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| 1 | Hepcidin/ferroportin expression levels involve efficacy of pegylated-interferon plus ribavirin in hepatitis C virusinfected liver显示文摘AIM:To investigate the relationship between the ironmetabolism-related gene expression profiles and efficacy of antiviral therapy in chronic hepatitis C patients.METHODS:The hepatic expression profile of ironmetabolism-related genes was analyzed and its association with virological response to pegylated-interferon plus ribavirin combination therapy was evaluated.A hundred patients with chronic hepatitis C(genotype1b,n = 50; genotype 2,n = 50) were enrolled and retrospectively analyzed.Liver biopsy samples were subjected to quantitative polymerase chain reaction for iron-metabolismrelated genes and protein expression(Western blotting analysis) for ferroportin.As a control,normal liver tissue was obtained from 18 living donors of liver transplantation.Serum hepcidin level was measured by sensitive liquid chromatography/electrospray ionization tandem mass spectrometry.RESULTS:Iron overload is associated with liver damage by increasing oxidative stress and hepatitis C virus(HCV)is reported to induce iron accumulation in hepatocytes in vivo.Conversely,iron administration suppresses HCV replication in vitro.Therefore,the association between HCV infection and iron metabolism remains unclear.Compared with controls,patients had significantly higher gene expression for transferrin,iron-regulatoryproteins 1 and 2,divalent metal transporter 1,and ferroportin,but similar for transferrin receptors 1 and2,and hepcidin.When the expression profiles were compared between sustained virological response(SVR)and non-SVR patients,the former showed significantly lower transcription and protein expression of hepcidin and ferroportin.Expression of hepcidin-regulating genes,BMPR1,BMPR2,and hemojuvelin,was significantly increased,whereas BMP2 was decreased in HCV-infected liver.BMPR2 and hemojuvelin expression was significantly lower in the SVR than non-SVR group.HCV infection affects the expression of iron-metabolism-related genes,leading to iron accumulation in hepatocytes.CONCLUSION:Decreased expression of hepcidin and ferroportin in SVR patients indicates the importance of hepatocytic iron retention for viral response during pegylated-interferon plus ribavirin treatment. | Motoyuki Kohjima Tsuyoshi Yoshimoto Munechika Enjoji Nobuyoshi Fukushima Kunitaka Fukuizumi Tsukasa Nakamura Miho Kurokawa Nao Fujimori Yusuke Sasaki Yasushi Shimonaka Yusuke Murata Susumu Koyama Ken Kawabe Kazuhiro Haraguchi Yorinobu Sumida Naohiko Harada Masaki Kato Kazuhiro Kotoh Makoto Nakamuta | 2015 | World Journal of Gastroenterology2015，21，11： | 4 |
| 2 | Autologous peripheral blood stem cell transplantation with granulocyte colony-stimulating factor combined conditioning regimen as a postremission therapy for acute myelogenous leukemia in first complete remission显示文摘 | Tetsuya Eto Ken Takase Toshihiro Miyamoto Yuju Ohno Tomohiko Kamimura Koji Nagafuji Yasushi Takamatsu Takanori Teshima Hisashi Gondo Shuichi Taniguchi Koichi Akashi Mine Harada | 2013 | International Journal of Hematology2013，，2： | 2 |
| 3 | Esophageal motor dysfunction plays a key role in GERD with globus sensation – Analysis of factors promoting resistance to PPI therapy显示文摘 | Hideaki Tsutsui Noriaki Manabe Masako Uno Hiroshi Imamura Tomoari Kamada Hiroaki Kusunoki Akiko Shiotani Jiro Hata Tamotsu Harada Ken Haruma | 2012 | Scandinavian Journal of Gastroenterology (-)2012，，8： | 1 |
| 4 | Clinical significance of gastrointestinal bleeding after living donor liver transplantation显示文摘 | Koichi Kimura Toru Ikegami Yuki Bekki Mizuki Ninomiya Yo‐ichi Yamashita Tomoharu Yoshizumi Shohei Yoshiya Yuji Soejima Noboru Harada Ken Shirabe Yoshihiko Maehara | 2014 | Transpl Int2014，，7： | 1 |
| 5 | Quantitative assessment of technical proficiency in performing needle-knife precut papillotomy显示文摘 | Hirotoshi Fukatsu Hirofumi Kawamoto Ryo Harada Koichiro Tsutsumi Masakuni Fujii Hironari Kato Ken Hirao Takashi Nakanishi Osamu Mizuno Tsuneyoshi Ogawa Etsuji Ishida Hiroyuki Okada Kohsaku Sakaguchi | 2009 | Surgical Endoscopy2009，，9： | 1 |
| 6 | Cardiac 64-Multislice Computed Tomography Reveals Increased Epicardial Fat Volume in Patients With Acute Coronary Syndrome显示文摘 | Ken Harada Tetsuya Amano Tadayuki Uetani Yoshiyuki Tokuda Katsuhide Kitagawa Yusaku Shimbo Ayako Kunimura Soichiro Kumagai Tomohiro Yoshida Bunichi Kato Masataka Kato Nobuyuki Marui Hideki Ishii Tatsuaki Matsubara Toyoaki Murohara | 2011 | The American Journal of Cardiology2011，，8： | 1 |
| 7 | Endoscopic 3-branched partial stent-in-stent deployment of metallic stents in high-grade malignant hilar biliary stricture (with videos) 显示文摘 | Hirofumi Kawamoto Koichiro Tsutsumi Masakuni Fujii Ryo Harada Hironari Kato Ken Hirao Naoko Kurihara Takashi Nakanishi Osamu Mizuno Etsuji Ishida Tsuneyoshi Ogawa Hirotoshi Fukatsu Kohsaku Sakaguchi | 2007 | Gastrointestinal Endoscopy2007，，： | 1 |
| 8 | IL-32 expression is an independent prognostic marker for gastric cancer显示文摘 | Sumiya Ishigami Takaaki Arigami Yasuto Uchikado Tetsuro Setoyama Yoshiaki Kita Ken Sasaki Hiroshi Okumura Hiroshi Kurahara Yuko Kijima Aya Harada Shinichi Ueno Shoji Natsugoe | 2013 | Medical Oncology2013，，2： | 1 |
| 9 | Mass spectrometric screening method for microcystins in cyanobacteria 显示文摘 | Ken - Ichi Harada Hideaki Murata | 1996 | Toxicon1996，34，6： | 1 |
| 10 | 显示文摘 | Sang-Bum Kim Ken Harada Takakazu Yamamoto | 1998 | Macromolecules1998，31，： | 1 |
| 11 | Effect of corticosteroid therapy on the progression of IgA nephropathy with moderate proteinuria显示文摘 | Takashi Uzu Tamaki Harada Mie Ko Masafumi Yamato Ken Takahara Atsushi Yamauchi | 2003 | Journal of Clinical and Experimental Nephrology2003，，3： | 1 |
| 12 | TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth显示文摘 | Ken Inoki Hongjiao Ouyang Tianqing Zhu Charlotta Lindvall Yian Wang Xiaojie Zhang Qian Yang Christina Bennett Yuko Harada Kryn Stankunas Cun-yu Wang Xi He Ormond A. MacDougald Ming You Bart O. Williams Kun-Liang Guan | 2006 | Cell2006，，5： | 1 |
| 13 | Preparation of poly (diphenylamine-4,4'-diyl) and a related random copolymers by organometallie polyeondensation:Electrieal,electrochemical and optical properties显示文摘 | Sang-Bum Kim Ken Harada Takakazu Yamamoto | 1998 | Macromolecules1998，31，： | 1 |
| 14 | Clinical characteristics of multiple primary carcinomas of the oral cavity显示文摘 | Yumi Mochizuki Hiroyuki Harada Minoru Ikuta Hiroaki Shimamoto Hirofumi Tomioka Kae Tanaka Hideaki Hirai Ken Omura | 2014 | Oral Oncology2014，，： | 1 |
| 15 | Usefulness of procalcitonin serum level for the discrimination of severe sepsis from sepsis: a multicenter prospective study显示文摘 | Shigeatsu Endo Naoki Aikawa Seitaro Fujishima Isao Sekine Kazuhiro Kogawa Yasuhiro Yamamoto Shigeki Kushimoto Hidekazu Yukioka Noboru Kato Kyoichi Totsuka Ken Kikuchi Toshiaki Ikeda Kazumi Ikeda Hiroyuki Yamada Kazuaki Harada Shinji Satomura | 2008 | Journal of Infection and Chemotherapy2008，，3： | 1 |
| 16 | Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis显示文摘 | Kosuke Okada Eiji Warabi Hirokazu Sugimoto Masaki Horie Katsutoshi Tokushige Tetsuya Ueda Nobuhiko Harada Keiko Taguchi Etsuko Hashimoto Ken Itoh Tetsuro Ishii Hirotoshi Utsunomiya Masayuki Yamamoto Junichi Shoda | 2012 | Journal of Gastroenterology2012，，8： | 1 |
| 17 | Asymmetric total synthesisofan iboga-type indole alkaloid, Voacangalaetone, Newly Isolated from Voacanga africana 显示文摘 | Masaya Harada Ken Nunettsu Asaba | 2012 | Organic Lett2012，14，22： | 1 |
| 18 | Comprehensive analysis system using liquid chromatography -mass spectrometry for the biosynthetic study of peptides produced by cyanobacteria显示文摘 | Ken ichi Harada Tomoyo Nakano Kiyonaga Fujii | 2004 | Journal of Chromatography A2004，1033，： | 1 |
| 19 | Coronary angioscopy and optical coherence tomography for confirmation of drug-coated neointimal plaque after paclitaxel-coated balloon angioplasty for in-stent restenosis显示文摘 | Kihei Yoneyama Kohei Koyama Yasuhiro Tanabe Takanobu Mitarai Ryo Kamijima Shingo Kuwata Hiroshi Yamazaki Emi Nakano Ken Kongoji Tomoo Harada Yoshihiro J. Akashi | 2014 | International Journal of Cardiology2014，，3： | 1 |
| 20 | Multicenter prospective study of procalcitonin as an indicator of sepsis显示文摘 | Naoki Aikawa Seitaro Fujishima Shigeatu Endo Isao Sekine Kazuhiro Kogawa Yasuhiro Yamamoto Shigeki Kushimoto Hidekazu Yukioka Noboru Kato Kyoichi Totsuka Ken Kikuchi Toshiaki Ikeda Kazumi Ikeda Kazuaki Harada Shinji Satomura | 2005 | Journal of Infection and Chemotherapy2005，，3： | 1 |
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