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| 1 | Extremely well-differentiated adenocarcinoma of the stomach: Clinicopathological and immunohistochemical features显示文摘瞄准:否则作为极其区分得好的腺癌(EWDA ) 知道,子宫的宫颈的最小的偏差癌被它的良性的显微镜的外观与它的好攻击的行为相对照描绘。以便阐明 clinicopathological 特征和 EWDA 的胃的对应物的生物行为,用免疫组织化学,我们为联系 oncogene 的产品的表型的表示,增生的活动,和表示分析了九损害。方法:包括外科手术前的活体检视诊断, Clinicopathological 特征被考察。用免疫组织化学,在胃的损害把 p53 和 c-erbB-2 蛋白质的索引和表示标记的 Ki-67 被检测。结果:在中间的地点或上面第三个胃和水虫息似的宏观的特征胃的 EWDA 是特征的。尽管 9 损害中的 4 个显示出仅仅焦点的淋巴或静脉的侵略,淋巴节点转移不是现在,任何一个都没损害死于病人(吝啬的后续时期, 56 瞬间) 。EWDA 的所有 9 个盒子能被分类进胃的显型(5 损害) 和肠的显型(4 损害) 。以前的类似于的胃的小凹的上皮,颈部粘液细胞或幽门的腺,而是他们的乳突的结构经常被伸长,肿瘤房间和他们的原子核稍微更大并且更亢奋与正常上皮相比色彩。后者与最小的原子非典型和不规则的腺类似于肠的组织变形;二这些损害表明了完全的肠的显型,当二表明了不完全的肠的显型时。把索引标记的 Ki-67 是低的,任何一个都没盒子揭示 p53 和 c-erbB-2 蛋白质的在表示上。结论:不同于宫颈的最小的偏差癌,这些调查结果建议胃的 EWDA 是低档恶意的损害。这有利生物行为被把索引和 p53 或 c-erbB-2 蛋白质在表示上的缺乏标记的低 Ki-67 的数据支持。因为它到有肠的组织变形的正常胃粘膜或粘膜的相似, EWDA 经常被误诊。阻止如此的损害的错误诊断,临床、病理学的特征应该被考虑。 | Takashi Yao Takashi Utsunomiya Masafumi Oya Kenichi Nishiyama Masazumi Tsuneyoshi | 2006 | World Journal of Gastroenterology2006，12，16： | 16 |
| 2 | Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations显示文摘BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD.AIM To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.METHODS This was a transactional study of 20 patients with CEAS and 98 patients with CD.CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve analysis.RESULTS Twenty Japanese patients with CEAS and 98 patients with CD were enrolled.PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% specificity.CONCLUSION PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD. | Yuichi Matsuno Junji Umeno Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto | 2019 | World Journal of Gastroenterology2019，25，14： | 5 |
| 3 | Adult case of an omphalomesenteric cyst resected by laparoscopic-assisted surgery显示文摘这份报告由帮助 laparoscopic 的外科描述脐肠系膜包囊 resected 的一个极其稀罕的成年案例。A 29-years-old 日语人被提交并且因为一个腹的团和提高的浆液 CEA (carcinoembryonic 抗原) ,承认了到九州大学医院在 2001 年 8 月的水平(21.3 ng/mL ) 。腹的 CT 和美国与中隔和石灰化表明了一个膀胱的团。腹腔镜检查显示了一个大团被纳入他的腹壁,测量 110 公里 x 70 公里 x 50 公里并且充满了粘液。团是由帮助 laparoscopic 的外科的 resected。它的墙的组织检查所见显示出纤维肌性织物,脂肪组织,石灰化,和肠的结构。是脐肠系膜包囊最后被诊断。 | Fumi Sawada Rie Yoshimura Kenichi Ito Kazuhiko Nakamura Hajime Nawata Kazuhiro Mizumoto Shuji Shimizu Takahiro Inoue Takashi Yao Masazumi Tsuneyoshi Atushi Kondo Naohiko Harada | 2006 | World Journal of Gastroenterology2006，12，5： | 2 |
| 4 | A new stereoscopic endoscopy system: Accurate 3-dimensional measurement in vitro and in vivo with distortion-correction function显示文摘 | Kenshi Yao Toshiyuki Matsui Hisashi Furukawa Tsuneyoshi Yao Toshihiro Sakurai Tomoko Mitsuyasu | 2002 | Gastrointestinal Endoscopy2002，，3： | 2 |
| 5 | Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor 显示文摘 | Fukudome K Ye X Tsuneyoshi N | 1998 | J Exp Med1998，187，7： | 1 |
| 6 | Experimental study of hexagonal and square diesel particulate filters under controlled and uncontrolled catalyzed regeneration显示文摘 | Koji Tsuneyoshi Kazuhiro Yamamoto | 2013 | Energy2013，，： | 1 |
| 7 | Subclinicai gallbladder carcinoma显示文摘 | Yamaguchi K Tsuneyoshi M | 1992 | Am J Surg1992，163，4： | 1 |
| 8 | Intramuscular myxoma:aclinicopathologic,immunohistochemical,and electron microscopic study显示文摘 | Hashimoto H Tsuneyoshi M Daimaru Y | 1986 | Cancer1986，58，3： | 1 |
| 9 | Atrial natriuretic peptide helps prevent late remodeling after left ventricular aneurysm repair 显示文摘 | Tsuneyoshi H Nishina T Nomoto T | 2004 | Circulation2004，110，11： | 1 |
| 10 | Mesenteric Phlebosclerosis显示文摘 | Akinori Iwashita M.D. Ph.D. Tsuneyoshi Yao M.D. Ph.D. Ronald J. Schlemper M.D. Ph.D. Yasuyuki Kuwano M.D. Takashi Yao M.D. Ph.D. Mitsuo Iida M.D. Ph.D. Takayuki Matsumoto M.D. Ph.D. Masahiro Kikuchi M.D. Ph.D | 2003 | Diseases of the Colon & Rectum2003，，2： | 1 |
| 11 | VEGF-C and VEGFR-3 in a series of lymphangiomas: Is superficial lymphangioma a true lymphangioma?显示文摘 | Eijun Itakura Hidetaka Yamamoto Yoshinao Oda Masutaka Furue Masazumi Tsuneyoshi | 2009 | Virchows Archiv2009，，： | 1 |
| 12 | Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock显示文摘 | TSUNEYOSHI I YAMADA H KAKIHANA Y | 2001 | Cdt Care Med2001，29，： | 1 |
| 13 | Evaluating administrative efficiency change in the post -merger period: a study on ibaraki prefecture (1979 -2004)显示文摘 | HANEDA S HASHIMOTO A TSUNEYOSHI T | 2012 | International Regional Science Review2012，35，2： | 1 |
| 14 | Low dose vasopressin infusion in patients with severe vasodilatory hypotension after prolonged hemorrhage during general anesthesia显示文摘 | Tsuneyoshi I Onomoto M Yonetani A | 2005 | J Anesth2005，19，2： | 1 |
| 15 | Giant cell tumor of bone: oncological and functional results of long-term follow-up 显示文摘 | Oda Y Miura H Tsuneyoshi M | 1998 | Jpn J Clin Oncol1998，28，5： | 1 |
| 16 | Expressionand anticoagulant function of the endothelial cell protein Creceptor (EPCR) in cancer cell lines显示文摘 | Tsuneyoshi N Fukudome K Horiguchi S | 2001 | Thromb Haemost2001，85，2： | 1 |
| 17 | The endothelial cell protein C receptor(EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries,veins,and capillaries显示文摘 | Ye X Fukudome K Tsuneyoshi N | 1999 | Biochem Biophys Res Commun1999，259，3： | 1 |
| 18 | Giant cell tumor of tile tendon sheath (nodular tenosynovitis):A study of 207 eases to eomnmn digit group显示文摘 | Ushijima M ttashimoto H Tsuneyoshi M | 1986 | Caneer1986，57，4： | 1 |
| 19 | Giant cell tumor of bone: oncological and functional results of long-term follow-up 显示文摘 | Oda Y Miura H Tsuneyoshi M | 1998 | Jpn J Clin Oncol1998，28，5： | 1 |
| 20 | Relationship between biologic behavior and phenotypic expression in intramucosal gastric carcinomas显示文摘 | Kabashima A Yao T sugimachi K Tsuneyoshi M | 2002 | Hum Pathol2002，33，1： | 1 |
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