.Data on the prevalence of exposure were derived from a Chinese nutrition and health survey.Data on relative risks were mainly derived from meta-analysis.Attributable fractions were calculated based on the counterfactual scenario which was a shift in the exposure distribution.Results:The total cancer burden attributable to inadequate consumption of fruit was up to 233,000 deaths (13.0% of all cancers) and 300,000 cases (11.6% of all cancers) in 2005.Increasing consumption of vegetable to the highest quintile could avoid total cancer deaths and cases by 3.6% (64,000 persons) and 3.4% (88,000 persons).The contributions to cancer burden were higher in rural areas than in urban areas.They have greater influence on men than on women.The largest proportions of cancer burden attributable to low fruit and vegetable intake were for oral and pharyngeal cancers.Conclusion:This study showed that inadequate intake of fruit and vegetable makes a significant contribution to the cancer burden.Increasing consumption of fruit and vegetable could prevent many cancer deaths and save many lives.Promoting the consumption of fruit and vegetable is an important component in diet-based strategies for preventing cancer. | Hui-juan Xiao Hao Liang Jian-bing Wang Cheng-Yu Huang Wen-qiang Wei Mathieu Boniol You-lin Qiao Paolo Boffetta | 2011 | Chinese Journal of Cancer Research2011，23，3： | 5 |
| 3 | Smokeless tobacco and cancer显示文摘 | Paolo Boffetta Stephen Hecht Nigel Gray Prakash Gupta Kurt Straif | 2008 | Lancet Oncology2008，，7： | 2 |
| 4 | Assessment of lung- cancer mortality reduction from CT screening 显示文摘 | Henschke CI Boffetta P Gorlova O | 2011 | Lung Cancer2011，71，： | 1 |
| 5 | Classic Kaposi Sarcoma-Epidemiology and Risk Factors显示文摘 | Iscovich J Boffetta P Franceshi S | 2002 | Cancer2002，88，3： | 1 |
| 6 | CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in caucasian non-smokers:a pooled analysis 显示文摘 | Hung RJ Boffetta P Broekmoller J | 2003 | Carcinogenesis2003，24，5： | 1 |
| 7 | Critical review and synthesis of the epidemiologic evidence on formaldehyde exposure and risk of leukemia and other lymph hematopoietic malignancies 显示文摘 | Checkoway H Boffetta P Mundt DJ | 2012 | Cancer Causes Control2012，23，： | 1 |
| 8 | Genome-wide associ- ation studies,field synopses,and the development of the knowledge base on genetic variation and human diseases显示文摘 | Khoury MJ Bertram L Boffetta P | 2009 | Am J Epidemiol2009，170，3： | 1 |
| 9 | Health Effects of Passive Smoking显示文摘 | Merletti F Rchiardi L Boffetta P | 1998 | Med Lay1998，89，2： | 1 |
| 10 | Lack of interaction between asbestos exposure and glutathione S-stranferase M1 and T1 genotypes in lung carcinogenesis显示文摘 | Stucker I Boffetta P Antilla S | 2001 | Cancer Epidemiol Biomarkers Prev2001，10，12： | 1 |
| 11 | Dietary patterns and risk of gastric cancer: a case-control study in Uruguay显示文摘 | Eduardo De Stefani Pelayo Correa Paolo Boffetta Hugo Deneo-Pellegrini Alvaro L. Ronco María Mendilaharsu | 2004 | Gastric Cancer2004，，4： | 1 |
| 12 | Hepatitis B virus infec- tion and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph显示文摘 | Becker N Schnitzler P Boffetta P | 2012 | J Cancer Res Clin Oncol2012，138，12： | 1 |
| 13 | Polymorphisms in CYP1A1,GSTM1 GSTT1 and lung cancer below t he age of 45 years显示文摘 | Taioli E Benhamou S Boffetta P | 2003 | Int J Epidemiology2003，32，1： | 1 |
| 14 | GST, NAT, SULT |A|, CYP |B| genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population 显示文摘 | Hung RJ Boffetta P Brennan P | 2004 | Int J Cancer2004，110，4： | 1 |
| 15 | Evidence for an important role of alcohol and aldehyde metabolizing genes in cancers of the upper aerodigestive tract 显示文摘 | Hashibe M Boffetta P Zaridze D | 2006 | Cancer Epidemiol Biomarkers Prey2006，15，4： | 1 |
| 16 | Plant foods and risk of gas- tric cancer: a case-control study in Uruguay 显示文摘 | De Stefani E Correa P Boffetta P | 2001 | Eur J Cancer Prev2001，10，4： | 1 |
| 17 | Lung cancer in never smokers:clinical epidemiology and environmental risk factors显示文摘 | Samet JM Avila-Tang E Boffetta P | 2009 | Clin Cancer Res2009，15，18： | 1 |
| 18 | p53 mutations and exposure to environmental tobacco smoke in a multicenter study on lung cancer显示文摘 | Husgafvel PK Boffetta P Kannio A | 2000 | Can Res2000，60，11： | 1 |
| 19 | A prospective study of gout and cancer显示文摘 | Boffetta P Nordenvall C Nyrén O | 2009 | Eur J Cancer Prev2009，18，2： | 1 |
| 20 | A meta-analysis of epidemiological studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma 显示文摘 | Donato F Boffetta P Puoti M | 1998 | Int J Cancer1998，75，3： | 1 |
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